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Entry version 166 (16 Jan 2019)
Sequence version 3 (03 Oct 2012)
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Protein

Endoribonuclease dcr-1

Gene

dcr-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway (PubMed:11641272, PubMed:20223951). It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs (PubMed:11641272, PubMed:20223951). Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing (PubMed:11641272).2 Publications
tDCR-1 acts as a deoxyribonuclease (DNase) initiating DNA fragmentation during apoptosis, upstream of nucleases cps-6, crn-2 and nuc-1.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1682Magnesium or manganese1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1787Important for activityBy similarity1
Metal bindingi1791Magnesium or manganeseBy similarity1
Metal bindingi1794Magnesium or manganese1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi33 – 40ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Helicase, Hydrolase, Nuclease, RNA-binding
Biological processApoptosis, RNA-mediated gene silencing
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoribonuclease dcr-1 (EC:3.1.26.-2 Publications)
Cleaved into the following chain:
Death-promoting deoxyribonuclease1 Publication (EC:3.1.21.-1 Publication)
Short name:
tDCR-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dcr-11 Publication
ORF Names:K12H4.8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
K12H4.8 ; CE47418 ; WBGene00000939 ; dcr-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in a cps-6 mutant background reduces the number of DNA breaks in embryonic cells undergoing apoptosis.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1537D → E: Loss of cleavage by ced-3. Loss of deoxyribonuclease (DNase) activity. Reduced number of cell corpses in embryos. 1 Publication1
Mutagenesisi1682E → A: Severe reduction in both dsRNA dicing and DNase activities; when associated with A-1794. Loss of dsRNA dicing and DNase activities, bursting and protruding vulva and reduction in the number of cell corpses in embryos; when associated with A-1794 and A-1686. 1 Publication1
Mutagenesisi1686D → A: Loss of dsRNA dicing and DNase activities, bursting and protruding vulva and reduction in the number of cell corpses in embryos; when associated with A-1794 and A-1682. 1 Publication1
Mutagenesisi1794E → A: Severe reduction in both dsRNA dicing and DNase activities; when associated with A-1682. Loss of dsRNA dicing and DNase activities, bursting and protruding vulva and reduction in the number of cell corpses in embryos; when associated with A-1682 and A-1686. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001804731 – 1910Endoribonuclease dcr-1Add BLAST1910
ChainiPRO_00004411211538 – 1910Death-promoting deoxyribonucleaseCuratedAdd BLAST373

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei1537 – 1538Cleavage; by ced-31 Publication2

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34529

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P34529

PeptideAtlas

More...
PeptideAtlasi
P34529

PRoteomics IDEntifications database

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PRIDEi
P34529

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00000939 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May interact with pir-1.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41344, 2 interactors

Database of interacting proteins

More...
DIPi
DIP-25340N

Protein interaction database and analysis system

More...
IntActi
P34529, 88 interactors

STRING: functional protein association networks

More...
STRINGi
6239.K12H4.8

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P34529

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 201Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST182
Domaini371 – 542Helicase C-terminalPROSITE-ProRule annotationAdd BLAST172
Domaini571 – 667Dicer dsRNA-binding foldPROSITE-ProRule annotationAdd BLAST97
Domaini847 – 1003PAZPROSITE-ProRule annotationAdd BLAST157
Domaini1381 – 1589RNase III 1PROSITE-ProRule annotationAdd BLAST209
Domaini1643 – 1805RNase III 2PROSITE-ProRule annotationAdd BLAST163
Domaini1833 – 1896DRBMPROSITE-ProRule annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1245 – 1280Sequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi145 – 148DEAH boxPROSITE-ProRule annotation4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. Dicer subfamily.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0701 Eukaryota
COG0571 LUCA
COG1111 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156287

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000022395

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34529

KEGG Orthology (KO)

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KOi
K11592

Identification of Orthologs from Complete Genome Data

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OMAi
PKPDQPC

Database of Orthologous Groups

More...
OrthoDBi
1337630at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1520.10, 1 hit
3.30.160.380, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00104 RNase_III, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P34529-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVRVRADLQC FNPRDYQVEL LDKATKKNTI VQLGTGSGKT FIAVLLLKEY
60 70 80 90 100
GVQLFAPLDQ GGKRAFFVVE KVNLVEQQAI HIEVHTSFKV GQVHGQTSSG
110 120 130 140 150
LWDSKEQCDQ FMKRHHVVVI TAQCLLDLIR HAYLKIEDMC VLIFDECHHA
160 170 180 190 200
LGSQHPYRSI MVDYKLLKKD KPVPRVLGLT ASLIKAKVAP EKLMEQLKKL
210 220 230 240 250
ESAMDSVIET ASDLVSLSKY GAKPYEVVII CKDFEIGCLG IPNFDTVIEI
260 270 280 290 300
FDETVAFVNT TTEFHPDLDL DPRRPIKDSL KTTRAVFRQL GPWAAWRTAQ
310 320 330 340 350
VWEKELGKII KSQVLPDKTL RFLNMAKTSM ITIKRLLEPE MKKIKSIEAL
360 370 380 390 400
RPYVPQRVIR LFEILETFNP EFQKERMKLE KAEHLSAIIF VDQRYIAYSL
410 420 430 440 450
LLMMRHIKSW EPKFKFVNPD YVVGASGRNL ASSDSQGLHK RQTEVLRRFH
460 470 480 490 500
RNEINCLIAT SVLEEGVDVK QCNLVIKFDR PLDMRSYVQS KGRARRAGSR
510 520 530 540 550
YVITVEEKDT AACDSDLKDF QQIEKILLSR HRTVNNPIED DSDRFEEFDV
560 570 580 590 600
DSQMEPYVVE KTGATLKMST AIALINRYCS KLPSDIFTRL VPHNQIIPIE
610 620 630 640 650
ENGVTKYCAE LLLPINSPIK HAIVLKNPMP NKKTAQMAVA LEACRQLHLE
660 670 680 690 700
GELDDNLLPK GRESIAKLLE HIDEEPDEYA PGIAAKVGSS KRKQLYDKKI
710 720 730 740 750
ARALNESFVE ADKECFIYAF ELERFREAEL TLNPKRRKFE DPFNYEYCFG
760 770 780 790 800
FLSAKEIPKI PPFPVFLRQG NMKVRLIVAP KKTTVTAAQL QEIQLFHNYL
810 820 830 840 850
FTQVLQMCKT GNLEFDGTSN APLNTLIVPL NKRKDDMSYT INMKYVSEVV
860 870 880 890 900
ANMENMPRIP KDEVRRQYKF NAEDYKDAIV MPWYRNLEQP VFYYVAEILP
910 920 930 940 950
EWRPSSKFPD THFETFNEYF IKKYKLEIYD QNQSLLDVDF TSTRLNLLQP
960 970 980 990 1000
RIQNQPRRSR TVSNSSTSNI PQASASDSKE SNTSVPHSSQ RQILVPELMD
1010 1020 1030 1040 1050
IHPISATLWN VIAALPSIFY RVNQLLLTDE LRETILVKAF GKEKTKLDDN
1060 1070 1080 1090 1100
VEWNSLAYAT EYEEKQTIIV KKIQQLRDLN QKSIEDQERE TRENDKIDDG
1110 1120 1130 1140 1150
EELFNIGVWD PEEAVRIGVE ISSRDDRMDG EDQDTVGLTQ GLHDGNISDE
1160 1170 1180 1190 1200
DDELPFVMHD YTARLTSNRN GIGAWSGSES IVPSGWGDWD GPEPDNSPMP
1210 1220 1230 1240 1250
FQILGGPGGL NVQALMADVG RVFDPSTASS SLSQTVQEST VSPPKQLTKE
1260 1270 1280 1290 1300
EEQFKKLQND LLKQAKERLE ALEMSEDMEK PRRLEDTVNL EDYGDDQENQ
1310 1320 1330 1340 1350
EDENTPTNFP KTIDEEIEEL SIGARKKQEI DDNAAKTDVL ERENCEVLPV
1360 1370 1380 1390 1400
AINEKSRSFS FEKESKAING RLIRQRSEEY VSHIDSDIGL GVSPCLLLTA
1410 1420 1430 1440 1450
LTTSNAADGM SLERFETIGD SFLKFATTDY LYHTLLDQHE GKLSFARSKE
1460 1470 1480 1490 1500
VSNCNLYRLG KKLGIPQLIV ANKFDAHDSW LPPCYIPTCD FKAPNTDDAE
1510 1520 1530 1540 1550
EKDNEIERIL DGQVIEEKPE NKTGWDIGGD VSKSTTDGIE TITFPKQARV
1560 1570 1580 1590 1600
GNDDISPLPY NLLTQQHISD KSIADAVEAL IGVHLLTLGP NPTLKVMNWM
1610 1620 1630 1640 1650
GLKVIQKDQK SDVPSPLLRF IDTPTNPNAS LNFLNNLWQQ FQFTQLEEKI
1660 1670 1680 1690 1700
GYRFKERAYL VQAFTHASYI NNRVTGCYQR LEFLGDAVLD YMITRYLFED
1710 1720 1730 1740 1750
SRQYSPGVLT DLRSALVNNT IFASLAVKFE FQKHFIAMCP GLYHMIEKFV
1760 1770 1780 1790 1800
KLCSERNFDT NFNAEMYMVT TEEEIDEGQE EDIEVPKAMG DIFESVAGAI
1810 1820 1830 1840 1850
YLDSGRNLDT TWQVIFHMMR GTIELCCANP PRSPIRELME FEQSKVRFSK
1860 1870 1880 1890 1900
MERILESGKV RVTVEVVNNM RFTGMGRNYR IAKATAAKRA LKYLHQIEQQ
1910
RRQSPSLTTV
Length:1,910
Mass (Da):218,423
Last modified:October 3, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB49D19D7B3730F80
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FO081380 Genomic DNA Translation: CCD71200.2

Protein sequence database of the Protein Information Resource

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PIRi
S44849

NCBI Reference Sequences

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RefSeqi
NP_498761.2, NM_066360.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.38691

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K12H4.8.1; K12H4.8.1; WBGene00000939
K12H4.8.2; K12H4.8.2; WBGene00000939

Database of genes from NCBI RefSeq genomes

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GeneIDi
176138

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_K12H4.8

UCSC genome browser

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UCSCi
K12H4.8 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081380 Genomic DNA Translation: CCD71200.2
PIRiS44849
RefSeqiNP_498761.2, NM_066360.3
UniGeneiCel.38691

3D structure databases

ProteinModelPortaliP34529
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41344, 2 interactors
DIPiDIP-25340N
IntActiP34529, 88 interactors
STRINGi6239.K12H4.8

Proteomic databases

EPDiP34529
PaxDbiP34529
PeptideAtlasiP34529
PRIDEiP34529

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiK12H4.8.1; K12H4.8.1; WBGene00000939
K12H4.8.2; K12H4.8.2; WBGene00000939
GeneIDi176138
KEGGicel:CELE_K12H4.8
UCSCiK12H4.8 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
42693
WormBaseiK12H4.8 ; CE47418 ; WBGene00000939 ; dcr-1

Phylogenomic databases

eggNOGiKOG0701 Eukaryota
COG0571 LUCA
COG1111 LUCA
GeneTreeiENSGT00940000156287
HOGENOMiHOG000022395
InParanoidiP34529
KOiK11592
OMAiPKPDQPC
OrthoDBi1337630at2759

Miscellaneous databases

Protein Ontology

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PROi
PR:P34529

Gene expression databases

BgeeiWBGene00000939 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

CDDicd00048 DSRM, 1 hit
cd00079 HELICc, 1 hit
cd00593 RIBOc, 2 hits
Gene3Di1.10.1520.10, 1 hit
3.30.160.380, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR038248 Dicer_dimer_sf
IPR005034 Dicer_dimerisation_dom
IPR014720 dsRBD_dom
IPR006935 Helicase/UvrB_N
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF03368 Dicer_dimer, 1 hit
PF00271 Helicase_C, 1 hit
PF02170 PAZ, 1 hit
PF04851 ResIII, 1 hit
PF00636 Ribonuclease_3, 2 hits
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SM00949 PAZ, 1 hit
SM00535 RIBOc, 2 hits
SUPFAMiSSF101690 SSF101690, 1 hit
SSF52540 SSF52540, 1 hit
SSF69065 SSF69065, 2 hits
PROSITEiView protein in PROSITE
PS51327 DICER_DSRBF, 1 hit
PS50137 DS_RBD, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS50821 PAZ, 1 hit
PS00517 RNASE_3_1, 1 hit
PS50142 RNASE_3_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCR1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34529
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 3, 2012
Last modified: January 16, 2019
This is version 166 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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