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Entry version 123 (18 Sep 2019)
Sequence version 4 (25 Jan 2012)
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Protein

Nuclear pore complex protein 15

Gene

npp-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for early nematode development.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein 15
Alternative name(s):
Nucleoporin npp-15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:npp-15
Synonyms:nup133
ORF Names:C29E4.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
C29E4.4 ; CE46384 ; WBGene00003801 ; npp-15

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002048401 – 1129Nuclear pore complex protein 15Add BLAST1129

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34343

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34343

PeptideAtlas

More...
PeptideAtlasi
P34343

PRoteomics IDEntifications database

More...
PRIDEi
P34343

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34343

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00003801 Expressed in 5 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.C29E4.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34343

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nucleoporin Nup133 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JDWI Eukaryota
ENOG410XNUX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000011529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000019608

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34343

KEGG Orthology (KO)

More...
KOi
K14300

Identification of Orthologs from Complete Genome Data

More...
OMAi
WHASAHR

Database of Orthologous Groups

More...
OrthoDBi
51227at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007187 Nucleoporin_Nup133/Nup155_C
IPR014908 Nucleoporin_Nup133/Nup155_N
IPR037624 Nup133-like
IPR015943 WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13405 PTHR13405, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03177 Nucleoporin_C, 1 hit
PF08801 Nucleoporin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34343-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRDLELTL DRVSSIEYPA LVKEAFLNNW HASAHRSEVT SNCASLNDRY
60 70 80 90 100
CWVLSRNQIF IWERAKSSHR AIIPTQLPLP TSGLPRSVKC VVVYDGVHRG
110 120 130 140 150
ANKTPCPGIL VVSPEGVLRH WTSIESQTYI EEVLDINNEV ALRVELTDEP
160 170 180 190 200
IDGKSASFLL TTTSGTVYFL NGKGQDSAKT GALECNKVAG REAHGFRRRL
210 220 230 240 250
SSIMFGGESK ESTSLITNSF QHQSKDLLVV TVSPDVLTVY NMYTPCELWS
260 270 280 290 300
LKTKEFFQPK IASFFEADLK RTPLKVRARL IDAAVFRDGL MILIGGTHEE
310 320 330 340 350
SQSVHMFMVW MSANWQTEQP TGVVWSARVP MNEHRALFSK IDDSIYSNLT
360 370 380 390 400
LCIPKNTAES KKADRTDGII IINPYFAVSL YLPFDLAKPK KPESLYRHVS
410 420 430 440 450
IPPRDQLLGY AICSQYVYIM MLESGVSTIR LLPRGFADSS IYTHEQVVVP
460 470 480 490 500
SLSVGTDDWP ILSELLSEMV ASGLPKTPLY QSLHRAFELF AEKHMAESEE
510 520 530 540 550
ELKAIIKMPD QEIARIVSQF LYAIIDYSDA ANKTDTELHA KRVLTSRIML
560 570 580 590 600
FLKHMGVYER IISSPLGISR GGILSLRVGG TMLGEVSERV AASTAIWTWK
610 620 630 640 650
TSNETNSAVF DAIIEKVLRI PEVQDLGLKD KDALFGRCGL VHHIPVVAAQ
660 670 680 690 700
QLEKNVIGKT KSHRFEVFHA VCELLSGIKE TIISWRNCRT KVAIPKFPIW
710 720 730 740 750
WTLETFASCY RDVAEKIIEE LKNGSSTDSE RARLLMYILS IYDFYLSESD
760 770 780 790 800
SQPDNDKVLQ EMIALGKPAD AMELAEKHKD FGTLVKNYLT TDVGTRQKTF
810 820 830 840 850
ERYKKMFEKD DFEMYLCDYL KEHGRNDVLL QQGGSRVDAY LDNFKELRYS
860 870 880 890 900
REIANKQFGK AALTLMSLAD AETKSFSKFV EFLTRAYYCA CSSIDGTDVS
910 920 930 940 950
EVLDFYKRRY PEMKHRKRIP TEILKICFGN DLDAMMSVED MLEWNMAVQP
960 970 980 990 1000
NDEASVEGFA RAFHLLADLL AVHPDSDELK KKIDKTWKAL VDYDEWNRVR
1010 1020 1030 1040 1050
SKEDVEKKTI FGKFCNYLIN SYPADKGDSF PIWMPISRRL IFPTDIDTVL
1060 1070 1080 1090 1100
DECIANTTGN HLSWIKGHLK WIGEQLCKQA LLPKSAFFRP DMKQVGSISQ
1110 1120
AALEAFGPIL QRREQRFIDQ LNRDSMMET
Length:1,129
Mass (Da):128,190
Last modified:January 25, 2012 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8DC884B295983965
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080706 Genomic DNA Translation: CCD66018.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S44772

NCBI Reference Sequences

More...
RefSeqi
NP_498724.4, NM_066323.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C29E4.4.1; C29E4.4.1; WBGene00003801

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176114

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C29E4.4

UCSC genome browser

More...
UCSCi
C29E4.4 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080706 Genomic DNA Translation: CCD66018.1
PIRiS44772
RefSeqiNP_498724.4, NM_066323.5

3D structure databases

SMRiP34343
ModBaseiSearch...

Protein-protein interaction databases

STRINGi6239.C29E4.4

PTM databases

iPTMnetiP34343

Proteomic databases

EPDiP34343
PaxDbiP34343
PeptideAtlasiP34343
PRIDEiP34343

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC29E4.4.1; C29E4.4.1; WBGene00003801
GeneIDi176114
KEGGicel:CELE_C29E4.4
UCSCiC29E4.4 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176114
WormBaseiC29E4.4 ; CE46384 ; WBGene00003801 ; npp-15

Phylogenomic databases

eggNOGiENOG410JDWI Eukaryota
ENOG410XNUX LUCA
GeneTreeiENSGT00390000011529
HOGENOMiHOG000019608
InParanoidiP34343
KOiK14300
OMAiWHASAHR
OrthoDBi51227at2759

Enzyme and pathway databases

ReactomeiR-CEL-159227 Transport of the SLBP independent Mature mRNA
R-CEL-159230 Transport of the SLBP Dependant Mature mRNA
R-CEL-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-CEL-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-CEL-3301854 Nuclear Pore Complex (NPC) Disassembly
R-CEL-3371453 Regulation of HSF1-mediated heat shock response
R-CEL-4085377 SUMOylation of SUMOylation proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34343

Gene expression databases

BgeeiWBGene00003801 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR007187 Nucleoporin_Nup133/Nup155_C
IPR014908 Nucleoporin_Nup133/Nup155_N
IPR037624 Nup133-like
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR13405 PTHR13405, 1 hit
PfamiView protein in Pfam
PF03177 Nucleoporin_C, 1 hit
PF08801 Nucleoporin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU133_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34343
Secondary accession number(s): Q5WRU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 25, 2012
Last modified: September 18, 2019
This is version 123 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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