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Entry version 120 (07 Oct 2020)
Sequence version 2 (01 Feb 1995)
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Protein

Putative protein tag-76

Gene

tag-76

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-203927, MicroRNA (miRNA) biogenesis
R-CEL-426486, Small interfering RNA (siRNA) biogenesis
R-CEL-5578749, Transcriptional regulation by small RNAs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative protein tag-76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tag-76
ORF Names:ZK757.3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
ZK757.3a ; CE01117 ; WBGene00006449 ; tag-76
ZK757.3b ; CE24737 ; WBGene00006449 ; tag-76
ZK757.3c ; CE24738 ; WBGene00006449 ; tag-76

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000655471 – 1040Putative protein tag-76Add BLAST1040

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34681

PRoteomics IDEntifications database

More...
PRIDEi
P34681

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006449, Expressed in multi-cellular organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZK757.3a.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34681

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini378 – 486PAZPROSITE-ProRule annotationAdd BLAST109
Domaini660 – 966PiwiPROSITE-ProRule annotationAdd BLAST307

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1041, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174399

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34681

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARIFCKY

Database of Orthologous Groups

More...
OrthoDBi
159407at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34681

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014811, ArgoL1
IPR032472, ArgoL2
IPR032473, Argonaute_Mid_dom
IPR032474, Argonaute_N
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08699, ArgoL1, 1 hit
PF16488, ArgoL2, 1 hit
PF16487, ArgoMid, 1 hit
PF16486, ArgoN, 1 hit
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01163, DUF1785, 1 hit
SM00950, Piwi, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: P34681-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRRNATSFV DNNTLTSSGI SGSGSMSPPI TSRPASGQAS PLTSNGSLSP
60 70 80 90 100
PQYADDQGSV SYNLDSPRDL SPLLLSELAC LNMREVVARP GLGTIGRQIP
110 120 130 140 150
VKSNFFAMDL KNPKMVVIQY HVEIHHPGCR KLDKDEMRII FWKAVSDHPN
160 170 180 190 200
IFHNKFALAY DGAHQLYTVA RLEFPDDQGS VRLDCEASLP KDNRDRTRCA
210 220 230 240 250
ISIQNVGPVL LEMQRTRTNN LDERVLTPIQ ILDIICRQSL TCPLLKNSAN
260 270 280 290 300
FYTWKSSCYR IPTAAGQALD LEGGKEMWTG FFSSAHIASN YRPLLNIDVA
310 320 330 340 350
HTAFYKTRIT VLQFMCDVLN ERTSKPNRNN PRGPGGPGGP GGYRGGRGGG
360 370 380 390 400
RGGSYGNFGN RGPPGANVRD DFGGNGLTFT MDTLSRDTQL SSFETRIFGD
410 420 430 440 450
AIRGMKIRAA HRPNAIRVYK VNSLQLPADK LMFQGIDEEG RQVVCSVADY
460 470 480 490 500
FSEKYGPLKY PKLPCLHVGP PTRNIFLPME HCLIDSPQKY NKKMSEKQTS
510 520 530 540 550
AIIKAAAVDA TQREDRIKQL AAQASFGTDP FLKEFGVAVS SQMIQTTARV
560 570 580 590 600
IQPPPIMFGG NNRSVNPVVF PKDGSWTMDN QTLYMPATCR SYSMIALVDP
610 620 630 640 650
RDQTSLQTFC QSLTMKATAM GMNFPRWPDL VKYGRSKEDV CTLFTEIADE
660 670 680 690 700
YRVTNTVCDC IIVVLQSKNS DIYMTVKEQS DIVHGIMSQC VLMKNVSRPT
710 720 730 740 750
PATCANIVLK LNMKMGGINS RIVADKITNK YLVDQPTMVV GIDVTHPTQA
760 770 780 790 800
EMRMNMPSVA AIVANVDLLP QSYGANVKVQ KKCRESVVYL LDAIRERIIT
810 820 830 840 850
FYRHTKQKPA RIIVYRDGVS EGQFSEVLRE EIQSIRTACL AIAEDFRPPI
860 870 880 890 900
TYIVVQKRHH ARIFCKYQND MVGKAKNVPP GTTVDTGIVS PEGFDFYLCS
910 920 930 940 950
HYGVQGTSRP ARYHVLLDEC KFTADEIQSI TYGMCHTYGR CTRSVSIPTP
960 970 980 990 1000
VYYADLVATR ARCHVKRKLG LADNNDCDTN SRSSTLASLL NVRTGSGKGK
1010 1020 1030 1040
KSYAPSVDDE SYSLSDATSD QILQDCVSVA TDFKSRMYFI
Length:1,040
Mass (Da):115,416
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C8483C1F1D72338
GO
Isoform b (identifier: P34681-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-21: Missing.

Show »
Length:1,037
Mass (Da):115,159
Checksum:i05A279EE47A44636
GO
Isoform c (identifier: P34681-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-55: GISGSGSMSPPITSRPASGQASPLTSNGSLSPPQYAD → EGLTSGVFSWALERLPTCLREELQLPLTDTGSCWQTN
     56-1040: Missing.

Show »
Length:55
Mass (Da):6,136
Checksum:i5D2285747F99A03A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01190119 – 55GISGS…PQYAD → EGLTSGVFSWALERLPTCLR EELQLPLTDTGSCWQTN in isoform c. CuratedAdd BLAST37
Alternative sequenceiVSP_01190019 – 21Missing in isoform b. Curated3
Alternative sequenceiVSP_01190256 – 1040Missing in isoform c. CuratedAdd BLAST985

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z29121, Z30215 Genomic DNA Translation: CAA82389.1
Z29121, Z30215 Genomic DNA Translation: CAB54514.1
Z30215 Genomic DNA Translation: CAB54245.1

Protein sequence database of the Protein Information Resource

More...
PIRi
D88568
S41013

NCBI Reference Sequences

More...
RefSeqi
NP_499191.1, NM_066790.3 [P34681-1]
NP_499192.1, NM_066791.4 [P34681-2]
NP_499193.1, NM_066792.3 [P34681-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
ZK757.3a.1; ZK757.3a.1; WBGene00006449 [P34681-1]
ZK757.3a.2; ZK757.3a.2; WBGene00006449 [P34681-1]
ZK757.3b.1; ZK757.3b.1; WBGene00006449 [P34681-2]
ZK757.3c.1; ZK757.3c.1; WBGene00006449 [P34681-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_ZK757.3

UCSC genome browser

More...
UCSCi
ZK757.3b, c. elegans [P34681-1]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z29121, Z30215 Genomic DNA Translation: CAA82389.1
Z29121, Z30215 Genomic DNA Translation: CAB54514.1
Z30215 Genomic DNA Translation: CAB54245.1
PIRiD88568
S41013
RefSeqiNP_499191.1, NM_066790.3 [P34681-1]
NP_499192.1, NM_066791.4 [P34681-2]
NP_499193.1, NM_066792.3 [P34681-3]

3D structure databases

SMRiP34681
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.ZK757.3a.1

Proteomic databases

PaxDbiP34681
PRIDEiP34681

Genome annotation databases

EnsemblMetazoaiZK757.3a.1; ZK757.3a.1; WBGene00006449 [P34681-1]
ZK757.3a.2; ZK757.3a.2; WBGene00006449 [P34681-1]
ZK757.3b.1; ZK757.3b.1; WBGene00006449 [P34681-2]
ZK757.3c.1; ZK757.3c.1; WBGene00006449 [P34681-3]
GeneIDi176400
KEGGicel:CELE_ZK757.3
UCSCiZK757.3b, c. elegans [P34681-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176400
WormBaseiZK757.3a ; CE01117 ; WBGene00006449 ; tag-76
ZK757.3b ; CE24737 ; WBGene00006449 ; tag-76
ZK757.3c ; CE24738 ; WBGene00006449 ; tag-76

Phylogenomic databases

eggNOGiKOG1041, Eukaryota
GeneTreeiENSGT00940000174399
InParanoidiP34681
OMAiARIFCKY
OrthoDBi159407at2759
PhylomeDBiP34681

Enzyme and pathway databases

ReactomeiR-CEL-203927, MicroRNA (miRNA) biogenesis
R-CEL-426486, Small interfering RNA (siRNA) biogenesis
R-CEL-5578749, Transcriptional regulation by small RNAs

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34681

Gene expression databases

BgeeiWBGene00006449, Expressed in multi-cellular organism and 3 other tissues

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR014811, ArgoL1
IPR032472, ArgoL2
IPR032473, Argonaute_Mid_dom
IPR032474, Argonaute_N
IPR003100, PAZ_dom
IPR036085, PAZ_dom_sf
IPR003165, Piwi
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
PfamiView protein in Pfam
PF08699, ArgoL1, 1 hit
PF16488, ArgoL2, 1 hit
PF16487, ArgoMid, 1 hit
PF16486, ArgoN, 1 hit
PF02170, PAZ, 1 hit
PF02171, Piwi, 1 hit
SMARTiView protein in SMART
SM01163, DUF1785, 1 hit
SM00950, Piwi, 1 hit
SUPFAMiSSF101690, SSF101690, 1 hit
SSF53098, SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821, PAZ, 1 hit
PS50822, PIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAG76_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34681
Secondary accession number(s): Q7JMT0, Q9TW94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: October 7, 2020
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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