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Protein

Peroxisomal long-chain fatty acid import protein 1

Gene

PXA2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the import of activated long-chain fatty acids from the cytosol to the peroxisomal matrix.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi505 – 512ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: SGD
  • ATP binding Source: UniProtKB-KW
  • long-chain fatty acid transporter activity Source: UniProtKB

GO - Biological processi

  • fatty acid beta-oxidation Source: UniProtKB
  • fatty acid transmembrane transport Source: SGD
  • fatty-acyl-CoA transport Source: UniProtKB
  • long-chain fatty acid catabolic process Source: UniProtKB
  • peroxisomal long-chain fatty acid import Source: UniProtKB
  • very long-chain fatty acid catabolic process Source: UniProtKB

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31951-MONOMER
BRENDAi3.6.3.47 984

Protein family/group databases

TCDBi3.A.1.203.2 the atp-binding cassette (abc) superfamily
3.A.1.203.6 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal long-chain fatty acid import protein 1
Alternative name(s):
Peroxisomal ABC transporter 2
Gene namesi
Name:PXA2
Synonyms:PAT1
Ordered Locus Names:YKL188C
ORF Names:YKL741
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL188C
SGDiS000001671 PXA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei122 – 142HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei166 – 186HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei269 – 289HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei364 – 384HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933151 – 853Peroxisomal long-chain fatty acid import protein 1Add BLAST853

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi230N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi647N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi836N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP34230
PRIDEiP34230
TopDownProteomicsiP34230

Interactioni

Subunit structurei

Forms a heterodimer with PXA1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi33934, 106 interactors
ComplexPortaliCPX-1730 Peroxisomal ABC transporter complex PXA1-PXA2
DIPiDIP-741N
IntActiP34230, 5 interactors
MINTiP34230
STRINGi4932.YKL188C

Structurei

3D structure databases

ProteinModelPortaliP34230
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 417ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini472 – 747ABC transporterPROSITE-ProRule annotationAdd BLAST276

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000206081
InParanoidiP34230
KOiK15628
OMAiCAVTINR
OrthoDBiEOG092C1PEY

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR005283 FA_transporter
IPR027417 P-loop_NTPase
IPR031238 Pxa2
PANTHERiPTHR11384:SF36 PTHR11384:SF36, 1 hit
PfamiView protein in Pfam
PF06472 ABC_membrane_2, 1 hit
PF00005 ABC_tran, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 1 hit
TIGRFAMsiTIGR00954 3a01203, 1 hit
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 1 hit
PS50893 ABC_TRANSPORTER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISTASAFYQ KHRVNLLRSS YIILLLATLY NSNSSSSNNK TDKKDSESTV
60 70 80 90 100
LENKKIEEGK ETAVDREEDE SSKEELTIVS KHSTDSEDGA IIIDKESKTN
110 120 130 140 150
HKGGERKGKV DFLFKLLLHD KKCLILFITQ AILLNIRTLL SLRVATLDGQ
160 170 180 190 200
LVSTLVRAQY ANFTKILLGK WMILGIPASF INSLISYTTK LCAVTINRKV
210 220 230 240 250
SDFLLSKYLS NHHTFYSVAS AESVSEIQDN LTKDIYTFSM NSSLLLNQLL
260 270 280 290 300
KPMLDLILCS FKLLTSNTSV MGEGTLALGL IVYASNSLLK LIQPNFTRLT
310 320 330 340 350
MASASLESWF RSLHSNLHSS NEEIALLRGQ KRELENVDYS FYRLVLFLNR
360 370 380 390 400
EIKARAIYDV ATAFVIKYTW GAAGLVLCSI PIFFKNKPSE DTLQLKEPGN
410 420 430 440 450
DMTADFITNR RLLVTASSSI GRFVELKRNI QQLRGIRLRL NKFNDLLDAN
460 470 480 490 500
KGDDEKEPRD ERCIVEYDDS RIKFENIPLI TPANQVLVPE LSFDLKHGNH
510 520 530 540 550
LLIIGPNGCG KSSLFRILGG LWPIRATPNK NHQSKLIMPR RTVDRDCAIF
560 570 580 590 600
YLPQRPYMGN RSTFREQIIY PDSIEQFKER YHNDYDLGDA DLIKILQLLD
610 620 630 640 650
LEDLVTENMS LLLAQRTSKN DSQQLSTEDN QSPCAIKVRD AFSIVRNWSE
660 670 680 690 700
ELTIGVQQRL AMARMYYHKP KFAVLDECTS AVAPEMEQRM YENAQNFGIS
710 720 730 740 750
LISVCHRTSL WHFHNYLLKF DGKGGYQFGP FNPKERLCNE EKLLELNAIL
760 770 780 790 800
DQQVPLWERK LKDLTIAKES NIIRKSETNL NLFEKIEDPK TSKSNALFNA
810 820 830 840 850
NKGQRITSPT GQETSKRLPL FSQPSSSASS NLLRNNKSLN KKVKTKKEEG

KER
Length:853
Mass (Da):97,126
Last modified:February 1, 1994 - v1
Checksum:iBDD37FB2A6A220DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93584 Genomic DNA Translation: AAB51597.1
X74151 Genomic DNA Translation: CAA52250.1
X76133 Genomic DNA Translation: CAA53736.1
Z28188 Genomic DNA Translation: CAA82031.1
BK006944 Genomic DNA Translation: DAA08978.1
PIRiS34682
RefSeqiNP_012733.1, NM_001179754.1

Genome annotation databases

EnsemblFungiiYKL188C; YKL188C; YKL188C
GeneIDi853647
KEGGisce:YKL188C

Similar proteinsi

Entry informationi

Entry nameiPXA2_YEAST
AccessioniPrimary (citable) accession number: P34230
Secondary accession number(s): D6VX12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 18, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

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