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Entry version 160 (23 Feb 2022)
Sequence version 2 (16 May 2003)
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Protein

Voltage-dependent calcium channel unc-36

Gene

unc-36

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as an auxiliary subunit of the unc-2 voltage-gated calcium channel which appears to trigger calcium-activated signaling pathways that control the serotonin response. Inhibiting serotonin sensitivity of the vulval muscles results in egg laying defects. May act in both neurons and muscle cells to enhance motor activity as it is required for coordinated movement. Has a role in neural depolarization-induced calcium influx and pharyngeal pumping (PubMed:8462849, PubMed:8807295, PubMed:16838374).

Involved in restricting the expression of the putative olfactory receptor str-2 to only one of the two AWC neurons (PubMed:10571181).

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channel, Ion channel, Voltage-gated channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-112308, Presynaptic depolarization and calcium channel opening
R-CEL-422356, Regulation of insulin secretion
R-CEL-5576892, Phase 0 - rapid depolarisation
R-CEL-5576893, Phase 2 - plateau phase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent calcium channel unc-36
Alternative name(s):
Pharyngeal calcium channel subunit alpha-2
Uncoordinated protein 36
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-36
Synonyms:unc-72
ORF Names:C50C3.9/C50C3.10/C50C3.11
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
C50C3.9a ; CE32168 ; WBGene00006772 ; unc-36
C50C3.9b ; CE39702 ; WBGene00006772 ; unc-36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1228ExtracellularSequence analysisAdd BLAST1209
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1229 – 1248HelicalSequence analysisAdd BLAST20
Topological domaini1249CytoplasmicSequence analysis1

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit a weak egg-laying constitutive (Egl-c) phenotype and slow irregular pharyngeal pumping.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002262720 – 1249Voltage-dependent calcium channel unc-36Add BLAST1230

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi100N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi558N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi757N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi838N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi903N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi923N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1130N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34374

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34374

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Decendants of the cells AB and AB.p (that give rise to nearly all non-pharyngeal neurons), decendants of P1 (that give rise to body muscle) and cell lineages that give rise to the adult and juvenile motor neurons. Expressed in body wall, vulval muscle and pharyngeal muscle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006772, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34374, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41360, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.C50C3.9a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34374

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini250 – 479VWFAPROSITE-ProRule annotationAdd BLAST230

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2353, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000166626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34374

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKANDVC

Database of Orthologous Groups

More...
OrthoDBi
69856at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34374

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013680, VDCC_a2/dsu
IPR013608, VWA_N
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08473, VGCC_alpha2, 1 hit
PF13519, VWA_2, 1 hit
PF13768, VWA_3, 1 hit
PF08399, VWA_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform a (identifier: P34374-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVVHLLVVL ATYVSTTSSF NKESIKECAK VLSEHMKETF SKISHETILK
60 70 80 90 100
QNYEKLVEEE QFDPRAELKK SKHRIEDYLK VRSQFAYKAK ISLEARSVRN
110 120 130 140 150
DSTVNDPQSK SFIRFMSAKQ GNDGTTIYES NHLGKRLKVN ETKSFNLTQN
160 170 180 190 200
ANFYTLPTSS VSSAVHIPTP LYDRNEDLLR KIDWSDIDAV YRTNREETKD
210 220 230 240 250
LAFQLFCSEA GYMRYYPAAS WFWDNQDEHL DLFDCRNTEW YINSATNSKN
260 270 280 290 300
VLIMLDMSGS MLGQRYEVAK QTTEAILETL SHNDYFNIMT FSKNTFLLDG
310 320 330 340 350
CNGTNGLLQA TMRNKKALRR KMDTYQSEGK AEYEKALPLA FSVLLDLKGS
360 370 380 390 400
YALYTKEEMS MMSANATNEY QFHLELPEHV LAATKQYIDS INNGGGDNNR
410 420 430 440 450
GACENVIMLI TDGAPNAYKK IFDMYNADKK VRVFTFLVGD EAIDFNEVRE
460 470 480 490 500
MACNNRGYMV HVANMADVDE KIHHYIRRMS RVVGRHYKES GQLSWWTGVY
510 520 530 540 550
RERLYLPRPE IFAEPVPITN QSFAVMNKMA SRRKIRLQKS EARSRMFVTT
560 570 580 590 600
VSYPVIVNET FMGVAAVNIP LTEVAQKSHP ANIGSKSYFF MLDQNGFVMT
610 620 630 640 650
HPQLRPIDPF TKYHKQNYNN MDLLELEVGQ NQNVRSSQKS QAVSDLVCES
660 670 680 690 700
GANYAECVDD LRKAVRKMII DCDNSDVQQL DVLYATELLD RVYPQTNTYY
710 720 730 740 750
AECINHANFV LGLAVAKGDD YRVVKKQKKY DFGRVKMDWM GDKRWRLHPH
760 770 780 790 800
WRYCFLNDTD THMSKEEAFE IYAQQMSDSG KAPLLCEYRR NLVEKLLLDM
810 820 830 840 850
EATSNLIDSW DTQFNFMKNN LIHLAFFATP SGMIRYYNLT LQDYDYIDPY
860 870 880 890 900
WSIFEHIGHL LSIEHAQESY NHFITDLNRK STDDRYYRRA VRMKDTIMFD
910 920 930 940 950
VSNNSKIWYK SETQLTGYGL NENLTMLGQA FKAIYLDKAV LGVSGFEFAY
960 970 980 990 1000
DHVVDTMAEH GCPASDDRKW CVLLDEHAYV FFSNQNDISY EDYLVGKGKH
1010 1020 1030 1040 1050
ISQYFGGLNR IAQRAMALLV ENKFYTKLTY TDNQAVCKAE KVVTTSGNRL
1060 1070 1080 1090 1100
RPFYPIFRFL MQTFNFMVRL ASQISGGFLI WLPNIQFTEA YTASFHEGTD
1110 1120 1130 1140 1150
VYPCPKQSSF YFSNKDGKNR PGTTHLVNGN RSERPCKMNA KCSVKMEASF
1160 1170 1180 1190 1200
VDGTNLVMVW ITQDKASENC YDESECSMEI SNQVPFGFEE VKNEETCEEN
1210 1220 1230 1240
EKRKSKANDV CYSIDDDDSE NERRPCSTSP TIVSIFQILF GVFLHFCIF
Length:1,249
Mass (Da):144,376
Last modified:May 16, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i533FF6059D375FB2
GO
Isoform b (identifier: P34374-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1145: Missing.

Show »
Length:104
Mass (Da):11,942
Checksum:iA36E1FA05E6E9B46
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G4S4A1G4S4A1_CAEEL
VWFA domain-containing protein
unc-36 C50C3.9, CELE_C50C3.9
1,205Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0360071 – 1145Missing in isoform b. CuratedAdd BLAST1145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080718 Genomic DNA Translation: CCD66125.1
FO080718 Genomic DNA Translation: CCD66126.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S44617
S44618
S44619

NCBI Reference Sequences

More...
RefSeqi
NP_001040851.1, NM_001047386.2 [P34374-1]
NP_001040852.1, NM_001047387.2 [P34374-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C50C3.9a.1; C50C3.9a.1; WBGene00006772 [P34374-1]
C50C3.9b.1; C50C3.9b.1; WBGene00006772 [P34374-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176155

UCSC genome browser

More...
UCSCi
C50C3.9a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080718 Genomic DNA Translation: CCD66125.1
FO080718 Genomic DNA Translation: CCD66126.1
PIRiS44617
S44618
S44619
RefSeqiNP_001040851.1, NM_001047386.2 [P34374-1]
NP_001040852.1, NM_001047387.2 [P34374-2]

3D structure databases

SMRiP34374
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41360, 1 interactor
STRINGi6239.C50C3.9a

PTM databases

iPTMnetiP34374

Proteomic databases

PaxDbiP34374

Genome annotation databases

EnsemblMetazoaiC50C3.9a.1; C50C3.9a.1; WBGene00006772 [P34374-1]
C50C3.9b.1; C50C3.9b.1; WBGene00006772 [P34374-2]
GeneIDi176155
UCSCiC50C3.9a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176155
WormBaseiC50C3.9a ; CE32168 ; WBGene00006772 ; unc-36
C50C3.9b ; CE39702 ; WBGene00006772 ; unc-36

Phylogenomic databases

eggNOGiKOG2353, Eukaryota
GeneTreeiENSGT00940000166626
InParanoidiP34374
OMAiSKANDVC
OrthoDBi69856at2759
PhylomeDBiP34374

Enzyme and pathway databases

ReactomeiR-CEL-112308, Presynaptic depolarization and calcium channel opening
R-CEL-422356, Regulation of insulin secretion
R-CEL-5576892, Phase 0 - rapid depolarisation
R-CEL-5576893, Phase 2 - plateau phase

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34374

Gene expression databases

BgeeiWBGene00006772, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues
ExpressionAtlasiP34374, baseline and differential

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013680, VDCC_a2/dsu
IPR013608, VWA_N
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PfamiView protein in Pfam
PF08473, VGCC_alpha2, 1 hit
PF13519, VWA_2, 1 hit
PF13768, VWA_3, 1 hit
PF08399, VWA_N, 1 hit
SMARTiView protein in SMART
SM00327, VWA, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
PROSITEiView protein in PROSITE
PS50234, VWFA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUNC36_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34374
Secondary accession number(s): A9Z1J5, P34372, P34373
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: May 16, 2003
Last modified: February 23, 2022
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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