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Entry version 146 (12 Aug 2020)
Sequence version 2 (01 Nov 1995)
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Protein

DNA utilization protein HofQ

Gene

hofQ

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the use of extracellular DNA as a nutrient (PubMed:11591672). Could be the porin responsible for transport of DNA across the outer membrane (PubMed:16707682).1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA binding Source: EcoliWiki

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG12113-MONOMER
ECOL316407:JW3354-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA utilization protein HofQ
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hofQ
Synonyms:hopQ
Ordered Locus Names:b3391, JW3354
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants show a stationary-phase competition defect during coculture with wild-type cells and an inability to utilize extracellular DNA as the sole source of carbon or energy. They have no defects in DNA uptake by electroporation or when made chemically competent (PubMed:11591672).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001310719 – 412DNA utilization protein HofQAdd BLAST394

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34749

PRoteomics IDEntifications database

More...
PRIDEi
P34749

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261394, 17 interactors

Protein interaction database and analysis system

More...
IntActi
P34749, 6 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b3391

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34749

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG4796, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006756_2_1_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34749

KEGG Orthology (KO)

More...
KOi
K02507

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34749

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1370.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001775, GspD/PilQ
IPR005644, NolW-like
IPR038591, NolW-like_sf
IPR013355, Pilus_4_PilQ
IPR011662, Secretin/TonB_short_N
IPR004846, T2SS/T3SS
IPR004845, T2SS_GspD_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00263, Secretin, 1 hit
PF03958, Secretin_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00811, BCTERIALGSPD

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00965, STN, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02515, IV_pilus_PilQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00875, T2SP_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P34749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKQWIAALLL MLIPGVQAAK PQKVTLMVDD VPVAQVLQAL AEQEKLNLVV
60 70 80 90 100
SPDVSGTVSL HLTDVPWKQA LQTVVKSAGL ITRQEGNILS VHSIAWQNNN
110 120 130 140 150
IARQEAEQAR AQANLPLENR SITLQYADAG ELAKAGEKLL SAKGSMTVDK
160 170 180 190 200
RTNRLLLRDN KTALSALEQW VAQMDLPVGQ VELSAHIVTI NEKSLRELGV
210 220 230 240 250
KWTLADAQHA GGVGQVTTLG SDLSVATATT HVGFNIGRIN GRLLDLELSA
260 270 280 290 300
LEQKQQLDII ASPRLLASHL QPASIKQGSE IPYQVSSGES GATSVEFKEA
310 320 330 340 350
VLGMEVTPTV LQKGRIRLKL HISQNVPGQV LQQADGEVLA IDKQEIETQV
360 370 380 390 400
EVKSGETLAL GGIFTRKNKS GQDSVPLLGD IPWFGQLFRH DGKEDERREL
410
VVFITPRLVS SE
Length:412
Mass (Da):44,716
Last modified:November 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99FEAEE2606682E5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z19601 Genomic DNA No translation available.
U18997 Genomic DNA Translation: AAA58188.1
U00096 Genomic DNA Translation: AAC76416.1
AP009048 Genomic DNA Translation: BAE77900.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B65134

NCBI Reference Sequences

More...
RefSeqi
NP_417850.1, NC_000913.3
WP_000815987.1, NZ_SSZK01000008.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76416; AAC76416; b3391
BAE77900; BAE77900; BAE77900

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
947901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3354
eco:b3391

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|511145.12.peg.3484

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z19601 Genomic DNA No translation available.
U18997 Genomic DNA Translation: AAA58188.1
U00096 Genomic DNA Translation: AAC76416.1
AP009048 Genomic DNA Translation: BAE77900.1
PIRiB65134
RefSeqiNP_417850.1, NC_000913.3
WP_000815987.1, NZ_SSZK01000008.1

3D structure databases

SMRiP34749
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261394, 17 interactors
IntActiP34749, 6 interactors
STRINGi511145.b3391

Proteomic databases

PaxDbiP34749
PRIDEiP34749

Genome annotation databases

EnsemblBacteriaiAAC76416; AAC76416; b3391
BAE77900; BAE77900; BAE77900
GeneIDi947901
KEGGiecj:JW3354
eco:b3391
PATRICifig|511145.12.peg.3484

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2036

Phylogenomic databases

eggNOGiCOG4796, Bacteria
HOGENOMiCLU_006756_2_1_6
InParanoidiP34749
KOiK02507
PhylomeDBiP34749

Enzyme and pathway databases

BioCyciEcoCyc:EG12113-MONOMER
ECOL316407:JW3354-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34749

Family and domain databases

Gene3Di3.30.1370.120, 1 hit
InterProiView protein in InterPro
IPR001775, GspD/PilQ
IPR005644, NolW-like
IPR038591, NolW-like_sf
IPR013355, Pilus_4_PilQ
IPR011662, Secretin/TonB_short_N
IPR004846, T2SS/T3SS
IPR004845, T2SS_GspD_CS
PfamiView protein in Pfam
PF00263, Secretin, 1 hit
PF03958, Secretin_N, 1 hit
PRINTSiPR00811, BCTERIALGSPD
SMARTiView protein in SMART
SM00965, STN, 1 hit
TIGRFAMsiTIGR02515, IV_pilus_PilQ, 1 hit
PROSITEiView protein in PROSITE
PS00875, T2SP_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHOFQ_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34749
Secondary accession number(s): Q2M756
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 1, 1995
Last modified: August 12, 2020
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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