UniProtKB - P34240 (ZRT3_YEAST)
Protein
Zinc-regulated transporter 3
Gene
ZRT3
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Transports zinc from storage in the vacuole to the cytoplasm.1 Publication
GO - Molecular functioni
- zinc ion transmembrane transporter activity Source: SGD
GO - Biological processi
- cellular zinc ion homeostasis Source: SGD
- zinc ion transmembrane transport Source: GO_Central
- zinc ion transport Source: SGD
Keywordsi
Biological process | Ion transport, Transport, Zinc transport |
Ligand | Zinc |
Protein family/group databases
TCDBi | 2.A.5.5.3, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc-regulated transporter 3Alternative name(s): Vacuolar membrane zinc transporter |
Gene namesi | Name:ZRT3 Ordered Locus Names:YKL175W ORF Names:YKL640 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YKL175W |
SGDi | S000001658, ZRT3 |
Subcellular locationi
Vacuole
- Vacuole membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: SGD
Vacuole
- fungal-type vacuole membrane Source: SGD
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 8 – 28 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 336 – 356 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 371 – 391 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 438 – 458 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 482 – 502 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000203140 | 1 – 503 | Zinc-regulated transporter 3Add BLAST | 503 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 178 | PhosphoserineCombined sources | 1 | |
Modified residuei | 188 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P34240 |
PaxDbi | P34240 |
PRIDEi | P34240 |
TopDownProteomicsi | P34240 |
PTM databases
iPTMneti | P34240 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33963, 107 interactors |
DIPi | DIP-5610N |
IntActi | P34240, 1 interactor |
MINTi | P34240 |
STRINGi | 4932.YKL175W |
Miscellaneous databases
RNActi | P34240, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 102 – 139 | His-richAdd BLAST | 38 | |
Compositional biasi | 153 – 158 | Poly-Ser | 6 | |
Compositional biasi | 322 – 325 | Poly-His | 4 | |
Compositional biasi | 464 – 467 | Poly-His | 4 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2474, Eukaryota |
GeneTreei | ENSGT00390000006167 |
HOGENOMi | CLU_023518_0_0_1 |
InParanoidi | P34240 |
OMAi | AGSMITT |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
i Sequence
Sequence statusi: Complete.
P34240-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKIPRWLLF SLISSVLCIL GALCVPLLSV AFDSKRNSQS KLVNYGLSLS
60 70 80 90 100
AGSMITTSLY MLLPRIEKSN RFKVFPGLLL GICLSFFLNY LVHAFASESL
110 120 130 140 150
VHCADSGDHA TGSHIHSKSH SHSHSHSHAD SHSNFSNDHD LENAPSEHGY
160 170 180 190 200
ATSSSSVSEN DPLITKDSDR PQMKKKMSLI DLLTRRKSEG ECCDLNKCTP
210 220 230 240 250
LLQSEQPEYI ACVPPVIKSS QSERNVPHGC EGSEDNGQSD DKDHRGLVCV
260 270 280 290 300
ENNIGYDLEN LSLYRKNFLS SRHHHSSESP ENYGSNQLSH SFSSPLGNDV
310 320 330 340 350
TENPAALADT QYHPENGSLY PHHHHLETPF SKLLSIGMQT CLVLALHKFP
360 370 380 390 400
EGFIIFYTNR SDSSKSLGFS IFLSLTIHNF VEGFAMTLPF YTVFESKWVA
410 420 430 440 450
ILITAVLGGG SQPLGALIGY FIFKGSTPRD HEPNMDFLLS VTAGFLLVIG
460 470 480 490 500
LQMFQTGIGF SDGHHHHQGE GDEEMKQSHS SGTTCLKWCC TGVLLILASA
LFT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26878 Genomic DNA Translation: CAA81511.1 X74151 Genomic DNA Translation: CAA52263.1 Z28175 Genomic DNA Translation: CAA82017.1 BK006944 Genomic DNA Translation: DAA08991.1 |
PIRi | S38005 |
RefSeqi | NP_012746.1, NM_001179741.1 |
Genome annotation databases
EnsemblFungii | YKL175W_mRNA; YKL175W; YKL175W |
GeneIDi | 853679 |
KEGGi | sce:YKL175W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26878 Genomic DNA Translation: CAA81511.1 X74151 Genomic DNA Translation: CAA52263.1 Z28175 Genomic DNA Translation: CAA82017.1 BK006944 Genomic DNA Translation: DAA08991.1 |
PIRi | S38005 |
RefSeqi | NP_012746.1, NM_001179741.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33963, 107 interactors |
DIPi | DIP-5610N |
IntActi | P34240, 1 interactor |
MINTi | P34240 |
STRINGi | 4932.YKL175W |
Protein family/group databases
TCDBi | 2.A.5.5.3, the zinc (zn(2+))-iron (fe(2+)) permease (zip) family |
PTM databases
iPTMneti | P34240 |
Proteomic databases
MaxQBi | P34240 |
PaxDbi | P34240 |
PRIDEi | P34240 |
TopDownProteomicsi | P34240 |
Genome annotation databases
EnsemblFungii | YKL175W_mRNA; YKL175W; YKL175W |
GeneIDi | 853679 |
KEGGi | sce:YKL175W |
Organism-specific databases
EuPathDBi | FungiDB:YKL175W |
SGDi | S000001658, ZRT3 |
Phylogenomic databases
eggNOGi | KOG2474, Eukaryota |
GeneTreei | ENSGT00390000006167 |
HOGENOMi | CLU_023518_0_0_1 |
InParanoidi | P34240 |
OMAi | AGSMITT |
Miscellaneous databases
PROi | PR:P34240 |
RNActi | P34240, protein |
Family and domain databases
InterProi | View protein in InterPro IPR003689, ZIP |
Pfami | View protein in Pfam PF02535, Zip, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZRT3_YEAST | |
Accessioni | P34240Primary (citable) accession number: P34240 Secondary accession number(s): D6VX25 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XI
Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD