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Protein

Probable glutathione transferase omega-2

Gene

gsto-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Exhibits glutathione-dependent thiol transferase activity. Has dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) (By similarity).By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.
2 glutathione + dehydroascorbate = glutathione disulfide + ascorbate.
Methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35NucleophileBy similarity1
Binding sitei62GlutathioneBy similarity1
Binding sitei75Glutathione; via amide nitrogen and carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Transferase

Enzyme and pathway databases

ReactomeiR-CEL-156581 Methylation
R-CEL-156590 Glutathione conjugation
R-CEL-196836 Vitamin C (ascorbate) metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione transferase omega-2 (EC:2.5.1.18)
Alternative name(s):
Glutathione-dependent dehydroascorbate reductase (EC:1.8.5.1)
Monomethylarsonic acid reductase (EC:1.20.4.2)
Short name:
MMA(V) reductase
Gene namesi
Name:gsto-2
ORF Names:C02D5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiC02D5.3 ; CE39555 ; WBGene00015337 ; gsto-2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858901 – 254Probable glutathione transferase omega-2Add BLAST254

Proteomic databases

PaxDbiP34277
PeptideAtlasiP34277

Expressioni

Gene expression databases

BgeeiWBGene00015337

Interactioni

Protein-protein interaction databases

STRINGi6239.C02D5.3

Structurei

3D structure databases

ProteinModelPortaliP34277
SMRiP34277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 105GST N-terminalAdd BLAST81
Domaini110 – 239GST C-terminalAdd BLAST130

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni89 – 90Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Omega family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
GeneTreeiENSGT00390000005479
InParanoidiP34277
KOiK00799
OMAiIMEDATR
OrthoDBiEOG091G0IEA
PhylomeDBiP34277

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR005442 GST_omega
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
PRINTSiPR01625 GSTRNSFRASEO
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

P34277-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLSGLNTK VVKNGDPAPA PPASGTIRIY NMRYCPWAQR ALIFASLKKI
60 70 80 90 100
PTEVINIHLD QKPDWFFTKH YKGQVPALEH DEGKKIVIES AVIPEYLDDI
110 120 130 140 150
YPEPRIIPTD HYEKVQQKLL LDRISGQLSS AFYGVVQAAK ISDLLKEKLV
160 170 180 190 200
ELAKAYDTAE ELLTGDFYSG TSKPGFVDYL IYPNIQRAFW TSHIIKDFPL
210 220 230 240 250
KVESFPGPNY PKLSKWYKRL DSIPEVIATS QPTETAVEFF KSWIIGAPNF

DYGL
Length:254
Mass (Da):28,799
Last modified:February 8, 2011 - v5
Checksum:iC648FE7E6889CCB5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080279 Genomic DNA Translation: CCD62560.1
PIRiS44745
RefSeqiNP_871705.3, NM_181976.3
UniGeneiCel.39460

Genome annotation databases

EnsemblMetazoaiC02D5.3.1; C02D5.3.1; WBGene00015337
C02D5.3.2; C02D5.3.2; WBGene00015337
GeneIDi353420
KEGGicel:CELE_C02D5.3

Similar proteinsi

Entry informationi

Entry nameiGSTO2_CAEEL
AccessioniPrimary (citable) accession number: P34277
Secondary accession number(s): Q2L6Y9
, Q304F1, Q304F2, Q8I7N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 8, 2011
Last modified: February 28, 2018
This is version 129 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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