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Entry version 153 (13 Feb 2019)
Sequence version 4 (28 Nov 2006)
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Protein

Putative transcription factor SEF1

Gene

SEF1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative transcription factor that seems to be involved in the sporulation process. Suppresses the lethal phenotype of RPM2 deletion.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi57 – 87Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processSporulation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28962-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative transcription factor SEF1
Alternative name(s):
Suppressor of essential function protein 1
Suppressor protein SEF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEF1
Ordered Locus Names:YBL066C
ORF Names:YBL0501, YBL0526
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:YBL066C

Saccharomyces Genome Database

More...
SGDi
S000000162 SEF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001149771 – 1148Putative transcription factor SEF1Add BLAST1148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei8PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei806PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34228

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34228

PRoteomics IDEntifications database

More...
PRIDEi
P34228

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34228

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32634, 107 interactors

Database of interacting proteins

More...
DIPi
DIP-2559N

Protein interaction database and analysis system

More...
IntActi
P34228, 9 interactors

Molecular INTeraction database

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MINTi
P34228

STRING: functional protein association networks

More...
STRINGi
4932.YBL066C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P34228

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P34228

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi278 – 322Thr-richAdd BLAST45
Compositional biasi536 – 539Poly-Asn4

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176683

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247882

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDCSYRF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00067 GAL4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57701 SSF57701, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34228-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKDNRDSDQ DQDFSSAHMK RQPEQQQLQQ HQFPSKKQRI SHHDDSHQIN
60 70 80 90 100
HRPVTSCTHC RQHKIKCDAS QNFPHPCSRC EKIGLHCEIN PQFRPKKGSQ
110 120 130 140 150
LQLLRQDVDE IKSKLDTLLA NDSVFVHLLQ QIPMGNSLLN KLNLHPTPTP
160 170 180 190 200
GTIIPNPDSS PSSGSPTSSA AQRDSKVSVQ TYLSREPQLL QANQGSNTNK
210 220 230 240 250
FKANNEASSH MTLRASSLAQ DSKGLVATEP NKLPPLLNDS ALPNNSKESL
260 270 280 290 300
PPALQMAFYK NNSAGNTPNG PFSPIQKTYS PHTTSTTVTT TTNQPPFAAT
310 320 330 340 350
SHVATNNNAD RTKTPVVATT TTMPLLPSPH ANVDEFVLGD ISISIEKANR
360 370 380 390 400
LHHIFVTRYL PYFPIMYSNN ATELYSQSQL LFWTVMLTAC LSDPEPTMYC
410 420 430 440 450
KLSSLIKQLA IETCWIRTPR STHISQALLI LCIWPLPNQK VLDDCSYRFV
460 470 480 490 500
GLAKSLSYQL GLHRGEFISE FTRTQTSMPN AEKWRTRTWL GIFFAELCWA
510 520 530 540 550
SILGLPPTSQ TDYLLEKALS CGDEESEEDN NDSIDNNNND KRNKKDEPHV
560 570 580 590 600
ESKYKLPGSF RRLLSLANFQ AKLSHIIGSS TSSPDGLLEP KYRAETLSIL
610 620 630 640 650
GKELDLLAKT LNFQSDDTVN IYFLYVKLTV CCFAFLPETP PTDQIPYVTE
660 670 680 690 700
AYLTATKIVT LLNNLLETHQ LIELPIYIRQ AATFSALILF KLQLTPLLPD
710 720 730 740 750
KYFDSARQSV VTIHRLYRNQ LTAWATSVEN DISRTASMLE KLNFVLIMHP
760 770 780 790 800
EVFVEEDGII SRMRSHLTGS LFYDLVWCVH EARRREMDPE YNKQALEKAA
810 820 830 840 850
KKRKFSSNGI YNGTSSTGGI TDRKLYPLPL YNHISRDDFE TVTKTTPSGT
860 870 880 890 900
TVTTLVPTKN ALKQAEKLAK TNNGDSDGSI MEINGIPLSM LGETGSVKFQ
910 920 930 940 950
SLFANTSNSN DYNNNRTLLD ASNDISIPSN SIYPVASVPA SNNNPQSTKV
960 970 980 990 1000
DYYSNGPSVI PDLSMKRSVS TPVNHFPASV PGLRNHPVGN LSNNVTLGID
1010 1020 1030 1040 1050
HPIPREHSNL QNVTMNYNNQ FSNANAIGRS QSSMSHSRTP IASKSNNMTD
1060 1070 1080 1090 1100
LHSVVSDPGS SKSTAYPPLS LFSKSNDINS NKTNQRFSTG TNTVTSSNFQ
1110 1120 1130 1140
TIDNENNVKT PGNKLTDFFQ QQSAGWIEGN SSNDDFFGWF DMNMEQGF
Length:1,148
Mass (Da):127,992
Last modified:November 28, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i41553B72ED667645
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA84885 differs from that shown. Sequencing errors.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z35827 Genomic DNA Translation: CAA84885.1 Sequence problems.
Z23261 Genomic DNA Translation: CAA80783.1
BK006936 Genomic DNA Translation: DAA07055.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45801

NCBI Reference Sequences

More...
RefSeqi
NP_009487.2, NM_001178306.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBL066C_mRNA; YBL066C_mRNA; YBL066C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852214

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBL066C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35827 Genomic DNA Translation: CAA84885.1 Sequence problems.
Z23261 Genomic DNA Translation: CAA80783.1
BK006936 Genomic DNA Translation: DAA07055.1
PIRiS45801
RefSeqiNP_009487.2, NM_001178306.1

3D structure databases

ProteinModelPortaliP34228
SMRiP34228
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32634, 107 interactors
DIPiDIP-2559N
IntActiP34228, 9 interactors
MINTiP34228
STRINGi4932.YBL066C

PTM databases

iPTMnetiP34228

Proteomic databases

MaxQBiP34228
PaxDbiP34228
PRIDEiP34228

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL066C_mRNA; YBL066C_mRNA; YBL066C
GeneIDi852214
KEGGisce:YBL066C

Organism-specific databases

EuPathDBiFungiDB:YBL066C
SGDiS000000162 SEF1

Phylogenomic databases

GeneTreeiENSGT00940000176683
HOGENOMiHOG000247882
OMAiDDCSYRF

Enzyme and pathway databases

BioCyciYEAST:G3O-28962-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34228

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEF1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34228
Secondary accession number(s): D6VPT5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 28, 2006
Last modified: February 13, 2019
This is version 153 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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