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Protein

Probable protein disulfide-isomerase A4

Gene

C14B9.2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein disulfide-isomerase A4 (EC:5.3.4.1)
Alternative name(s):
ERp-72 homolog
Gene namesi
ORF Names:C14B9.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC14B9.2 ; CE30601 ; WBGene00015752

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003423222 – 618Probable protein disulfide-isomerase A4Add BLAST597

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 68Redox-activePROSITE-ProRule annotation
Disulfide bondi176 ↔ 179Redox-activePROSITE-ProRule annotation
Disulfide bondi529 ↔ 532Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP34329
PaxDbiP34329
PeptideAtlasiP34329
PRIDEiP34329

Expressioni

Gene expression databases

BgeeiWBGene00015752 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Interactioni

Protein-protein interaction databases

BioGridi41353, 1 interactor
STRINGi6239.C14B9.2

Structurei

3D structure databases

ProteinModelPortaliP34329
SMRiP34329
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 139Thioredoxin 1PROSITE-ProRule annotationAdd BLAST118
Domaini138 – 254Thioredoxin 2PROSITE-ProRule annotationAdd BLAST117
Domaini480 – 609Thioredoxin 3PROSITE-ProRule annotationAdd BLAST130

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi615 – 618Prevents secretion from ER4

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.Curated

Keywords - Domaini

Redox-active center, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000162459
InParanoidiP34329
KOiK09582
OMAiYRAATQF
OrthoDBiEOG091G05J9
PhylomeDBiP34329

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34329-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFDRRFFAL VVLLCVSAVR STEDASDDEL NYEMDEGVVV LTDKNFDAFL
60 70 80 90 100
KKNPSVLVKF YAPWCGHCKH LAPEYEKASS KVSIPLAKVD ATVETELGKR
110 120 130 140 150
FEIQGYPTLK FWKDGKGPND YDGGRDEAGI VEWVESRVDP NYKPPPEEVV
160 170 180 190 200
TLTTENFDDF ISNNELVLVE FYAPWCGHCK KLAPEYEKAA QKLKAQGSKV
210 220 230 240 250
KLGKVDATIE KDLGTKYGVS GYPTMKIIRN GRRFDYNGPR EAAGIIKYMT
260 270 280 290 300
DQSKPAAKKL PKLKDVERFM SKDDVTIIGF FATEDSTAFE AFSDSAEMLR
310 320 330 340 350
EEFKTMGHTS DPAAFKKWDA KPNDIIIFYP SLFHSKFEPK SRTYNKAAAT
360 370 380 390 400
SEDLLAFFRE HSAPLVGKMT KKNAATRYTK KPLVVVYYNA DFSVQYREGS
410 420 430 440 450
EYWRSKVLNI AQKYQKDKYK FAVADEEEFA KELEELGLGD SGLEHNVVVF
460 470 480 490 500
GYDGKKYPMN PDEFDGELDE NLEAFMKQIS SGKAKAHVKS APAPKDDKGP
510 520 530 540 550
VKTVVGSNFD KIVNDESKDV LIEFYAPWCG HCKSFESKYV ELAQALKKTQ
560 570 580 590 600
PNVVLAKMDA TINDAPSQFA VEGFPTIYFA PAGKKSEPIK YSGNRDLEDL
610
KKFMTKHGVK SFQKKDEL
Length:618
Mass (Da):69,797
Last modified:February 21, 2001 - v2
Checksum:i1DC0207A71444220
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080531 Genomic DNA Translation: CCD64436.1
PIRiS44756
RefSeqiNP_498775.2, NM_066374.7
UniGeneiCel.17287

Genome annotation databases

EnsemblMetazoaiC14B9.2; C14B9.2; WBGene00015752
GeneIDi176147
KEGGicel:CELE_C14B9.2
UCSCiC14B9.2.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080531 Genomic DNA Translation: CCD64436.1
PIRiS44756
RefSeqiNP_498775.2, NM_066374.7
UniGeneiCel.17287

3D structure databases

ProteinModelPortaliP34329
SMRiP34329
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41353, 1 interactor
STRINGi6239.C14B9.2

Proteomic databases

EPDiP34329
PaxDbiP34329
PeptideAtlasiP34329
PRIDEiP34329

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC14B9.2; C14B9.2; WBGene00015752
GeneIDi176147
KEGGicel:CELE_C14B9.2
UCSCiC14B9.2.1 c. elegans

Organism-specific databases

CTDi176147
WormBaseiC14B9.2 ; CE30601 ; WBGene00015752

Phylogenomic databases

eggNOGiKOG0190 Eukaryota
COG0526 LUCA
GeneTreeiENSGT00860000133691
HOGENOMiHOG000162459
InParanoidiP34329
KOiK09582
OMAiYRAATQF
OrthoDBiEOG091G05J9
PhylomeDBiP34329

Miscellaneous databases

PROiPR:P34329

Gene expression databases

BgeeiWBGene00015752 Expressed in 5 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

InterProiView protein in InterPro
IPR005788 Disulphide_isomerase
IPR005792 Prot_disulphide_isomerase
IPR017068 Protein_diS-isomerase_A4
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 3 hits
PIRSFiPIRSF036862 Disulphide_isom_A4, 1 hit
SUPFAMiSSF52833 SSF52833, 5 hits
TIGRFAMsiTIGR01130 ER_PDI_fam, 1 hit
TIGR01126 pdi_dom, 3 hits
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00194 THIOREDOXIN_1, 3 hits
PS51352 THIOREDOXIN_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPDIA4_CAEEL
AccessioniPrimary (citable) accession number: P34329
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 21, 2001
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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