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Protein

Mating hormone A-factor 1

Gene

MFA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The active factor is excreted into the culture medium by haploid cells of the A mating type and acts on cells of the opposite mating type (type alpha). It mediates the conjugation process between the two types by inhibiting the initiation of DNA synthesis in type alpha cells and synchronizing them with type A.

Miscellaneous

Present with 28900 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • mating pheromone activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionPheromone

Enzyme and pathway databases

BioCyciYEAST:G3O-29989-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mating hormone A-factor 1
Gene namesi
Name:MFA1
Ordered Locus Names:YDR461W
ORF Names:D8035.5
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR461W
SGDiS000002869 MFA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000216901 – 211 PublicationAdd BLAST21
PeptideiPRO_000002169122 – 33Mating hormone A-factor 1Add BLAST12
PropeptideiPRO_000002169234 – 36Removed in mature form3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei33Cysteine methyl ester1 Publication1
Lipidationi33S-farnesyl cysteine1 Publication1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP34165
PRIDEiP34165

Miscellaneous databases

PMAP-CutDBiP34165

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32515, 14 interactors
DIPiDIP-4646N
IntActiP34165, 1 interactor
STRINGi4932.YDR461W

Structurei

3D structure databases

ProteinModelPortaliP34165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

InParanoidiP34165
KOiK11235
OrthoDBiEOG092C5ZYC

Family and domain databases

InterProiView protein in InterPro
IPR035296 Mfa1/2
PfamiView protein in Pfam
PF17317 MFA1_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026230 PD026230, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34165-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30 
MQPSTATAAP KEKTSSEKKD NYIIKGVFWD PACVIA
Length:36
Mass (Da):3,927
Last modified:February 1, 1994 - v1
Checksum:i03E051D7D6C2522F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20817 Genomic DNA Translation: AAA68601.1
U26203 Genomic DNA Translation: AAA67687.1
U33050 Genomic DNA Translation: AAB64920.1
AY557797 Genomic DNA Translation: AAS56123.1
BK006938 Genomic DNA Translation: DAA12295.1
PIRiS59735
RefSeqiNP_010749.3, NM_001180769.3

Genome annotation databases

EnsemblFungiiYDR461W; YDR461W; YDR461W
GeneIDi852072
KEGGisce:YDR461W

Similar proteinsi

Entry informationi

Entry nameiMFA1_YEAST
AccessioniPrimary (citable) accession number: P34165
Secondary accession number(s): D6VT85
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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