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UniProtKB - P34477 (UBC7_CAEEL)
Protein
Probable ubiquitin-conjugating enzyme E2 7
Gene
ubc-7
Organism
Caenorhabditis elegans
Status
Functioni
Catalyzes the covalent attachment of ubiquitin to other proteins.
PROSITE-ProRule annotationCatalytic activityi
- S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation EC:2.3.2.23
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 88 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ubiquitin conjugating enzyme activity Source: GO_Central
GO - Biological processi
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein polyubiquitination Source: GO_Central
- ubiquitin-dependent protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Transferase |
Biological process | Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-CEL-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation |
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ubiquitin-conjugating enzyme E2 7 (EC:2.3.2.23)Alternative name(s): E2 ubiquitin-conjugating enzyme 7 Ubiquitin carrier protein 7 Ubiquitin-protein ligase 7 |
Gene namesi | Name:ubc-7 ORF Names:F58A4.10 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F58A4.10 ; CE00216 ; WBGene00006704 ; ubc-7 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082516 | 1 – 164 | Probable ubiquitin-conjugating enzyme E2 7Add BLAST | 164 |
Proteomic databases
EPDi | P34477 |
PaxDbi | P34477 |
PeptideAtlasi | P34477 |
Expressioni
Gene expression databases
Bgeei | WBGene00006704, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Protein-protein interaction databases
BioGRIDi | 41558, 4 interactors |
STRINGi | 6239.F58A4.10 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P34477 |
SMRi | P34477 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P34477 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 3 – 163 | UBC corePROSITE-ProRule annotationAdd BLAST | 161 |
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0425, Eukaryota |
GeneTreei | ENSGT00940000155228 |
HOGENOMi | CLU_030988_10_1_1 |
InParanoidi | P34477 |
OMAi | RKVTRCV |
OrthoDBi | 1317014at2759 |
PhylomeDBi | P34477 |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P34477-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG
60 70 80 90 100
GFFKAILDFP RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW
110 120 130 140 150
GYERPEERWL PVHTVETILL SVISMLTDPN FESPANVDAA KMQRENYAEF
160
KKKVAQCVRR SQEE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22179 Genomic DNA Translation: CAA80166.1 |
PIRi | S40982 |
RefSeqi | NP_499133.1, NM_066732.4 |
Genome annotation databases
EnsemblMetazoai | F58A4.10.1; F58A4.10.1; WBGene00006704 |
GeneIDi | 176363 |
KEGGi | cel:CELE_F58A4.10 |
UCSCi | F58A4.10.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z22179 Genomic DNA Translation: CAA80166.1 |
PIRi | S40982 |
RefSeqi | NP_499133.1, NM_066732.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1PZV | X-ray | 2.52 | A | 1-164 | [»] | |
AlphaFoldDBi | P34477 | |||||
SMRi | P34477 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 41558, 4 interactors |
STRINGi | 6239.F58A4.10 |
Proteomic databases
EPDi | P34477 |
PaxDbi | P34477 |
PeptideAtlasi | P34477 |
Genome annotation databases
EnsemblMetazoai | F58A4.10.1; F58A4.10.1; WBGene00006704 |
GeneIDi | 176363 |
KEGGi | cel:CELE_F58A4.10 |
UCSCi | F58A4.10.1, c. elegans |
Organism-specific databases
CTDi | 176363 |
WormBasei | F58A4.10 ; CE00216 ; WBGene00006704 ; ubc-7 |
Phylogenomic databases
eggNOGi | KOG0425, Eukaryota |
GeneTreei | ENSGT00940000155228 |
HOGENOMi | CLU_030988_10_1_1 |
InParanoidi | P34477 |
OMAi | RKVTRCV |
OrthoDBi | 1317014at2759 |
PhylomeDBi | P34477 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Reactomei | R-CEL-8866652, Synthesis of active ubiquitin: roles of E1 and E2 enzymes R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
EvolutionaryTracei | P34477 |
PROi | PR:P34477 |
Gene expression databases
Bgeei | WBGene00006704, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
CDDi | cd00195, UBCc, 1 hit |
Gene3Di | 3.10.110.10, 1 hit |
InterProi | View protein in InterPro IPR000608, UBQ-conjugat_E2 IPR023313, UBQ-conjugating_AS IPR016135, UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179, UQ_con, 1 hit |
SUPFAMi | SSF54495, SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183, UBC_1, 1 hit PS50127, UBC_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBC7_CAEEL | |
Accessioni | P34477Primary (citable) accession number: P34477 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families