Negative regulator of RAS-cAMP pathway

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• mitochondria-nucleus signaling pathway Source: SGD <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p."
    Liu Z., Sekito T., Spirek M., Thornton J., Butow R.A.
    Mol Cell 12:401-411(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: SGD <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae."
    Dilova I., Chen C.Y., Powers T.
    Curr Biol 12:389-395(2002) [PubMed] [Europe PMC] [Abstract]
• regulation of nitrogen utilization Source: SGDInferred from mutant phenotypeⁱ
  • "Mks1p is a regulator of nitrogen catabolism upstream of Ure2p in Saccharomyces cerevisiae."
    Edskes H.K., Hanover J.A., Wickner R.B.
    Genetics 153:585-594(1999) [PubMed] [Europe PMC] [Abstract]
• regulation of pseudohyphal growth Source: SGDInferred from mutant phenotypeⁱ
  • "Multiple TORC1-associated proteins regulate nitrogen starvation-dependent cellular differentiation in Saccharomyces cerevisiae."
    Laxman S., Tu B.P.
    PLoS One 6:e26081-e26081(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSREAFDVPN IGTNKFLKVT PNLFTPERLN LFDDVELYLT LIKASKCVEQ 
        60         70         80         90        100
GERLHNISWR ILNKAVLKEH NINRSKKRDG VKNIYYVLNP NNKQPIKPKQ 
       110        120        130        140        150
AAVKQPPLQK ANLPPTTAKQ NVLTRPMTSP AIAQGAHDRS LDNPNSTNND 
       160        170        180        190        200
VKNDVAPNRQ FSKSTTSGLF SNFADKYQKM KNVNHVANKE EPQTIITGFD 
       210        220        230        240        250
TSTVITKKPL QSRRSRSPFQ HIGDMNMNCI DNETSKSTSP TLENMGSRKS 
       260        270        280        290        300
SFPQKESLFG RPRSYKNDQN GQLSLSKTSS RKGKNKIFFS SEDEDSDWDS 
       310        320        330        340        350
VSNDSEFYAD EDDEEYDDYN EEEADQYYRR QWDKLLFAKN QQNLDSTKSS 
       360        370        380        390        400
VSSANTINSN TSHDPVRKSL LSGLFLSEAN SNSNNHNTAH SEYASKHVSP 
       410        420        430        440        450
TPQSSHSNIG PQPQQNPPSA NGIKQQKPSL KTSNVTALAS LSPPQPSNNE 
       460        470        480        490        500
RLSMDIQKDF KTDNESNHLY ESNAPLTAQT ILPTALSTHM FLPNNIHQQR 
       510        520        530        540        550
MAIATGSNTR HRFSRRQSMD IPSKNRNTGF LKTRMEISEE EKMVRTISRL 
       560        570        580 
DNTSIANSNG NGNDDTSNQR TEALGRKTSN GGRI                  

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Yeast chromosome XIV
   Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names
2. Yeast
   Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD