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Protein

Protein phosphatase 2C homolog 3

Gene

PTC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible, together with PTC2, for the dephosphorylation of the cyclin-dependent protein kinase CDC28.1 Publication

Miscellaneous

Present with 19700 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Manganese 1By similarity1
Metal bindingi62Manganese 2By similarity1
Metal bindingi63Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi234Manganese 2By similarity1
Metal bindingi284Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: SGD

GO - Biological processi

  • inactivation of MAPK activity Source: SGD
  • protein dephosphorylation Source: SGD
  • regulation of cyclin-dependent protein serine/threonine kinase activity Source: SGD

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandMagnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28954-MONOMER
ReactomeiR-SCE-1169408 ISG15 antiviral mechanism
R-SCE-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 2C homolog 3 (EC:3.1.3.16)
Short name:
PP2C-3
Gene namesi
Name:PTC3
Ordered Locus Names:YBL056W
ORF Names:YBL0511, YBL0513
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL056W
SGDiS000000152 PTC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000577761 – 468Protein phosphatase 2C homolog 3Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei324PhosphoserineCombined sources1
Modified residuei332PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34221
PaxDbiP34221
PRIDEiP34221

PTM databases

iPTMnetiP34221

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAA1Q124476EBI-12805,EBI-33397

Protein-protein interaction databases

BioGridi32643, 146 interactors
DIPiDIP-3944N
IntActiP34221, 35 interactors
MINTiP34221
STRINGi4932.YBL056W

Structurei

3D structure databases

ProteinModelPortaliP34221
SMRiP34221
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 293PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST271

Sequence similaritiesi

Belongs to the PP2C family.Curated

Phylogenomic databases

GeneTreeiENSGT00880000137909
HOGENOMiHOG000233896
KOiK14803
OMAiAKFAGKH
OrthoDBiEOG092C1UK5

Family and domain databases

CDDicd00143 PP2Cc, 1 hit
Gene3Di3.60.40.10, 1 hit
InterProiView protein in InterPro
IPR015655 PP2C
IPR000222 PP2C_BS
IPR036457 PPM-type_dom_sf
IPR001932 PPM-type_phosphatase_dom
PANTHERiPTHR13832 PTHR13832, 1 hit
PfamiView protein in Pfam
PF00481 PP2C, 1 hit
SMARTiView protein in SMART
SM00332 PP2Cc, 1 hit
SUPFAMiSSF81606 SSF81606, 1 hit
PROSITEiView protein in PROSITE
PS01032 PPM_1, 1 hit
PS51746 PPM_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34221-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQILSNPII DKEHHSGTDC LTAFGLCAMQ GWRMSMEDAH IVEPNLLAES
60 70 80 90 100
DEEHLAFYGI FDGHGGSSVA EFCGSKMISI LKKQESFKSG MLEQCLIDTF
110 120 130 140 150
LATDVELLKD EKLKDDHSGC TATVILVSQL KKLLICANSG DSRTVLSTGG
160 170 180 190 200
NSKAMSFDHK PTLLSEKSRI VAADGFVEMD RVNGNLALSR AIGDFEFKSN
210 220 230 240 250
TKLGPHEQVV TCVPDIICHN LNYDEDEFVI LACDGIWDCL TSQECVDLVH
260 270 280 290 300
YGISQGNMTL SDISSRIVDV CCSPTTEGSG IGCDNMSISI VALLKENESE
310 320 330 340 350
SQWFERMRSK NYNIQTSFVQ RRKSIFDFHD FSDDDNEVFA ITTKKLQDRL
360 370 380 390 400
NRSKDNDDME IDDLDTELGS SATPSKLSGE DRTGPIDLFS LEALLEAGIQ
410 420 430 440 450
IRQRPSSDSD GNTSYFHGAS LSDMLASLSN AAAGETEPND ADDNDDNDGE
460
ENGKNENAKK GSKIEEIE
Length:468
Mass (Da):51,332
Last modified:July 27, 2011 - v4
Checksum:i70AC2707C7FA2122
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti369G → D in CAA80791 (PubMed:8154187).Curated1
Sequence conflicti369G → D in CAA84876 (PubMed:7813418).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U72346 Genomic DNA Translation: AAB17351.1
Z23261 Genomic DNA Translation: CAA80791.1
Z35817 Genomic DNA Translation: CAA84876.1
AY692754 Genomic DNA Translation: AAT92773.1
BK006936 Genomic DNA Translation: DAA07064.2
PIRiS39832
RefSeqiNP_009497.2, NM_001178296.2

Genome annotation databases

EnsemblFungiiYBL056W; YBL056W; YBL056W
GeneIDi852224
KEGGisce:YBL056W

Similar proteinsi

Entry informationi

Entry nameiPP2C3_YEAST
AccessioniPrimary (citable) accession number: P34221
Secondary accession number(s): D6VPU4, Q92330
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names

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