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Entry version 142 (26 Feb 2020)
Sequence version 1 (01 Feb 1994)
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Protein

Pre-mRNA-splicing factor 8 homolog

Gene

prp-8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72165 mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-splicing factor 8 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prp-8
ORF Names:C50C3.6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
C50C3.6 ; CE00122 ; WBGene00004187 ; prp-8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000970391 – 2329Pre-mRNA-splicing factor 8 homologAdd BLAST2329

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34369

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34369

PeptideAtlas

More...
PeptideAtlasi
P34369

PRoteomics IDEntifications database

More...
PRIDEi
P34369

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34369

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004187 Expressed in multi-cellular organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the U5 snRNP complex and of the U4/U6-U5 tri-snRNP complex.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
41358, 34 interactors

Database of interacting proteins

More...
DIPi
DIP-27427N

STRING: functional protein association networks

More...
STRINGi
6239.C50C3.6

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34369

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P34369

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2096 – 2227MPNPROSITE-ProRule annotationAdd BLAST132

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni804 – 1295Reverse transcriptase homology domainAdd BLAST492
Regioni1296 – 1570LinkerAdd BLAST275
Regioni1506 – 1519Important for branch point selectionBy similarityAdd BLAST14
Regioni1574 – 1745Restriction endonuclease homology domainAdd BLAST172
Regioni1760 – 2013RNase H homology domainAdd BLAST254

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MPN (JAB/Mov34) domain has structural similarity with deubiquitinating enzymes, but lacks the residues that would bind the catalytic metal ion.
Contains a region with structural similarity to reverse transcripase, presenting the classical thumb, fingers and palm architecture, but lacks enzyme activity, since the essential metal-binding residues are not conserved.By similarity
Contains a region with structural similarity to type-2 restriction endonucleases, but the residues that would bind catalytic metal ions in endonucleases are instead involved in hydrogen bonds that stabilize the protein structure.By similarity
Contains a region with structural similarity to RNase H, but lacks RNase H activity.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1795 Eukaryota
COG5178 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000380_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34369

KEGG Orthology (KO)

More...
KOi
K12856

Identification of Orthologs from Complete Genome Data

More...
OMAi
WVDRSDN

Database of Orthologous Groups

More...
OrthoDBi
156083at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34369

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13838 RNase_H_like_Prp8_IV, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.1750, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR012591 PRO8NT
IPR012592 PROCN
IPR012984 PROCT
IPR027652 PRP8
IPR021983 PRP8_domainIV
IPR019581 Prp8_U5-snRNA-bd
IPR042516 Prp8_U5-snRNA-bd_sf
IPR019580 Prp8_U6-snRNA-bd
IPR012337 RNaseH-like_sf
IPR019582 RRM_spliceosomal_PrP8

The PANTHER Classification System

More...
PANTHERi
PTHR11140 PTHR11140, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01398 JAB, 1 hit
PF08082 PRO8NT, 1 hit
PF08083 PROCN, 1 hit
PF08084 PROCT, 1 hit
PF12134 PRP8_domainIV, 1 hit
PF10598 RRM_4, 1 hit
PF10597 U5_2-snRNA_bdg, 1 hit
PF10596 U6-snRNA_bdg, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00232 JAB_MPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53098 SSF53098, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50249 MPN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34369-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANYGGHPQT EPHAIPDSIL EEKSRKWKQL QGKRYSEKKK FGMSDTQKEE
60 70 80 90 100
MPPEHVRKVI RDHGDMTSRK YRHDKRVYLG ALKYMPHAVL KLLENMPMPW
110 120 130 140 150
EQIRDVKVLY HITGAITFVN DIPRVIEPVY MAQWGTMWIM MRREKRDRRH
160 170 180 190 200
FKRMRFPPFD DEEPPLDYAD NILDVEPLEP IQMELDPEED GAVAEWFYDH
210 220 230 240 250
KPLATTRFVN GPTYRKWAFS IPQMSTLYRL ANQLLTDLVD DNYFYLFDMK
260 270 280 290 300
SFFTAKALNV AIPGGPKFEP LVKDLHTDED WNEFNDINKV IIRAPIRTEY
310 320 330 340 350
RIAFPFMYNN LISSLPVQVS WYHTPSVVFI KTEDPDLPAF YYDPLINPIV
360 370 380 390 400
LSNLKATEEN LPEGEEEDEW ELPEDVRPIF EDVPLYTDNT ANGLALLWAP
410 420 430 440 450
RPFNLRSGRT RRAVDVPLVK SWYREHCPAG MPVKVRVSYQ KLLKVFVLNA
460 470 480 490 500
LKHRPPKPQK RRYLFRSFKA TKFFQTTTLD WVEAGLQVLR QGYNMLNLLI
510 520 530 540 550
HRKNLNYLHL DYNFNLKPVK TLTTKERKKS RFGNAFHLCR EILRLTKLVV
560 570 580 590 600
DAHVQYRLNN VDAYQLADGL QYIFAHVGQL TGMYRYKYKL MRQVRMCKDL
610 620 630 640 650
KHLIYYRFNT GPVGKGPGCG FWAPGWRVWL FFLRGITPLL ERWLGNLLSR
660 670 680 690 700
QFEGRHSKGV AKTVTKQRVE SHFDLELRAA VMHDILDMMP DGIKQNKARV
710 720 730 740 750
ILQHLSEAWR CWKANIPWKV PGLPTPVENM ILRYVKAKAD WWTNSAHYNR
760 770 780 790 800
ERVRRGATVD KTVCKKNLGR LTRLYLKSEQ ERQHNYLKDG PYISAEEAVA
810 820 830 840 850
IYTTTVHWLE SRRFSPIPFP PLSYKHDTKL LILALERLKE SYSVKNRLNQ
860 870 880 890 900
SQREELALIE QAYDNPHEAL SRIKRHMLTQ RAFKEVGIEF MDLYTHLIPV
910 920 930 940 950
YDIEPLEKVT DAYLDQYLWY EADKRRLFPA WVKPGDTEPP PLLTYKWCQG
960 970 980 990 1000
LNNLQDVWET SEGECNVIME TKLEKIAEKM DLTLLNRLLR LIVDHNIADY
1010 1020 1030 1040 1050
MTSKNNVLIN YKDMNHTNSF GIIRGLQFAS FIVQFYGLVL DLLVLGLRRA
1060 1070 1080 1090 1100
SEIAGPPQCP NEFLQFQDVA TEIGHPIRLY CRYIDRVWIM FRFSADEARD
1110 1120 1130 1140 1150
LIQRYLTEHP DPNNENIVGY NNKKCWPRDA RMRLMKHDVN LGRAVFWDIK
1160 1170 1180 1190 1200
NRLPRSITTV EWENSFVSVY SKDNPNMLFD MSGFECRILP KCRTANEEFV
1210 1220 1230 1240 1250
HRDGVWNLQN EVTKERTAQC FLKVDEESLS KFHNRIRQIL MSSGSTTFTK
1260 1270 1280 1290 1300
IVNKWNTALI GLMTYFREAV VNTQELLDLL VKCENKIQTR IKIGLNSKMP
1310 1320 1330 1340 1350
SRFPPVVFYT PKEIGGLGML SMGHVLIPQS DLRWMQQTEA GGVTHFRSGM
1360 1370 1380 1390 1400
SHDEDQLIPN LYRYIQPWEA EFVDSVRVWA EYALKRQEAN AQNRRLTLED
1410 1420 1430 1440 1450
LDDSWDRGIP RINTLFQKDR HTLAYDKGWR VRTEFKAYQI LKQNPFWWTH
1460 1470 1480 1490 1500
QRHDGKLWNL NNYRTDMIQA LGGVEGILEH TLFRGTYFPT WEGLFWERAS
1510 1520 1530 1540 1550
GFEESMKFKK LTNAQRSGLN QIPNRRFTLW WSPTINRANV YVGFQVQLDL
1560 1570 1580 1590 1600
TGIFMHGKIP TLKISLIQIF RAHLWQKIHE SVVMDLCQVF DQELDALEIQ
1610 1620 1630 1640 1650
TVQKETIHPR KSYKMNSSCA DVLLFAQYKW NVSRPSLMAD SKDVMDNTTT
1660 1670 1680 1690 1700
QKYWLDVQLR WGDYDSHDVE RYARAKFLDY TTDNMSIYPS PTGVLIAIDL
1710 1720 1730 1740 1750
AYNLYSAYGN WFPGMKPLIR QAMAKIIKAN PAFYVLRERI RKGLQLYSSE
1760 1770 1780 1790 1800
PTEPYLTSQN YGELFSNQII WFVDDTNVYR VTIHKTFEGN LTTKPINGAI
1810 1820 1830 1840 1850
FIFNPRTGQL FLKIIHTSVW AGQKRLSQLA KWKTAEEVAA LIRSLPVEEQ
1860 1870 1880 1890 1900
PRQIIVTRKA MLDPLEVHLL DFPNIVIKGS ELMLPFQAIM KVEKFGDLIL
1910 1920 1930 1940 1950
KATEPQMVLF NLYDDWLKTI SSYTAFSRVV LIMRGMHINP DKTKVILKPD
1960 1970 1980 1990 2000
KTTITEPHHI WPTLSDDDWI KVELALKDMI LADYGKKNNV NVASLTQSEV
2010 2020 2030 2040 2050
RDIILGMEIS APSQQRQQIA DIEKQTKEQS QVTATTTRTV NKHGDEIITA
2060 2070 2080 2090 2100
TTSNYETASF ASRTEWRVRA ISSTNLHLRT QHIYVNSDDV KDTGYTYILP
2110 2120 2130 2140 2150
KNILKKFITI SDLRTQIAGF MYGVSPPDNP QVKEIRCIVL VPQTGSHQQV
2160 2170 2180 2190 2200
NLPTQLPDHE LLRDFEPLGW MHTQPNELPQ LSPQDVTTHA KLLTDNISWD
2210 2220 2230 2240 2250
GEKTVMITCS FTPGSVSLTA YKLTPSGYEW GKANTDKGNN PKGYMPTHYE
2260 2270 2280 2290 2300
KVQMLLSDRF LGYFMVPSNG VWNYNFQGQR WSPAMKFDVC LSNPKEYYHE
2310 2320
DHRPVHFHNF KAFDDPLGTG SADREDAFA
Length:2,329
Mass (Da):272,028
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i626F9F97C800960C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080718 Genomic DNA Translation: CCD66122.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S44625

NCBI Reference Sequences

More...
RefSeqi
NP_498785.1, NM_066384.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C50C3.6.1; C50C3.6.1; WBGene00004187

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176153

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C50C3.6

UCSC genome browser

More...
UCSCi
C50C3.6 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080718 Genomic DNA Translation: CCD66122.1
PIRiS44625
RefSeqiNP_498785.1, NM_066384.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2P87X-ray2.30A2057-2329[»]
2P8RX-ray2.10A2057-2329[»]
SMRiP34369
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi41358, 34 interactors
DIPiDIP-27427N
STRINGi6239.C50C3.6

PTM databases

iPTMnetiP34369

Proteomic databases

EPDiP34369
PaxDbiP34369
PeptideAtlasiP34369
PRIDEiP34369

Genome annotation databases

EnsemblMetazoaiC50C3.6.1; C50C3.6.1; WBGene00004187
GeneIDi176153
KEGGicel:CELE_C50C3.6
UCSCiC50C3.6 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176153
WormBaseiC50C3.6 ; CE00122 ; WBGene00004187 ; prp-8

Phylogenomic databases

eggNOGiKOG1795 Eukaryota
COG5178 LUCA
GeneTreeiENSGT00390000015210
HOGENOMiCLU_000380_3_0_1
InParanoidiP34369
KOiK12856
OMAiWVDRSDN
OrthoDBi156083at2759
PhylomeDBiP34369

Enzyme and pathway databases

ReactomeiR-CEL-72163 mRNA Splicing - Major Pathway
R-CEL-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

EvolutionaryTraceiP34369

Protein Ontology

More...
PROi
PR:P34369

Gene expression databases

BgeeiWBGene00004187 Expressed in multi-cellular organism and 4 other tissues

Family and domain databases

CDDicd13838 RNase_H_like_Prp8_IV, 1 hit
Gene3Di1.20.58.1750, 1 hit
InterProiView protein in InterPro
IPR000555 JAMM/MPN+_dom
IPR037518 MPN
IPR012591 PRO8NT
IPR012592 PROCN
IPR012984 PROCT
IPR027652 PRP8
IPR021983 PRP8_domainIV
IPR019581 Prp8_U5-snRNA-bd
IPR042516 Prp8_U5-snRNA-bd_sf
IPR019580 Prp8_U6-snRNA-bd
IPR012337 RNaseH-like_sf
IPR019582 RRM_spliceosomal_PrP8
PANTHERiPTHR11140 PTHR11140, 1 hit
PfamiView protein in Pfam
PF01398 JAB, 1 hit
PF08082 PRO8NT, 1 hit
PF08083 PROCN, 1 hit
PF08084 PROCT, 1 hit
PF12134 PRP8_domainIV, 1 hit
PF10598 RRM_4, 1 hit
PF10597 U5_2-snRNA_bdg, 1 hit
PF10596 U6-snRNA_bdg, 1 hit
SMARTiView protein in SMART
SM00232 JAB_MPN, 1 hit
SUPFAMiSSF53098 SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS50249 MPN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRP8_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34369
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 26, 2020
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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