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Entry version 159 (17 Jun 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Integrin alpha pat-2

Gene

pat-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for muscle development probably through the regulation of the actin-myosin cytoskeleton (PubMed:8106547, PubMed:12915588). Component of an integrin containing attachment complex, which is required for muscle maintenance (PubMed:22253611). During the formation of neuromuscular junctions at the larval stage, negatively regulates membrane protrusion from body wall muscles, probably through lamins such as epi-1, lam-2 and unc-52 (PubMed:16495308). Required for distal tip cell migration and dorsal pathfinding (PubMed:17606640). Required for egg-laying (PubMed:12915588). May play a role in cell motility and cell-cell interactions (By similarity). Plays a role in vulval development (PubMed:28135265). Probably within the alpha pat-2/beta pat-3 integrin receptor complex, plays a role in the negative regulation of let-23 signaling and vulval induction. This is probably partly by restricting the mobility of the let-23 receptor on the plasma membrane of vulval cells which thereby attenuates let-23 signaling (PubMed:28135265).By similarity6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-114608 Platelet degranulation
R-CEL-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-CEL-1566977 Fibronectin matrix formation
R-CEL-202733 Cell surface interactions at the vascular wall
R-CEL-210990 PECAM1 interactions
R-CEL-2129379 Molecules associated with elastic fibres
R-CEL-216083 Integrin cell surface interactions
R-CEL-3000170 Syndecan interactions
R-CEL-3000178 ECM proteoglycans
R-CEL-354192 Integrin signaling
R-CEL-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CEL-445355 Smooth Muscle Contraction
R-CEL-5674135 MAP2K and MAPK activation
R-CEL-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P34446

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin alpha pat-2
Alternative name(s):
Paralyzed arrest at two-fold protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pat-2Imported
ORF Names:F54F2.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
F54F2.1 ; CE00194 ; WBGene00003929 ; pat-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1154ExtracellularSequence analysisAdd BLAST1129
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1155 – 1177HelicalSequence analysisAdd BLAST23
Topological domaini1178 – 1226CytoplasmicSequence analysisAdd BLAST49

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Severe paralysis at the 1-fold stage of embryonic development followed by an arrest in elongation at 2-fold stage (PubMed:8106547). Loss of myosin and actin organization in embryonic body wall muscles and loss of muscle cell polarization (PubMed:8106547). RNAi-mediated knockdown in post-hatching animals causes paralysis associated with severe disorganization of body wall muscle actin filaments and defects in egg-laying associated with embryonic hatching within the mother (the bag of worms phenotype) (PubMed:12915588). Few surviving adults, are uncoordinated with abnormal body size and shape and have defects in distal tip cells (DTC) migration resulting in abnormal gonad formation (PubMed:17606640). RNAi-mediated knockdown in L4 larval stage, causes ectopic membrane extensions from body wall muscles (PubMed:16495308). RNAi-mediated knockdown results in impaired mobility, mitochondrial fragmentation and disrupted integrin attachment complexes in muscle (PubMed:22253611). This leads to degradation of muscle proteins in the cytosol, myofibrillar defects and disruption of sarcomere organization (PubMed:22253611). RNAi-mediated knockdown in vulval precursor cells in a let-60 gain of function mutant background results in increased vulval induction and an adjacent primary fate (Apf) phenotype whereby secondary vulval precursor cells transform into primary-like vulval cells (PubMed:28135265).6 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi441G → D in st567; severe paralysis at embryonic 1-fold stage followed by an arrest in elongation at 2-fold stage. Loss of myosin and actin organization in embryonic muscles. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001633226 – 1226Integrin alpha pat-2Add BLAST1201

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi108N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi228N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi290N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi608N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi679N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi775N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi819N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P34446

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34446

PeptideAtlas

More...
PeptideAtlasi
P34446

PRoteomics IDEntifications database

More...
PRIDEi
P34446

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34446

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in body-wall muscle cells, distal tip cells, and vulval tissue.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Up-regulated during L3 developmental stage in distal tip cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003929 Expressed in multi-cellular organism and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit (Probable).

Interacts with beta subunit pat-3 (Probable).

Interacts with dep-1 (PubMed:28135265).

Component of an integrin containing attachment complex, composed of at least pat-2, pat-3, pat-4, pat-6, unc-52, unc-97 and unc-112 (PubMed:22253611).

Curated1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
41442, 4 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F54F2.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P34446

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati27 – 94FG-GAP 1PROSITE-ProRule annotationAdd BLAST68
Repeati108 – 171FG-GAP 2PROSITE-ProRule annotationAdd BLAST64
Repeati178 – 233FG-GAP 3PROSITE-ProRule annotationAdd BLAST56
Repeati234 – 290FG-GAP 4PROSITE-ProRule annotationAdd BLAST57
Repeati291 – 345FG-GAP 5PROSITE-ProRule annotationAdd BLAST55
Repeati362 – 421FG-GAP 6PROSITE-ProRule annotationAdd BLAST60
Repeati425 – 488FG-GAP 7PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi620 – 622Cell attachment siteSequence analysis3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3637 Eukaryota
ENOG410XPVZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169118

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004111_4_2_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P34446

Identification of Orthologs from Complete Genome Data

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OMAi
NNEDAFE

Database of Orthologous Groups

More...
OrthoDBi
743479at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34446

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.130, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01185 INTEGRINA

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00191 Int_alpha, 5 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF69179 SSF69179, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P34446-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MREGSFPRRI GLLLGLLGLL AGVATFNIDT KNVVVHHMAG NYFGYSLDFY
60 70 80 90 100
HEQKGMPVLV VGAPEAESNN PNLAGIRRPG AVYACSVNRA TCREVHVDKM
110 120 130 140 150
KGNLKKLNGS HLVPIEEKSH QFFGATVRSN DKHDKIVVCA PKYTYFYSKF
160 170 180 190 200
EVIEPVGTCF YAENGFDNAE EFSSCKQEPA RHGRHRLGYG QCGFSAAVPG
210 220 230 240 250
KKNQNRVFIG APGVWYWQGA MFSQNIKNQT DRPNTEYGSK EYDHDMMGYS
260 270 280 290 300
TATGDFDGDG IDDIVAGVPR GNDLHGKLVL YTSKLKMMIN LTDEVSTQHG
310 320 330 340 350
QYCGGSVAVA DVNKDGRDDI IMGCPFYTDY GSVKDAKTQE RKPQYDVGKV
360 370 380 390 400
IVMLQTAPGV FGKQIAVVGD DQWGRFGHAV AAAGDLNLDG YNDVIVGAPY
410 420 430 440 450
AGKNKQGAVY VIHGSKDGVR ELPTQKIEGA NIGHGNIKSF GFSLTGNEDV
460 470 480 490 500
DGNGMPDIAV GAWKSGNAAV LLTKPVVTVT GQTEPESALI SVEDKNCDVD
510 520 530 540 550
GKLGKQACKH INTCFKYEGK GDTPNDLEFD LRFNLDDHSP EPRAYFLQKD
560 570 580 590 600
VKSDRSIKVA QGSKTRDHPS SIEQRVRLEK GRQKCFRHRF FASSTMKDKL
610 620 630 640 650
SPIHWSVNYT YVESKTGKLR GDKLEPAIDT TVPLSFQNKI NIANNCGKDD
660 670 680 690 700
LCVPDLKVTA VADREKFLLG TQDNTMLINV TVQNGGEDSY ETKLYFDVPQ
710 720 730 740 750
GFEYGGIESV GGDGSKSAPA CSPTSDEPDS DGKWTFACDL GNPLPANKVV
760 770 780 790 800
SSVVRVTASS DKPPLAPISI NAHVNSSNDE EAHTVADNKV TFTIPVDFKN
810 820 830 840 850
QLSLNGRSNP EQVDFSMTNK TRVDAFDDNE IGPVVSHLYQ ISNRGPSEVD
860 870 880 890 900
SATLDIFWPS FSTEGGHLLY IITEPVVNPP NKGRCRVKQL QNVNPLNLRI
910 920 930 940 950
TNEHVPTEPP VAKTPNEYSR EEDDESYEDE TTTQSQSTRH QSTQHQTHHQ
960 970 980 990 1000
SGPVHVYEKD EEKIRQNTGN WQYVEDKKKK GDYEYIPDDQ EYDGDDFEEE
1010 1020 1030 1040 1050
DDEDFDRAGS KRVKRNPTPK KKKKGGEHRG EPRSDKARFS DLREAVKLSK
1060 1070 1080 1090 1100
EAGGVVDYKG PLSRASVDCN SLRCTHIECD IYDLKEDEFV LVEIFSRLYT
1110 1120 1130 1140 1150
NTLVDEKNPG GDISSLALAR VTSTKYNLPH KPTLITAVST NMNAIASEEG
1160 1170 1180 1190 1200
RDLPWWLYLL AILIGLAILI LLILLLWRCG FFKRNRPPTE HAELRADRQP
1210 1220
NAQYADSQSR YTSQDQYNQG RHGQML
Length:1,226
Mass (Da):135,940
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9169AD75B88901D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD71234.1

Protein sequence database of the Protein Information Resource

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PIRi
S44824

NCBI Reference Sequences

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RefSeqi
NP_498948.1, NM_066547.3

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
F54F2.1.1; F54F2.1.1; WBGene00003929

Database of genes from NCBI RefSeq genomes

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GeneIDi
176240

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F54F2.1

UCSC genome browser

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UCSCi
F54F2.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CCD71234.1
PIRiS44824
RefSeqiNP_498948.1, NM_066547.3

3D structure databases

SMRiP34446
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41442, 4 interactors
STRINGi6239.F54F2.1

PTM databases

iPTMnetiP34446

Proteomic databases

EPDiP34446
PaxDbiP34446
PeptideAtlasiP34446
PRIDEiP34446

Genome annotation databases

EnsemblMetazoaiF54F2.1.1; F54F2.1.1; WBGene00003929
GeneIDi176240
KEGGicel:CELE_F54F2.1
UCSCiF54F2.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176240
WormBaseiF54F2.1 ; CE00194 ; WBGene00003929 ; pat-2

Phylogenomic databases

eggNOGiKOG3637 Eukaryota
ENOG410XPVZ LUCA
GeneTreeiENSGT00940000169118
HOGENOMiCLU_004111_4_2_1
InParanoidiP34446
OMAiNNEDAFE
OrthoDBi743479at2759
PhylomeDBiP34446

Enzyme and pathway databases

ReactomeiR-CEL-114608 Platelet degranulation
R-CEL-1236973 Cross-presentation of particulate exogenous antigens (phagosomes)
R-CEL-1566977 Fibronectin matrix formation
R-CEL-202733 Cell surface interactions at the vascular wall
R-CEL-210990 PECAM1 interactions
R-CEL-2129379 Molecules associated with elastic fibres
R-CEL-216083 Integrin cell surface interactions
R-CEL-3000170 Syndecan interactions
R-CEL-3000178 ECM proteoglycans
R-CEL-354192 Integrin signaling
R-CEL-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-CEL-445355 Smooth Muscle Contraction
R-CEL-5674135 MAP2K and MAPK activation
R-CEL-6798695 Neutrophil degranulation
SignaLinkiP34446

Miscellaneous databases

Protein Ontology

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PROi
PR:P34446

Gene expression databases

BgeeiWBGene00003929 Expressed in multi-cellular organism and 3 other tissues

Family and domain databases

Gene3Di2.130.10.130, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SUPFAMiSSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPAT2_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34446
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 17, 2020
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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