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Protein

Syndecan-2

Gene

SDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • PDZ domain binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3000170 Syndecan interactions
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP34741

Names & Taxonomyi

Protein namesi
Recommended name:
Syndecan-2
Short name:
SYND2
Alternative name(s):
Fibroglycan
Heparan sulfate proteoglycan core protein
Short name:
HSPG
CD_antigen: CD362
Gene namesi
Name:SDC2
Synonyms:HSPG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000169439.11
HGNCiHGNC:10659 SDC2
MIMi142460 gene
neXtProtiNX_P34741

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 144ExtracellularSequence analysisAdd BLAST126
Transmembranei145 – 169HelicalSequence analysisAdd BLAST25
Topological domaini170 – 201CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6383
OpenTargetsiENSG00000169439
PharmGKBiPA35589

Chemistry databases

DrugBankiDB00020 Sargramostim

Polymorphism and mutation databases

BioMutaiSDC2
DMDMi158962336

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000003350319 – 201Syndecan-2Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi41O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi55O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi57O-linked (Xyl...) (heparan sulfate) serineSequence analysis1
Glycosylationi101O-linked (GalNAc...) threonine1 Publication1
Modified residuei115Phosphoserine; by FAM20C1 Publication1
Modified residuei187PhosphoserineCombined sources1

Post-translational modificationi

O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei142 – 143Cleavage of ectodomainSequence analysis2

Keywords - PTMi

Glycoprotein, Heparan sulfate, Phosphoprotein, Proteoglycan

Proteomic databases

EPDiP34741
PaxDbiP34741
PeptideAtlasiP34741
PRIDEiP34741
ProteomicsDBi54941

PTM databases

GlyConnecti707
iPTMnetiP34741
PhosphoSitePlusiP34741
UniCarbKBiP34741

Expressioni

Gene expression databases

BgeeiENSG00000169439 Expressed in 231 organ(s), highest expression level in tibia
CleanExiHS_SDC2
ExpressionAtlasiP34741 baseline and differential
GenevisibleiP34741 HS

Organism-specific databases

HPAiCAB025123
HPA044416

Interactioni

Subunit structurei

Interacts (via cytoplasmic domain) with SARM1 (By similarity). Forms a complex with SDCBP and PDCD6IP (PubMed:22660413).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112285, 91 interactors
DIPiDIP-29943N
IntActiP34741, 20 interactors
MINTiP34741
STRINGi9606.ENSP00000307046

Structurei

3D structure databases

ProteinModelPortaliP34741
SMRiP34741
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiP34741
KOiK16336
OMAiMQRAWIL
OrthoDBiEOG091G0OOE
PhylomeDBiP34741
TreeFamiTF320463

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P34741-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD
60 70 80 90 100
YASASGSGAD EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ
110 120 130 140 150
TKSPEETDKE KVHLSDSERK MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI
160 170 180 190 200
AGGVIGFLFA IFLILLLVYR MRKKDEGSYD LGERKPSSAA YQKAPTKEFY

A
Length:201
Mass (Da):22,160
Last modified:August 21, 2007 - v2
Checksum:i7DA4159D54741054
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7ESK6E7ESK6_HUMAN
Syndecan
SDC2
165Annotation score:
E9PBI9E9PBI9_HUMAN
Syndecan
SDC2
172Annotation score:
E5RJB8E5RJB8_HUMAN
Syndecan-2
SDC2
137Annotation score:
E5RHU3E5RHU3_HUMAN
Syndecan-2
SDC2
145Annotation score:

Sequence cautioni

The sequence AAA52701 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150I → T in BAB15150 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03467559A → T1 PublicationCorresponds to variant dbSNP:rs3816208Ensembl.1
Natural variantiVAR_03467671S → T2 PublicationsCorresponds to variant dbSNP:rs1042381Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04621 mRNA Translation: AAA52701.1 Different initiation.
AK025488 mRNA Translation: BAB15150.1
AK074530 mRNA Translation: BAG51965.1
AK097839 mRNA Translation: BAG53540.1
CH471060 Genomic DNA Translation: EAW91755.1
BC030133 mRNA Translation: AAH30133.1
BC049836 mRNA Translation: AAH49836.1
CCDSiCCDS6272.1
PIRiA33880
RefSeqiNP_002989.2, NM_002998.3
UniGeneiHs.1501
Hs.598247

Genome annotation databases

EnsembliENST00000302190; ENSP00000307046; ENSG00000169439
GeneIDi6383
KEGGihsa:6383
UCSCiuc003yhv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04621 mRNA Translation: AAA52701.1 Different initiation.
AK025488 mRNA Translation: BAB15150.1
AK074530 mRNA Translation: BAG51965.1
AK097839 mRNA Translation: BAG53540.1
CH471060 Genomic DNA Translation: EAW91755.1
BC030133 mRNA Translation: AAH30133.1
BC049836 mRNA Translation: AAH49836.1
CCDSiCCDS6272.1
PIRiA33880
RefSeqiNP_002989.2, NM_002998.3
UniGeneiHs.1501
Hs.598247

3D structure databases

ProteinModelPortaliP34741
SMRiP34741
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112285, 91 interactors
DIPiDIP-29943N
IntActiP34741, 20 interactors
MINTiP34741
STRINGi9606.ENSP00000307046

Chemistry databases

DrugBankiDB00020 Sargramostim

PTM databases

GlyConnecti707
iPTMnetiP34741
PhosphoSitePlusiP34741
UniCarbKBiP34741

Polymorphism and mutation databases

BioMutaiSDC2
DMDMi158962336

Proteomic databases

EPDiP34741
PaxDbiP34741
PeptideAtlasiP34741
PRIDEiP34741
ProteomicsDBi54941

Protocols and materials databases

DNASUi6383
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302190; ENSP00000307046; ENSG00000169439
GeneIDi6383
KEGGihsa:6383
UCSCiuc003yhv.2 human

Organism-specific databases

CTDi6383
DisGeNETi6383
EuPathDBiHostDB:ENSG00000169439.11
GeneCardsiSDC2
HGNCiHGNC:10659 SDC2
HPAiCAB025123
HPA044416
MIMi142460 gene
neXtProtiNX_P34741
OpenTargetsiENSG00000169439
PharmGKBiPA35589
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW5I Eukaryota
ENOG4111QSA LUCA
GeneTreeiENSGT00530000063116
HOGENOMiHOG000263414
HOVERGENiHBG004501
InParanoidiP34741
KOiK16336
OMAiMQRAWIL
OrthoDBiEOG091G0OOE
PhylomeDBiP34741
TreeFamiTF320463

Enzyme and pathway databases

ReactomeiR-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-HSA-2022928 HS-GAG biosynthesis
R-HSA-2024096 HS-GAG degradation
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3000170 Syndecan interactions
R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type
R-HSA-3560801 Defective B3GAT3 causes JDSSDHD
R-HSA-3656237 Defective EXT2 causes exostoses 2
R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1
R-HSA-8957275 Post-translational protein phosphorylation
R-HSA-975634 Retinoid metabolism and transport
SIGNORiP34741

Miscellaneous databases

ChiTaRSiSDC2 human
GeneWikiiSDC2
GenomeRNAii6383
PROiPR:P34741
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169439 Expressed in 231 organ(s), highest expression level in tibia
CleanExiHS_SDC2
ExpressionAtlasiP34741 baseline and differential
GenevisibleiP34741 HS

Family and domain databases

InterProiView protein in InterPro
IPR003585 Neurexin-like
IPR001050 Syndecan
IPR031201 Syndecan-2
IPR027789 Syndecan/Neurexin_dom
IPR030479 Syndecan_CS
PANTHERiPTHR10915 PTHR10915, 1 hit
PTHR10915:SF6 PTHR10915:SF6, 1 hit
PfamiView protein in Pfam
PF01034 Syndecan, 1 hit
SMARTiView protein in SMART
SM00294 4.1m, 1 hit
PROSITEiView protein in PROSITE
PS00964 SYNDECAN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSDC2_HUMAN
AccessioniPrimary (citable) accession number: P34741
Secondary accession number(s): B3KQA3, Q6PIS6, Q9H6V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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