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UniProtKB - P34096 (RNAS4_HUMAN)
Protein
Ribonuclease 4
Gene
RNASE4
Organism
Homo sapiens (Human)
Status
Functioni
This RNase has marked specificity towards the 3' side of uridine nucleotides.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 38 | Substrate | 1 | |
Active sitei | 40 | Proton acceptor | 1 | |
Binding sitei | 93 | Substrate | 1 | |
Binding sitei | 110 | Substrate | 1 | |
Active sitei | 144 | Proton donor | 1 |
GO - Molecular functioni
- nucleic acid binding Source: InterPro
- ribonuclease A activity Source: UniProtKB
- ribonuclease activity Source: BHF-UCL
GO - Biological processi
- mRNA cleavage Source: UniProtKB
- RNA phosphodiester bond hydrolysis Source: BHF-UCL
Keywordsi
Molecular function | Endonuclease, Hydrolase, Nuclease |
Enzyme and pathway databases
PathwayCommonsi | P34096 |
SignaLinki | P34096 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RNASE4 Synonyms:RNS4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10047, RNASE4 |
MIMi | 601030, gene |
neXtProti | NX_P34096 |
VEuPathDBi | HostDB:ENSG00000258818 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6038 |
MalaCardsi | RNASE4 |
OpenTargetsi | ENSG00000258818 |
PharmGKBi | PA34415 |
Miscellaneous databases
Pharosi | P34096, Tbio |
Chemistry databases
DrugBanki | DB03448, 2'-Deoxyuridine 3'-Monophosphate |
Genetic variation databases
BioMutai | RNASE4 |
DMDMi | 1710614 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 28 | 1 PublicationAdd BLAST | 28 | |
ChainiPRO_0000030883 | 29 – 147 | Ribonuclease 4Add BLAST | 119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 29 | Pyrrolidone carboxylic acid1 Publication | 1 | |
Disulfide bondi | 53 ↔ 109 | 1 Publication | ||
Disulfide bondi | 67 ↔ 120 | 1 Publication | ||
Disulfide bondi | 85 ↔ 135 | 1 Publication | ||
Disulfide bondi | 92 ↔ 99 | 1 Publication |
Keywords - PTMi
Disulfide bond, Pyrrolidone carboxylic acidProteomic databases
jPOSTi | P34096 |
MassIVEi | P34096 |
PaxDbi | P34096 |
PeptideAtlasi | P34096 |
PRIDEi | P34096 |
ProteomicsDBi | 54939 |
Expressioni
Gene expression databases
Bgeei | ENSG00000258818, Expressed in liver and 118 other tissues |
ExpressionAtlasi | P34096, baseline and differential |
Genevisiblei | P34096, HS |
Organism-specific databases
HPAi | ENSG00000258818, Tissue enriched (liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 111967, 13 interactors |
IntActi | P34096, 1 interactor |
STRINGi | 9606.ENSP00000452245 |
Miscellaneous databases
RNActi | P34096, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P34096 |
SMRi | P34096 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P34096 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 68 – 72 | Substrate binding | 5 |
Sequence similaritiesi
Belongs to the pancreatic ribonuclease family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S9Q1, Eukaryota |
GeneTreei | ENSGT00940000157645 |
HOGENOMi | CLU_117006_3_1_1 |
InParanoidi | P34096 |
OMAi | VPNCRYR |
PhylomeDBi | P34096 |
TreeFami | TF333393 |
Family and domain databases
Gene3Di | 3.10.130.10, 1 hit |
InterProi | View protein in InterPro IPR001427, RNaseA IPR036816, RNaseA-like_dom_sf IPR023411, RNaseA_AS IPR023412, RNaseA_domain |
PANTHERi | PTHR11437, PTHR11437, 1 hit |
Pfami | View protein in Pfam PF00074, RnaseA, 1 hit |
PRINTSi | PR00794, RIBONUCLEASE |
SMARTi | View protein in SMART SM00092, RNAse_Pc, 1 hit |
SUPFAMi | SSF54076, SSF54076, 1 hit |
PROSITEi | View protein in PROSITE PS00127, RNASE_PANCREATIC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P34096-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALQRTHSLL LLLLLTLLGL GLVQPSYGQD GMYQRFLRQH VHPEETGGSD
60 70 80 90 100
RYCNLMMQRR KMTLYHCKRF NTFIHEDIWN IRSICSTTNI QCKNGKMNCH
110 120 130 140
EGVVKVTDCR DTGSSRAPNC RYRAIASTRR VVIACEGNPQ VPVHFDG
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 | N → D in AAA96750 (PubMed:7501448).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024618 | 16 | T → S. Corresponds to variant dbSNP:rs3748338Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D37931 mRNA Translation: BAA07150.1 BC015520 mRNA Translation: AAH15520.1 U36775 Genomic DNA Translation: AAA96750.1 |
CCDSi | CCDS9555.1 |
PIRi | I52489 |
RefSeqi | NP_001269121.1, NM_001282192.1 NP_001269122.1, NM_001282193.1 NP_002928.1, NM_002937.4 NP_919412.1, NM_194431.2 |
Genome annotation databases
Ensembli | ENST00000397995.2; ENSP00000381081.2; ENSG00000258818.4 ENST00000555597.1; ENSP00000451624.1; ENSG00000258818.4 ENST00000555835.3; ENSP00000452245.1; ENSG00000258818.4 |
GeneIDi | 6038 |
KEGGi | hsa:6038 |
MANE-Selecti | ENST00000555835.3; ENSP00000452245.1; NM_002937.5; NP_002928.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D37931 mRNA Translation: BAA07150.1 BC015520 mRNA Translation: AAH15520.1 U36775 Genomic DNA Translation: AAA96750.1 |
CCDSi | CCDS9555.1 |
PIRi | I52489 |
RefSeqi | NP_001269121.1, NM_001282192.1 NP_001269122.1, NM_001282193.1 NP_002928.1, NM_002937.4 NP_919412.1, NM_194431.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RNF | X-ray | 2.10 | A/B | 29-147 | [»] | |
2RNF | X-ray | 2.40 | A/B | 29-147 | [»] | |
AlphaFoldDBi | P34096 | |||||
SMRi | P34096 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111967, 13 interactors |
IntActi | P34096, 1 interactor |
STRINGi | 9606.ENSP00000452245 |
Chemistry databases
DrugBanki | DB03448, 2'-Deoxyuridine 3'-Monophosphate |
Genetic variation databases
BioMutai | RNASE4 |
DMDMi | 1710614 |
Proteomic databases
jPOSTi | P34096 |
MassIVEi | P34096 |
PaxDbi | P34096 |
PeptideAtlasi | P34096 |
PRIDEi | P34096 |
ProteomicsDBi | 54939 |
Protocols and materials databases
Antibodypediai | 57712, 77 antibodies from 15 providers |
DNASUi | 6038 |
Genome annotation databases
Ensembli | ENST00000397995.2; ENSP00000381081.2; ENSG00000258818.4 ENST00000555597.1; ENSP00000451624.1; ENSG00000258818.4 ENST00000555835.3; ENSP00000452245.1; ENSG00000258818.4 |
GeneIDi | 6038 |
KEGGi | hsa:6038 |
MANE-Selecti | ENST00000555835.3; ENSP00000452245.1; NM_002937.5; NP_002928.1 |
Organism-specific databases
CTDi | 6038 |
DisGeNETi | 6038 |
GeneCardsi | RNASE4 |
HGNCi | HGNC:10047, RNASE4 |
HPAi | ENSG00000258818, Tissue enriched (liver) |
MalaCardsi | RNASE4 |
MIMi | 601030, gene |
neXtProti | NX_P34096 |
OpenTargetsi | ENSG00000258818 |
PharmGKBi | PA34415 |
VEuPathDBi | HostDB:ENSG00000258818 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9Q1, Eukaryota |
GeneTreei | ENSGT00940000157645 |
HOGENOMi | CLU_117006_3_1_1 |
InParanoidi | P34096 |
OMAi | VPNCRYR |
PhylomeDBi | P34096 |
TreeFami | TF333393 |
Enzyme and pathway databases
PathwayCommonsi | P34096 |
SignaLinki | P34096 |
Miscellaneous databases
BioGRID-ORCSi | 6038, 10 hits in 1063 CRISPR screens |
ChiTaRSi | RNASE4, human |
EvolutionaryTracei | P34096 |
GeneWikii | Ribonuclease_4 |
GenomeRNAii | 6038 |
Pharosi | P34096, Tbio |
PROi | PR:P34096 |
RNActi | P34096, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000258818, Expressed in liver and 118 other tissues |
ExpressionAtlasi | P34096, baseline and differential |
Genevisiblei | P34096, HS |
Family and domain databases
Gene3Di | 3.10.130.10, 1 hit |
InterProi | View protein in InterPro IPR001427, RNaseA IPR036816, RNaseA-like_dom_sf IPR023411, RNaseA_AS IPR023412, RNaseA_domain |
PANTHERi | PTHR11437, PTHR11437, 1 hit |
Pfami | View protein in Pfam PF00074, RnaseA, 1 hit |
PRINTSi | PR00794, RIBONUCLEASE |
SMARTi | View protein in SMART SM00092, RNAse_Pc, 1 hit |
SUPFAMi | SSF54076, SSF54076, 1 hit |
PROSITEi | View protein in PROSITE PS00127, RNASE_PANCREATIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RNAS4_HUMAN | |
Accessioni | P34096Primary (citable) accession number: P34096 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 189 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families