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Protein

Proteasome subunit alpha type-4

Gene

psmA4

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • proteolysis Source: dictyBase
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Threonine protease

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Protein family/group databases

MEROPSiT01.973

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-4 (EC:3.4.25.1)
Alternative name(s):
Proteasome component DD4
Gene namesi
Name:psmA4
Synonyms:prdD
ORF Names:DDB_G0280969
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0280969 psmA4

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • nucleus Source: dictyBase
  • proteasome core complex, alpha-subunit complex Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001241081 – 250Proteasome subunit alpha type-4Add BLAST250

Proteomic databases

PaxDbiP34119
PRIDEiP34119

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Protein-protein interaction databases

STRINGi44689.DDB0214953

Structurei

3D structure databases

ProteinModelPortaliP34119
SMRiP34119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0178 Eukaryota
COG0638 LUCA
InParanoidiP34119
KOiK02728
OMAiMSKTMDS
PhylomeDBiP34119

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR000426 Proteasome_asu_N
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR034647 Proteasome_subunit_alpha4
PANTHERiPTHR11599:SF13 PTHR11599:SF13, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit

Sequencei

Sequence statusi: Complete.

P34119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARRYDQRTT IFSPEGRVYQ VEYAMTAIRH AGATVGILAK DGIVLAAEKK
60 70 80 90 100
TTAKLLDSST SISEKMFKID EHVVCAVAGI TSDANILINY ARLSSQRFFY
110 120 130 140 150
QYQEPMPVEQ LVSQICDTKQ GYTQYGGLRP FGVSFLYAGW DRHYGFQLYQ
160 170 180 190 200
SDPSGNFAGW KATSIGGENS QVAQSVLRSN YKPDISLKEA LQLALKVLTK
210 220 230 240 250
TMDRSNINSE KLEFSYFTKQ GDNVVYHIFT AAELDAFIKE TDLEQETEDN
Length:250
Mass (Da):28,101
Last modified:February 1, 1994 - v1
Checksum:i39387786A34999DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22212 mRNA Translation: AAA33233.1
AAFI02000040 Genomic DNA Translation: EAL66781.1
RefSeqiXP_640858.1, XM_635766.1

Genome annotation databases

EnsemblProtistsiEAL66781; EAL66781; DDB_G0280969
GeneIDi8622914
KEGGiddi:DDB_G0280969

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22212 mRNA Translation: AAA33233.1
AAFI02000040 Genomic DNA Translation: EAL66781.1
RefSeqiXP_640858.1, XM_635766.1

3D structure databases

ProteinModelPortaliP34119
SMRiP34119
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0214953

Protein family/group databases

MEROPSiT01.973

Proteomic databases

PaxDbiP34119
PRIDEiP34119

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL66781; EAL66781; DDB_G0280969
GeneIDi8622914
KEGGiddi:DDB_G0280969

Organism-specific databases

dictyBaseiDDB_G0280969 psmA4

Phylogenomic databases

eggNOGiKOG0178 Eukaryota
COG0638 LUCA
InParanoidiP34119
KOiK02728
OMAiMSKTMDS
PhylomeDBiP34119

Enzyme and pathway databases

ReactomeiR-DDI-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DDI-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DDI-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DDI-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DDI-349425 Autodegradation of the E3 ubiquitin ligase COP1
R-DDI-5632684 Hedgehog 'on' state
R-DDI-5658442 Regulation of RAS by GAPs
R-DDI-5689603 UCH proteinases
R-DDI-5689880 Ub-specific processing proteases
R-DDI-68949 Orc1 removal from chromatin
R-DDI-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DDI-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DDI-8948751 Regulation of PTEN stability and activity
R-DDI-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

PROiPR:P34119

Family and domain databases

Gene3Di3.60.20.10, 1 hit
InterProiView protein in InterPro
IPR029055 Ntn_hydrolases_N
IPR023332 Proteasome_alpha-type
IPR000426 Proteasome_asu_N
IPR016050 Proteasome_bsu_CS
IPR001353 Proteasome_sua/b
IPR034647 Proteasome_subunit_alpha4
PANTHERiPTHR11599:SF13 PTHR11599:SF13, 1 hit
PfamiView protein in Pfam
PF00227 Proteasome, 1 hit
PF10584 Proteasome_A_N, 1 hit
SMARTiView protein in SMART
SM00948 Proteasome_A_N, 1 hit
SUPFAMiSSF56235 SSF56235, 1 hit
PROSITEiView protein in PROSITE
PS00388 PROTEASOME_ALPHA_1, 1 hit
PS51475 PROTEASOME_ALPHA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSA4_DICDI
AccessioniPrimary (citable) accession number: P34119
Secondary accession number(s): Q54UB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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