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Protein

Neurotrophin-4

Gene

NTF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Target-derived survival factor for peripheral sensory sympathetic neurons.

GO - Molecular functioni

GO - Biological processi

  • activation of phospholipase C activity Source: Reactome
  • adult locomotory behavior Source: UniProtKB
  • cell-cell signaling Source: GO_Central
  • epidermis development Source: UniProtKB
  • ganglion mother cell fate determination Source: UniProtKB
  • innervation Source: Ensembl
  • long-term memory Source: UniProtKB
  • mechanoreceptor differentiation Source: Ensembl
  • negative regulation of neuron apoptotic process Source: GO_Central
  • neuron projection morphogenesis Source: GO_Central
  • neurotrophin TRK receptor signaling pathway Source: Reactome
  • regulation of neuron differentiation Source: GO_Central
  • sensory organ boundary specification Source: UniProtKB
  • taste bud development Source: Ensembl
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-9026357 NTF4 activates NTRK2 (TRKB) signaling
R-HSA-9026519 Activated NTRK2 signals through RAS
R-HSA-9026527 Activated NTRK2 signals through PLCG1
R-HSA-9028335 Activated NTRK2 signals through PI3K
R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3
SIGNORiP34130

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotrophin-4
Short name:
NT-4
Alternative name(s):
Neurotrophin-5
Short name:
NT-5
Neutrophic factor 4
Gene namesi
Name:NTF4
Synonyms:NTF5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000225950.7
HGNCiHGNC:8024 NTF4
MIMi162662 gene
neXtProtiNX_P34130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Glaucoma 1, open angle, O (GLC1O)2 Publications
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of primary open angle glaucoma (POAG). POAG is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. However, glaucoma can occur at any intraocular pressure. The disease is generally asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
See also OMIM:613100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0631967C → Y in GLC1O; unknown pathological significance. 1 Publication1
Natural variantiVAR_06319784E → K in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756962734Ensembl.1
Natural variantiVAR_06320190R → H in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766504681Ensembl.1
Natural variantiVAR_063205206R → Q in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918428EnsemblClinVar.1
Natural variantiVAR_063206206R → W in GLC1O; also found in patients with normal pressure glaucoma; unknown pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 PublicationsCorresponds to variant dbSNP:rs121918427EnsemblClinVar.1
Natural variantiVAR_063209209R → G in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200675509Ensembl.1

Keywords - Diseasei

Glaucoma

Organism-specific databases

DisGeNETi4909
MalaCardsiNTF4
MIMi613100 phenotype
OpenTargetsiENSG00000225950
Orphaneti353225 Primary adult open-angle glaucoma
PharmGKBiPA162398206

Chemistry databases

DrugBankiDB05066 AV411

Polymorphism and mutation databases

BioMutaiNTF4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
PropeptideiPRO_000001966925 – 80Add BLAST56
ChainiPRO_000001967081 – 210Neurotrophin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 170
Disulfide bondi141 ↔ 199
Disulfide bondi158 ↔ 201

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP34130
PeptideAtlasiP34130
PRIDEiP34130
ProteomicsDBi54940

PTM databases

iPTMnetiP34130
PhosphoSitePlusiP34130

Expressioni

Tissue specificityi

Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Gene expression databases

BgeeiENSG00000225950
CleanExiHS_NTF4
ExpressionAtlasiP34130 baseline and differential
GenevisibleiP34130 HS

Organism-specific databases

HPAiHPA049376

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-3907456,EBI-10173507

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110964, 5 interactors
CORUMiP34130
IntActiP34130, 6 interactors
STRINGi9606.ENSP00000301411

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi83 – 85Combined sources3
Helixi88 – 90Combined sources3
Beta strandi94 – 97Combined sources4
Beta strandi99 – 104Combined sources6
Beta strandi109 – 112Combined sources4
Beta strandi117 – 120Combined sources4
Beta strandi122 – 125Combined sources4
Beta strandi127 – 133Combined sources7
Beta strandi136 – 141Combined sources6
Turni146 – 148Combined sources3
Beta strandi153 – 156Combined sources4
Turni163 – 165Combined sources3
Beta strandi166 – 182Combined sources17
Beta strandi184 – 186Combined sources3
Beta strandi188 – 205Combined sources18

3D structure databases

ProteinModelPortaliP34130
SMRiP34130
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP34130

Family & Domainsi

Sequence similaritiesi

Belongs to the NGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIFY Eukaryota
ENOG4111839 LUCA
GeneTreeiENSGT00390000007725
HOGENOMiHOG000231516
HOVERGENiHBG006494
InParanoidiP34130
KOiK12457
OMAiSVPMEPH
OrthoDBiEOG091G0GHL
PhylomeDBiP34130
TreeFamiTF106463

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR020408 Nerve_growth_factor-like
IPR002072 Nerve_growth_factor-rel
IPR019846 Nerve_growth_factor_CS
IPR020432 Neurotrophin-4
PANTHERiPTHR11589 PTHR11589, 1 hit
PTHR11589:SF8 PTHR11589:SF8, 1 hit
PfamiView protein in Pfam
PF00243 NGF, 1 hit
PIRSFiPIRSF001789 NGF, 1 hit
PRINTSiPR01915 NEUROTROPHN4
PR00268 NGF
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002052 Nerve_growth_factor-rel, 1 hit
SMARTiView protein in SMART
SM00140 NGF, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00248 NGF_1, 1 hit
PS50270 NGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34130-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPLPSCSLP ILLLFLLPSV PIESQPPPST LPPFLAPEWD LLSPRVVLSR
60 70 80 90 100
GAPAGPPLLF LLEAGAFRES AGAPANRSRR GVSETAPASR RGELAVCDAV
110 120 130 140 150
SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG
160 170 180 190 200
PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV
210
CTLLSRTGRA
Length:210
Mass (Da):22,427
Last modified:February 1, 1994 - v1
Checksum:iDBC6A30195E139AD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0631967C → Y in GLC1O; unknown pathological significance. 1 Publication1
Natural variantiVAR_06319784E → K in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs756962734Ensembl.1
Natural variantiVAR_06319888A → V2 PublicationsCorresponds to variant dbSNP:rs61732310EnsemblClinVar.1
Natural variantiVAR_06319989S → N1 PublicationCorresponds to variant dbSNP:rs374367338Ensembl.1
Natural variantiVAR_06320090R → C1 PublicationCorresponds to variant dbSNP:rs751743400Ensembl.1
Natural variantiVAR_06320190R → H in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs766504681Ensembl.1
Natural variantiVAR_063202114R → G1 PublicationCorresponds to variant dbSNP:rs377553005Ensembl.1
Natural variantiVAR_063203133R → H1 PublicationCorresponds to variant dbSNP:rs977260366Ensembl.1
Natural variantiVAR_063204140R → C1 PublicationCorresponds to variant dbSNP:rs201069064Ensembl.1
Natural variantiVAR_063205206R → Q in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs121918428EnsemblClinVar.1
Natural variantiVAR_063206206R → W in GLC1O; also found in patients with normal pressure glaucoma; unknown pathological significance; impaired ligand-mediated TRKB signaling and reduced neurite outgrowth. 2 PublicationsCorresponds to variant dbSNP:rs121918427EnsemblClinVar.1
Natural variantiVAR_063207207T → I1 PublicationCorresponds to variant dbSNP:rs371861346Ensembl.1
Natural variantiVAR_063208207T → S1 Publication1
Natural variantiVAR_063209209R → G in GLC1O; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200675509Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86528 Genomic DNA Translation: AAA60154.1
BT019368 mRNA Translation: AAV38175.1
BT019369 mRNA Translation: AAV38176.1
CR541900 mRNA Translation: CAG46698.1
BC012421 mRNA Translation: AAH12421.1
CCDSiCCDS12754.1
PIRiA42687
RefSeqiNP_006170.1, NM_006179.4
XP_005259019.1, XM_005258962.3
XP_006723295.1, XM_006723232.3
XP_011525311.1, XM_011527009.2
XP_011525312.1, XM_011527010.2
UniGeneiHs.266902
Hs.743915

Genome annotation databases

EnsembliENST00000593537; ENSP00000469455; ENSG00000225950
GeneIDi4909
KEGGihsa:4909
UCSCiuc061ayz.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNTF4_HUMAN
AccessioniPrimary (citable) accession number: P34130
Secondary accession number(s): Q6FH56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 20, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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