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Entry version 126 (16 Oct 2019)
Sequence version 1 (01 Feb 1994)
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Protein

Sex-determining transformer protein 2

Gene

tra-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a major role in controlling sexual cell fates. Promotes female development in XX animals where it sequesters one or more of the FEM proteins to the membrane thereby freeing the tra-1 protein (a putative transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis. Also required for feminizing tra-3 activity.8 Publications

Miscellaneous

Isoform Tra-2B is likely to be cytoplasmic because it lacks an N-terminal sequence and potential membrane spanning domains.
The MX region mediates a post-translational regulation, essential for the onset of hermaphrodite spermatogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processDifferentiation, Sexual differentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sex-determining transformer protein 2
Alternative name(s):
Ce-Tra-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tra-2
ORF Names:C15F1.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C15F1.3a ; CE23546 ; WBGene00006605 ; tra-2
C15F1.3b ; CE23547 ; WBGene00006605 ; tra-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Transmembranei496 – 516HelicalSequence analysisAdd BLAST21
Transmembranei589 – 609HelicalSequence analysisAdd BLAST21
Transmembranei737 – 757HelicalSequence analysisAdd BLAST21
Transmembranei902 – 922HelicalSequence analysisAdd BLAST21
Transmembranei928 – 948HelicalSequence analysisAdd BLAST21
Transmembranei952 – 972HelicalSequence analysisAdd BLAST21
Transmembranei979 – 999HelicalSequence analysisAdd BLAST21
Transmembranei1034 – 1054HelicalSequence analysisAdd BLAST21
Transmembranei1060 – 1080HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1392C → Y: Prevents binding with tra-1. 1 Publication1
Mutagenesisi1393E → K: Causes weak somatic masculinization; prevents binding with tra-1. 2 Publications1
Mutagenesisi1400R → Q: Causes weak somatic masculinization; prevents binding with tra-1. 2 Publications1
Mutagenesisi1411P → L: Causes weak somatic masculinization. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002257432 – 1475Sex-determining transformer protein 2Add BLAST1444

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes cleavage by tra-3 to produce a feminizing carboxy-terminal isoform Tra-2B.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1088 – 1089Cleavage; by tra-32

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34709

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34709

PRoteomics IDEntifications database

More...
PRIDEi
P34709

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34709

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P34709

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Somatic and germline tissues. Isoform Tra-2B is specific to oocytes.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006605 Expressed in 5 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34709 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tra-1 and fem-3.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
39475, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P34709, 2 interactors

Molecular INTeraction database

More...
MINTi
P34709

STRING: functional protein association networks

More...
STRINGi
6239.C15F1.3a

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1133 – 1273Interaction with fem-3Add BLAST141
Regioni1392 – 1413MX regulatory domain; required for tra-1 bindingAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1100 – 1475Pro-richAdd BLAST376

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410K9HH Eukaryota
ENOG4110JA7 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34709

Identification of Orthologs from Complete Genome Data

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OMAi
SIWTIER

Database of Orthologous Groups

More...
OrthoDBi
1388750at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032848 Ce-Tra-2

The PANTHER Classification System

More...
PANTHERi
PTHR39365 PTHR39365, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Tra-2A (identifier: P34709-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLKYNKLLV SVVIVTFVTF GLLLAECFGK SIDYQEKSIF PSFVSQGFFE
60 70 80 90 100
TRTNNEEYII EKIAQTQENG VDMRSTLHFT QHGYLLNNIS NLKIKFRQKT
110 120 130 140 150
YTLNDVCFKP HITIFQQSSS SDQNEYPHYI QRLLLEMQRL SPCLIVTPLN
160 170 180 190 200
CFYDIYRIHG EISNWNKNTD FLNRRLRNSY IEAIGENDER PYVKSNYGPS
210 220 230 240 250
LIKSWADHMF DLPSKSFTNS TKDALFQKIK LWLLSIEPRQ KTCAASIHSC
260 270 280 290 300
DTPLDSEHYF NICTDMQSVD NFAEKKTKFK LEDVDEEFAM NLDCVDDQEQ
310 320 330 340 350
FIEWMQELEI RKMYSHVTEK PDYPNVVNQT CDKIFHDLNS TGIEFFDGSR
360 370 380 390 400
SFSSTKSQFD TMQTEIVLLT PEMLLSAMQH SDFVNGFESI WTIEKAEELI
410 420 430 440 450
HEFRLALKEE TEKFKENRMS KMIRVTSRVL DNTVTTKLQS FSEKQTIHFV
460 470 480 490 500
VNVHSLIVIL FTIFVWSGAP LRSAFMFFVR DALTCLLFCF VCSTDGVIVL
510 520 530 540 550
DTELIKYIIV LTLANLYFTT RSSFCTERLS RCIQREKRFP INSNFASLIT
560 570 580 590 600
VDTMTDSRQI QYFLSTVTKY QAAQDSYSNE LFERFPKNWG CTSILIFPIV
610 620 630 640 650
FVYWYFIDSN FDKICVSVLP SFCLAAGEEL FAKNMFWKER EAMQAKQRLE
660 670 680 690 700
NEEQAESITG SSLEKLFAGN KPVSNTDKAN IVKKSSIIRN QKPCLQDLSP
710 720 730 740 750
GTYDVSNFMK YPHQASRIFR EKIIGLYLRI LKLRTLGVIL CIPAILLIVI
760 770 780 790 800
SIGLLFIPVK RETLHTDSKQ DDIFIEFEIF NFSTNWKIVN QNLKQFSEDI
810 820 830 840 850
ESIGTLYTIS NWQKSFERFE QETNKNASAE WNILFKWIND EPINSAVTLF
860 870 880 890 900
SEKSSGNQTI ANPFKFRLRY GFDAKNETTV IEIVQKIDEL LSKCSKNLSP
910 920 930 940 950
KAVGVLYEHY HRIAVVWNLF AFNQLTTAGI FIILLSIITF IFAITPTIKA
960 970 980 990 1000
TFLFSLLVVG TQIEVAALVH LFSLDHHQIY TNLALFAGFL AAWDPFCALL
1010 1020 1030 1040 1050
RYRRRILYKS ETRRTPELAS KRRVLLPIVA TADIAQFFVL LITAFSILAI
1060 1070 1080 1090 1100
ICSIVPELNI FFVPTVILIV IQIVAVFNSI IVSIATKQMF ESEVRHYLHR
1110 1120 1130 1140 1150
DLRGSTTAVR VYNLVQKQRL ASSLDEPQVE LDEFSIKRSS PPCRYYAPPP
1160 1170 1180 1190 1200
KYSCKKRSRS SDEDEDSDPN QPGPSNRRSP KTGNKRVRGN GDNTELYIPN
1210 1220 1230 1240 1250
RYELIVSGKS VGGNTSAAWN GPGSTLEQNM NALEECFELG VDEYDFDEHD
1260 1270 1280 1290 1300
GDEGCELVQD MLDRERNLMN KRSTAQRRES RNIEKMKKSQ ENLDKEKSEE
1310 1320 1330 1340 1350
KISESKKNQD DSIESPNLPG TPANLPVDEP LPPVGRLYIV EHVLPEEYRR
1360 1370 1380 1390 1400
DPLTEPPSME DCIRAHSDPN LPPHPRADQY PASFTRPMVE YCEDIYWTHR
1410 1420 1430 1440 1450
TGQLPPGLQV PRRPYDYYHI TERTPPPEDL NWVPPAESPP IPIPQQAFDL
1460 1470
LEERRRNHRE QQDEAREGDL SDPEV
Length:1,475
Mass (Da):170,353
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8C6456B3D3654BE
GO
Isoform b (identifier: P34709-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1044-1147: AFSILAIICS...RSSPPCRYYA → EFPKREVTCQ...EKGTQKESGC
     1148-1475: Missing.

Note: No experimental confirmation available.
Show »
Length:1,147
Mass (Da):133,168
Checksum:i5B083B97EB9AA13D
GO
Isoform Tra-2B (identifier: P34709-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1088: Missing.

Note: Produced by alternative initiation at Met-1089 of isoform Tra-2A.
Show »
Length:387
Mass (Da):44,562
Checksum:i320ACB21F322928A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G8JY28G8JY28_CAEEL
Sex-determining transformer protein...
tra-2 C15F1.3, CELE_C15F1.3
387Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti134 – 139LLEMQR → FLKCNV in AAM09789 (PubMed:12019226).Curated6

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0188231 – 1088Missing in isoform Tra-2B. CuratedAdd BLAST1088
Alternative sequenceiVSP_0117461044 – 1147AFSIL…CRYYA → EFPKREVTCQNWWPFSSSRS SICSFFFHSHPSSIILATLS IFRQYIYLFSLFSFSHSSSD VSNKKSRGYCRCMSCFSIFF QRVWPQEHWNTANNEKGTQK ESGC in isoform b. CuratedAdd BLAST104
Alternative sequenceiVSP_0117471148 – 1475Missing in isoform b. CuratedAdd BLAST328

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M91371 mRNA Translation: AAA28150.1
S42187 mRNA Translation: AAB22845.1
FO080553 Genomic DNA Translation: CCD64611.1
FO080553 Genomic DNA Translation: CCD64612.1
AF491489 Genomic DNA Translation: AAM09771.1
AF491490 Genomic DNA Translation: AAM09772.1
AF491491 Genomic DNA Translation: AAM09773.1
AF491492 Genomic DNA Translation: AAM09774.1
AF491493 Genomic DNA Translation: AAM09775.1
AF491494 Genomic DNA Translation: AAM09776.1
AF491495 Genomic DNA Translation: AAM09777.1
AF491496 Genomic DNA Translation: AAM09778.1
AF491497 Genomic DNA Translation: AAM09779.1
AF491498 Genomic DNA Translation: AAM09780.1
AF491499 Genomic DNA Translation: AAM09781.1
AF491500 Genomic DNA Translation: AAM09782.1
AF491501 Genomic DNA Translation: AAM09783.1
AF491502 Genomic DNA Translation: AAM09784.1
AF491503 Genomic DNA Translation: AAM09785.1
AF491504 Genomic DNA Translation: AAM09786.1
AF491505 Genomic DNA Translation: AAM09787.1
AF491506 Genomic DNA Translation: AAM09788.1
AF491507 Genomic DNA Translation: AAM09789.1

Protein sequence database of the Protein Information Resource

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PIRi
A60026

NCBI Reference Sequences

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RefSeqi
NP_001021954.1, NM_001026783.3 [P34709-2]
NP_495426.1, NM_063025.7 [P34709-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C15F1.3a.1; C15F1.3a.1; WBGene00006605 [P34709-1]
C15F1.3b.1; C15F1.3b.1; WBGene00006605 [P34709-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
174137

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_C15F1.3

UCSC genome browser

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UCSCi
C15F1.3a.1 c. elegans [P34709-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91371 mRNA Translation: AAA28150.1
S42187 mRNA Translation: AAB22845.1
FO080553 Genomic DNA Translation: CCD64611.1
FO080553 Genomic DNA Translation: CCD64612.1
AF491489 Genomic DNA Translation: AAM09771.1
AF491490 Genomic DNA Translation: AAM09772.1
AF491491 Genomic DNA Translation: AAM09773.1
AF491492 Genomic DNA Translation: AAM09774.1
AF491493 Genomic DNA Translation: AAM09775.1
AF491494 Genomic DNA Translation: AAM09776.1
AF491495 Genomic DNA Translation: AAM09777.1
AF491496 Genomic DNA Translation: AAM09778.1
AF491497 Genomic DNA Translation: AAM09779.1
AF491498 Genomic DNA Translation: AAM09780.1
AF491499 Genomic DNA Translation: AAM09781.1
AF491500 Genomic DNA Translation: AAM09782.1
AF491501 Genomic DNA Translation: AAM09783.1
AF491502 Genomic DNA Translation: AAM09784.1
AF491503 Genomic DNA Translation: AAM09785.1
AF491504 Genomic DNA Translation: AAM09786.1
AF491505 Genomic DNA Translation: AAM09787.1
AF491506 Genomic DNA Translation: AAM09788.1
AF491507 Genomic DNA Translation: AAM09789.1
PIRiA60026
RefSeqiNP_001021954.1, NM_001026783.3 [P34709-2]
NP_495426.1, NM_063025.7 [P34709-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi39475, 6 interactors
IntActiP34709, 2 interactors
MINTiP34709
STRINGi6239.C15F1.3a

PTM databases

iPTMnetiP34709

Proteomic databases

EPDiP34709
PaxDbiP34709
PRIDEiP34709

Genome annotation databases

EnsemblMetazoaiC15F1.3a.1; C15F1.3a.1; WBGene00006605 [P34709-1]
C15F1.3b.1; C15F1.3b.1; WBGene00006605 [P34709-2]
GeneIDi174137
KEGGicel:CELE_C15F1.3
UCSCiC15F1.3a.1 c. elegans [P34709-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
174137
WormBaseiC15F1.3a ; CE23546 ; WBGene00006605 ; tra-2
C15F1.3b ; CE23547 ; WBGene00006605 ; tra-2

Phylogenomic databases

eggNOGiENOG410K9HH Eukaryota
ENOG4110JA7 LUCA
InParanoidiP34709
OMAiSIWTIER
OrthoDBi1388750at2759

Miscellaneous databases

PMAP-CutDBiP34709

Protein Ontology

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PROi
PR:P34709

Gene expression databases

BgeeiWBGene00006605 Expressed in 5 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiP34709 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR032848 Ce-Tra-2
PANTHERiPTHR39365 PTHR39365, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRA2_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34709
Secondary accession number(s): Q8STA8
, Q8STE2, Q8T5X5, Q8T5X6, Q8T5X7, Q8T5X8, Q8T5X9, Q8T5Y0, Q8T5Y1, Q8T5Y2, Q8T5Y3, Q8T5Y4, Q8T5Y5, Q9N5Y5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 16, 2019
This is version 126 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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