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Entry version 170 (13 Feb 2019)
Sequence version 2 (01 Oct 1994)
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Protein

EH domain-containing and endocytosis protein 1

Gene

EDE1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions at the internalization step of the clathrin-mediated endocytosis (CME) as an early-acting scaffold protein. Requires clathrin adapter proteins, ENT1/2 and YAP1801/2, for normal spatiotemporal dynamics and viability. Binds to biological membranes in a ubiquitin-dependent manner.7 Publications

Miscellaneous

Present with 1380 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • ubiquitin binding Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processEndocytosis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-28947-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-193648 NRAGE signals death through JNK
R-SCE-194840 Rho GTPase cycle
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EH domain-containing and endocytosis protein 1
Alternative name(s):
Bud site selection protein 15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EDE1
Synonyms:BUD15
Ordered Locus Names:YBL047C
ORF Names:YBL0501, YBL0520
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YBL047C

Saccharomyces Genome Database

More...
SGDi
S000000143 EDE1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Random budding pattern and morphological defects. Defects in fluid-phase endocytosis and defective internalization of the pheromone alpha-factor and uracil permease. Deletion has only a small impact on actin cytoskeleton organization. Deletion shows synthetic growth defects with thermosensitive mutants of PAN1, END3 and RSP5.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56W → A: Abnormal spatiotemporal behavior. 1 Publication1
Mutagenesisi176W → A: Abnormal spatiotemporal behavior. 1 Publication1
Mutagenesisi319W → A: Abnormal spatiotemporal behavior. 1 Publication1
Mutagenesisi1352M → A: Reduced ubiquitin-binding. 1 Publication1
Mutagenesisi1370L → A: Reduced ubiquitin-binding. 1 Publication1
Mutagenesisi1374T → A: Enhanced ubiquitin-binding. 1 Publication1
Mutagenesisi1378L → A: Reduced ubiquitin-binding. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002024571 – 1381EH domain-containing and endocytosis protein 1Add BLAST1381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei238PhosphothreonineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei245PhosphothreonineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei251PhosphothreonineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei419PhosphoserineCombined sources1
Modified residuei450PhosphothreonineCombined sources1
Modified residuei477PhosphothreonineCombined sources1
Modified residuei487PhosphothreonineCombined sources1
Modified residuei495PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki674Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei848PhosphoserineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei950PhosphoserineCombined sources1
Modified residuei964PhosphoserineCombined sources1
Modified residuei1008PhosphoserineCombined sources1
Modified residuei1012PhosphoserineCombined sources1
Modified residuei1020PhosphoserineCombined sources1
Modified residuei1046PhosphothreonineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1093PhosphoserineCombined sources1
Modified residuei1095PhosphoserineCombined sources1
Modified residuei1096PhosphoserineCombined sources1
Modified residuei1100PhosphoserineCombined sources1
Modified residuei1111PhosphothreonineCombined sources1
Modified residuei1181PhosphoserineCombined sources1
Modified residuei1187PhosphoserineCombined sources1
Modified residuei1307PhosphothreonineCombined sources1
Cross-linki1329Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei1343PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34216

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34216

PRoteomics IDEntifications database

More...
PRIDEi
P34216

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34216

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via UBA domain) with monoubiquitin and ENT1 (via asparagine-proline-phenylalanine tripeptide motif called NPF). Interacts with PAL1 and SYP1.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SYP1P256236EBI-21243,EBI-21900

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
32650, 268 interactors

Database of interacting proteins

More...
DIPi
DIP-5817N

Protein interaction database and analysis system

More...
IntActi
P34216, 29 interactors

Molecular INTeraction database

More...
MINTi
P34216

STRING: functional protein association networks

More...
STRINGi
4932.YBL047C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11381
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G3QNMR-A1339-1381[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P34216

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P34216

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P34216

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 113EH 1PROSITE-ProRule annotationAdd BLAST100
Domaini135 – 227EH 2PROSITE-ProRule annotationAdd BLAST93
Domaini277 – 366EH 3PROSITE-ProRule annotationAdd BLAST90
Domaini1338 – 1380UBAPROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1217 – 1381Able to bind biological membranesAdd BLAST165

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili593 – 882Sequence analysisAdd BLAST290

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi550 – 575Ala-richAdd BLAST26

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VDP/USO1/EDE1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000112328

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34216

KEGG Orthology (KO)

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KOi
K12472

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDWDAIF

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052 EH, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR015940 UBA
IPR009060 UBA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12763 EF-hand_4, 3 hits
PF00627 UBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054 EFh, 2 hits
SM00027 EH, 3 hits
SM00165 UBA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit
SSF47473 SSF47473, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
PS50031 EH, 3 hits
PS50030 UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34216-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASITFRTPL SSQEQAFYNQ KFHQLDTEDL GVVTGEAVRP LFASSGLPGQ
60 70 80 90 100
LLSQVWATVD IDNKGFLNLN EFSAALRMIA QLQNAPNQPI SAALYESTPT
110 120 130 140 150
QLASFSINQN PAPMQSGSAT GNTNNTDIPA LSSNDIAKFS QLFDRTAKGA
160 170 180 190 200
QTVAGDKAKD IFLKARLPNQ TLGEIWALCD RDASGVLDKS EFIMAMYLIQ
210 220 230 240 250
LCMSHHPSMN TPPAVLPTQL WDSIRLEPVV VNQPNRTTPL SANSTGVSSL
260 270 280 290 300
TRHSTISRLS TGAFSNAASD WSLSFEKKQQ FDAIFDSLDK QHAGSLSSAV
310 320 330 340 350
LVPFFLSSRL NQETLATIWD LADIHNNAEF TKLEFAIAMF LIQKKNAGVE
360 370 380 390 400
LPDVIPNELL QSPALGLYPP NPLPQQQSAP QIAIPSRASK PSLQDMPHQV
410 420 430 440 450
SAPAVNTQPT VPQVLPQNSN NGSLNDLLAL NPSFSSPSPT KAQTVVQNNT
460 470 480 490 500
NNSFSYDNNN GQATLQQQQP QQPPPLTHSS SGLKKFTPTS NFGQSIIKEE
510 520 530 540 550
PEEQEQLRES SDTFSAQPPP VPKHASSPVK RTASTTLPQV PNFSVFSMPA
560 570 580 590 600
GAATSAATGA AVGAAVGAAA LGASAFSRSS NNAFKNQDLF ADGEASAQLS
610 620 630 640 650
NATTEMANLS NQVNSLSKQA SITNDKKSRA TQELKRVTEM KNSIQIKLNN
660 670 680 690 700
LRSTHDQNVK QTEQLEAQVL QVNKENETLA QQLAVSEANY HAAESKLNEL
710 720 730 740 750
TTDLQESQTK NAELKEQITN LNSMTASLQS QLNEKQQQVK QERSMVDVNS
760 770 780 790 800
KQLELNQVTV ANLQKEIDGL GEKISVYLTK QKELNDYQKT VEEQHAQLQA
810 820 830 840 850
KYQDLSNKDT DLTDREKQLE ERNRQIEEQE NLYHQHVSKL QEMFDDLSQR
860 870 880 890 900
KASFEKADQE LKERNIEYAN NVRELSERQM NLAMGQLPED AKDIIAKSAS
910 920 930 940 950
NTDTTTKEAT SRGNVHEDTV SKFVETTVEN SNLNVNRVKD DEEKTERTES
960 970 980 990 1000
DVFDRDVPTL GSQSDSENAN TNNGTQSGNE TANPNLTETL SDRFDGDLNE
1010 1020 1030 1040 1050
YGIPRSQSLT SSVANNAPQS VRDDVELPET LEERDTINNT ANRDNTGNLS
1060 1070 1080 1090 1100
HIPGEWEATP ATASTDVLSN ETTEVIEDGS TTKRANSNED GESVSSIQES
1110 1120 1130 1140 1150
PKISAQPKAK TINEEFPPIQ ELHIDESDSS SSDDDEFEDT REIPSATVKT
1160 1170 1180 1190 1200
LQTPYNAQPT SSLEIHTEQV IKYPAPGTSP SHNEGNSKKA STNSILPVKD
1210 1220 1230 1240 1250
EFDDEFAGLE QAAVEEDNGA DSESEFENVA NAGSMEQFET IDHKDLDDEL
1260 1270 1280 1290 1300
QMNAFTGTLT SSSNPTIPKP QVQQQSTSDP AQVSNDEWDE IFAGFGNSKA
1310 1320 1330 1340 1350
EPTKVATPSI PQQPIPLKND PIVDASLSKG PIVNRGVATT PKSLAVEELS
1360 1370 1380
GMGFTEEEAH NALEKCNWDL EAATNFLLDS A
Length:1,381
Mass (Da):150,783
Last modified:October 1, 1994 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i626FD261DCBA7D99
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z35808 Genomic DNA Translation: CAA84867.1
X78214 Genomic DNA Translation: CAA55048.1
Z23261 Genomic DNA Translation: CAA80797.1
BK006936 Genomic DNA Translation: DAA07071.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S45781

NCBI Reference Sequences

More...
RefSeqi
NP_009506.1, NM_001178287.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YBL047C_mRNA; YBL047C_mRNA; YBL047C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
852233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YBL047C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35808 Genomic DNA Translation: CAA84867.1
X78214 Genomic DNA Translation: CAA55048.1
Z23261 Genomic DNA Translation: CAA80797.1
BK006936 Genomic DNA Translation: DAA07071.1
PIRiS45781
RefSeqiNP_009506.1, NM_001178287.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2G3QNMR-A1339-1381[»]
ProteinModelPortaliP34216
SMRiP34216
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32650, 268 interactors
DIPiDIP-5817N
IntActiP34216, 29 interactors
MINTiP34216
STRINGi4932.YBL047C

PTM databases

iPTMnetiP34216

Proteomic databases

MaxQBiP34216
PaxDbiP34216
PRIDEiP34216

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYBL047C_mRNA; YBL047C_mRNA; YBL047C
GeneIDi852233
KEGGisce:YBL047C

Organism-specific databases

EuPathDBiFungiDB:YBL047C
SGDiS000000143 EDE1

Phylogenomic databases

GeneTreeiENSGT00940000170943
HOGENOMiHOG000112328
InParanoidiP34216
KOiK12472
OMAiHDWDAIF

Enzyme and pathway databases

BioCyciYEAST:G3O-28947-MONOMER
ReactomeiR-SCE-193648 NRAGE signals death through JNK
R-SCE-194840 Rho GTPase cycle
R-SCE-8856825 Cargo recognition for clathrin-mediated endocytosis

Miscellaneous databases

EvolutionaryTraceiP34216

Protein Ontology

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PROi
PR:P34216

Family and domain databases

CDDicd00052 EH, 3 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR000261 EH_dom
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF12763 EF-hand_4, 3 hits
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SM00027 EH, 3 hits
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
SSF47473 SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 3 hits
PS50031 EH, 3 hits
PS50030 UBA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEDE1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34216
Secondary accession number(s): D6VPV1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1994
Last modified: February 13, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome II
    Yeast (Saccharomyces cerevisiae) chromosome II: entries and gene names
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