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UniProtKB - P34096 (RNAS4_HUMAN)

Entry version 189 (25 May 2022)
Sequence version 3 (01 Oct 1996)
Previous versions | rss
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Protein

Ribonuclease 4

Gene

RNASE4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This RNase has marked specificity towards the 3' side of uridine nucleotides.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei38Substrate1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei40Proton acceptor1
Binding sitei93Substrate1
Binding sitei110Substrate1
Active sitei144Proton donor1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P34096

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P34096

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease 4 (EC:3.1.27.-)
Short name:
RNase 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASE4
Synonyms:RNS4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10047, RNASE4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601030, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P34096

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000258818

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6038

MalaCards human disease database

More...MalaCardsi		RNASE4

Open Targets

More...OpenTargetsi		ENSG00000258818

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34415

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P34096, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB03448, 2'-Deoxyuridine 3'-Monophosphate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNASE4

Domain mapping of disease mutations (DMDM)

More...DMDMi		1710614

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003088329 – 147Ribonuclease 4Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei29Pyrrolidone carboxylic acid1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 1091 Publication
Disulfide bondi67 ↔ 1201 Publication
Disulfide bondi85 ↔ 1351 Publication
Disulfide bondi92 ↔ 991 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P34096

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P34096

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P34096

PeptideAtlas

More...PeptideAtlasi		P34096

PRoteomics IDEntifications database

More...PRIDEi		P34096

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54939

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000258818, Expressed in liver and 118 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P34096, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P34096, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000258818, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111967, 13 interactors

Protein interaction database and analysis system

More...IntActi		P34096, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000452245

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P34096, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P34096

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P34096

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P34096

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni68 – 72Substrate binding5

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S9Q1, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157645

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_117006_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P34096

Identification of Orthologs from Complete Genome Data

More...OMAi		VPNCRYR

Database for complete collections of gene phylogenies

More...PhylomeDBi		P34096

TreeFam database of animal gene trees

More...TreeFami		TF333393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001427, RNaseA
IPR036816, RNaseA-like_dom_sf
IPR023411, RNaseA_AS
IPR023412, RNaseA_domain

The PANTHER Classification System

More...PANTHERi		PTHR11437, PTHR11437, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00074, RnaseA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00794, RIBONUCLEASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00092, RNAse_Pc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54076, SSF54076, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00127, RNASE_PANCREATIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P34096-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALQRTHSLL LLLLLTLLGL GLVQPSYGQD GMYQRFLRQH VHPEETGGSD 
        60         70         80         90        100
RYCNLMMQRR KMTLYHCKRF NTFIHEDIWN IRSICSTTNI QCKNGKMNCH 
       110        120        130        140 
EGVVKVTDCR DTGSSRAPNC RYRAIASTRR VVIACEGNPQ VPVHFDG
Length:147
Mass (Da):16,840
Last modified:October 1, 1996 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4C24FEA249F3EC2F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54N → D in AAA96750 (PubMed:7501448).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02461816T → S. Corresponds to variant dbSNP:rs3748338Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D37931 mRNA Translation: BAA07150.1
BC015520 mRNA Translation: AAH15520.1
U36775 Genomic DNA Translation: AAA96750.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS9555.1

Protein sequence database of the Protein Information Resource

More...PIRi		I52489

NCBI Reference Sequences

More...RefSeqi		NP_001269121.1, NM_001282192.1
NP_001269122.1, NM_001282193.1
NP_002928.1, NM_002937.4
NP_919412.1, NM_194431.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397995.2; ENSP00000381081.2; ENSG00000258818.4
ENST00000555597.1; ENSP00000451624.1; ENSG00000258818.4
ENST00000555835.3; ENSP00000452245.1; ENSG00000258818.4

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6038

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6038

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000555835.3; ENSP00000452245.1; NM_002937.5; NP_002928.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37931 mRNA Translation: BAA07150.1
BC015520 mRNA Translation: AAH15520.1
U36775 Genomic DNA Translation: AAA96750.1
CCDSiCCDS9555.1
PIRiI52489
RefSeqiNP_001269121.1, NM_001282192.1
NP_001269122.1, NM_001282193.1
NP_002928.1, NM_002937.4
NP_919412.1, NM_194431.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RNFX-ray2.10A/B29-147[»]
2RNFX-ray2.40A/B29-147[»]
AlphaFoldDBiP34096
SMRiP34096
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111967, 13 interactors
IntActiP34096, 1 interactor
STRINGi9606.ENSP00000452245

Chemistry databases

DrugBankiDB03448, 2'-Deoxyuridine 3'-Monophosphate

Genetic variation databases

BioMutaiRNASE4
DMDMi1710614

Proteomic databases

jPOSTiP34096
MassIVEiP34096
PaxDbiP34096
PeptideAtlasiP34096
PRIDEiP34096
ProteomicsDBi54939

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		57712, 77 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		6038

Genome annotation databases

EnsembliENST00000397995.2; ENSP00000381081.2; ENSG00000258818.4
ENST00000555597.1; ENSP00000451624.1; ENSG00000258818.4
ENST00000555835.3; ENSP00000452245.1; ENSG00000258818.4
GeneIDi6038
KEGGihsa:6038
MANE-SelectiENST00000555835.3; ENSP00000452245.1; NM_002937.5; NP_002928.1

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6038
DisGeNETi6038

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNASE4
HGNCiHGNC:10047, RNASE4
HPAiENSG00000258818, Tissue enriched (liver)
MalaCardsiRNASE4
MIMi601030, gene
neXtProtiNX_P34096
OpenTargetsiENSG00000258818
PharmGKBiPA34415
VEuPathDBiHostDB:ENSG00000258818

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S9Q1, Eukaryota
GeneTreeiENSGT00940000157645
HOGENOMiCLU_117006_3_1_1
InParanoidiP34096
OMAiVPNCRYR
PhylomeDBiP34096
TreeFamiTF333393

Enzyme and pathway databases

PathwayCommonsiP34096
SignaLinkiP34096

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6038, 10 hits in 1063 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNASE4, human
EvolutionaryTraceiP34096

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Ribonuclease_4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6038
PharosiP34096, Tbio

Protein Ontology

More...PROi		PR:P34096
RNActiP34096, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000258818, Expressed in liver and 118 other tissues
ExpressionAtlasiP34096, baseline and differential
GenevisibleiP34096, HS

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427, RNaseA
IPR036816, RNaseA-like_dom_sf
IPR023411, RNaseA_AS
IPR023412, RNaseA_domain
PANTHERiPTHR11437, PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074, RnaseA, 1 hit
PRINTSiPR00794, RIBONUCLEASE
SMARTiView protein in SMART
SM00092, RNAse_Pc, 1 hit
SUPFAMiSSF54076, SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127, RNASE_PANCREATIC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNAS4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34096
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: October 1, 1996
Last modified: May 25, 2022
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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