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Protein

Protein LTV1

Gene

LTV1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in protein transport. Non-ribosomal factor required for efficient nuclear export of the ribosomal 40S subunit. Component of the GSE complex, a GTPase complex required for intracellular sorting of GAP1 out of the endosome.2 Publications

Miscellaneous

Present with 589 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-31918-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein LTV1
Alternative name(s):
Low-temperature viability protein 1
Gene namesi
Name:LTV1
Ordered Locus Names:YKL143W
ORF Names:YKL2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

SGDiS000001626 LTV1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000845222 – 463Protein LTV1Add BLAST462

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated, leading to its dissociation from the 40S pre-40S ribosome.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP34078
PaxDbiP34078
PRIDEiP34078

PTM databases

iPTMnetiP34078

Interactioni

Subunit structurei

Associates with the pre-40S ribosomal subunit. Component of the GSE complex composed of GTR1, GTR2, SLM4, MEH1 and LTV1. Interacts directly with GTR1. Interacts with CRM1.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi33993, 150 interactors
ComplexPortaliCPX-1604 Small ribosomal subunit processome, variant 1
CPX-1607 Small ribosomal subunit processome, variant 2
CPX-1608 Small ribosomal subunit processome, variant 3
CPX-3233 GSE complex
DIPiDIP-2801N
IntActiP34078, 12 interactors
MINTiP34078
STRINGi4932.YKL143W

Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP34078
SMRiP34078
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili355 – 462Sequence analysisAdd BLAST108

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi168 – 179Nuclear export signalAdd BLAST12

Sequence similaritiesi

Belongs to the LTV1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000172553
InParanoidiP34078
KOiK14798
OMAiKKWDCES
OrthoDBiEOG092C2XSD

Family and domain databases

InterProiView protein in InterPro
IPR007307 LTV
PANTHERiPTHR21531 PTHR21531, 1 hit
PfamiView protein in Pfam
PF04180 LTV, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P34078-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKFSSKNS QRYVVVHRPH DDPSFYDTDA SAHVLVPVSN PNKTSPEADL
60 70 80 90 100
RKKDVSSTKP KGRRAHVGEA ALYGINFDDS EYDYTQHLKP IGLDPENSIF
110 120 130 140 150
IASKGNEQKV EKKNIEDLFI EPKYRRDEIE KDDALPVFQR GMAKPEYLLH
160 170 180 190 200
QQDTTDEIRG FKPDMNPALR EVLEALEDEA YVVNDDVVVE DISKKTQLQG
210 220 230 240 250
DNYGEEEKED DIFAQLLGSG EAKDEDEFED EFDEWDIDNV ENFEDENYVK
260 270 280 290 300
EMAQFDNIEN LEDLENIDYQ ADVRRFQKDN SILEKHNSDD EFSNAGLDSV
310 320 330 340 350
NPSEEEDVLG ELPSIQDKSK TGKKKRKSRQ KKGAMSDVSG FSMSSSAIAR
360 370 380 390 400
TETMTVLDDQ YDQIINGYEN YEEELEEDEE QNYQPFDMSA ERSDFESMLD
410 420 430 440 450
DFLDNYELES GGRKLAKKDK EIERLKEAAD EVSKGKLSQR RNRERQEKKK
460
LEKVTNTLSS LKF
Length:463
Mass (Da):53,390
Last modified:June 1, 1994 - v2
Checksum:iF432C239B3B0A68A
GO

Sequence cautioni

The sequence CAA80955 differs from that shown. Reason: Frameshift at positions 134 and 145.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25464 Genomic DNA Translation: CAA80955.1 Frameshift.
Z28143 Genomic DNA Translation: CAA81984.1
BK006944 Genomic DNA Translation: DAA09019.1
PIRiS37972
RefSeqiNP_012779.1, NM_001179709.1

Genome annotation databases

EnsemblFungiiYKL143W; YKL143W; YKL143W
GeneIDi853714
KEGGisce:YKL143W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25464 Genomic DNA Translation: CAA80955.1 Frameshift.
Z28143 Genomic DNA Translation: CAA81984.1
BK006944 Genomic DNA Translation: DAA09019.1
PIRiS37972
RefSeqiNP_012779.1, NM_001179709.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WWOX-ray2.40C333-463[»]
6FAIelectron microscopy3.40j1-463[»]
ProteinModelPortaliP34078
SMRiP34078
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33993, 150 interactors
ComplexPortaliCPX-1604 Small ribosomal subunit processome, variant 1
CPX-1607 Small ribosomal subunit processome, variant 2
CPX-1608 Small ribosomal subunit processome, variant 3
CPX-3233 GSE complex
DIPiDIP-2801N
IntActiP34078, 12 interactors
MINTiP34078
STRINGi4932.YKL143W

PTM databases

iPTMnetiP34078

Proteomic databases

MaxQBiP34078
PaxDbiP34078
PRIDEiP34078

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYKL143W; YKL143W; YKL143W
GeneIDi853714
KEGGisce:YKL143W

Organism-specific databases

SGDiS000001626 LTV1

Phylogenomic databases

HOGENOMiHOG000172553
InParanoidiP34078
KOiK14798
OMAiKKWDCES
OrthoDBiEOG092C2XSD

Enzyme and pathway databases

BioCyciYEAST:G3O-31918-MONOMER

Miscellaneous databases

PROiPR:P34078

Family and domain databases

InterProiView protein in InterPro
IPR007307 LTV
PANTHERiPTHR21531 PTHR21531, 1 hit
PfamiView protein in Pfam
PF04180 LTV, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTV1_YEAST
AccessioniPrimary (citable) accession number: P34078
Secondary accession number(s): D6VX53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: June 1, 1994
Last modified: November 7, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names
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Main funding by: National Institutes of Health

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