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Entry version 178 (11 Dec 2019)
Sequence version 2 (27 May 2002)
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Protein

Protein skinhead-1

Gene

skn-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor required to specify the fate of ventral blastomeres in the early embryo, and postembryonically for the development of the intestine. Directly regulates expression of zygotically expressed med-1 and med-2 to direct mesendoderm development (PubMed:1547503, PubMed:11463373). Required for stl-1 mRNA up-regulation in response to oxidative stress and anoxia. Required for the up-regulation of gcs-1 and several glutathione-S-transferase mRNAs in response to oxidative stress generated during pathogenic bacterial infection (PubMed:22216003). In neurons, involved in mitochondrial fusion and behavioral recovery during reoxygenation (PubMed:24385935). Required for riok-1 mRNA expression in the intestine (PubMed:25688864). Downstream of the let-60/Ras, mek-2 and pmk-1 pathway, positively regulates lifespan probably by preventing transcription of insulin-like peptides such as ins-39 (PubMed:20624915). Prevents degeneration of dopaminergic CEP neurons in response to high Al3+ or Mn2+ levels, probably by promoting the expression of glutathione-S-transferase gst-1 (PubMed:23106139, PubMed:23721876).8 Publications
Directed by the ER-associated degradation pathway (ERAD), mediates proteasomal homeostasis by regulating the expression of proteasomal subunits such as rpt-3 to confer resistance to proteasomal dysfunction.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processStress response, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-983231 Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P34707

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein skinhead-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:skn-1
ORF Names:T19E7.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

WormBase

More...
WormBasei
T19E7.2a ; CE27591 ; WBGene00004804 ; skn-1
T19E7.2b ; CE31238 ; WBGene00004804 ; skn-1
T19E7.2c ; CE31239 ; WBGene00004804 ; skn-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable, but there is failed activation of the expression of the proteasomal subunit rpt-3 in all tissues (PubMed:27528192). Treatment with the proteasome inhibitor bortezomib or knockout with rpn-10 RNAi results in larval lethality (PubMed:27528192). Double knockout with pbs-5 results in failed expression the proteasomal subunit rpt-3 (PubMed:27528192). RNAi-mediated knockdown of all isoforms results in a severe reduction in transcription of gst-4, gst-5, gst-7 and gcs-1 mRNAs during infection by P.aeruginosa or P.faecalis (PubMed:22216003). Susceptibility to P.aeruginosa and P.faecalis is characterized by a decrease in survival rate (PubMed:22216003). Also causes a loss of transcription of riok-1 mRNA in intestine (PubMed:25688864). Reduces life span (PubMed:20624915). Moderate increase in transcription of ins-39 mRNA (PubMed:20624915). Moderate increase in CEP neuron death in response to high Al3+ levels (PubMed:23106139). RNAi-mediated knockdown causes an increase in Mn2+-mediated dopaminergic CEP neuron degeneration and a reduction in expression levels of glutathione S-transferase gst-1 (PubMed:23721876).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi164S → A: Abolishes phosphorylation by pmk-1. Loss of nuclear translocation and increased susceptibility in response to arsenite treatment; when associated with A-430. Loss of nuclear translocation in a trx-1(ok1449) mutant background; when associated with A-430. 2 Publications1
Mutagenesisi430S → A: Abolishes phosphorylation by pmk-1. Loss of nuclear translocation and increased susceptibility in response to arsenite treatment; when associated with A-164. Loss of nuclear translocation in a trx-1(ok1449) mutant background; when associated with A-164. 2 Publications1

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2146298

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000766391 – 623Protein skinhead-1Add BLAST623

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei164Phosphoserine; by pmk-12 Publications1
Modified residuei430Phosphoserine; by pmk-12 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Cleaved by the aspartic protease ddi-1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34707

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P34707

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Postembryonic intestinal cells.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004804 Expressed in 6 organ(s), highest expression level in multi-cellular organism

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34707 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
42465, 5 interactors

Protein interaction database and analysis system

More...
IntActi
P34707, 5 interactors

STRING: functional protein association networks

More...
STRINGi
6239.T19E7.2a

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P34707

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1623
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P34707

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P34707

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni540 – 623Basic motifBy similarityAdd BLAST84

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Alternative DNA-binding strategy due to lack of a leucine zipper dimerization segment: DNA binding domain binds to its cognate half-site, an N-terminal arm recognizes adjacent 5' AT-rich sequences in the minor groove and the intervening residues stabilize interactions of these two subdomains with DNA.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. Skn1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3863 Eukaryota
ENOG410ZGMS LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00970000196407

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000021747

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P34707

KEGG Orthology (KO)

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KOi
K05638

Identification of Orthologs from Complete Genome Data

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OMAi
CNQVNIT

Database of Orthologous Groups

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OrthoDBi
1636216at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR008917 TF_DNA-bd_sf

Pfam protein domain database

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Pfami
View protein in Pfam
PF03131 bZIP_Maf, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47454 SSF47454, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00036 BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform a (identifier: P34707-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGSSRRQRS TSATRRDDKR RRRQCFSSVA DDEEETTSIY GVSSIFIWIL
60 70 80 90 100
ATSSLILVIS SPSSNTSIQS SSYDRITTKH LLDNISPTFK MYTDSNNRNF
110 120 130 140 150
DEVNHQHQQE QDFNGQSKYD YPQFNRPMGL RWRDDQRMME YFMSNGPVET
160 170 180 190 200
VPVMPILTEH PPASPFGRGP STERPTTSSR YEYSSPSLED IDLIDVLWRS
210 220 230 240 250
DIAGEKGTRQ VAPADQYECD LQTLTEKSTV APLTAEENAR YEDLSKGFYN
260 270 280 290 300
GFFESFNNNQ YQQKHQQQQR EQIKTPTLEH PTQKAELEDD LFDEDLAQLF
310 320 330 340 350
EDVSREEGQL NQLFDNKQQH PVINNVSLSE GIVYNQANLT EMQEMRDSCN
360 370 380 390 400
QVSISTIPTT STAQPETLFN VTDSQTVEQW LPTEVVPNDV FPTSNYAYIG
410 420 430 440 450
MQNDSLQAVV SNGQIDYDHS YQSTGQTPLS PLIIGSSGRQ QQTQTSPGSV
460 470 480 490 500
TVTATATQSL FDPYHSQRHS FSDCTTDSSS TCSRLSSESP RYTSESSTGT
510 520 530 540 550
HESRFYGKLA PSSGSRYQRS SSPRSSQSSI KIARVVPLAS GQRKRGRQSK
560 570 580 590 600
DEQLASDNEL PVSAFQISEM SLSELQQVLK NESLSEYQRQ LIRKIRRRGK
610 620
NKVAARTCRQ RRTDRHDKMS HYI
Length:623
Mass (Da):70,709
Last modified:May 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i31A70303AB7CC691
GO
Isoform b (identifier: P34707-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-313: Missing.
     314-389: FDNKQQHPVI...WLPTEVVPND → MSLPSDFASS...YSGVSSTFDR

Show »
Length:310
Mass (Da):34,588
Checksum:i21BD8A6536EE72B5
GO
Isoform c (identifier: P34707-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-90: Missing.

Show »
Length:533
Mass (Da):60,634
Checksum:iA911F45723ADCB13
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V6CLA3V6CLA3_CAEEL
BZIP domain-containing protein
skn-1 CELE_T19E7.2, T19E7.2
223Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0114881 – 313Missing in isoform b. CuratedAdd BLAST313
Alternative sequenceiVSP_0114871 – 90Missing in isoform c. CuratedAdd BLAST90
Alternative sequenceiVSP_011489314 – 389FDNKQ…VVPND → MSLPSDFASSLLASSTTTNT TNTAPAAVNSFDEQEEESKK ILNMYLQMFNQQQVDQHGHH HQHPYAYSGVSSTFDR in isoform b. CuratedAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080233 Genomic DNA Translation: CCD62212.1
FO080233 Genomic DNA Translation: CCD62213.1
FO080233 Genomic DNA Translation: CCD62214.1
M84359 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
A42143
F88694

NCBI Reference Sequences

More...
RefSeqi
NP_741404.1, NM_171345.4 [P34707-1]
NP_741405.1, NM_171346.3 [P34707-3]
NP_741406.1, NM_171347.5 [P34707-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T19E7.2a.1; T19E7.2a.1; WBGene00004804 [P34707-1]
T19E7.2b.1; T19E7.2b.1; WBGene00004804 [P34707-2]
T19E7.2c.1; T19E7.2c.1; WBGene00004804 [P34707-3]
T19E7.2c.2; T19E7.2c.2; WBGene00004804 [P34707-3]
T19E7.2c.3; T19E7.2c.3; WBGene00004804 [P34707-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
177343

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T19E7.2

UCSC genome browser

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UCSCi
T19E7.2b c. elegans [P34707-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080233 Genomic DNA Translation: CCD62212.1
FO080233 Genomic DNA Translation: CCD62213.1
FO080233 Genomic DNA Translation: CCD62214.1
M84359 Genomic DNA No translation available.
PIRiA42143
F88694
RefSeqiNP_741404.1, NM_171345.4 [P34707-1]
NP_741405.1, NM_171346.3 [P34707-3]
NP_741406.1, NM_171347.5 [P34707-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1SKNX-ray2.50P540-623[»]
SMRiP34707
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi42465, 5 interactors
IntActiP34707, 5 interactors
STRINGi6239.T19E7.2a

Chemistry databases

BindingDBiP34707
ChEMBLiCHEMBL2146298

PTM databases

iPTMnetiP34707

Proteomic databases

PaxDbiP34707

Genome annotation databases

EnsemblMetazoaiT19E7.2a.1; T19E7.2a.1; WBGene00004804 [P34707-1]
T19E7.2b.1; T19E7.2b.1; WBGene00004804 [P34707-2]
T19E7.2c.1; T19E7.2c.1; WBGene00004804 [P34707-3]
T19E7.2c.2; T19E7.2c.2; WBGene00004804 [P34707-3]
T19E7.2c.3; T19E7.2c.3; WBGene00004804 [P34707-3]
GeneIDi177343
KEGGicel:CELE_T19E7.2
UCSCiT19E7.2b c. elegans [P34707-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
177343
WormBaseiT19E7.2a ; CE27591 ; WBGene00004804 ; skn-1
T19E7.2b ; CE31238 ; WBGene00004804 ; skn-1
T19E7.2c ; CE31239 ; WBGene00004804 ; skn-1

Phylogenomic databases

eggNOGiKOG3863 Eukaryota
ENOG410ZGMS LUCA
GeneTreeiENSGT00970000196407
HOGENOMiHOG000021747
InParanoidiP34707
KOiK05638
OMAiCNQVNIT
OrthoDBi1636216at2759

Enzyme and pathway databases

ReactomeiR-CEL-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP34707

Miscellaneous databases

EvolutionaryTraceiP34707

Protein Ontology

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PROi
PR:P34707

Gene expression databases

BgeeiWBGene00004804 Expressed in 6 organ(s), highest expression level in multi-cellular organism
ExpressionAtlasiP34707 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR004826 bZIP_Maf
IPR008917 TF_DNA-bd_sf
PfamiView protein in Pfam
PF03131 bZIP_Maf, 1 hit
SUPFAMiSSF47454 SSF47454, 1 hit
PROSITEiView protein in PROSITE
PS00036 BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKN1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34707
Secondary accession number(s): Q8MPW2, Q8MPW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 27, 2002
Last modified: December 11, 2019
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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