UniProtKB - P34741 (SDC2_HUMAN)
Protein
Syndecan-2
Gene
SDC2
Organism
Homo sapiens (Human)
Status
Functioni
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).By similarity
GO - Molecular functioni
- identical protein binding Source: IntAct
- PDZ domain binding Source: BHF-UCL
GO - Biological processi
- cell migration Source: GO_Central
- cellular protein metabolic process Source: Reactome
- dendrite morphogenesis Source: GO_Central
- ephrin receptor signaling pathway Source: Reactome
- glycosaminoglycan biosynthetic process Source: Reactome
- glycosaminoglycan catabolic process Source: Reactome
- leukocyte migration Source: Reactome
- post-translational protein modification Source: Reactome
- regulation of dendrite morphogenesis Source: UniProtKB
- retinoid metabolic process Source: Reactome
Keywordsi
Biological process | Differentiation, Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | P34741 |
Reactomei | R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928, HS-GAG biosynthesis R-HSA-2024096, HS-GAG degradation R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-3000170, Syndecan interactions R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801, Defective B3GAT3 causes JDSSDHD R-HSA-3656237, Defective EXT2 causes exostoses 2 R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-3928662, EPHB-mediated forward signaling R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275, Post-translational protein phosphorylation R-HSA-975634, Retinoid metabolism and transport |
SIGNORi | P34741 |
Names & Taxonomyi
Protein namesi | Recommended name: Syndecan-2Short name: SYND2 Alternative name(s): Fibroglycan Heparan sulfate proteoglycan core protein Short name: HSPG CD_antigen: CD362 |
Gene namesi | Name:SDC2 Synonyms:HSPG1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10659, SDC2 |
MIMi | 142460, gene |
neXtProti | NX_P34741 |
VEuPathDBi | HostDB:ENSG00000169439.11 |
Subcellular locationi
Other locations
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Golgi apparatus
- Golgi lumen Source: Reactome
Lysosome
- lysosomal lumen Source: Reactome
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cell surface Source: GO_Central
- collagen-containing extracellular matrix Source: BHF-UCL
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 144 | ExtracellularSequence analysisAdd BLAST | 126 | |
Transmembranei | 145 – 169 | HelicalSequence analysisAdd BLAST | 25 | |
Topological domaini | 170 – 201 | CytoplasmicSequence analysisAdd BLAST | 32 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 6383 |
OpenTargetsi | ENSG00000169439 |
PharmGKBi | PA35589 |
Miscellaneous databases
Pharosi | P34741, Tbio |
Chemistry databases
DrugBanki | DB00020, Sargramostim |
Genetic variation databases
BioMutai | SDC2 |
DMDMi | 158962336 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000033503 | 19 – 201 | Syndecan-2Add BLAST | 183 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 41 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 55 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 57 | O-linked (Xyl...) (heparan sulfate) serineSequence analysis | 1 | |
Glycosylationi | 101 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Modified residuei | 115 | Phosphoserine; by FAM20C1 Publication | 1 | |
Modified residuei | 187 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 142 – 143 | Cleavage of ectodomainSequence analysis | 2 |
Keywords - PTMi
Glycoprotein, Heparan sulfate, Phosphoprotein, ProteoglycanProteomic databases
EPDi | P34741 |
jPOSTi | P34741 |
MassIVEi | P34741 |
PaxDbi | P34741 |
PeptideAtlasi | P34741 |
PRIDEi | P34741 |
ProteomicsDBi | 54941 |
PTM databases
GlyConnecti | 707, 1 O-Linked glycan (1 site) |
GlyGeni | P34741, 5 sites, 3 O-linked glycans (2 sites) |
iPTMneti | P34741 |
PhosphoSitePlusi | P34741 |
Expressioni
Gene expression databases
Bgeei | ENSG00000169439, Expressed in tibia and 240 other tissues |
ExpressionAtlasi | P34741, baseline and differential |
Genevisiblei | P34741, HS |
Organism-specific databases
HPAi | ENSG00000169439, Tissue enhanced (liver, thyroid gland) |
Interactioni
Subunit structurei
Interacts (via cytoplasmic domain) with SARM1 (By similarity).
Forms a complex with SDCBP and PDCD6IP (PubMed:22660413).
By similarity1 PublicationBinary interactionsi
Hide detailsP34741
GO - Molecular functioni
- identical protein binding Source: IntAct
- PDZ domain binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112285, 98 interactors |
CORUMi | P34741 |
DIPi | DIP-29943N |
IntActi | P34741, 87 interactors |
MINTi | P34741 |
STRINGi | 9606.ENSP00000307046 |
Miscellaneous databases
RNActi | P34741, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P34741 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the syndecan proteoglycan family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZ6V, Eukaryota |
GeneTreei | ENSGT00940000157222 |
HOGENOMi | CLU_046599_2_1_1 |
InParanoidi | P34741 |
OMAi | MNPAEEN |
OrthoDBi | 1362808at2759 |
PhylomeDBi | P34741 |
TreeFami | TF320463 |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031201, Syndecan-2 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF6, PTHR10915:SF6, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
P34741-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD
60 70 80 90 100
YASASGSGAD EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ
110 120 130 140 150
TKSPEETDKE KVHLSDSERK MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI
160 170 180 190 200
AGGVIGFLFA IFLILLLVYR MRKKDEGSYD LGERKPSSAA YQKAPTKEFY
A
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7ESK6 | E7ESK6_HUMAN | Syndecan | SDC2 | 165 | Annotation score: | ||
E9PBI9 | E9PBI9_HUMAN | Syndecan | SDC2 | 172 | Annotation score: | ||
E5RHU3 | E5RHU3_HUMAN | Syndecan-2 | SDC2 | 145 | Annotation score: | ||
E5RJB8 | E5RJB8_HUMAN | Syndecan-2 | SDC2 | 137 | Annotation score: |
Sequence cautioni
The sequence AAA52701 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 150 | I → T in BAB15150 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034675 | 59 | A → T1 PublicationCorresponds to variant dbSNP:rs3816208Ensembl. | 1 | |
Natural variantiVAR_034676 | 71 | S → T2 PublicationsCorresponds to variant dbSNP:rs1042381Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04621 mRNA Translation: AAA52701.1 Different initiation. AK025488 mRNA Translation: BAB15150.1 AK074530 mRNA Translation: BAG51965.1 AK097839 mRNA Translation: BAG53540.1 CH471060 Genomic DNA Translation: EAW91755.1 BC030133 mRNA Translation: AAH30133.1 BC049836 mRNA Translation: AAH49836.1 |
CCDSi | CCDS6272.1 |
PIRi | A33880 |
RefSeqi | NP_002989.2, NM_002998.3 |
Genome annotation databases
Ensembli | ENST00000302190; ENSP00000307046; ENSG00000169439 |
GeneIDi | 6383 |
KEGGi | hsa:6383 |
UCSCi | uc003yhv.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J04621 mRNA Translation: AAA52701.1 Different initiation. AK025488 mRNA Translation: BAB15150.1 AK074530 mRNA Translation: BAG51965.1 AK097839 mRNA Translation: BAG53540.1 CH471060 Genomic DNA Translation: EAW91755.1 BC030133 mRNA Translation: AAH30133.1 BC049836 mRNA Translation: AAH49836.1 |
CCDSi | CCDS6272.1 |
PIRi | A33880 |
RefSeqi | NP_002989.2, NM_002998.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6ITH | NMR | - | A | 143-173 | [»] | |
SMRi | P34741 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112285, 98 interactors |
CORUMi | P34741 |
DIPi | DIP-29943N |
IntActi | P34741, 87 interactors |
MINTi | P34741 |
STRINGi | 9606.ENSP00000307046 |
Chemistry databases
DrugBanki | DB00020, Sargramostim |
PTM databases
GlyConnecti | 707, 1 O-Linked glycan (1 site) |
GlyGeni | P34741, 5 sites, 3 O-linked glycans (2 sites) |
iPTMneti | P34741 |
PhosphoSitePlusi | P34741 |
Genetic variation databases
BioMutai | SDC2 |
DMDMi | 158962336 |
Proteomic databases
EPDi | P34741 |
jPOSTi | P34741 |
MassIVEi | P34741 |
PaxDbi | P34741 |
PeptideAtlasi | P34741 |
PRIDEi | P34741 |
ProteomicsDBi | 54941 |
Protocols and materials databases
Antibodypediai | 25987, 284 antibodies |
DNASUi | 6383 |
Genome annotation databases
Ensembli | ENST00000302190; ENSP00000307046; ENSG00000169439 |
GeneIDi | 6383 |
KEGGi | hsa:6383 |
UCSCi | uc003yhv.2, human |
Organism-specific databases
CTDi | 6383 |
DisGeNETi | 6383 |
GeneCardsi | SDC2 |
HGNCi | HGNC:10659, SDC2 |
HPAi | ENSG00000169439, Tissue enhanced (liver, thyroid gland) |
MIMi | 142460, gene |
neXtProti | NX_P34741 |
OpenTargetsi | ENSG00000169439 |
PharmGKBi | PA35589 |
VEuPathDBi | HostDB:ENSG00000169439.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZ6V, Eukaryota |
GeneTreei | ENSGT00940000157222 |
HOGENOMi | CLU_046599_2_1_1 |
InParanoidi | P34741 |
OMAi | MNPAEEN |
OrthoDBi | 1362808at2759 |
PhylomeDBi | P34741 |
TreeFami | TF320463 |
Enzyme and pathway databases
PathwayCommonsi | P34741 |
Reactomei | R-HSA-1971475, A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928, HS-GAG biosynthesis R-HSA-2024096, HS-GAG degradation R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-3000170, Syndecan interactions R-HSA-3560783, Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801, Defective B3GAT3 causes JDSSDHD R-HSA-3656237, Defective EXT2 causes exostoses 2 R-HSA-3656253, Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-3928662, EPHB-mediated forward signaling R-HSA-4420332, Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275, Post-translational protein phosphorylation R-HSA-975634, Retinoid metabolism and transport |
SIGNORi | P34741 |
Miscellaneous databases
BioGRID-ORCSi | 6383, 4 hits in 992 CRISPR screens |
ChiTaRSi | SDC2, human |
GeneWikii | SDC2 |
GenomeRNAii | 6383 |
Pharosi | P34741, Tbio |
PROi | PR:P34741 |
RNActi | P34741, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169439, Expressed in tibia and 240 other tissues |
ExpressionAtlasi | P34741, baseline and differential |
Genevisiblei | P34741, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003585, Neurexin-like IPR001050, Syndecan IPR031201, Syndecan-2 IPR027789, Syndecan/Neurexin_dom IPR030479, Syndecan_CS |
PANTHERi | PTHR10915, PTHR10915, 1 hit PTHR10915:SF6, PTHR10915:SF6, 1 hit |
Pfami | View protein in Pfam PF01034, Syndecan, 1 hit |
SMARTi | View protein in SMART SM00294, 4.1m, 1 hit |
PROSITEi | View protein in PROSITE PS00964, SYNDECAN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SDC2_HUMAN | |
Accessioni | P34741Primary (citable) accession number: P34741 Secondary accession number(s): B3KQA3, Q6PIS6, Q9H6V1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | August 21, 2007 | |
Last modified: | April 7, 2021 | |
This is version 192 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families