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Entry version 154 (16 Oct 2019)
Sequence version 2 (01 Feb 1995)
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Protein

Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1

Gene

mog-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi464 – 471ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Helicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72187 mRNA 3'-end processing
R-CEL-73856 RNA Polymerase II Transcription Termination

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 (EC:3.6.4.13)
Alternative name(s):
Masculinization of germline protein 1
Sex determination protein mog-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mog-1
ORF Names:K03H1.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
K03H1.2 ; CE01027 ; WBGene00003389 ; mog-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000551481 – 1131Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1Add BLAST1131

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34498

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34498

PeptideAtlas

More...
PeptideAtlasi
P34498

PRoteomics IDEntifications database

More...
PRIDEi
P34498

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34498

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003389 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41603, 9 interactors

Protein interaction database and analysis system

More...
IntActi
P34498, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.K03H1.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34498

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini451 – 614Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini629 – 812Helicase C-terminalPROSITE-ProRule annotationAdd BLAST184

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi561 – 564DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0925 Eukaryota
COG1643 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156898

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000175261

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34498

KEGG Orthology (KO)

More...
KOi
K12815

Identification of Orthologs from Complete Genome Data

More...
OMAi
NGYSDGW

Database of Orthologous Groups

More...
OrthoDBi
354219at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34498

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34498-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDKRADGRL EGTSDTFGGL VIKKKKVEGD SKPTEPSGKS LLGLDRLAST
60 70 80 90 100
KREHARKRLE DDDDRGVTES VRKGIEKVHE KHRDRDDRGM KYKSRDDDRR
110 120 130 140 150
RDRDRSERRE PSSRRGWKDR SGDQTPRFKV PDTPSRMSWD QDDREGSSRK
160 170 180 190 200
RNSWDMPTPR GERDRKRYMD SERSISSAWR SERRNRDDEK RRRHRKPEDS
210 220 230 240 250
VRSVKEEKAE PTFHDDEERA QWEEEQKNLD REWYDNEGAF DDEYNPFNKV
260 270 280 290 300
SDEFVEKREK QWQEKTQKPR LTVKQQAIKR ENELWENNRL HRSGVVAMAD
310 320 330 340 350
ELSSIFEDET DENRVTILVQ NIVPPFLDGR IVFTKQAQPI IPVVDTTCDM
360 370 380 390 400
AVSAARGSVA VRKRREVEDR KKAQDKHWEL AGSKLGNLMG VKEKKDETAD
410 420 430 440 450
PEDDDSGNYK ESHQFASHMK DNEAVSDFAM EKSIKQQREY LPVFACRQKM
460 470 480 490 500
MNVIRENNVV IIVGETGSGK TTQLAQYLLE DGFGDSGLIG CTQPRRVAAM
510 520 530 540 550
SVARRVADEM GVDLGQDVGY AIRFEDCTSE KTIIKYMTDG ILLRECLGDG
560 570 580 590 600
SLDQYSAIIM DEAHERSLNT DVLFGLLREV IAKRADLKLI VTSATMDADK
610 620 630 640 650
FADFFGGNCP TFTIPGRTFP VELFHARTPV EDYVDAAVKQ AVTIHLGGMD
660 670 680 690 700
GDILIFMPGQ EDIECTCEMI KEKLGELDEA PPLAVLPIYS QLPSDLQAKI
710 720 730 740 750
FQRAPGGMRK AIVATNIAET SLTVDGILFV IDPGFCKMKV YNPRIGMDAL
760 770 780 790 800
SIFPVSQASA NQRTGRAGRT GPGQCYRLYT ERQFKDELLK STVPEIQRTN
810 820 830 840 850
LANVVLLLKS LGVDDLLKFH FMDAPPQDNM LNSMYQLWTL GALDNTGQLT
860 870 880 890 900
PMGRKMVEFP LDPTLSKMLI MSAEMGCSDE VLTIVSMLSV PAIFFRPKGR
910 920 930 940 950
EEEADAKKEK FQVPESDHLT FLNVYIQWRT HKYSAKWCAD NYLHVKALKK
960 970 980 990 1000
VREVRAQLKE IMQDLKLPLI SNGSEWDIVR KCICSAYFHN AARLKGIGEY
1010 1020 1030 1040 1050
VNVRTGIPCF LHPTSALFGM GFMPDYVVYH ELIMTAKEYM QCVTAVDAIW
1060 1070 1080 1090 1100
LAELGPMFYS IKESKQSRKE LKMESVRTVE TMEAEMREAQ KEMERRKEES
1110 1120 1130
DKAFKRPESS RRVVEVGSKS ARSERRKLWG L
Length:1,131
Mass (Da):129,424
Last modified:February 1, 1995 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i258C85D6584FAF3A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF120269 mRNA Translation: AAD13795.1
Z29560 Genomic DNA Translation: CAA82662.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F88570
S41025

NCBI Reference Sequences

More...
RefSeqi
NP_499212.1, NM_066811.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
K03H1.2.1; K03H1.2.1; WBGene00003389
K03H1.2.2; K03H1.2.2; WBGene00003389

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_K03H1.2

UCSC genome browser

More...
UCSCi
K03H1.2.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF120269 mRNA Translation: AAD13795.1
Z29560 Genomic DNA Translation: CAA82662.1
PIRiF88570
S41025
RefSeqiNP_499212.1, NM_066811.6

3D structure databases

SMRiP34498
ModBaseiSearch...

Protein-protein interaction databases

BioGridi41603, 9 interactors
IntActiP34498, 4 interactors
STRINGi6239.K03H1.2

PTM databases

iPTMnetiP34498

Proteomic databases

EPDiP34498
PaxDbiP34498
PeptideAtlasiP34498
PRIDEiP34498

Genome annotation databases

EnsemblMetazoaiK03H1.2.1; K03H1.2.1; WBGene00003389
K03H1.2.2; K03H1.2.2; WBGene00003389
GeneIDi176409
KEGGicel:CELE_K03H1.2
UCSCiK03H1.2.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176409
WormBaseiK03H1.2 ; CE01027 ; WBGene00003389 ; mog-1

Phylogenomic databases

eggNOGiKOG0925 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00940000156898
HOGENOMiHOG000175261
InParanoidiP34498
KOiK12815
OMAiNGYSDGW
OrthoDBi354219at2759
PhylomeDBiP34498

Enzyme and pathway databases

ReactomeiR-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72187 mRNA 3'-end processing
R-CEL-73856 RNA Polymerase II Transcription Termination

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34498

Gene expression databases

BgeeiWBGene00003389 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR002464 DNA/RNA_helicase_DEAH_CS
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF04408 HA2, 1 hit
PF00271 Helicase_C, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00847 HA2, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00690 DEAH_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOG1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34498
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1995
Last modified: October 16, 2019
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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