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Entry version 164 (02 Jun 2021)
Sequence version 1 (01 Feb 1994)
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Protein

Cadherin-3

Gene

cdh-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion protein involved in the control of epithelial morphogenesis (PubMed:9012534).

Together with metalloproteinase zmp-1 and hemicentin him-4, plays a role in anchor cell (AC) invasion during postembryonic vulval development (PubMed:15960981).

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • structural molecule activity Source: WormBase

GO - Biological processi

  • basement membrane disassembly Source: UniProtKB
  • cell adhesion Source: GO_Central
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
  • morphogenesis of embryonic epithelium Source: WormBase
  • nematode male tail tip morphogenesis Source: WormBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandCalcium, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-114608, Platelet degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cadherin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cdh-3
ORF Names:ZK112.7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
ZK112.7 ; CE50490 ; WBGene00000395 ; cdh-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 3228ExtracellularSequence analysisAdd BLAST3202
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3229 – 3250HelicalSequence analysisAdd BLAST22
Topological domaini3251 – 3343CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

2 percent of mutants have a delay in anchor cell invasion. In 7 percent of zmp-1 and cdh-3 double mutants and in 25 percent of cdh-3, him-4 and zmp-1 triple mutants, anchor cell invasion is delayed.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000402027 – 3343Cadherin-3Add BLAST3317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi369N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi612N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi752N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi806N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi941N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi966N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi970N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi985N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1042N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1335N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1425N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1557N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1597N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1624N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1695N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1702N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1895N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1900N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2053N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2382N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2410N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2414N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2527N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2564N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2621N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2665N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2712N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2798N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2809N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2927N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2976N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3045N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi3172 ↔ 3205PROSITE-ProRule annotation
Glycosylationi3222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi3225N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34616

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34616

PeptideAtlas

More...
PeptideAtlasi
P34616

PRoteomics IDEntifications database

More...
PRIDEi
P34616

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the anchor cell.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000395, Expressed in material anatomical entity and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.ZK112.7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34616

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 117Cadherin 1PROSITE-ProRule annotationAdd BLAST90
Domaini118 – 229Cadherin 2PROSITE-ProRule annotationAdd BLAST112
Domaini242 – 330Cadherin 3PROSITE-ProRule annotationAdd BLAST89
Domaini632 – 738Cadherin 4PROSITE-ProRule annotationAdd BLAST107
Domaini1279 – 1368Cadherin 5PROSITE-ProRule annotationAdd BLAST90
Domaini1545 – 1648Cadherin 6PROSITE-ProRule annotationAdd BLAST104
Domaini1676 – 1756Cadherin 7PROSITE-ProRule annotationAdd BLAST81
Domaini1757 – 1857Cadherin 8PROSITE-ProRule annotationAdd BLAST101
Domaini1954 – 2045Cadherin 9PROSITE-ProRule annotationAdd BLAST92
Domaini2046 – 2145Cadherin 10PROSITE-ProRule annotationAdd BLAST100
Domaini2146 – 2245Cadherin 11PROSITE-ProRule annotationAdd BLAST100
Domaini3040 – 3205Laminin G-likePROSITE-ProRule annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3257 – 3277DisorderedSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1219, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167267

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_225093_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34616

Database of Orthologous Groups

More...
OrthoDBi
34489at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34616

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR001791, Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00028, Cadherin, 7 hits
PF02210, Laminin_G_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205, CADHERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112, CA, 13 hits
SM00282, LamG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49313, SSF49313, 14 hits
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232, CADHERIN_1, 8 hits
PS50268, CADHERIN_2, 11 hits
PS50025, LAM_G_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P34616-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTIRIFFSIF LLNHLIFFHL FNFTHQFSEE TIKFSVSEDA KLNTIIGHLE
60 70 80 90 100
AEIGYTYRLS RGNSKIKFDE QTLELSVSSP LDRESENAID MLIITSPPSI
110 120 130 140 150
IHILIDVLDV NDNSPIFPID VQRVEIPETA PIGWRVQISG ATDPDEGKNG
160 170 180 190 200
TIGKYELVDS LATVDTMSPF GIVQSDGFLF LEVTGKLDRE TRDLYSMRLT
210 220 230 240 250
AIDQGVPELS SSCHLNILIL DINDNPPNFG IRSLTLNWNG LPNTKLFSLN
260 270 280 290 300
ATDLDSNENS LLTYRILPSG PTSEMFSISD ENILVTQNNT ECLQRCEFVV
310 320 330 340 350
EARDSGVPPL STTLNIVVNM EYGNEHEPNI NIRFYPSDYP FIIVQPEDVN
360 370 380 390 400
GKTLAILSIT DSDGPLGANS TIWIENGNEQ SIFSLISRQS INILTVKHVE
410 420 430 440 450
NANQEQYILE FRANDGQSPA DRITRKELKI FFKKYVKSTQ IHVERESHVT
460 470 480 490 500
VEKDTVPGSF VAHVETNCTD MCSFELANSD VFKIDPFNGI IVTSSILPEG
510 520 530 540 550
VTSYHLPIRI HLPPPSTQLV EADVFVKVIQ ESVPKNLIRS SESPIHLKRA
560 570 580 590 600
YTFTTWQDVS LGTVIGRLPK AQIYSTIDTV SELGVFPDGS VFVGKTITSD
610 620 630 640 650
FVTLPVTLVN RNTTQTSIIT LIVKPLNQHS PICQITEIHV LENAPIGTIF
660 670 680 690 700
GRIQARDEDS GLSGVVSYKI LTKSDDYDGI FHLDSTSGSL RSLKAFDAEK
710 720 730 740 750
KRSYTFEYEA KDLGTPSKTT NCPATIFIED VNDNVPKFGS RYYTATISGK
760 770 780 790 800
SNETVAIVQA NDNDVDVKNQ KLQYHLLNYH DFFQLDKETG KVTTIQDVPM
810 820 830 840 850
TWQRLNISIS AVNMDSERFL QSKTFLLVTV TSSSKLAVQL NSGNLIRIFK
860 870 880 890 900
NDKIGEKVGH LDIASSETVY WSTLDPRLHV DSSGNIILIR RNAKQASTGF
910 920 930 940 950
DIILTSENGE KTEKVNFEVE FVDSERSEDV EKVMDIVLNE NTTEVSNLMN
960 970 980 990 1000
DWKNWKISRV ILENANNSGN NTFFLEHKKL WRTKNATVSN AYIILESEDQ
1010 1020 1030 1040 1050
EGSPKSFKLL HVTTSPSPSS ESSCISPAHL ISPPSTVPLP SNCSNVKLQN
1060 1070 1080 1090 1100
LKTSLQIHEN NLLIPTQSEL INHVDLVSTQ NSDMKPFMMT LIKDYLSEDV
1110 1120 1130 1140 1150
RFSTNNVLML LSSIHPIGTS FGRVTAESGY RIRYYIVGTD KISIDADTGE
1160 1170 1180 1190 1200
LILKERFYRN LNDILIVAVI PKGIAKAKIT IEVIEDRLIL PQSNFFIPSP
1210 1220 1230 1240 1250
PSFNSKSKIG KIPIDRDDVT IDVIDEHFYV RNFEIFVKRH FIPNSNFYDL
1260 1270 1280 1290 1300
KGTVKKGKLS APISVTLFFG EKMKSREIRE NELMFEIEEN SPIGTVVGVV
1310 1320 1330 1340 1350
PNSDTTKYRL VDPTCGLLID QEGIIRTTTV FDRENTSLLK TKMIEPSENR
1360 1370 1380 1390 1400
IWNLLIFIAD VNDNKPKILN APGRIIVYDD LNYKLEWEDL DAIASDVSFS
1410 1420 1430 1440 1450
IVDGDVFGNL EIEDSGVISL NSIPNESFNA TIRIYDNRPP FKVHFDDVTI
1460 1470 1480 1490 1500
EFQVTQKLRA VTCEDAEFWM FFGNEDVGML IASEIVTWRI VPQIGSDSFK
1510 1520 1530 1540 1550
IDPITGIIQS TPNTKPTSDI AKLKIQAISY DGERVGFCDV KIHIDKAAFV
1560 1570 1580 1590 1600
ENVVLSNGTF EFNISETADR FTEVGKIVIL GAGLEGSVFR IQDNDYNFTI
1610 1620 1630 1640 1650
SPFDGTIFTN SPLDFENIKT YRFNITAGKS TSQVIIHVTD ENDEAPRFIT
1660 1670 1680 1690 1700
GDVVNLKVLE ELDTVSYPLI IGSSIAEDLD EGQNGLVTYS ILSGNTSLFA
1710 1720 1730 1740 1750
VNSTTGDILS LIPLDREESS LHELLIEAKD AGIPSLSATS KILIHVGDIN
1760 1770 1780 1790 1800
DNTPEFELSS YFIKISENSK IGSKIIRILA TDKDKDAELQ YSLESNDEIT
1810 1820 1830 1840 1850
IPFRINVATG WITVAGKVNR EENEEFRFFV KVTDGEKSSK VIVEIHVEDF
1860 1870 1880 1890 1900
NDNHPMINDR NSDIFVPDPT RSVEIIHVIN VHDLDKSDHL KFSLNNSNLN
1910 1920 1930 1940 1950
LSENGEITLK SPLQTAVPVR VTVSDDAGHV AFMEYLFHPH SRKHFPVFVE
1960 1970 1980 1990 2000
KLDTVSVREH DEQELAVFKA NGDSIRYSIV SRCSDHLEME KSTGILKTKS
2010 2020 2030 2040 2050
SLDAEEYSEC LVFIIATTYF DNKPLSTITK ATIKIVDIND NSPRFDQQLY
2060 2070 2080 2090 2100
RFNVTENSGP KLIGHVIARD IDRSSRVFYE IVGGDANHEF MVTESGQIES
2110 2120 2130 2140 2150
VRDLDRETKS EYHLIVEAID DGKPRRRGNT TVIVTVLDED DNAPRFSRIF
2160 2170 2180 2190 2200
HVEVPEDVRI GEPVIQLSAS DADEHSNHRF ELDGGGEGIP FRVDENTGMV
2210 2220 2230 2240 2250
FVNDSLDFEK KQSYRIKVKL TDGAWLIETS LFVNVKDVND NAPIFEKPEY
2260 2270 2280 2290 2300
LFISEENSAE IGQFHASDMD SENNGKIRYS VTSPYFKIEP STGVLSRFRQ
2310 2320 2330 2340 2350
QLPQPLMSLK VTATDHGVPR LQKTVLAHLV DKSSFGKIKQ RRIRETTKVG
2360 2370 2380 2390 2400
DVIGKKIDSG ATIFPLDVAT VTRDGDVVLK KNATQFWILE NDTIYEFVKT
2410 2420 2430 2440 2450
DAMESTKNEN ITLNITSDIS MNSDNFKVLR NGSLIVFGFS GNQAHLKIQC
2460 2470 2480 2490 2500
DDGFWPKQDR KIINLVVNNL DADRNSFPLA RQPTIRKSMS LPKTMILNIP
2510 2520 2530 2540 2550
FDSPTGTIIW KNLENAVQYM ENQKNVNFSN GSKNLILKTP LEETMQIDIF
2560 2570 2580 2590 2600
GQNFERSALT ITPNRSLMAC PVFQKNFYFF ESVANLDSKH PTEIHNFGWS
2610 2620 2630 2640 2650
SDEIKGCQID IFDKTHLFYQ NGSSLIFLKP LLPGTYQFSL QIKSQSDSKI
2660 2670 2680 2690 2700
RSACHVVVTV IPPTNLTTWN IPSVIFATRN YNIPNLFHLP SGYSLSSDQR
2710 2720 2730 2740 2750
TFSLIGSGTG KNISKLSSGV YQVNVVGKDE KKEIVRILLD DVADDVTSKD
2760 2770 2780 2790 2800
IEYHVVSSTL SNLKIPTPID VECFPRTEEN LYEITKDCRL LFNSDVINTT
2810 2820 2830 2840 2850
IPVVTSPANS TWNLRIINES PETVKSLENN AVSLEIITQK SSIPRLITDL
2860 2870 2880 2890 2900
RVTYSDMKIY CLGTWQTSED IKYHITFVIV DRNGVVIEES EARQTLTSFL
2910 2920 2930 2940 2950
KKHRPGYLDF VDFDKDPCDG VTCIQKNSTC QPTLVGDSAS RLVSRSSSVI
2960 2970 2980 2990 3000
FDLPLKKLTA RCFCSSGIDC YDDTTNETIQ KTQKINVITT CDDIDCGPRG
3010 3020 3030 3040 3050
KCFMEESSQP ICRCGQGFES MYSCERADDV FSMSTGGSVE ISVRNGTSHL
3060 3070 3080 3090 3100
LKCSENCDGR DIQKIEFDFR TVQLEKSELF RVDFGKQVAL IELIGGSLTF
3110 3120 3130 3140 3150
SITDAYARPI ETRIEKRVND GRWHRLLFQM SEDGRRISIQ VNGRGKEVKS
3160 3170 3180 3190 3200
RVPLQMLFTA KKIQLMTPAA FCFRRLLAQN QFVHPILNRN KFFEISSTGT
3210 3220 3230 3240 3250
SRNECQFDSI QSGSGGFRLF SNFSNTTTLI LLITLALISL IGFSVCLLAI
3260 3270 3280 3290 3300
RRRWRQKSPG DQKQTERSNG WTGHVMPRRR GHINRSMVKS PDDDTYDVAT
3310 3320 3330 3340
VYGMKSTSTD DITHIYTSSS SRRYQPPTAP SYRRDGHINM AYL
Length:3,343
Mass (Da):375,752
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i063E6F17FCC15D18
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FO080308 Genomic DNA Translation: CCD62768.1

Protein sequence database of the Protein Information Resource

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PIRi
S44887

NCBI Reference Sequences

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RefSeqi
NP_498687.2, NM_066286.4

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
ZK112.7.1; ZK112.7.1; WBGene00000395

Database of genes from NCBI RefSeq genomes

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GeneIDi
176085

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_ZK112.7

UCSC genome browser

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UCSCi
ZK112.7, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080308 Genomic DNA Translation: CCD62768.1
PIRiS44887
RefSeqiNP_498687.2, NM_066286.4

3D structure databases

SMRiP34616
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.ZK112.7

Proteomic databases

EPDiP34616
PaxDbiP34616
PeptideAtlasiP34616
PRIDEiP34616

Genome annotation databases

EnsemblMetazoaiZK112.7.1; ZK112.7.1; WBGene00000395
GeneIDi176085
KEGGicel:CELE_ZK112.7
UCSCiZK112.7, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176085
WormBaseiZK112.7 ; CE50490 ; WBGene00000395 ; cdh-3

Phylogenomic databases

eggNOGiKOG1219, Eukaryota
GeneTreeiENSGT00940000167267
HOGENOMiCLU_225093_0_0_1
InParanoidiP34616
OrthoDBi34489at2759
PhylomeDBiP34616

Enzyme and pathway databases

ReactomeiR-CEL-114608, Platelet degranulation

Miscellaneous databases

Protein Ontology

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PROi
PR:P34616

Gene expression databases

BgeeiWBGene00000395, Expressed in material anatomical entity and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR002126, Cadherin-like_dom
IPR015919, Cadherin-like_sf
IPR020894, Cadherin_CS
IPR013320, ConA-like_dom_sf
IPR000742, EGF-like_dom
IPR001791, Laminin_G
PfamiView protein in Pfam
PF00028, Cadherin, 7 hits
PF02210, Laminin_G_2, 1 hit
PRINTSiPR00205, CADHERIN
SMARTiView protein in SMART
SM00112, CA, 13 hits
SM00282, LamG, 1 hit
SUPFAMiSSF49313, SSF49313, 14 hits
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00232, CADHERIN_1, 8 hits
PS50268, CADHERIN_2, 11 hits
PS50025, LAM_G_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCADH3_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34616
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 2, 2021
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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