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Protein

Proteasome subunit beta type-1

Gene

pbs-6

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity).By similarity

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-6798695 Neutrophil degranulation
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit beta type-1 (EC:3.4.25.1)
Alternative name(s):
Proteasome subunit beta 6
Gene namesi
Name:pbs-6
ORF Names:C02F5.9
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC02F5.9 ; CE26745 ; WBGene00003952 ; pbs-6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001480351 – 258Proteasome subunit beta type-1Add BLAST258

Proteomic databases

EPDiP34286
PaxDbiP34286
PeptideAtlasiP34286
PRIDEiP34286

Expressioni

Gene expression databases

BgeeiWBGene00003952

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi41365, 17 interactors
DIPiDIP-24619N
IntActiP34286, 14 interactors
STRINGi6239.C02F5.9.1

Structurei

3D structure databases

ProteinModelPortaliP34286
SMRiP34286
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1B family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0179 Eukaryota
COG0638 LUCA
GeneTreeiENSGT00550000075035
HOGENOMiHOG000091081
InParanoidiP34286
KOiK02732
OMAiGTHRECI
OrthoDBiEOG091G0FUK
PhylomeDBiP34286

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR035202 Proteasome_beta1
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR023333 Proteasome_suB-type
PANTHERiPTHR11599:SF59 PTHR11599:SF59, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00854 PROTEASOME_BETA_1, 1 hit
PS51476 PROTEASOME_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34286-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFTGITAV ANATNEMAMF KQAMKEVAAH PEWMSSRQIE RQRWNPYSME
60 70 80 90 100
GGSTCAISGE NFAIVASDTR MTQNDINILT RDAEKIQILN DNIILTTSGF
110 120 130 140 150
YGDVLQLKKV LQSRLHKYRF DYRSDMSVDL CAELLSRNLY YRRFFPYYTG
160 170 180 190 200
AILAGIDEHG KGAVFSYDPI GCIERLGYSA SGAAEPMIIP FLDCQIGHVT
210 220 230 240 250
LSEGYERPEL TLDRAISLMK DSFRGAAERE ISTGDKIHLV IAEAGKPVVV

KFLPLRED
Length:258
Mass (Da):28,930
Last modified:July 11, 2002 - v2
Checksum:i0ADDB88824AFD87D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080288 Genomic DNA Translation: CCD62635.1
AF303265 mRNA Translation: AAG50223.1
PIRiS44611
RefSeqiNP_498806.1, NM_066405.4
UniGeneiCel.23369

Genome annotation databases

EnsemblMetazoaiC02F5.9; C02F5.9; WBGene00003952
GeneIDi176161
KEGGicel:CELE_C02F5.9
UCSCiC02F5.9.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSB1_CAEEL
AccessioniPrimary (citable) accession number: P34286
Secondary accession number(s): Q9BMU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 11, 2002
Last modified: May 23, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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