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Entry version 143 (02 Jun 2021)
Sequence version 2 (01 Jun 1994)
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Protein

Nucleolar pre-ribosomal-associated protein 1

Gene

URB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for 60S ribosomal subunit formation and pre-rRNA processing. Required for normal accumulation of 25S and 5.8S rRNAs.

3 Publications

Miscellaneous

Present with 5890 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processRibosome biogenesis, rRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar pre-ribosomal-associated protein 1
Alternative name(s):
Unhealthy ribosome biogenesis protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:URB1
Synonyms:NPA1
Ordered Locus Names:YKL014C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000001497, URB1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YKL014C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002031901 – 1764Nucleolar pre-ribosomal-associated protein 1Add BLAST1764

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34241

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34241

PRoteomics IDEntifications database

More...
PRIDEi
P34241

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34241

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Associates with pre-60S ribosomal particles. Predominantly associated with the 27SA2 pre-rRNA. Can associate with a subset of box H/ACA and box C/D small nucleolar RNPs (snoRNPs) required for peptidyl transferase center modification and with small RNAs snR37 and snR42.

Interacts with URB2. Together with DBP6, NOP8, URB2 and RSA3, forms an RNA-independent complex, which is required during early maturation of nascent 60S ribosomal subunits.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
34118, 124 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1421, NOP8 60s ribosome pre-assembly complex

Database of interacting proteins

More...
DIPi
DIP-2701N

Protein interaction database and analysis system

More...
IntActi
P34241, 26 interactors

Molecular INTeraction database

More...
MINTi
P34241

STRING: functional protein association networks

More...
STRINGi
4932.YKL014C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P34241, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 23Basic and acidic residuesSequence analysisAdd BLAST16

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1791, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003174_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34241

Identification of Orthologs from Complete Genome Data

More...
OMAi
SYYAQVN

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032436, NopRA1_C
IPR021714, Npa1_N
IPR039844, URB1

The PANTHER Classification System

More...
PANTHERi
PTHR13500, PTHR13500, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16201, NopRA1, 1 hit
PF11707, Npa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34241-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNHSEAYGS RDQRREKYTQ GKEFEDGTLE TLESIISAVE DETLSKDYQP
60 70 80 90 100
LIVFFQRGFG AQLVQTWSYY AQVNNHGKFS KTTSLLTKTL RVLSSDTSTV
110 120 130 140 150
TIGSGLIRLI LTDYTKVLYR GLNNMRAQLT NPILRLLKQI VNFNNGQHIE
160 170 180 190 200
ELVSYFDFSL PILPRLLVPS KSELANGNSS ADSSKHDSLR FTFIKFWLTL
210 220 230 240 250
ISNASPFVRK ELLTENFKIM SNLFKFMNKA DSDKLSEHIL SVFINDILKE
260 270 280 290 300
KSFKRTTKTK ILNELAASKI HHFYYSSNKN LVKKANEFFL TFGASRDFSV
310 320 330 340 350
AFPDNCVWFK NSVADGASHG APITVNQVEF QIHNKLLFNT LRLFKPWEDT
360 370 380 390 400
LQLGTLIKIL ENVPELVAPY SIFLTTNGNY DPKMTSYWFG ITLLINKIIN
410 420 430 440 450
LKIPQFMEKV DSNIPPATSL VIENILPSLL TKSSLVKSLQ FETPIIRQLA
460 470 480 490 500
CQSIVLALKK LEKVSTFYDQ KGWRNEKTIL LNEFHTRIPD LPIFVSTLSN
510 520 530 540 550
SLASNKDNRI LPLSISIIFN YYSKMFPNLF SINLPSSNIY TDIMQKSKIS
560 570 580 590 600
GIEFAILDNY LQFQEFNSTQ TRWWNPSSGG NSLFTLLLKL ASSKNASNVI
610 620 630 640 650
TTRISNLLDE LTRTNVIFNI SLISPVMALV NSLQGLSLQV SEIDNMEQVW
660 670 680 690 700
KWFDETISRV VKTPYKYVDM AKEYNYISPF IMCLSEQWKY VDKSGNPEFL
710 720 730 740 750
IKWLILFLRN MIFIGEDHIG IDKLVKNVFP EVSDHDVNIY LKLDSFEENI
760 770 780 790 800
KKTNSSNSLI SSMKSSSFFQ YISALPSKNL MNISRLPVNK LDAAGILFRV
810 820 830 840 850
QLLVEDDSVV YDNWFEATAC ELTGKIASYM VTDTEFPIIK VLERYINFAL
860 870 880 890 900
PKLAIEKRNA LLMKKSRFMC NLIGAVCFET GHQLVEFREI IQKVVFSGEN
910 920 930 940 950
VEEYANYNEL YQKEDVNAFL TSVSEYLSTS ALTSLLMCST KLESTRNILQ
960 970 980 990 1000
KLFNEGKTIK ISLVKNILNK AANEDPASIK EVNISLAKFF EENKVCVDAS
1010 1020 1030 1040 1050
SDPMGKLSLS ETTSLINSFV SSDLNYLVLK AFYRWEHFSF PSFIPSIWRI
1060 1070 1080 1090 1100
KDSPLLSIVT TAALFKHMQD KDFSAFAHET ISKYGNEIAK STYTTSKSEI
1110 1120 1130 1140 1150
FDEILNMITT YIDFYDETKR NEILKCVLSQ SDHKYHAATV RYIAAHNNFT
1160 1170 1180 1190 1200
YPGVETWLHK TLLYLTKYLS ERKVISNSFF ELLRAMAELL KLEEVPNKLN
1210 1220 1230 1240 1250
VKIINSQLEA ILGSEWIKQI KVLEYVIVLI FCVSKKSIQS QRMVQLLLSN
1260 1270 1280 1290 1300
DSYSSIMIKD NDEDSSYRKF LSTMILFSLF SIDPVVNSTP IVQEKLLTFY
1310 1320 1330 1340 1350
SGTISSNDKL ILKILETIES HTATSWTNMI FSWEFIKDEE EEILEAIGDT
1360 1370 1380 1390 1400
RLITKEREGL ILTLQKNMIK KSIDRYVLER PQVPELYTDS NTNNYDATTR
1410 1420 1430 1440 1450
CDLVKKYYDD TERSGVDMYD PLFLLLLIIH NKELVKMVKD DEGNVTYRYE
1460 1470 1480 1490 1500
FENFLDCKIF QFIICSLSDC HTVANISYEH LSNLASSLEK KTAQMNLEKQ
1510 1520 1530 1540 1550
ITSKDNERKE SDSDLIKYNS IYQVLIKRIL YQRQQNQDPI NPLIWFSISR
1560 1570 1580 1590 1600
IVDLLGSPTA PLHEKAYRWV LSNSTIRSWD IPMVSDVMMS YNKRQQDDNK
1610 1620 1630 1640 1650
KEIDMEIYYG ELSWVLTTIC KGIKTDEDYK MLEKKGVFEW LLNLINMPYL
1660 1670 1680 1690 1700
KERLRELIYF IFYKVQRVAD DGGLNLISRN GIVSFFEVLN NNIKSRLPQD
1710 1720 1730 1740 1750
DILNNIGTLR NENRGTLNTT LRLAQEQNGI EKLLLGYNEL VKSQKRLILW
1760
TEGDSDNVVK RLRK
Length:1,764
Mass (Da):203,287
Last modified:June 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD4EC1FA19E051367
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X74152 Genomic DNA Translation: CAA52264.1
Z28014 Genomic DNA Translation: CAA81849.1
BK006944 Genomic DNA Translation: DAA09142.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S37827

NCBI Reference Sequences

More...
RefSeqi
NP_012911.3, NM_001179580.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YKL014C_mRNA; YKL014C; YKL014C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
853855

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YKL014C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74152 Genomic DNA Translation: CAA52264.1
Z28014 Genomic DNA Translation: CAA81849.1
BK006944 Genomic DNA Translation: DAA09142.1
PIRiS37827
RefSeqiNP_012911.3, NM_001179580.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34118, 124 interactors
ComplexPortaliCPX-1421, NOP8 60s ribosome pre-assembly complex
DIPiDIP-2701N
IntActiP34241, 26 interactors
MINTiP34241
STRINGi4932.YKL014C

PTM databases

iPTMnetiP34241

Proteomic databases

MaxQBiP34241
PaxDbiP34241
PRIDEiP34241

Genome annotation databases

EnsemblFungiiYKL014C_mRNA; YKL014C; YKL014C
GeneIDi853855
KEGGisce:YKL014C

Organism-specific databases

SGDiS000001497, URB1
VEuPathDBiFungiDB:YKL014C

Phylogenomic databases

eggNOGiKOG1791, Eukaryota
GeneTreeiENSGT00390000014210
HOGENOMiCLU_003174_0_0_1
InParanoidiP34241
OMAiSYYAQVN

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34241
RNActiP34241, protein

Family and domain databases

InterProiView protein in InterPro
IPR032436, NopRA1_C
IPR021714, Npa1_N
IPR039844, URB1
PANTHERiPTHR13500, PTHR13500, 1 hit
PfamiView protein in Pfam
PF16201, NopRA1, 1 hit
PF11707, Npa1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiURB1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34241
Secondary accession number(s): D6VXS2, P34242
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: June 2, 2021
This is version 143 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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