UniProtKB - P34315 (NCX6_CAEEL)
Protein
Putative sodium/calcium exchanger 6
Gene
ncx-6
Organism
Caenorhabditis elegans
Status
Functioni
GO - Molecular functioni
- calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential Source: GO_Central
- cation transmembrane transporter activity Source: GO_Central
GO - Biological processi
- cation transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
Keywordsi
Biological process | Antiport, Calcium transport, Ion transport, Sodium transport, Transport |
Ligand | Calcium, Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Putative sodium/calcium exchanger 6Alternative name(s): Na(+)/Ca(2+)-exchange protein 6 |
Gene namesi | Name:ncx-6 ORF Names:C07A9.4 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | C07A9.4 ; CE33595 ; WBGene00003571 ; ncx-6 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 97 – 117 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 173 – 193 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 230 – 250 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 368 – 388 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 397 – 417 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 440 – 460 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 499 – 519 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 535 – 555 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 568 – 588 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000019386 | 20 – 590 | Putative sodium/calcium exchanger 6Add BLAST | 571 |
Proteomic databases
PaxDbi | P34315 |
PeptideAtlasi | P34315 |
Expressioni
Gene expression databases
Bgeei | WBGene00003571, Expressed in multi-cellular organism and 3 other tissues |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2399, Eukaryota |
GeneTreei | ENSGT00970000196614 |
HOGENOMi | CLU_004979_3_1_1 |
InParanoidi | P34315 |
OMAi | QGWPRMA |
OrthoDBi | 478735at2759 |
PhylomeDBi | P34315 |
Family and domain databases
InterProi | View protein in InterPro IPR004837, NaCa_Exmemb |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P34315-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRIHFFAFLI ILSLVGCDGW QADVGKLVRK WNNQRTIDGN DIEKCIPDDG
60 70 80 90 100
EQCTIQAGWN STQVCEYVKC NDDNCEGGGY VLWTRYVECA SSPAVRIILI
110 120 130 140 150
ITGVIYMLVL FIMVSSAADD FFSPSISSIV AHLRISESVA GVTFMAFGNG
160 170 180 190 200
APDVFGAIAS VLSSPTPKAD LALGELFGAG LFVTTMVLAV TIFTRPFKAE
210 220 230 240 250
VFSSIRDIAF YLVALAFLAF CFVYYDHVEI WMPITFLGVY LIYVCTVILS
260 270 280 290 300
QILHNRHKKD EEKVDEVKTV DTDSLEDDDD IYVSHGHHVL HAHEVMKMEA
310 320 330 340 350
EIEAVEPLKT WSFRGVVHDF KEHLKPWPSM DEWDEMNIFQ KVIAVLNTIP
360 370 380 390 400
NFLFKLTIPH SEQPWSKPIT LLQCLICPVF LLFCIQVCSI SPFPNSPGLW
410 420 430 440 450
MYGLILSVLL TAAVLFFTEL HKEPPFYKSL ISYAGFLMSI AWIYLISSEV
460 470 480 490 500
VNVVTMLGVV SRVSHEVLGL TILAWSNSIG DLIADVSVAK QGYPRMAMAA
510 520 530 540 550
AIGGQLFNLL IGFGLPFTIA KIQGKSISMI INPTYRLLML FLAISLIFTL
560 570 580 590
IAMFAQKYFL RRIHSYSLVF IYISFFVFIG LSLDDILVWN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z29094 Genomic DNA Translation: CAA82339.3 |
PIRi | S40705 |
RefSeqi | NP_499146.2, NM_066745.2 |
Genome annotation databases
EnsemblMetazoai | C07A9.4.1; C07A9.4.1; WBGene00003571 |
GeneIDi | 182354 |
KEGGi | cel:CELE_C07A9.4 |
UCSCi | C07A9.4, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z29094 Genomic DNA Translation: CAA82339.3 |
PIRi | S40705 |
RefSeqi | NP_499146.2, NM_066745.2 |
3D structure databases
SMRi | P34315 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 6239.C07A9.4 |
Proteomic databases
PaxDbi | P34315 |
PeptideAtlasi | P34315 |
Genome annotation databases
EnsemblMetazoai | C07A9.4.1; C07A9.4.1; WBGene00003571 |
GeneIDi | 182354 |
KEGGi | cel:CELE_C07A9.4 |
UCSCi | C07A9.4, c. elegans |
Organism-specific databases
CTDi | 182354 |
WormBasei | C07A9.4 ; CE33595 ; WBGene00003571 ; ncx-6 |
Phylogenomic databases
eggNOGi | KOG2399, Eukaryota |
GeneTreei | ENSGT00970000196614 |
HOGENOMi | CLU_004979_3_1_1 |
InParanoidi | P34315 |
OMAi | QGWPRMA |
OrthoDBi | 478735at2759 |
PhylomeDBi | P34315 |
Miscellaneous databases
PROi | PR:P34315 |
Gene expression databases
Bgeei | WBGene00003571, Expressed in multi-cellular organism and 3 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004837, NaCa_Exmemb |
Pfami | View protein in Pfam PF01699, Na_Ca_ex, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NCX6_CAEEL | |
Accessioni | P34315Primary (citable) accession number: P34315 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | March 1, 2004 | |
Last modified: | December 2, 2020 | |
This is version 115 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families