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UniProtKB - P34739 (TTF2_DROME)
Protein
Transcription termination factor 2
Gene
lds
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 465 – 472 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent activity, acting on DNA Source: FlyBase
- ATP-dependent chromatin remodeler activity Source: InterPro
- DNA binding Source: UniProtKB-KW
- helicase activity Source: UniProtKB-KW
- hydrolase activity Source: UniProtKB-KW
GO - Biological processi
- DNA-templated transcription, termination Source: FlyBase
- female meiotic nuclear division Source: FlyBase
- microtubule anchoring at centrosome Source: FlyBase
- spermatogenesis Source: FlyBase
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | Transcription, Transcription regulation, Transcription termination |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | P34739 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription termination factor 2 (EC:3.6.4.-)Alternative name(s): Protein lodestar RNA polymerase II termination factor Transcription release factor 2 |
Gene namesi | Name:lds ORF Names:CG2684 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0002542, lds |
VEuPathDBi | VectorBase:FBgn0002542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074378 | 1 – 1061 | Transcription termination factor 2Add BLAST | 1061 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 108 | Phosphoserine1 Publication | 1 | |
Modified residuei | 110 | Phosphoserine1 Publication | 1 | |
Modified residuei | 214 | Phosphoserine1 Publication | 1 | |
Modified residuei | 215 | Phosphoserine1 Publication | 1 | |
Modified residuei | 216 | Phosphothreonine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P34739 |
PRIDEi | P34739 |
PTM databases
iPTMneti | P34739 |
Expressioni
Gene expression databases
Bgeei | FBgn0002542, Expressed in female gonad and 30 other tissues |
ExpressionAtlasi | P34739, baseline and differential |
Genevisiblei | P34739, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 69962, 9 interactors |
DIPi | DIP-20026N |
IntActi | P34739, 6 interactors |
MINTi | P34739 |
STRINGi | 7227.FBpp0081255 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 452 – 652 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 201 | |
Domaini | 891 – 1056 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 166 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 163 | DisorderedSequence analysisAdd BLAST | 163 | |
Regioni | 212 – 253 | DisorderedSequence analysisAdd BLAST | 42 | |
Regioni | 485 – 523 | DisorderedSequence analysisAdd BLAST | 39 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 603 – 606 | DEAH box | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 15 – 52 | Polar residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 212 – 229 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 237 – 253 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 487 – 523 | Basic and acidic residuesSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the SNF2/RAD54 helicase family.Curated
Phylogenomic databases
eggNOGi | KOG4439, Eukaryota |
GeneTreei | ENSGT00940000162718 |
HOGENOMi | CLU_000315_2_9_1 |
InParanoidi | P34739 |
OMAi | FAQFLFQ |
OrthoDBi | 132523at2759 |
PhylomeDBi | P34739 |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
P34739-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSENSEYYS DKEEDSVVNN SSLGRSRKSS RLSKSSRLSK SSRPSSAGVV
60 70 80 90 100
IDETQSEEEE SQSSETAESE KSDESDNSQN SQESEDSEDD SVRPSARNTK
110 120 130 140 150
RKPLGIPSDS EDEEDELEQR ALSPSTRMSI TGVRPQDLSD DDSEIEYSDE
160 170 180 190 200
VQEGPTEAPT AEAVVPRYTT QFAGNIQNDL HSTIGAADSE VLDDSSGSDV
210 220 230 240 250
LILSNKETPI EILSSTDDDA TTNKENMSGP PFERPSKSLS PRSSAGASVV
260 270 280 290 300
KTSKNLSQPT IQAVLKQKTS PAAPRRSRIK SEDQKVVSQV VYDEEMRKLA
310 320 330 340 350
EKRVQVSDAE KLFEKVAHKL PDKGSQIMKR IDTLRRELAM DEQWISALRV
360 370 380 390 400
QQSNVPAVRV VKPTLNPPRA PSIDTLDWDE LSEAVNEIKP VYTGAQGMAT
410 420 430 440 450
FNNQKALTLE SLKDLHVSLE DLPGPEVLAE DPVGLKVSLM NHQKHALAWM
460 470 480 490 500
SWRERKLPRG GILADDMGLG KTLTMISSVL ACKNGQEMSE GKDESSDSDS
510 520 530 540 550
EDDKNKKRKS VTGWKSKGRK DTRRGGTLVV CPASLLRQWE SEVESKVSRQ
560 570 580 590 600
KLTVCVHHGN NRETKGKYLR DYDIVVTTYQ IVAREHKSLS AVFGVKWRRI
610 620 630 640 650
ILDEAHVVRN HKSQSSLAVC DLRGKYRWAL TGTPIQNKEL DVYALLKFLR
660 670 680 690 700
CSPFDDLHTW KKWIDNKSAG GQNRLNLLMK SLMLRRTKAQ LQSDGKLNSL
710 720 730 740 750
PNKELRLIEI SLDKEEMNVY QTVMTYSRTL FAQFLHQRAE RETDFNYRSD
760 770 780 790 800
ANKPTYNQIK DPNGAYYKMH EKFARMAGSK KEVKSHDILV LLLRLRQICC
810 820 830 840 850
HPGLIDAMLD GEESQTMGDH SSDSDTPEID LLAQLNKLAI TDTSTDGQQS
860 870 880 890 900
VANAGDDGPP LLPDEARIAK ASKNLLKRSN PVFNLHRPSS KINMVIQILK
910 920 930 940 950
TSILKSSDDK AIVVSQWTSV LDILRDHLSK DGVATLSLNG TIPVKNRQDI
960 970 980 990 1000
VNEFNDRNNQ KRVLLLSLTA GGVGLNLIGA NHLLLLDLHW NPQLEAQAQD
1010 1020 1030 1040 1050
RIYRVGQKKN VIIYKFMCVD TVEQRIKGLQ DKKLDLADGV LTGAKVSSKL
1060
TIDDLKGLFG M
Sequence cautioni
The sequence CAA44496 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | R → G in CAA44496 (PubMed:1916263).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62629 mRNA Translation: CAA44496.1 Frameshift. AE014297 Genomic DNA Translation: AAF54167.1 |
PIRi | A40580 |
RefSeqi | NP_524850.2, NM_080111.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0081758; FBpp0081255; FBgn0002542 |
GeneIDi | 45894 |
KEGGi | dme:Dmel_CG2684 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62629 mRNA Translation: CAA44496.1 Frameshift. AE014297 Genomic DNA Translation: AAF54167.1 |
PIRi | A40580 |
RefSeqi | NP_524850.2, NM_080111.4 |
3D structure databases
AlphaFoldDBi | P34739 |
SMRi | P34739 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 69962, 9 interactors |
DIPi | DIP-20026N |
IntActi | P34739, 6 interactors |
MINTi | P34739 |
STRINGi | 7227.FBpp0081255 |
PTM databases
iPTMneti | P34739 |
Proteomic databases
PaxDbi | P34739 |
PRIDEi | P34739 |
Genome annotation databases
EnsemblMetazoai | FBtr0081758; FBpp0081255; FBgn0002542 |
GeneIDi | 45894 |
KEGGi | dme:Dmel_CG2684 |
Organism-specific databases
CTDi | 45894 |
FlyBasei | FBgn0002542, lds |
VEuPathDBi | VectorBase:FBgn0002542 |
Phylogenomic databases
eggNOGi | KOG4439, Eukaryota |
GeneTreei | ENSGT00940000162718 |
HOGENOMi | CLU_000315_2_9_1 |
InParanoidi | P34739 |
OMAi | FAQFLFQ |
OrthoDBi | 132523at2759 |
PhylomeDBi | P34739 |
Enzyme and pathway databases
SignaLinki | P34739 |
Miscellaneous databases
BioGRID-ORCSi | 45894, 1 hit in 3 CRISPR screens |
GenomeRNAii | 45894 |
PROi | PR:P34739 |
Gene expression databases
Bgeei | FBgn0002542, Expressed in female gonad and 30 other tissues |
ExpressionAtlasi | P34739, baseline and differential |
Genevisiblei | P34739, DM |
Family and domain databases
Gene3Di | 3.40.50.10810, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR038718, SNF2-like_sf IPR000330, SNF2_N |
Pfami | View protein in Pfam PF00271, Helicase_C, 1 hit PF00176, SNF2-rel_dom, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TTF2_DROME | |
Accessioni | P34739Primary (citable) accession number: P34739 Secondary accession number(s): Q9VHY1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | May 9, 2003 | |
Last modified: | May 25, 2022 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families