We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P34343 (NU133_CAEEL)
Protein
Nuclear pore complex protein 15
Gene
npp-15
Organism
Caenorhabditis elegans
Status
Functioni
Important for early nematode development.
1 PublicationGO - Molecular functioni
- structural constituent of nuclear pore Source: GO_Central
GO - Biological processi
- poly(A)+ mRNA export from nucleus Source: GO_Central
- protein import into nucleus Source: GO_Central
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | mRNA transport, Protein transport, Translocation, Transport |
Enzyme and pathway databases
Reactomei | R-CEL-159227, Transport of the SLBP independent Mature mRNA R-CEL-159230, Transport of the SLBP Dependant Mature mRNA R-CEL-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-CEL-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-CEL-191859, snRNP Assembly R-CEL-3108214, SUMOylation of DNA damage response and repair proteins R-CEL-3301854, Nuclear Pore Complex (NPC) Disassembly R-CEL-3371453, Regulation of HSF1-mediated heat shock response R-CEL-4085377, SUMOylation of SUMOylation proteins R-CEL-4551638, SUMOylation of chromatin organization proteins R-CEL-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear pore complex protein 15Alternative name(s): Nucleoporin npp-15 |
Gene namesi | Name:npp-15 Synonyms:nup133 ORF Names:C29E4.4 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C29E4.4 ; CE46384 ; WBGene00003801 ; npp-15 |
Subcellular locationi
Nucleus
- Nucleus envelope 1 Publication
- nuclear pore complex 1 Publication
Note: Recruited early during nuclear envelope assembly after mitosis.1 Publication
Nucleus
- nuclear membrane Source: UniProtKB
- nuclear pore Source: UniProtKB
- nuclear pore outer ring Source: GO_Central
Other locations
- kinetochore Source: UniProtKB
Keywords - Cellular componenti
Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204840 | 1 – 1129 | Nuclear pore complex protein 15Add BLAST | 1129 |
Proteomic databases
EPDi | P34343 |
PaxDbi | P34343 |
PeptideAtlasi | P34343 |
PRIDEi | P34343 |
PTM databases
iPTMneti | P34343 |
Expressioni
Gene expression databases
Bgeei | WBGene00003801, Expressed in multi-cellular organism and 5 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the nucleoporin Nup133 family.Curated
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00390000011529 |
HOGENOMi | CLU_277093_0_0_1 |
InParanoidi | P34343 |
OMAi | WHASAHR |
OrthoDBi | 51227at2759 |
PhylomeDBi | P34343 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR007187, Nucleoporin_Nup133/Nup155_C IPR014908, Nucleoporin_Nup133/Nup155_N IPR037624, Nup133-like IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR13405, PTHR13405, 1 hit |
Pfami | View protein in Pfam PF03177, Nucleoporin_C, 1 hit PF08801, Nucleoporin_N, 1 hit |
i Sequence
Sequence statusi: Complete.
P34343-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRDLELTL DRVSSIEYPA LVKEAFLNNW HASAHRSEVT SNCASLNDRY
60 70 80 90 100
CWVLSRNQIF IWERAKSSHR AIIPTQLPLP TSGLPRSVKC VVVYDGVHRG
110 120 130 140 150
ANKTPCPGIL VVSPEGVLRH WTSIESQTYI EEVLDINNEV ALRVELTDEP
160 170 180 190 200
IDGKSASFLL TTTSGTVYFL NGKGQDSAKT GALECNKVAG REAHGFRRRL
210 220 230 240 250
SSIMFGGESK ESTSLITNSF QHQSKDLLVV TVSPDVLTVY NMYTPCELWS
260 270 280 290 300
LKTKEFFQPK IASFFEADLK RTPLKVRARL IDAAVFRDGL MILIGGTHEE
310 320 330 340 350
SQSVHMFMVW MSANWQTEQP TGVVWSARVP MNEHRALFSK IDDSIYSNLT
360 370 380 390 400
LCIPKNTAES KKADRTDGII IINPYFAVSL YLPFDLAKPK KPESLYRHVS
410 420 430 440 450
IPPRDQLLGY AICSQYVYIM MLESGVSTIR LLPRGFADSS IYTHEQVVVP
460 470 480 490 500
SLSVGTDDWP ILSELLSEMV ASGLPKTPLY QSLHRAFELF AEKHMAESEE
510 520 530 540 550
ELKAIIKMPD QEIARIVSQF LYAIIDYSDA ANKTDTELHA KRVLTSRIML
560 570 580 590 600
FLKHMGVYER IISSPLGISR GGILSLRVGG TMLGEVSERV AASTAIWTWK
610 620 630 640 650
TSNETNSAVF DAIIEKVLRI PEVQDLGLKD KDALFGRCGL VHHIPVVAAQ
660 670 680 690 700
QLEKNVIGKT KSHRFEVFHA VCELLSGIKE TIISWRNCRT KVAIPKFPIW
710 720 730 740 750
WTLETFASCY RDVAEKIIEE LKNGSSTDSE RARLLMYILS IYDFYLSESD
760 770 780 790 800
SQPDNDKVLQ EMIALGKPAD AMELAEKHKD FGTLVKNYLT TDVGTRQKTF
810 820 830 840 850
ERYKKMFEKD DFEMYLCDYL KEHGRNDVLL QQGGSRVDAY LDNFKELRYS
860 870 880 890 900
REIANKQFGK AALTLMSLAD AETKSFSKFV EFLTRAYYCA CSSIDGTDVS
910 920 930 940 950
EVLDFYKRRY PEMKHRKRIP TEILKICFGN DLDAMMSVED MLEWNMAVQP
960 970 980 990 1000
NDEASVEGFA RAFHLLADLL AVHPDSDELK KKIDKTWKAL VDYDEWNRVR
1010 1020 1030 1040 1050
SKEDVEKKTI FGKFCNYLIN SYPADKGDSF PIWMPISRRL IFPTDIDTVL
1060 1070 1080 1090 1100
DECIANTTGN HLSWIKGHLK WIGEQLCKQA LLPKSAFFRP DMKQVGSISQ
1110 1120
AALEAFGPIL QRREQRFIDQ LNRDSMMET
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO080706 Genomic DNA Translation: CCD66018.1 |
PIRi | S44772 |
RefSeqi | NP_498724.4, NM_066323.5 |
Genome annotation databases
EnsemblMetazoai | C29E4.4.1; C29E4.4.1; WBGene00003801 |
GeneIDi | 176114 |
KEGGi | cel:CELE_C29E4.4 |
UCSCi | C29E4.4, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO080706 Genomic DNA Translation: CCD66018.1 |
PIRi | S44772 |
RefSeqi | NP_498724.4, NM_066323.5 |
3D structure databases
SMRi | P34343 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 41321, 9 interactors |
STRINGi | 6239.C29E4.4 |
PTM databases
iPTMneti | P34343 |
Proteomic databases
EPDi | P34343 |
PaxDbi | P34343 |
PeptideAtlasi | P34343 |
PRIDEi | P34343 |
Genome annotation databases
EnsemblMetazoai | C29E4.4.1; C29E4.4.1; WBGene00003801 |
GeneIDi | 176114 |
KEGGi | cel:CELE_C29E4.4 |
UCSCi | C29E4.4, c. elegans |
Organism-specific databases
CTDi | 176114 |
WormBasei | C29E4.4 ; CE46384 ; WBGene00003801 ; npp-15 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00390000011529 |
HOGENOMi | CLU_277093_0_0_1 |
InParanoidi | P34343 |
OMAi | WHASAHR |
OrthoDBi | 51227at2759 |
PhylomeDBi | P34343 |
Enzyme and pathway databases
Reactomei | R-CEL-159227, Transport of the SLBP independent Mature mRNA R-CEL-159230, Transport of the SLBP Dependant Mature mRNA R-CEL-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-CEL-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript R-CEL-191859, snRNP Assembly R-CEL-3108214, SUMOylation of DNA damage response and repair proteins R-CEL-3301854, Nuclear Pore Complex (NPC) Disassembly R-CEL-3371453, Regulation of HSF1-mediated heat shock response R-CEL-4085377, SUMOylation of SUMOylation proteins R-CEL-4551638, SUMOylation of chromatin organization proteins R-CEL-9615933, Postmitotic nuclear pore complex (NPC) reformation |
Miscellaneous databases
PROi | PR:P34343 |
Gene expression databases
Bgeei | WBGene00003801, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR007187, Nucleoporin_Nup133/Nup155_C IPR014908, Nucleoporin_Nup133/Nup155_N IPR037624, Nup133-like IPR015943, WD40/YVTN_repeat-like_dom_sf |
PANTHERi | PTHR13405, PTHR13405, 1 hit |
Pfami | View protein in Pfam PF03177, Nucleoporin_C, 1 hit PF08801, Nucleoporin_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NU133_CAEEL | |
Accessioni | P34343Primary (citable) accession number: P34343 Secondary accession number(s): Q5WRU8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | January 25, 2012 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families