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Protein

Transcription factor IIIA

Gene

gtf3a

Organism
Anaxyrus americanus (American toad) (Bufo americanus)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in ribosomal large subunit biogenesis. Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III. Also binds the transcribed 5S RNA's.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 97C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri104 – 128C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri134 – 158C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri161 – 187C2H2-type 6PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri190 – 212C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 244C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri250 – 274C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processRibosome biogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor IIIA
Short name:
TFIIIA
Gene namesi
Name:gtf3a
OrganismiAnaxyrus americanus (American toad) (Bufo americanus)
Taxonomic identifieri8389 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaHyloideaBufonidaeAnaxyrus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000470811 – 339Transcription factor IIIAAdd BLAST339

Structurei

3D structure databases

ProteinModelPortaliP34694
SMRiP34694
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri12 – 36C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri42 – 66C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri72 – 97C2H2-type 3PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri104 – 128C2H2-type 4PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri134 – 158C2H2-type 5PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri161 – 187C2H2-type 6PROSITE-ProRule annotationAdd BLAST27
Zinc fingeri190 – 212C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri219 – 244C2H2-type 8PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri250 – 274C2H2-type 9PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG017915

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

P34694-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEKLPVVYK RFICSFPDCN ATYNKNRKLQ AHLCKHTGER PFPCTYEGCE
60 70 80 90 100
KGFVTLHHLN RHVLSHTGEK PCKCETENCN LAFTTASNMR LHFKRAHSSP
110 120 130 140 150
AQVYVCYFAD CGQQFRKHNQ LKIHQYIHTN QQPFKCSHEG CDKCYASPSR
160 170 180 190 200
LKRHEKTHAG YPCRKDSTCP FVGKTWSDYM KHAAELHSEV TCSICNRTFK
210 220 230 240 250
RKSFLKEHKK IHREERIVYR CPRENCDRTY TTKFNLKSHI LTFHENLRPF
260 270 280 290 300
VCEHEGCGKT FAMKQSLDRH FNTHDPEKKK MVKPPRPVRS LASRLSGYKP
310 320 330
KKSKKKKKPS QTPAMESQEQ QPDASKADPL PVLENLTLK
Length:339
Mass (Da):39,500
Last modified:February 1, 1994 - v1
Checksum:i24CE3252696183C8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58366 mRNA Translation: CAA41259.1
PIRiJC1442

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X58366 mRNA Translation: CAA41259.1
PIRiJC1442

3D structure databases

ProteinModelPortaliP34694
SMRiP34694
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG017915

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTF3A_ANAAE
AccessioniPrimary (citable) accession number: P34694
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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