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Protein

Transcriptional regulatory protein TOD6

Gene

TOD6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. TOD6 binds to sequences containing the core CGATG, which resembles the PAC (Polymerase A and C) motif.2 Publications

Miscellaneous

Present with 830 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi97 – 120H-T-H motifPROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

  • sequence-specific DNA binding Source: SGD

GO - Biological processi

  • regulation of transcription by RNA polymerase II Source: SGD

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28952-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein TOD6
Alternative name(s):
PAC-binding factor 1
Twin of DOT6
Gene namesi
Name:TOD6
Synonyms:PBF1
Ordered Locus Names:YBL054W
ORF Names:YBL0509, YBL0513
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

EuPathDBiFungiDB:YBL054W
SGDiS000000150 TOD6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971461 – 525Transcriptional regulatory protein TOD6Add BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei280PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei366PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34219
PaxDbiP34219
PRIDEiP34219
TopDownProteomicsiP34219

PTM databases

iPTMnetiP34219

Interactioni

Subunit structurei

Component of the RPD3C(L) complex composed of at least ASH1, CTI6, DEP1, DOT6, PHO23, RPD3, RXT2, RXT3, SAP30, SDS3, SIN3, TOD6; UME1 and UME6.1 Publication

Protein-protein interaction databases

BioGridi32645, 74 interactors
DIPiDIP-2636N
IntActiP34219, 3 interactors
MINTiP34219
STRINGi4932.YBL054W

Structurei

3D structure databases

ProteinModelPortaliP34219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 124HTH myb-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Belongs to the DOT6 family.Curated

Phylogenomic databases

GeneTreeiENSGT00530000068139
InParanoidiP34219
OrthoDBiEOG092C51OF

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit

Sequencei

Sequence statusi: Complete.

P34219-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLPKLSSVS VSSGHVSANS HGFSILSKHP HPNNLVHSHS LSHTNAKSHL
60 70 80 90 100
PISSTSTKEN STNKEEAESL KKNNPSSWDP SDDIKLRHLK EIKNLGWKEI
110 120 130 140 150
AHHFPNRTPN ACQFRWRRLK SGNLKSNKTA VIDINKLFGV YATGDATPSA
160 170 180 190 200
GTPSAEEAVK EEAVEDEDIT AGSSAIEDSP PDFKPLVKPK YMDRKLITQR
210 220 230 240 250
STSTFSDHEP QHTKPRKLFV KPRSFSHSIT TNTPNVKTAQ QTNLSLYNTT
260 270 280 290 300
SAKTNKAVNS NDYENIGLVP KIIIRSRRNS FIPSTQIPHS TTKTRKNSHS
310 320 330 340 350
VISSRRSSFN MMHSRRSSFN SHAPTEPISR RASLVVSPYM SPRRLSTSQS
360 370 380 390 400
VHYHPQHQYY LNPIASPNCK TDHANDKITH TRTFLDMQKF ANKHPWSRED
410 420 430 440 450
DEVLLNNTKD KQNHLSPLEI SIVLPNNRSE LEIQQRMDYL KRKGRVSGFH
460 470 480 490 500
TNEGCKDEEE EDDIDPLHKE NGINTPSQQS QNYGMLEAKH DNPKSSELSS
510 520
MTSANDIRNE QDELPGINSI FKNIF
Length:525
Mass (Da):59,226
Last modified:February 1, 1994 - v1
Checksum:i8663DFE2641AA72E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA Translation: CAA80793.1
Z35815 Genomic DNA Translation: CAA84874.1
AY692625 Genomic DNA Translation: AAT92644.1
BK006936 Genomic DNA Translation: DAA07066.1
PIRiS39834
RefSeqiNP_009499.1, NM_001178294.1

Genome annotation databases

EnsemblFungiiYBL054W; YBL054W; YBL054W
GeneIDi852226
KEGGisce:YBL054W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA Translation: CAA80793.1
Z35815 Genomic DNA Translation: CAA84874.1
AY692625 Genomic DNA Translation: AAT92644.1
BK006936 Genomic DNA Translation: DAA07066.1
PIRiS39834
RefSeqiNP_009499.1, NM_001178294.1

3D structure databases

ProteinModelPortaliP34219
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32645, 74 interactors
DIPiDIP-2636N
IntActiP34219, 3 interactors
MINTiP34219
STRINGi4932.YBL054W

PTM databases

iPTMnetiP34219

Proteomic databases

MaxQBiP34219
PaxDbiP34219
PRIDEiP34219
TopDownProteomicsiP34219

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL054W; YBL054W; YBL054W
GeneIDi852226
KEGGisce:YBL054W

Organism-specific databases

EuPathDBiFungiDB:YBL054W
SGDiS000000150 TOD6

Phylogenomic databases

GeneTreeiENSGT00530000068139
InParanoidiP34219
OrthoDBiEOG092C51OF

Enzyme and pathway databases

BioCyciYEAST:G3O-28952-MONOMER

Miscellaneous databases

PROiPR:P34219

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017930 Myb_dom
IPR001005 SANT/Myb
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51294 HTH_MYB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTOD6_YEAST
AccessioniPrimary (citable) accession number: P34219
Secondary accession number(s): D6VPU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: September 12, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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Main funding by: National Institutes of Health

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