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Protein

Neurotrophin-4

Gene

NTF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Target-derived survival factor for peripheral sensory sympathetic neurons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • growth factor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P34130

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTF4
Synonyms:NTF5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000225950.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8024 NTF4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
162662 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P34130

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glaucoma 1, open angle, O (GLC1O)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
See also OMIM:613100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0631967C → Y in GLC1O; unknown pathological significance. 1 Publication1
Natural variantiVAR_06319784E → K in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756962734Ensembl.1
Natural variantiVAR_06320190R → H in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766504681Ensembl.1
Natural variantiVAR_063205206R → Q in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918428EnsemblClinVar.1
Natural variantiVAR_063206206R → W in GLC1O; also found in patients with normal pressure glaucoma; unknown pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 PublicationsCorresponds to variant dbSNP:rs121918427EnsemblClinVar.1
Natural variantiVAR_063209209R → G in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200675509Ensembl.1

Keywords - Diseasei

Glaucoma

Organism-specific databases

DisGeNET

More...
DisGeNETi
4909

MalaCards human disease database

More...
MalaCardsi
NTF4
MIMi613100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000225950

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
353225 NON RARE IN EUROPE: Primary adult open-angle glaucoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398206

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB05066 AV411

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NTF4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001966925 – 80Add BLAST56
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001967081 – 210Neurotrophin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi97 ↔ 170
Disulfide bondi141 ↔ 199
Disulfide bondi158 ↔ 201

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34130

PeptideAtlas

More...
PeptideAtlasi
P34130

PRoteomics IDEntifications database

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PRIDEi
P34130

ProteomicsDB human proteome resource

More...
ProteomicsDBi
54940

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34130

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P34130

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000225950 Expressed in 65 organ(s), highest expression level in skin of abdomen

CleanEx database of gene expression profiles

More...
CleanExi
HS_NTF4

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P34130 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P34130 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049376

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110964, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P34130

Protein interaction database and analysis system

More...
IntActi
P34130, 6 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000301411

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P34130

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34130

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P34130

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIFY Eukaryota
ENOG4111839 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007725

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231516

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG006494

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34130

KEGG Orthology (KO)

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KOi
K12457

Identification of Orthologs from Complete Genome Data

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OMAi
WLSECKA

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GHL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34130

TreeFam database of animal gene trees

More...
TreeFami
TF106463

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR020432 Neurotrophin-4

The PANTHER Classification System

More...
PANTHERi
PTHR11589 PTHR11589, 1 hit
PTHR11589:SF8 PTHR11589:SF8, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00243 NGF, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001789 NGF, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01915 NEUROTROPHN4
PR00268 NGF

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00140 NGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57501 SSF57501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P34130-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR
60 70 80 90 100
GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV
110 120 130 140 150
SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG
160 170 180 190 200
PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV
210
CTLLSRTGRA
Length:210
Mass (Da):22,427
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDBC6A30195E139AD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R0X2M0R0X2_HUMAN
Neurotrophin-4
NTF4
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0631967C → Y in GLC1O; unknown pathological significance. 1 Publication1
Natural variantiVAR_06319784E → K in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756962734Ensembl.1
Natural variantiVAR_06319888A → V2 PublicationsCorresponds to variant dbSNP:rs61732310EnsemblClinVar.1
Natural variantiVAR_06319989S → N1 PublicationCorresponds to variant dbSNP:rs374367338Ensembl.1
Natural variantiVAR_06320090R → C1 PublicationCorresponds to variant dbSNP:rs751743400Ensembl.1
Natural variantiVAR_06320190R → H in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766504681Ensembl.1
Natural variantiVAR_063202114R → G1 PublicationCorresponds to variant dbSNP:rs377553005Ensembl.1
Natural variantiVAR_063203133R → H1 PublicationCorresponds to variant dbSNP:rs977260366Ensembl.1
Natural variantiVAR_063204140R → C1 PublicationCorresponds to variant dbSNP:rs201069064Ensembl.1
Natural variantiVAR_063205206R → Q in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918428EnsemblClinVar.1
Natural variantiVAR_063206206R → W in GLC1O; also found in patients with normal pressure glaucoma; unknown pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 PublicationsCorresponds to variant dbSNP:rs121918427EnsemblClinVar.1
Natural variantiVAR_063207207T → I1 PublicationCorresponds to variant dbSNP:rs371861346Ensembl.1
Natural variantiVAR_063208207T → S1 Publication1
Natural variantiVAR_063209209R → G in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200675509Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86528 Genomic DNA Translation: AAA60154.1
BT019368 mRNA Translation: AAV38175.1
BT019369 mRNA Translation: AAV38176.1
CR541900 mRNA Translation: CAG46698.1
BC012421 mRNA Translation: AAH12421.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12754.1

Protein sequence database of the Protein Information Resource

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PIRi
A42687

NCBI Reference Sequences

More...
RefSeqi
NP_006170.1, NM_006179.4
XP_005259019.1, XM_005258962.3
XP_006723295.1, XM_006723232.3
XP_011525311.1, XM_011527009.2
XP_011525312.1, XM_011527010.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.266902
Hs.743915

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000593537; ENSP00000469455; ENSG00000225950

Database of genes from NCBI RefSeq genomes

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GeneIDi
4909

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4909

UCSC genome browser

More...
UCSCi
uc061ayz.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86528 Genomic DNA Translation: AAA60154.1
BT019368 mRNA Translation: AAV38175.1
BT019369 mRNA Translation: AAV38176.1
CR541900 mRNA Translation: CAG46698.1
BC012421 mRNA Translation: AAH12421.1
CCDSiCCDS12754.1
PIRiA42687
RefSeqiNP_006170.1, NM_006179.4
XP_005259019.1, XM_005258962.3
XP_006723295.1, XM_006723232.3
XP_011525311.1, XM_011527009.2
XP_011525312.1, XM_011527010.2
UniGeneiHs.266902
Hs.743915

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B8MX-ray2.75B81-210[»]
1B98X-ray2.75A/M81-210[»]
1HCFX-ray2.70A/B81-210[»]
ProteinModelPortaliP34130
SMRiP34130
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110964, 5 interactors
CORUMiP34130
IntActiP34130, 6 interactors
STRINGi9606.ENSP00000301411

Chemistry databases

DrugBankiDB05066 AV411

PTM databases

iPTMnetiP34130
PhosphoSitePlusiP34130

Polymorphism and mutation databases

BioMutaiNTF4

Proteomic databases

PaxDbiP34130
PeptideAtlasiP34130
PRIDEiP34130
ProteomicsDBi54940

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4909
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000593537; ENSP00000469455; ENSG00000225950
GeneIDi4909
KEGGihsa:4909
UCSCiuc061ayz.1 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4909
DisGeNETi4909
EuPathDBiHostDB:ENSG00000225950.7

GeneCards: human genes, protein and diseases

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GeneCardsi
NTF4
HGNCiHGNC:8024 NTF4
HPAiHPA049376
MalaCardsiNTF4
MIMi162662 gene
613100 phenotype
neXtProtiNX_P34130
OpenTargetsiENSG00000225950
Orphaneti353225 NON RARE IN EUROPE: Primary adult open-angle glaucoma
PharmGKBiPA162398206

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IIFY Eukaryota
ENOG4111839 LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP34130
KOiK12457
OMAiWLSECKA
OrthoDBiEOG091G0GHL
PhylomeDBiP34130
TreeFamiTF106463

Enzyme and pathway databases

ReactomeiR-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
SIGNORiP34130

Miscellaneous databases

EvolutionaryTraceiP34130

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4909

Protein Ontology

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PROi
PR:P34130

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000225950 Expressed in 65 organ(s), highest expression level in skin of abdomen
CleanExiHS_NTF4
ExpressionAtlasiP34130 baseline and differential
GenevisibleiP34130 HS

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR020432 Neurotrophin-4
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF8 PTHR11589:SF8, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01915 NEUROTROPHN4
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTF4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34130
Secondary accession number(s): Q6FH56
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: December 5, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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