UniProtKB - P34322 (NCX7_CAEEL)
Protein
Putative sodium/calcium exchanger 7
Gene
ncx-7
Organism
Caenorhabditis elegans
Status
Functioni
GO - Molecular functioni
- calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Source: GO_Central
- cation transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cation transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Biological process | Antiport, Calcium transport, Ion transport, Sodium transport, Transport |
Ligand | Calcium, Sodium |
Enzyme and pathway databases
Reactomei | R-CEL-425561, Sodium/Calcium exchangers R-CEL-8949215, Mitochondrial calcium ion transport |
Names & Taxonomyi
Protein namesi | Recommended name: Putative sodium/calcium exchanger 7Alternative name(s): Na(+)/Ca(2+)-exchange protein 7 |
Gene namesi | Name:ncx-7 ORF Names:C07A9.11 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C07A9.11 ; CE39219 ; WBGene00003572 ; ncx-7 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 130 – 150 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 164 – 184 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 216 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 221 – 241 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 451 – 471 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 479 – 499 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 522 – 542 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 551 – 571 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 581 – 601 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 620 – 640 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 649 – 669 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000019387 | 24 – 672 | Putative sodium/calcium exchanger 7Add BLAST | 649 |
Proteomic databases
EPDi | P34322 |
PaxDbi | P34322 |
PeptideAtlasi | P34322 |
Expressioni
Gene expression databases
Bgeei | WBGene00003572, Expressed in multi-cellular organism and 3 other tissues |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2399, Eukaryota |
GeneTreei | ENSGT00970000196614 |
HOGENOMi | CLU_004979_3_1_1 |
InParanoidi | P34322 |
OMAi | CAFVKRT |
OrthoDBi | 478735at2759 |
PhylomeDBi | P34322 |
Family and domain databases
InterProi | View protein in InterPro IPR004837, NaCa_Exmemb |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P34322-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQPSILFSL TLIFLISIKS CDAKYRTSFF KTPNCSIYPD AEKCELNKTW
60 70 80 90 100
TQEQVCDYVN CNDNACEGGG YLLWTQYVEC ASSTFSRVIL IIVGVIYMLV
110 120 130 140 150
LFIMVSSAAD DFFSPSISSI VAHLRISESV AGVTFMAFGN GAPDVFGSIA
160 170 180 190 200
SVLSSPTPKA DLALGELFGG GLFVTTMVVS TIILTSPFDV EVFSTIRDLL
210 220 230 240 250
FYLVALSFLA FCFVFYNRVT LWMPLTFLGL YLLYVITVIG AQAVHNRKRK
260 270 280 290 300
ALQKQNSTKS RKSIKSLRSR KSIHSVAPMP VIPEIEVHDQ EAPFPEISVV
310 320 330 340 350
TGAIDKLKEH MAEKAQTTRR YTKRASFMVN GDGNLNGLHP YATHNHLGIS
360 370 380 390 400
RRESELSDED EEFVVIHGHV FQGHEARSRA ASLVPEPMQI KSWRSKDILK
410 420 430 440 450
DLAEHLDPRP EAEDWEEMNI FSKVMAYINV VPNLLFKLTI PLNEMSWSKP
460 470 480 490 500
LTLLHAFTCP AFLLFSIQFF LETPFSGSPG LWVYGLAVSI VLAILIMVFT
510 520 530 540 550
ELSVQPKYYK EIYSYSGFIM SIAWIYLISS EVVNVVTMLG VVSRVSHEVL
560 570 580 590 600
GLTILAWSNS IGDLIADVSV VKQGYPRMAM AAAIGGPLFN LLMGFGLPFT
610 620 630 640 650
IAKLQGKYIS MTINPTYRLL ILFLAISLLA TLIGIPVQKF RLQRPHAAVL
660 670
ISIYIAFIVF VILSETGVLV WN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z29094 Genomic DNA Translation: CAA82341.3 |
PIRi | S40707 |
RefSeqi | NP_499147.3, NM_066746.6 |
Genome annotation databases
EnsemblMetazoai | C07A9.11.1; C07A9.11.1; WBGene00003572 |
GeneIDi | 176370 |
KEGGi | cel:CELE_C07A9.11 |
UCSCi | C07A9.11, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z29094 Genomic DNA Translation: CAA82341.3 |
PIRi | S40707 |
RefSeqi | NP_499147.3, NM_066746.6 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 6239.C07A9.11 |
Proteomic databases
EPDi | P34322 |
PaxDbi | P34322 |
PeptideAtlasi | P34322 |
Genome annotation databases
EnsemblMetazoai | C07A9.11.1; C07A9.11.1; WBGene00003572 |
GeneIDi | 176370 |
KEGGi | cel:CELE_C07A9.11 |
UCSCi | C07A9.11, c. elegans |
Organism-specific databases
CTDi | 176370 |
WormBasei | C07A9.11 ; CE39219 ; WBGene00003572 ; ncx-7 |
Phylogenomic databases
eggNOGi | KOG2399, Eukaryota |
GeneTreei | ENSGT00970000196614 |
HOGENOMi | CLU_004979_3_1_1 |
InParanoidi | P34322 |
OMAi | CAFVKRT |
OrthoDBi | 478735at2759 |
PhylomeDBi | P34322 |
Enzyme and pathway databases
Reactomei | R-CEL-425561, Sodium/Calcium exchangers R-CEL-8949215, Mitochondrial calcium ion transport |
Miscellaneous databases
PROi | PR:P34322 |
Gene expression databases
Bgeei | WBGene00003572, Expressed in multi-cellular organism and 3 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004837, NaCa_Exmemb |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCX7_CAEEL | |
Accessioni | P34322Primary (citable) accession number: P34322 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | May 30, 2006 | |
Last modified: | October 7, 2020 | |
This is version 111 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families