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UniProtKB - P34223 (UBX1_YEAST)
Protein
UBX domain-containing protein 1
Gene
SHP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in CDC48-dependent protein degradation through the ubiquitin/proteasome pathway. Direct or indirect positive regulator of GLC7 activity.
1 PublicationMiscellaneous
Present with 3200 molecules/cell in log phase SD medium.1 Publication
GO - Molecular functioni
- protein phosphatase regulator activity Source: SGD
- ubiquitin binding Source: GO_Central
GO - Biological processi
- ascospore formation Source: SGD
- autophagosome assembly Source: SGD
- glycogen metabolic process Source: SGD
- Golgi organization Source: GO_Central
- membrane fusion Source: GO_Central
- nuclear membrane reassembly Source: GO_Central
- piecemeal microautophagy of the nucleus Source: SGD
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
- sister chromatid biorientation Source: SGD
- ubiquitin-dependent ERAD pathway Source: SGD
Keywordsi
Biological process | Ubl conjugation pathway |
Names & Taxonomyi
Protein namesi | Recommended name: UBX domain-containing protein 1Alternative name(s): Suppressor of high-copy PP1 protein |
Gene namesi | Name:SHP1 Synonyms:UBX1 Ordered Locus Names:YBL058W ORF Names:YBL0509, YBL0515 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000154, SHP1 |
VEuPathDBi | FungiDB:YBL058W |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210998 | 1 – 423 | UBX domain-containing protein 1Add BLAST | 423 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 128 | PhosphoserineCombined sources | 1 | |
Modified residuei | 210 | PhosphoserineCombined sources | 1 | |
Modified residuei | 224 | PhosphoserineCombined sources | 1 | |
Cross-linki | 241 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 315 | PhosphoserineCombined sources | 1 | |
Modified residuei | 321 | PhosphoserineCombined sources | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 | |
Modified residuei | 331 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P34223 |
PaxDbi | P34223 |
PRIDEi | P34223 |
TopDownProteomicsi | P34223 |
PTM databases
iPTMneti | P34223 |
Interactioni
Subunit structurei
Binary interactionsi
P34223
With | #Exp. | IntAct |
---|---|---|
CDC48 [P25694] | 10 | EBI-17093,EBI-4308 |
DFM1 [Q12743] | 2 | EBI-17093,EBI-33192 |
UFD2 [P54860] | 3 | EBI-17093,EBI-20003 |
GO - Molecular functioni
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 32641, 447 interactors |
DIPi | DIP-2789N |
IntActi | P34223, 24 interactors |
MINTi | P34223 |
STRINGi | 4932.YBL058W |
Miscellaneous databases
RNActi | P34223, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 232 – 297 | SEPPROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 344 – 421 | UBXPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 44 – 167 | DisorderedSequence analysisAdd BLAST | 124 | |
Regioni | 299 – 348 | DisorderedSequence analysisAdd BLAST | 50 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 45 – 63 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 64 – 81 | Polar residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 91 – 130 | Polar residuesSequence analysisAdd BLAST | 40 | |
Compositional biasi | 148 – 162 | Polar residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG2086, Eukaryota |
GeneTreei | ENSGT00520000055567 |
HOGENOMi | CLU_029402_4_1_1 |
OMAi | IQSRPEF |
Family and domain databases
Gene3Di | 3.30.420.210, 1 hit |
InterProi | View protein in InterPro IPR036241, NSFL1C_SEP_dom_sf IPR012989, SEP_domain IPR029071, Ubiquitin-like_domsf IPR001012, UBX_dom |
Pfami | View protein in Pfam PF08059, SEP, 1 hit PF00789, UBX, 1 hit |
SMARTi | View protein in SMART SM00553, SEP, 1 hit SM00166, UBX, 1 hit |
SUPFAMi | SSF102848, SSF102848, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS51399, SEP, 1 hit PS50033, UBX, 1 hit |
i Sequence
Sequence statusi: Complete.
P34223-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD
60 70 80 90 100
RREEAHWNRQ QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY
110 120 130 140 150
LKRKGSTSPE PTKGSSRSGS GNNSRFMSFS DMVRGQADDD DEDQPRNTFA
160 170 180 190 200
GGETSGLEVT DPSDPNSLLK DLLEKARRGG QMGAENGFRD DEDHEMGANR
210 220 230 240 250
FTGRGFRLGS TIDAADEVVE DNTSQSQRRP EKVTREITFW KEGFQVADGP
260 270 280 290 300
LYRYDDPANS FYLSELNQGR APLKLLDVQF GQEVEVNVYK KLDESYKAPT
310 320 330 340 350
RKLGGFSGQG QRLGSPIPGE SSPAEVPKNE TPAAQEQPMP DNEPKQGDTS
360 370 380 390 400
IQIRYANGKR EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP
410 420
ISNDETTLKD ADLLNSVVVQ RWA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 223 | T → A in AAS56043 (PubMed:17322287).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23261 Genomic DNA Translation: CAA80789.1 Z35819 Genomic DNA Translation: CAA84878.1 AY557717 Genomic DNA Translation: AAS56043.1 BK006936 Genomic DNA Translation: DAA07062.1 |
PIRi | S39830 |
RefSeqi | NP_009495.1, NM_001178298.1 |
Genome annotation databases
EnsemblFungii | YBL058W_mRNA; YBL058W; YBL058W |
GeneIDi | 852222 |
KEGGi | sce:YBL058W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z23261 Genomic DNA Translation: CAA80789.1 Z35819 Genomic DNA Translation: CAA84878.1 AY557717 Genomic DNA Translation: AAS56043.1 BK006936 Genomic DNA Translation: DAA07062.1 |
PIRi | S39830 |
RefSeqi | NP_009495.1, NM_001178298.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OPC | electron microscopy | 3.70 | Z | 1-423 | [»] | |
AlphaFoldDBi | P34223 | |||||
SMRi | P34223 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 32641, 447 interactors |
DIPi | DIP-2789N |
IntActi | P34223, 24 interactors |
MINTi | P34223 |
STRINGi | 4932.YBL058W |
PTM databases
iPTMneti | P34223 |
Proteomic databases
MaxQBi | P34223 |
PaxDbi | P34223 |
PRIDEi | P34223 |
TopDownProteomicsi | P34223 |
Genome annotation databases
EnsemblFungii | YBL058W_mRNA; YBL058W; YBL058W |
GeneIDi | 852222 |
KEGGi | sce:YBL058W |
Organism-specific databases
SGDi | S000000154, SHP1 |
VEuPathDBi | FungiDB:YBL058W |
Phylogenomic databases
eggNOGi | KOG2086, Eukaryota |
GeneTreei | ENSGT00520000055567 |
HOGENOMi | CLU_029402_4_1_1 |
OMAi | IQSRPEF |
Miscellaneous databases
PROi | PR:P34223 |
RNActi | P34223, protein |
Family and domain databases
Gene3Di | 3.30.420.210, 1 hit |
InterProi | View protein in InterPro IPR036241, NSFL1C_SEP_dom_sf IPR012989, SEP_domain IPR029071, Ubiquitin-like_domsf IPR001012, UBX_dom |
Pfami | View protein in Pfam PF08059, SEP, 1 hit PF00789, UBX, 1 hit |
SMARTi | View protein in SMART SM00553, SEP, 1 hit SM00166, UBX, 1 hit |
SUPFAMi | SSF102848, SSF102848, 1 hit SSF54236, SSF54236, 1 hit |
PROSITEi | View protein in PROSITE PS51399, SEP, 1 hit PS50033, UBX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBX1_YEAST | |
Accessioni | P34223Primary (citable) accession number: P34223 Secondary accession number(s): D6VPU2, E9P8S9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome II
Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references