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Entry version 128 (07 Apr 2021)
Sequence version 3 (01 Feb 1996)
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Protein

Kinetochore null protein 1

Gene

knl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division (PubMed:14522947, PubMed:15371340, PubMed:17129783, PubMed:18070910). Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy (PubMed:15767665, PubMed:16273096). Has a role in the correct localization of the spindly-like protein spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Required for the recruitment of spindle-assembly checkpoint components bub-1 and mdf-1/2 to unattached kinetochores (PubMed:19109417, PubMed:20729837, PubMed:24567362).11 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Meiosis, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinetochore null protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:knl-1
ORF Names:C02F5.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
C02F5.1 ; CE02450 ; WBGene00002231 ; knl-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Kinetochore

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Perturbed spindle-kinetochore interactions, segregation defects and premature spindle elongation (PubMed:14522947, PubMed:15767665, PubMed:18070910). RNAi-mediated knockdown results in reduced localization of the spindly-like protein spdl-1 and the RZZ complex component zwl-1 to kinetochores (PubMed:18765790, PubMed:18936247). Does not affect spdl-1 localization to microtubules (PubMed:18936247).5 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000651071 – 1010Kinetochore null protein 1Add BLAST1010

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P34278

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34278

PeptideAtlas

More...
PeptideAtlasi
P34278

PRoteomics IDEntifications database

More...
PRIDEi
P34278

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed on chromosomes from early prophase until late anaphase.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00002231, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hcp-3 and hcp-4 to form a complex (PubMed:14522947).

Interacts with hcp-4, him-10, kbp-3, kbp-4, kbp-5, knl-3, and ndc-80 (PubMed:15371340).

Interacts with kbp-1, kbp-2 and mis-12; which make up the MIS12 complex (PubMed:17129783).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
41368, 27 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-808, Knl-1/Mis12/MIND complex
CPX-812, Knl1-Zwint1 complex

Database of interacting proteins

More...
DIPi
DIP-25115N

Protein interaction database and analysis system

More...
IntActi
P34278, 18 interactors

STRING: functional protein association networks

More...
STRINGi
6239.C02F5.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34278

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati85 – 881Curated4
Repeati109 – 1122Curated4
Repeati228 – 2313Curated4
Repeati255 – 2584Curated4
Repeati278 – 2815Curated4
Repeati323 – 3266Curated4
Repeati346 – 3497Curated4
Repeati402 – 4058Curated4
Repeati428 – 4319Curated4

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni85 – 4319 X 4 AA repeats of M-[D/E]-[I/L/M]-[S/T]CuratedAdd BLAST347

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili820 – 915Sequence analysisAdd BLAST96
Coiled coili956 – 988Sequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminus contains a number of repeats which contribute additively to bub-1 recruitment to unattached kinetochores. The repeats are not required for localization to kinetochores.1 Publication

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TGNI, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_296876_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34278

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDTMALF

Database of Orthologous Groups

More...
OrthoDBi
1487822at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34278

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34278-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMEPRKKRN SILKVRQAVE TIEETVMNSG PSSTTTNRRV SFHNVKHVKQ
60 70 80 90 100
YDRDHGKILD ATPVKEKITD TIGSDGILTP RGGNMDISES PACTSSFQVF
110 120 130 140 150
GGGNLDKTMD MSLETTINEN NETARLFETT RDPTLLYEKI VETTTKVTER
160 170 180 190 200
IVSMPLDDTL AMFNTTNQED KDMSVDRSVL FTIPKVPKHN ATMNRTIPMD
210 220 230 240 250
LDESKAAGGQ CDETMNVFNF TNLEAAEMDT SKLDENNTMN AIRIPINSNV
260 270 280 290 300
MPVDMDITEH HTLIEEKKND TFGPSQLMDI SAPQVQVNDT LAIFNSPRDI
310 320 330 340 350
CNKGLGVPQN LINIASNVVP VDMDITDQAV LNAEKKNDQF ETSQLMDISI
360 370 380 390 400
PKVLVNDTMA MFNSPKHVSK SSMDLEKTIE AADKSTKYPS IADEVEDLDM
410 420 430 440 450
DMDITEQQPC EAGNQQNDGL QLQKEDLMDI SVIRDSPAVN DTMAVFQSPA
460 470 480 490 500
RVKIGANNSI IDSQKSIVFG DEMSIDETQN DGTLTLPKSN VEVTTTNDVY
510 520 530 540 550
TSLERQEENA SENVSMINES SVHSEIDKKS FMLIEEERAF MHSSMIDVAQ
560 570 580 590 600
KLEDDGSSKT PVILASQSAS LATKEPSALH NSSATLNNSM ELDNNTLLKT
610 620 630 640 650
MQITTCEDIS MVHESIAVEL NSNKEQEQFG DETLQKNDTS NTGANFTFQG
660 670 680 690 700
HNETSQIMNN VDSEAVNTSK ISTYSAFNLS INQSISKRRR SLLNSARESP
710 720 730 740 750
RRVALENSIM SMNGQTMEAL TEYRQNKTMQ TSQDSMPSMS LNDSGRDILA
760 770 780 790 800
MNTSVRSPHL NSSKTAAPGT PSLMSQNVQL PPPSPQFEMP DFDPAVVNVV
810 820 830 840 850
YLTSEDPSTE QHPEALKFQR IVENEKMKVQ HEIDSLNSTN QLSAEKIDML
860 870 880 890 900
KTKELLKFSH DEREAIMIAR KDAEIKFLEL RLKFALEKKI ESDQEIAELE
910 920 930 940 950
QGNSKMAEQL RGLDKMAVVQ KELEKLRSLP PSREESGKIR KEWMEMKQWE
960 970 980 990 1000
FDQKMKALRN VRSNMIALRS EKNALEMKVA EEHEKFAQRN DLKKSRMLVF
1010
SKAVKKIVNF
Length:1,010
Mass (Da):113,231
Last modified:February 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i15E19DD975824D94
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080288 Genomic DNA Translation: CCD62626.1

NCBI Reference Sequences

More...
RefSeqi
NP_498811.1, NM_066410.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C02F5.1.1; C02F5.1.1; WBGene00002231

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176164

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C02F5.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080288 Genomic DNA Translation: CCD62626.1
RefSeqiNP_498811.1, NM_066410.3

3D structure databases

SMRiP34278
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi41368, 27 interactors
ComplexPortaliCPX-808, Knl-1/Mis12/MIND complex
CPX-812, Knl1-Zwint1 complex
DIPiDIP-25115N
IntActiP34278, 18 interactors
STRINGi6239.C02F5.1

Proteomic databases

EPDiP34278
PaxDbiP34278
PeptideAtlasiP34278
PRIDEiP34278

Genome annotation databases

EnsemblMetazoaiC02F5.1.1; C02F5.1.1; WBGene00002231
GeneIDi176164
KEGGicel:CELE_C02F5.1

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176164
WormBaseiC02F5.1 ; CE02450 ; WBGene00002231 ; knl-1

Phylogenomic databases

eggNOGiENOG502TGNI, Eukaryota
HOGENOMiCLU_296876_0_0_1
InParanoidiP34278
OMAiDDTMALF
OrthoDBi1487822at2759
PhylomeDBiP34278

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34278

Gene expression databases

BgeeiWBGene00002231, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKNL1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34278
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1996
Last modified: April 7, 2021
This is version 128 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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