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Entry version 155 (29 Sep 2021)
Sequence version 4 (13 Nov 2019)
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Protein

JNK-interacting protein

Gene

unc-16

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons (PubMed:30880001).

3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-525793, Myogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
JNK-interacting protein
Short name:
JIP
Alternative name(s):
JNK MAP kinase scaffold protein
Uncoordinated protein 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-16Imported
Synonyms:egl-39Imported
ORF Names:ZK1098.10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
ZK1098.10a ; CE00363 ; WBGene00006755 ; unc-16
ZK1098.10b ; CE31846 ; WBGene00006755 ; unc-16
ZK1098.10c ; CE41490 ; WBGene00006755 ; unc-16
ZK1098.10d ; CE41491 ; WBGene00006755 ; unc-16
ZK1098.10e ; CE43483 ; WBGene00006755 ; unc-16
ZK1098.10f ; CE44092 ; WBGene00006755 ; unc-16
ZK1098.10g ; CE48500 ; WBGene00006755 ; unc-16
ZK1098.10h ; CE48468 ; WBGene00006755 ; unc-16
ZK1098.10i ; CE48413 ; WBGene00006755 ; unc-16
ZK1098.10j ; CE48699 ; WBGene00006755 ; unc-16
ZK1098.10k ; CE48497 ; WBGene00006755 ; unc-16
ZK1098.10l ; CE48433 ; WBGene00006755 ; unc-16
ZK1098.10m ; CE48429 ; WBGene00006755 ; unc-16
ZK1098.10n ; CE48454 ; WBGene00006755 ; unc-16
ZK1098.10o ; CE48464 ; WBGene00006755 ; unc-16
ZK1098.10p ; CE48473 ; WBGene00006755 ; unc-16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi75L → P in ju146; increases the number of lgg-1-containing protein aggregates in the neurites of AIY interneurons. This is further increased in either an atg-4.2 ola316 or atg-4.2 gk628327 mutant background. Reduces the retrograde trafficking of autophagosomes in AIY neurites, but increases anterograde autophagosome trafficking and increases the number of autophagosomes which are not trafficked. This results in an abnormal accumulation of autophagic vacuoles in neurites. 1 Publication1
Mutagenesisi765 – 1157Missing in n730; increases the number of lgg-1-containing protein aggregates in the neurites of AIY interneurons. 1 PublicationAdd BLAST393

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002206371 – 1190JNK-interacting proteinAdd BLAST1190

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34609

PeptideAtlas

More...
PeptideAtlasi
P34609

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34609

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in neurons of the ventral cord, retrovesicular and preanal ganglia and nerve ring, intestinal cells, seam and hypodermal cells, body wall, head muscle and pharynx.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006755, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34609, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41544, 14 interactors

Database of interacting proteins

More...
DIPi
DIP-25590N

Protein interaction database and analysis system

More...
IntActi
P34609, 6 interactors

STRING: functional protein association networks

More...
STRINGi
6239.ZK1098.10e

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 112RH1PROSITE-ProRule annotationAdd BLAST89
Domaini456 – 542RH2PROSITE-ProRule annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 35DisorderedSequence analysisAdd BLAST35
Regioni263 – 364DisorderedSequence analysisAdd BLAST102
Regioni775 – 829DisorderedSequence analysisAdd BLAST55

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili78 – 165Sequence analysisAdd BLAST88
Coiled coili383 – 491Sequence analysisAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 24Polar residuesSequence analysisAdd BLAST24
Compositional biasi272 – 292Polar residuesSequence analysisAdd BLAST21
Compositional biasi810 – 824Pro residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2077, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153496

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003841_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34609

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLRRIKM

Database of Orthologous Groups

More...
OrthoDBi
324912at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039911, JIP3/JIP4
IPR032486, JIP_LZII
IPR019143, JNK/Rab-associated_protein-1_N
IPR011047, Quinoprotein_ADH-like_supfam
IPR034743, RH1
IPR034744, RH2
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13886, PTHR13886, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16471, JIP_LZII, 1 hit
PF09744, Jnk-SapK_ap_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50998, SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51776, RH1, 1 hit
PS51777, RH2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform eImported (identifier: P34609-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACNLSPVNE MADSITSSTP SEIVYGGPGS PDEHRTMSDK VQTMASAIYR
60 70 80 90 100
ELETMIKVHG EDGVKTLMPL VVNVLEALDL AYLERDEQTA ELEMLKEDNE
110 120 130 140 150
QLQTQYEREK ALRKQTEQKY IEIEDTLIGQ NKELDKKIES LESIMRMLEL
160 170 180 190 200
KAKNATDHAS RLEEREVEQK LEFDRLHERY NTLLRTHVDH MERTKYLMGS
210 220 230 240 250
EKFELMQNMP LPNMQLRNKM GMAASVDASS IRGVSDLISA HMTQSTTMDV
260 270 280 290 300
NLANHITNED WQDEFSSDIE PSPRDIPQSS ADALTSPITT KEPTPKREAA
310 320 330 340 350
SPKQSEEEEA DETTSVDPKE NNDLLGADLT DDESDWNGLG LIPRRHRPNE
360 370 380 390 400
MLDDDDTSDD GSLGMGREVE NLIKENSELL DMKNALNIVK NDLINQVDEL
410 420 430 440 450
NSENMILRDE NLSRQMVSEK MQEQITKHEE EIKTLKQKLM EKENEQEEDD
460 470 480 490 500
VPMAMRKRFT RSEMQRVLMD RNAYKEKLME LEESIKWTEM QRAKKMQQQQ
510 520 530 540 550
QNVNQKKSGG IWEFFSSLLG DSVTPPASSR GNRASSSRGK MTRSVEYIDP
560 570 580 590 600
DMISERRAAE RREQYKLVRE HVKKEDGRIE AYGWSLPNVE AEVSSVPIPV
610 620 630 640 650
CCRPLLDNEP SLKIWCATGV VLRGGRDERG QWIVGDPIYF APASMKKTKT
660 670 680 690 700
SNHRPELEDE IKRARNLDAR ESELDEWQSS SLVWVVSSNQ GKSLIAVLDA
710 720 730 740 750
NNPNNIIETF PACDSHLLCI QAVSGVMEGE PEMNEEQSKK YLSGGGKIKD
760 770 780 790 800
LPEGLDGTDL GACEWVELRK MEDSEDGVPT YCSNDMKPSP KRTRDFSISE
810 820 830 840 850
VAPVDSSAPV KEDPLPPPAN RPGGRAALPP HIRDAMSKYD GVSGQMSGAL
860 870 880 890 900
PTVWMGGQNQ YIYIHSAVTA WKQCLRRIKM PDAVLSIVHY KSRIFAALAN
910 920 930 940 950
GTIAIFHRNK HGEWSDEGYH SLRVGSATSS VRSLCLVSTN IWATYKNCVV
960 970 980 990 1000
VLDAESLQIV KVFAAHPRKD SQVRNMQWVG AGVWLSIRLD STLRLYHAHT
1010 1020 1030 1040 1050
YEHLQDVDIE PYVTKMLGTS KLDFSYMRTT ALLVSNRRLW IGTGTGVIIS
1060 1070 1080 1090 1100
VPFSGQLEKK IETKDSKRPA GPGGLVRVYG ATSENATNDE KTNDDFIPYC
1110 1120 1130 1140 1150
NLAHAQLSFH GHKDSVKFFL GVPGASKNGE DESAEVTLRR MLIMSGGDGY
1160 1170 1180 1190
IDFRIGEENE PELTGQSIRP RDMSHLIIWE VDAELPILSK
Length:1,190
Mass (Da):134,219
Last modified:November 13, 2019 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0AC346C0372882A2
GO
Isoform aImported (identifier: P34609-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     331-363: DDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL → GNLVDPAEFASAVNDTFI

Show »
Length:1,139
Mass (Da):128,609
Checksum:i65517DA05AF2A2B4
GO
Isoform bImported (identifier: P34609-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-363: Missing.

Show »
Length:1,157
Mass (Da):130,480
Checksum:i44FA445C96B78A59
GO
Isoform cImported (identifier: P34609-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-644: Missing.

Show »
Length:546
Mass (Da):60,514
Checksum:i034703031B506A01
GO
Isoform dImported (identifier: P34609-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-363: Missing.
     810-810: V → VKAKTKLSRVSENVVPDETPKLIPLEKLK

Show »
Length:1,185
Mass (Da):133,624
Checksum:i196A1D3FE811E38C
GO
Isoform fImported (identifier: P34609-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: MACNLSPVNE...VNLANHITNE → MNSNPQLTFI
     331-363: Missing.

Show »
Length:908
Mass (Da):101,979
Checksum:iE81242178ED41A2E
GO
Isoform gImported (identifier: P34609-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-350: Missing.

Show »
Length:840
Mass (Da):94,472
Checksum:i5C81EA702B68F40C
GO
Isoform hImported (identifier: P34609-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     330-363: TDDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL → TVNDTFI
     554-557: SERR → HLSR
     558-1190: Missing.

Show »
Length:530
Mass (Da):60,878
Checksum:iA31D01E0D42A3E8C
GO
Isoform iImported (identifier: P34609-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     554-1190: SERRAAERRE...VDAELPILSK → HLSR

Show »
Length:557
Mass (Da):63,928
Checksum:i54F06F49C4E21903
GO
Isoform jImported (identifier: P34609-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-36: Missing.
     330-330: T → TGNLVDPAEFASA
     363-363: L → LVNDTFI
     554-557: SERR → HLSR
     558-1190: Missing.

Show »
Length:539
Mass (Da):62,057
Checksum:i568D5F9581BC90EC
GO
Isoform kImported (identifier: P34609-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: MACNLSPVNE...VNLANHITNE → MNSNPQLTFI
     330-330: T → TGNLVDPAEFASA
     363-363: L → LVNDTFI
     554-557: SERR → HLSR
     558-1190: Missing.

Show »
Length:326
Mass (Da):37,288
Checksum:i80FB55DE06DEB56B
GO
Isoform lImported (identifier: P34609-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-363: DDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL → GNLVDPAEFASA
     554-557: SERR → HLSR
     558-1190: Missing.

Show »
Length:536
Mass (Da):61,361
Checksum:i9B4045EB9BB437A8
GO
Isoform mImported (identifier: P34609-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-219: K → NWFPISHRLHKSGDQSNLSL
     330-330: T → TGNLVDPAEFASA
     363-363: L → LVNDTFI
     554-557: SERR → HLSR
     558-1190: Missing.

Show »
Length:594
Mass (Da):67,980
Checksum:i096B3FC5F5D96705
GO
Isoform nImported (identifier: P34609-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     331-363: DDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSL → GNLVDPAEFASAVNDTFI
     554-557: SERR → HLSR
     558-1190: Missing.

Show »
Length:542
Mass (Da):62,051
Checksum:i3DC1E028D09A42FB
GO
Isoform oImported (identifier: P34609-17) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-350: Missing.
     363-363: L → LVNDTFI

Show »
Length:846
Mass (Da):95,162
Checksum:i952654A604497343
GO
Isoform pImported (identifier: P34609-18) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-644: Missing.
     810-810: V → VKAKTKLSRVSENVVPDETPKLIPLEKLK

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Length:574
Mass (Da):63,657
Checksum:i1EF4D0FBFED6CC00
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0604141 – 644Missing in isoform c and isoform p. CuratedAdd BLAST644
Alternative sequenceiVSP_0604151 – 350Missing in isoform g and isoform o. CuratedAdd BLAST350
Alternative sequenceiVSP_0604161 – 259MACNL…HITNE → MNSNPQLTFI in isoform f and isoform k. CuratedAdd BLAST259
Alternative sequenceiVSP_0604171 – 36Missing in isoform a and isoform j. CuratedAdd BLAST36
Alternative sequenceiVSP_060418219K → NWFPISHRLHKSGDQSNLSL in isoform m. Curated1
Alternative sequenceiVSP_060419330 – 363TDDES…DDGSL → TVNDTFI in isoform h. CuratedAdd BLAST34
Alternative sequenceiVSP_060420330T → TGNLVDPAEFASA in isoform j, isoform k and isoform m. Curated1
Alternative sequenceiVSP_060421331 – 363DDESD…DDGSL → GNLVDPAEFASAVNDTFI in isoform a and isoform n. CuratedAdd BLAST33
Alternative sequenceiVSP_060422331 – 363Missing in isoform b, isoform d and isoform f. CuratedAdd BLAST33
Alternative sequenceiVSP_060423331 – 363DDESD…DDGSL → GNLVDPAEFASA in isoform l. CuratedAdd BLAST33
Alternative sequenceiVSP_060424363L → LVNDTFI in isoform j, isoform k, isoform m and isoform o. Curated1
Alternative sequenceiVSP_060425554 – 1190SERRA…PILSK → HLSR in isoform i. CuratedAdd BLAST637
Alternative sequenceiVSP_060426554 – 557SERR → HLSR in isoform h, isoform j, isoform k, isoform l, isoform m and isoform n. Curated4
Alternative sequenceiVSP_060427558 – 1190Missing in isoform h, isoform j, isoform k, isoform l, isoform m and isoform n. CuratedAdd BLAST633
Alternative sequenceiVSP_060428810V → VKAKTKLSRVSENVVPDETP KLIPLEKLK in isoform d and isoform p. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF424978 mRNA Translation: AAL23934.1
BX284603 Genomic DNA Translation: CAA80140.1
BX284603 Genomic DNA Translation: CAD45611.1
BX284603 Genomic DNA Translation: CAO82057.1
BX284603 Genomic DNA Translation: CAO82058.1
BX284603 Genomic DNA Translation: CAX51690.1
BX284603 Genomic DNA Translation: CBA11621.1
BX284603 Genomic DNA Translation: CDG24108.1
BX284603 Genomic DNA Translation: CDG24109.1
BX284603 Genomic DNA Translation: CDG24110.1
BX284603 Genomic DNA Translation: CDG24111.2
BX284603 Genomic DNA Translation: CDG24112.1
BX284603 Genomic DNA Translation: CDG24113.1
BX284603 Genomic DNA Translation: CDG24114.1
BX284603 Genomic DNA Translation: CDG24115.1
BX284603 Genomic DNA Translation: CDG24116.1
BX284603 Genomic DNA Translation: CDG24117.1

Protein sequence database of the Protein Information Resource

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PIRi
S40932

NCBI Reference Sequences

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RefSeqi
NP_001022981.1, NM_001027810.3 [P34609-5]
NP_001122747.1, NM_001129275.2 [P34609-6]
NP_001122748.1, NM_001129276.1 [P34609-7]
NP_001255008.1, NM_001268079.1 [P34609-1]
NP_001255009.1, NM_001268080.1 [P34609-8]
NP_001293608.1, NM_001306679.1 [P34609-9]
NP_001293609.1, NM_001306680.1 [P34609-10]
NP_001293610.1, NM_001306681.1
NP_001293611.1, NM_001306682.1 [P34609-12]
NP_001293612.1, NM_001306683.1 [P34609-13]
NP_001293613.1, NM_001306684.1 [P34609-14]
NP_001293614.1, NM_001306685.1 [P34609-15]
NP_001293615.1, NM_001306686.1 [P34609-16]
NP_001293616.1, NM_001306687.1 [P34609-17]
NP_001293617.1, NM_001306688.1 [P34609-18]
NP_741263.3, NM_171221.4 [P34609-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
ZK1098.10a.1; ZK1098.10a.1; WBGene00006755 [P34609-3]
ZK1098.10b.1; ZK1098.10b.1; WBGene00006755 [P34609-5]
ZK1098.10c.1; ZK1098.10c.1; WBGene00006755 [P34609-6]
ZK1098.10c.2; ZK1098.10c.2; WBGene00006755 [P34609-6]
ZK1098.10d.1; ZK1098.10d.1; WBGene00006755 [P34609-7]
ZK1098.10e.1; ZK1098.10e.1; WBGene00006755 [P34609-1]
ZK1098.10f.1; ZK1098.10f.1; WBGene00006755 [P34609-8]
ZK1098.10g.1; ZK1098.10g.1; WBGene00006755 [P34609-9]
ZK1098.10h.1; ZK1098.10h.1; WBGene00006755 [P34609-10]
ZK1098.10i.1; ZK1098.10i.1; WBGene00006755 [P34609-11]
ZK1098.10j.1; ZK1098.10j.1; WBGene00006755 [P34609-12]
ZK1098.10k.1; ZK1098.10k.1; WBGene00006755 [P34609-13]
ZK1098.10l.1; ZK1098.10l.1; WBGene00006755 [P34609-14]
ZK1098.10m.1; ZK1098.10m.1; WBGene00006755 [P34609-15]
ZK1098.10n.1; ZK1098.10n.1; WBGene00006755 [P34609-16]
ZK1098.10o.1; ZK1098.10o.1; WBGene00006755 [P34609-17]
ZK1098.10p.1; ZK1098.10p.1; WBGene00006755 [P34609-18]
ZK1098.10p.2; ZK1098.10p.2; WBGene00006755 [P34609-18]
ZK1098.10p.3; ZK1098.10p.3; WBGene00006755 [P34609-18]
ZK1098.10p.4; ZK1098.10p.4; WBGene00006755 [P34609-18]

Database of genes from NCBI RefSeq genomes

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GeneIDi
176349

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_ZK1098.10

UCSC genome browser

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UCSCi
ZK1098.10b.1, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF424978 mRNA Translation: AAL23934.1
BX284603 Genomic DNA Translation: CAA80140.1
BX284603 Genomic DNA Translation: CAD45611.1
BX284603 Genomic DNA Translation: CAO82057.1
BX284603 Genomic DNA Translation: CAO82058.1
BX284603 Genomic DNA Translation: CAX51690.1
BX284603 Genomic DNA Translation: CBA11621.1
BX284603 Genomic DNA Translation: CDG24108.1
BX284603 Genomic DNA Translation: CDG24109.1
BX284603 Genomic DNA Translation: CDG24110.1
BX284603 Genomic DNA Translation: CDG24111.2
BX284603 Genomic DNA Translation: CDG24112.1
BX284603 Genomic DNA Translation: CDG24113.1
BX284603 Genomic DNA Translation: CDG24114.1
BX284603 Genomic DNA Translation: CDG24115.1
BX284603 Genomic DNA Translation: CDG24116.1
BX284603 Genomic DNA Translation: CDG24117.1
PIRiS40932
RefSeqiNP_001022981.1, NM_001027810.3 [P34609-5]
NP_001122747.1, NM_001129275.2 [P34609-6]
NP_001122748.1, NM_001129276.1 [P34609-7]
NP_001255008.1, NM_001268079.1 [P34609-1]
NP_001255009.1, NM_001268080.1 [P34609-8]
NP_001293608.1, NM_001306679.1 [P34609-9]
NP_001293609.1, NM_001306680.1 [P34609-10]
NP_001293610.1, NM_001306681.1
NP_001293611.1, NM_001306682.1 [P34609-12]
NP_001293612.1, NM_001306683.1 [P34609-13]
NP_001293613.1, NM_001306684.1 [P34609-14]
NP_001293614.1, NM_001306685.1 [P34609-15]
NP_001293615.1, NM_001306686.1 [P34609-16]
NP_001293616.1, NM_001306687.1 [P34609-17]
NP_001293617.1, NM_001306688.1 [P34609-18]
NP_741263.3, NM_171221.4 [P34609-3]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi41544, 14 interactors
DIPiDIP-25590N
IntActiP34609, 6 interactors
STRINGi6239.ZK1098.10e

PTM databases

iPTMnetiP34609

Proteomic databases

PaxDbiP34609
PeptideAtlasiP34609

Genome annotation databases

EnsemblMetazoaiZK1098.10a.1; ZK1098.10a.1; WBGene00006755 [P34609-3]
ZK1098.10b.1; ZK1098.10b.1; WBGene00006755 [P34609-5]
ZK1098.10c.1; ZK1098.10c.1; WBGene00006755 [P34609-6]
ZK1098.10c.2; ZK1098.10c.2; WBGene00006755 [P34609-6]
ZK1098.10d.1; ZK1098.10d.1; WBGene00006755 [P34609-7]
ZK1098.10e.1; ZK1098.10e.1; WBGene00006755 [P34609-1]
ZK1098.10f.1; ZK1098.10f.1; WBGene00006755 [P34609-8]
ZK1098.10g.1; ZK1098.10g.1; WBGene00006755 [P34609-9]
ZK1098.10h.1; ZK1098.10h.1; WBGene00006755 [P34609-10]
ZK1098.10i.1; ZK1098.10i.1; WBGene00006755 [P34609-11]
ZK1098.10j.1; ZK1098.10j.1; WBGene00006755 [P34609-12]
ZK1098.10k.1; ZK1098.10k.1; WBGene00006755 [P34609-13]
ZK1098.10l.1; ZK1098.10l.1; WBGene00006755 [P34609-14]
ZK1098.10m.1; ZK1098.10m.1; WBGene00006755 [P34609-15]
ZK1098.10n.1; ZK1098.10n.1; WBGene00006755 [P34609-16]
ZK1098.10o.1; ZK1098.10o.1; WBGene00006755 [P34609-17]
ZK1098.10p.1; ZK1098.10p.1; WBGene00006755 [P34609-18]
ZK1098.10p.2; ZK1098.10p.2; WBGene00006755 [P34609-18]
ZK1098.10p.3; ZK1098.10p.3; WBGene00006755 [P34609-18]
ZK1098.10p.4; ZK1098.10p.4; WBGene00006755 [P34609-18]
GeneIDi176349
KEGGicel:CELE_ZK1098.10
UCSCiZK1098.10b.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176349
WormBaseiZK1098.10a ; CE00363 ; WBGene00006755 ; unc-16
ZK1098.10b ; CE31846 ; WBGene00006755 ; unc-16
ZK1098.10c ; CE41490 ; WBGene00006755 ; unc-16
ZK1098.10d ; CE41491 ; WBGene00006755 ; unc-16
ZK1098.10e ; CE43483 ; WBGene00006755 ; unc-16
ZK1098.10f ; CE44092 ; WBGene00006755 ; unc-16
ZK1098.10g ; CE48500 ; WBGene00006755 ; unc-16
ZK1098.10h ; CE48468 ; WBGene00006755 ; unc-16
ZK1098.10i ; CE48413 ; WBGene00006755 ; unc-16
ZK1098.10j ; CE48699 ; WBGene00006755 ; unc-16
ZK1098.10k ; CE48497 ; WBGene00006755 ; unc-16
ZK1098.10l ; CE48433 ; WBGene00006755 ; unc-16
ZK1098.10m ; CE48429 ; WBGene00006755 ; unc-16
ZK1098.10n ; CE48454 ; WBGene00006755 ; unc-16
ZK1098.10o ; CE48464 ; WBGene00006755 ; unc-16
ZK1098.10p ; CE48473 ; WBGene00006755 ; unc-16

Phylogenomic databases

eggNOGiKOG2077, Eukaryota
GeneTreeiENSGT00940000153496
HOGENOMiCLU_003841_0_0_1
InParanoidiP34609
OMAiCLRRIKM
OrthoDBi324912at2759

Enzyme and pathway databases

ReactomeiR-CEL-525793, Myogenesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34609

Gene expression databases

BgeeiWBGene00006755, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiP34609, baseline and differential

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR039911, JIP3/JIP4
IPR032486, JIP_LZII
IPR019143, JNK/Rab-associated_protein-1_N
IPR011047, Quinoprotein_ADH-like_supfam
IPR034743, RH1
IPR034744, RH2
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR13886, PTHR13886, 1 hit
PfamiView protein in Pfam
PF16471, JIP_LZII, 1 hit
PF09744, Jnk-SapK_ap_N, 1 hit
SUPFAMiSSF50998, SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS51776, RH1, 1 hit
PS51777, RH2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJIP_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34609
Secondary accession number(s): A7LPE3
, A7LPE4, C0P271, C7FZT6, Q95V72, S6EZN6, S6EZP3, S6F548, S6F556, S6FD02, S6FN04, S6FN08, S6FWP4, S6FWP6, U4MKU8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 13, 2019
Last modified: September 29, 2021
This is version 155 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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