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Entry version 166 (07 Apr 2021)
Sequence version 1 (01 Feb 1994)
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Protein

Transcription factor tau 138 kDa subunit

Gene

TFC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. TFC3 is essential for cell viability. Cooperates with TFC6 in DNA binding.3 Publications

Miscellaneous

Present with 125 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor tau 138 kDa subunit
Alternative name(s):
TFIIIC 138 kDa subunit
Transcription factor C subunit 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TFC3
Synonyms:TSV115
Ordered Locus Names:YAL001C
ORF Names:FUN24
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000000001, TFC3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YAL001C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi349G → E in TSV115; thermosensitive. Level of TFIIIC and its affinity for tDNA reduced. tDNA binding activity very sensitive to mild heat treatments, and TFIIIC-DNA interaction inhibited at moderate salt concentrations. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724971 – 1160Transcription factor tau 138 kDa subunitAdd BLAST1160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei546PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P34111

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34111

PRoteomics IDEntifications database

More...
PRIDEi
P34111

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P34111

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TFIIIC complex composed of TFC1, TFC3, TFC4, TFC6, TFC7 and TFC8. The subunits are organized in two globular domains, tauA and tauB, connected by a proteolysis-sensitive and flexible linker.

Interacts with TFC1, TFC4 and TFC6.

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31789, 171 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1656, Transcription factor TFIIIC complex

Database of interacting proteins

More...
DIPi
DIP-6739N

Protein interaction database and analysis system

More...
IntActi
P34111, 3 interactors

Molecular INTeraction database

More...
MINTi
P34111

STRING: functional protein association networks

More...
STRINGi
4932.YAL001C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P34111, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34111

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVPM, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005481_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34111

Identification of Orthologs from Complete Genome Data

More...
OMAi
IYKGHVV

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16169, Tau138_eWH, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044210, Tfc3-like
IPR035625, Tfc3_eWH
IPR007309, TFIIIC_Bblock-bd

The PANTHER Classification System

More...
PANTHERi
PTHR15180, PTHR15180, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04182, B-block_TFIIIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34111-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLTIYPDEL VQIVSDKIAS NKGKITLNQL WDISGKYFDL SDKKVKQFVL
60 70 80 90 100
SCVILKKDIE VYCDGAITTK NVTDIIGDAN HSYSVGITED SLWTLLTGYT
110 120 130 140 150
KKESTIGNSA FELLLEVAKS GEKGINTMDL AQVTGQDPRS VTGRIKKINH
160 170 180 190 200
LLTSSQLIYK GHVVKQLKLK KFSHDGVDSN PYINIRDHLA TIVEVVKRSK
210 220 230 240 250
NGIRQIIDLK RELKFDKEKR LSKAFIAAIA WLDEKEYLKK VLVVSPKNPA
260 270 280 290 300
IKIRCVKYVK DIPDSKGSPS FEYDSNSADE DSVSDSKAAF EDEDLVEGLD
310 320 330 340 350
NFNATDLLQN QGLVMEEKED AVKNEVLLNR FYPLQNQTYD IADKSGLKGI
360 370 380 390 400
STMDVVNRIT GKEFQRAFTK SSEYYLESVD KQKENTGGYR LFRIYDFEGK
410 420 430 440 450
KKFFRLFTAQ NFQKLTNAED EISVPKGFDE LGKSRTDLKT LNEDNFVALN
460 470 480 490 500
NTVRFTTDSD GQDIFFWHGE LKIPPNSKKT PNKNKRKRQV KNSTNASVAG
510 520 530 540 550
NISNPKRIKL EQHVSTAQEP KSAEDSPSSN GGTVVKGKVV NFGGFSARSL
560 570 580 590 600
RSLQRQRAIL KVMNTIGGVA YLREQFYESV SKYMGSTTTL DKKTVRGDVD
610 620 630 640 650
LMVESEKLGA RTEPVSGRKI IFLPTVGEDA IQRYILKEKD SKKATFTDVI
660 670 680 690 700
HDTEIYFFDQ TEKNRFHRGK KSVERIRKFQ NRQKNAKIKA SDDAISKKST
710 720 730 740 750
SVNVSDGKIK RRDKKVSAGR TTVVVENTKE DKTVYHAGTK DGVQALIRAV
760 770 780 790 800
VVTKSIKNEI MWDKITKLFP NNSLDNLKKK WTARRVRMGH SGWRAYVDKW
810 820 830 840 850
KKMLVLAIKS EKISLRDVEE LDLIKLLDIW TSFDEKEIKR PLFLYKNYEE
860 870 880 890 900
NRKKFTLVRD DTLTHSGNDL AMSSMIQREI SSLKKTYTRK ISASTKDLSK
910 920 930 940 950
SQSDDYIRTV IRSILIESPS TTRNEIEALK NVGNESIDNV IMDMAKEKQI
960 970 980 990 1000
YLHGSKLECT DTLPDILENR GNYKDFGVAF QYRCKVNELL EAGNAIVINQ
1010 1020 1030 1040 1050
EPSDISSWVL IDLISGELLN MDVIPMVRNV RPLTYTSRRF EIRTLTPPLI
1060 1070 1080 1090 1100
IYANSQTKLN TARKSAVKVP LGKPFSRLWV NGSGSIRPNI WKQVVTMVVN
1110 1120 1130 1140 1150
EIIFHPGITL SRLQSRCREV LSLHEISEIC KWLLERQVLI TTDFDGYWVN
1160
HNWYSIYEST
Length:1,160
Mass (Da):132,108
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3ACB7893ED536581
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M98261 Genomic DNA Translation: AAA34378.1
L22015 Genomic DNA Translation: AAC04956.1
BK006935 Genomic DNA Translation: DAA06985.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46423

NCBI Reference Sequences

More...
RefSeqi
NP_009400.1, NM_001178148.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YAL001C_mRNA; YAL001C; YAL001C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851262

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YAL001C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M98261 Genomic DNA Translation: AAA34378.1
L22015 Genomic DNA Translation: AAC04956.1
BK006935 Genomic DNA Translation: DAA06985.1
PIRiA46423
RefSeqiNP_009400.1, NM_001178148.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5AIMX-ray1.40A/B546-641[»]
SMRiP34111
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31789, 171 interactors
ComplexPortaliCPX-1656, Transcription factor TFIIIC complex
DIPiDIP-6739N
IntActiP34111, 3 interactors
MINTiP34111
STRINGi4932.YAL001C

PTM databases

iPTMnetiP34111

Proteomic databases

MaxQBiP34111
PaxDbiP34111
PRIDEiP34111

Genome annotation databases

EnsemblFungiiYAL001C_mRNA; YAL001C; YAL001C
GeneIDi851262
KEGGisce:YAL001C

Organism-specific databases

SGDiS000000001, TFC3
VEuPathDBiFungiDB:YAL001C

Phylogenomic databases

eggNOGiENOG502QVPM, Eukaryota
HOGENOMiCLU_005481_0_0_1
InParanoidiP34111
OMAiIYKGHVV

Enzyme and pathway databases

ReactomeiR-SCE-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-SCE-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34111
RNActiP34111, protein

Family and domain databases

CDDicd16169, Tau138_eWH, 1 hit
InterProiView protein in InterPro
IPR044210, Tfc3-like
IPR035625, Tfc3_eWH
IPR007309, TFIIIC_Bblock-bd
PANTHERiPTHR15180, PTHR15180, 2 hits
PfamiView protein in Pfam
PF04182, B-block_TFIIIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTFC3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34111
Secondary accession number(s): D6VPL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 7, 2021
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome I
    Yeast (Saccharomyces cerevisiae) chromosome I: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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