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Protein

RNA-binding protein PIN4

Gene

PIN4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in normal G2/M phase transition of the mitotic cell cycle. In association with RAD53, also involved in checkpoint control in response to DNA damage.1 Publication

Miscellaneous

Present with 4630 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mRNA binding Source: GO_Central

GO - Biological processi

  • DNA damage checkpoint Source: SGD
  • G2/M transition of mitotic cell cycle Source: SGD
  • nuclear mRNA surveillance Source: GO_Central
  • poly(A)+ mRNA export from nucleus Source: GO_Central
  • regulation of mRNA stability involved in response to oxidative stress Source: GO_Central

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-28950-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein PIN4
Alternative name(s):
Psi inducibility protein 4
Gene namesi
Name:PIN4
Synonyms:MDT1
Ordered Locus Names:YBL051C
ORF Names:YBL0506, YBL0516
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome II

Organism-specific databases

SGDiS000000147 PIN4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi305T → A: No interaction with RAD53. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000820281 – 668RNA-binding protein PIN4Add BLAST668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56PhosphoserineCombined sources1
Modified residuei189PhosphoserineCombined sources1
Modified residuei191PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei197PhosphoserineCombined sources1
Modified residuei305Phosphothreonine1 Publication1
Modified residuei393PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1
Modified residuei541PhosphoserineCombined sources1
Modified residuei636PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei653PhosphoserineCombined sources1
Modified residuei655PhosphoserineCombined sources1

Post-translational modificationi

Hyperphosphorylated in response to DNA damage by MEC1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP34217
PaxDbiP34217
PRIDEiP34217

PTM databases

iPTMnetiP34217

Interactioni

Subunit structurei

Interacts with RAD53.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RAD53P222163EBI-21256,EBI-17843

Protein-protein interaction databases

BioGridi32647, 318 interactors
DIPiDIP-1905N
ELMiP34217
IntActiP34217, 44 interactors
MINTiP34217
STRINGi4932.YBL051C

Structurei

3D structure databases

ProteinModelPortaliP34217
SMRiP34217
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34217

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 163RRMPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

HOGENOMiHOG000115549
OMAiKKMLPQA
OrthoDBiEOG092C3WNG

Family and domain databases

CDDicd02639 R3H_RRM, 1 hit
cd12253 RRM_PIN4_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034186 PIN4-like_RRM
IPR034069 R3H_Cip2
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

P34217-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
METSSFENAP PAAINDAQDN NINTETNDQE TNQQSIETRD AIDKENGVQT
60 70 80 90 100
ETGENSAKNA EQNVSSTNLN NAPTNGALDD DVIPNAIVIK NIPFAIKKEQ
110 120 130 140 150
LLDIIEEMDL PLPYAFNYHF DNGIFRGLAF ANFTTPEETT QVITSLNGKE
160 170 180 190 200
ISGRKLKVEY KKMLPQAERE RIEREKREKR GQLEEQHRSS SNLSLDSLSK
210 220 230 240 250
MSGSGNNNTS NNQLFSTLMN GINANSMMNS PMNNTINNNS SNNNNSGNII
260 270 280 290 300
LNQPSLSAQH TSSSLYQTNV NNQAQMSTER FYAPLPSTST LPLPPQQLDF
310 320 330 340 350
NDPDTLEIYS QLLLFKDREK YYYELAYPMG ISASHKRIIN VLCSYLGLVE
360 370 380 390 400
VYDPRFIIIR RKILDHANLQ SHLQQQGQMT SAHPLQPNST GGSMNRSQSY
410 420 430 440 450
TSLLQAHAAA AANSISNQAV NNSSNSNTIN SNNGNGNNVI INNNSASSTP
460 470 480 490 500
KISSQGQFSM QPTLTSPKMN IHHSSQYNSA DQPQQPQPQT QQNVQSAAQQ
510 520 530 540 550
QQSFLRQQAT LTPSSRIPSG YSANHYQINS VNPLLRNSQI SPPNSQIPIN
560 570 580 590 600
SQTLSQAQPP AQSQTQQRVP VAYQNASLSS QQLYNLNGPS SANSQSQLLP
610 620 630 640 650
QHTNGSVHSN FSYQSYHDES MLSAHNLNSA DLIYKSLSHS GLDDGLEQGL
660
NRSLSGLDLQ NQNKKNLW
Length:668
Mass (Da):73,776
Last modified:February 1, 1994 - v1
Checksum:iEA8EE581286436CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA Translation: CAA80795.1
Z35812 Genomic DNA Translation: CAA84871.1
BK006936 Genomic DNA Translation: DAA07068.1
PIRiS39836
RefSeqiNP_009502.1, NM_001178291.1

Genome annotation databases

EnsemblFungiiYBL051C; YBL051C; YBL051C
GeneIDi852229
KEGGisce:YBL051C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z23261 Genomic DNA Translation: CAA80795.1
Z35812 Genomic DNA Translation: CAA84871.1
BK006936 Genomic DNA Translation: DAA07068.1
PIRiS39836
RefSeqiNP_009502.1, NM_001178291.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A0TNMR-B301-310[»]
ProteinModelPortaliP34217
SMRiP34217
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32647, 318 interactors
DIPiDIP-1905N
ELMiP34217
IntActiP34217, 44 interactors
MINTiP34217
STRINGi4932.YBL051C

PTM databases

iPTMnetiP34217

Proteomic databases

MaxQBiP34217
PaxDbiP34217
PRIDEiP34217

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL051C; YBL051C; YBL051C
GeneIDi852229
KEGGisce:YBL051C

Organism-specific databases

SGDiS000000147 PIN4

Phylogenomic databases

HOGENOMiHOG000115549
OMAiKKMLPQA
OrthoDBiEOG092C3WNG

Enzyme and pathway databases

BioCyciYEAST:G3O-28950-MONOMER

Miscellaneous databases

EvolutionaryTraceiP34217
PROiPR:P34217

Family and domain databases

CDDicd02639 R3H_RRM, 1 hit
cd12253 RRM_PIN4_like, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034186 PIN4-like_RRM
IPR034069 R3H_Cip2
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPIN4_YEAST
AccessioniPrimary (citable) accession number: P34217
Secondary accession number(s): D6VPU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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Main funding by: National Institutes of Health

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