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Protein

Probable mannose-6-phosphate isomerase

Gene

ZK632.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.By similarity

Catalytic activityi

D-mannose 6-phosphate = D-fructose 6-phosphate.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Pathwayi: GDP-alpha-D-mannose biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable mannose-6-phosphate isomerase (ZK632.4)
  2. Probable phosphomannomutase (F52B11.2)
This subpathway is part of the pathway GDP-alpha-D-mannose biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-D-mannose 1-phosphate from D-fructose 6-phosphate, the pathway GDP-alpha-D-mannose biosynthesis and in Nucleotide-sugar biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi99ZincBy similarity1
Metal bindingi101ZincBy similarity1
Metal bindingi126ZincBy similarity1
Metal bindingi259ZincBy similarity1
Active sitei278By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-CEL-446205 Synthesis of GDP-mannose
UniPathwayiUPA00126; UER00423

Names & Taxonomyi

Protein namesi
Recommended name:
Probable mannose-6-phosphate isomerase (EC:5.3.1.8)
Alternative name(s):
Phosphohexomutase
Phosphomannose isomerase
Short name:
PMI
Gene namesi
ORF Names:ZK632.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK632.4 ; CE36417 ; WBGene00014013

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001942331 – 416Probable mannose-6-phosphate isomeraseAdd BLAST416

Proteomic databases

EPDiP34650
PaxDbiP34650
PeptideAtlasiP34650
PRIDEiP34650

Expressioni

Gene expression databases

BgeeiWBGene00014013

Interactioni

Protein-protein interaction databases

STRINGi6239.ZK632.4

Structurei

3D structure databases

ProteinModelPortaliP34650
SMRiP34650
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2757 Eukaryota
COG1482 LUCA
GeneTreeiENSGT00390000016075
HOGENOMiHOG000241277
InParanoidiP34650
KOiK01809
OMAiMGTHPSN
OrthoDBiEOG091G078D
PhylomeDBiP34650

Family and domain databases

Gene3Di2.60.120.10, 4 hits
InterProiView protein in InterPro
IPR001250 Man6P_Isoase-1
IPR016305 Mannose-6-P_Isomerase
IPR018050 Pmannose_isomerase-type1_CS
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR10309 PTHR10309, 1 hit
PfamiView protein in Pfam
PF01238 PMI_typeI, 1 hit
PIRSFiPIRSF001480 Mannose-6-phosphate_isomerase, 1 hit
PRINTSiPR00714 MAN6PISMRASE
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR00218 manA, 1 hit
PROSITEiView protein in PROSITE
PS00965 PMI_I_1, 1 hit
PS00966 PMI_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKLKCTVN NYAWGPKGNS SMAGSLALDG GHIPNLDKDK PYAEFWVGTH
60 70 80 90 100
ANGPAHVIEK DIALKQLLAT SPELQGKHEK GNLSFLFKVL SVLGPLSIQI
110 120 130 140 150
HPTKEQGKLL HATDPKNYPD DNHKPEIAIA LTEFELLSGF RQHSQISEYL
160 170 180 190 200
KLYSEIQELL TEEEKSQIDS LGSYGESSAQ VLKKIFSRIW RTPKEKLQIV
210 220 230 240 250
VDKLARRIQG HENKTALDEI IVYLFTLYPG DVGVFAPIFL NYFKLQPGEA
260 270 280 290 300
TFLEPNMPHA YLKGDCVECM ADSDNTIRAG LTPKYIDVES LVEMLNYDET
310 320 330 340 350
LLPKYIPNEL DDGSLLFTPR GIDEFWVQEV KGPAGSIYQL PYSESCSVLT
360 370 380 390 400
VLYGTATVTL GDASQVLNRG EVVFIGATHD AERPKINISD DFLAFRAFTP
410
SPRALESLSN KRLIID
Length:416
Mass (Da):46,384
Last modified:August 16, 2004 - v3
Checksum:i1C7DEDEE85DB8459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z22181 Genomic DNA Translation: CAA80181.3
PIRiS40936
RefSeqiNP_499174.3, NM_066773.4
UniGeneiCel.9546

Genome annotation databases

EnsemblMetazoaiZK632.4; ZK632.4; WBGene00014013
GeneIDi176388
KEGGicel:CELE_ZK632.4
UCSCiZK632.4 c. elegans

Similar proteinsi

Entry informationi

Entry nameiMPI_CAEEL
AccessioniPrimary (citable) accession number: P34650
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: August 16, 2004
Last modified: February 28, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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