Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).

UniProtKB - P34047 (HIS5A_ARATH)

Entry version 156 (07 Apr 2021)
Sequence version 1 (01 Feb 1994)
Previous versions | rss
Add a publicationFeedback
Protein

Imidazoleglycerol-phosphate dehydratase 1, chloroplastic

Gene

HISN5A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mn2+1 PublicationNote: Binds 2 manganese ions per subunit.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-histidine biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.1 Publication
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (AXX17_At1g09770), ATP phosphoribosyltransferase (AN1_LOCUS1062), ATP phosphoribosyltransferase (AN1_LOCUS4869), ATP phosphoribosyltransferase (C24_LOCUS4752), ATP phosphoribosyltransferase 2, chloroplastic (HISN1B), ATP phosphoribosyltransferase (C24_LOCUS976), ATP phosphoribosyltransferase 1, chloroplastic (HISN1A), ATP phosphoribosyltransferase (AXX17_At1g52040), ATP phosphoribosyltransferase (AT9943_LOCUS4139)
  2. Phosphoribosyl-AMP cyclohydrolase (C24_LOCUS3145), Phosphoribosyl-ATP diphosphatase (At1g31860), Phosphoribosyl-AMP cyclohydrolase (AT9943_LOCUS2684), Phosphoribosyl-AMP cyclohydrolase (At1g31860), Phosphoribosyl-AMP cyclohydrolase (AT-IE), Phosphoribosyl-AMP cyclohydrolase (AN1_LOCUS3233), Histidine biosynthesis bifunctional protein hisIE, chloroplastic (HISN2)
  3. Phosphoribosyl-AMP cyclohydrolase (C24_LOCUS3145), Phosphoribosyl-AMP cyclohydrolase (AT-IE), Phosphoribosyl-AMP cyclohydrolase (AT9943_LOCUS2684), Phosphoribosyl-AMP cyclohydrolase (At1g31860), Phosphoribosyl-AMP cyclohydrolase (AT-IE), Phosphoribosyl-AMP cyclohydrolase (AN1_LOCUS3233), Histidine biosynthesis bifunctional protein hisIE, chloroplastic (HISN2)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (At2g36230), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (AN1_LOCUS10075), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic, 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (AXX17_At2g32880), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (HISN3), 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, chloroplastic (AT9943_LOCUS8638)
  5. Imidazole glycerol phosphate synthase hisHF (AXX17_At4g31050), Imidazole glycerol phosphate synthase hisHF, chloroplastic (HISN4), Imidazole glycerol phosphate synthase hisHF (AN1_LOCUS19446), AT4G26900 protein (At4g26900)
  6. Imidazoleglycerol-phosphate dehydratase 2, chloroplastic (HISN5B), Imidazoleglycerol-phosphate dehydratase (AXX17_At4g17260), Imidazoleglycerol-phosphate dehydratase (HISN5B), Imidazoleglycerol-phosphate dehydratase (At3g22425), Imidazoleglycerol-phosphate dehydratase (AXX17_At3g24180), Imidazoleglycerol-phosphate dehydratase 1, chloroplastic (HISN5A), Imidazoleglycerol-phosphate dehydratase (At4g14910), Imidazoleglycerol-phosphate dehydratase (HISN5B)
  7. Histidinol-phosphate aminotransferase 2, chloroplastic (HISN6B), Histidinol-phosphate aminotransferase 1, chloroplastic (HISN6A)
  8. Histidinol-phosphatase (AT9943_LOCUS17907), Bifunctional phosphatase IMPL2, chloroplastic (HISN7), Histidinol-phosphatase (AXX17_At4g44500)
  9. Histidinol dehydrogenase, chloroplastic (AXX17_At5g63470), Histidinol dehydrogenase, chloroplastic (HISN8), Histidinol dehydrogenase, chloroplastic (AT9943_LOCUS22986)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei84SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi110Manganese 1; via tele nitrogenCombined sources1 Publication1
Metal bindingi136Manganese 2; via tele nitrogenCombined sources1 Publication1
Metal bindingi137Manganese 1; via tele nitrogenCombined sources1 Publication1
Metal bindingi140Manganese 2Combined sources1 Publication1
Binding sitei162SubstrateBy similarity1
Binding sitei184SubstrateBy similarity1
Metal bindingi208Manganese 2; via tele nitrogenCombined sources1 Publication1
Metal bindingi232Manganese 1; via tele nitrogenCombined sources1 Publication1
Metal bindingi233Manganese 2; via tele nitrogenCombined sources1 Publication1
Metal bindingi236Manganese 1Combined sources1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:AT3G22425-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00031;UER00011

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydratase 1, chloroplastic1 Publication (EC:4.2.1.191 Publication)
Short name:
IGPD 11 Publication
Alternative name(s):
Protein HISTIDINE BIOSYNTHESIS 5A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HISN5A1 Publication
Ordered Locus Names:At3g22425Imported
ORF Names:MCB17.17Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...Araporti		AT3G22425

The Arabidopsis Information Resource

More...TAIRi		locus:1005716545, AT3G22425

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chloroplast, Plastid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 62ChloroplastCombined sourcesAdd BLAST62
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000015825363 – 270Imidazoleglycerol-phosphate dehydratase 1, chloroplasticAdd BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei63N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P34047

PRoteomics IDEntifications database

More...PRIDEi		P34047

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		230245 [P34047-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P34047

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P34047, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P34047, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		7144, 1 interactor

Database of interacting proteins

More...DIPi		DIP-48462N

STRING: functional protein association networks

More...STRINGi		3702.AT3G22425.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P34047

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P34047

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni110 – 118Substrate bindingBy similarity9
Regioni136 – 140Substrate bindingBy similarity5
Regioni232 – 240Substrate bindingBy similarity9
Regioni262 – 264Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3143, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_044308_1_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		ARHGLFD

Database for complete collections of gene phylogenies

More...PhylomeDBi		P34047

Family and domain databases

Conserved Domains Database

More...CDDi		cd07914, IGPD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.230.40, 2 hits

HAMAP database of protein families

More...HAMAPi		MF_00076, HisB, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038494, IGPD_sf
IPR000807, ImidazoleglycerolP_deHydtase
IPR020565, ImidazoleglycerP_deHydtase_CS
IPR020568, Ribosomal_S5_D2-typ_fold

The PANTHER Classification System

More...PANTHERi		PTHR23133, PTHR23133, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00475, IGPD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54211, SSF54211, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00954, IGP_DEHYDRATASE_1, 1 hit
PS00955, IGP_DEHYDRATASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: P34047-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELSSASAIL SHSSSAAQLL RPKLGFIDLL PRRAMIVSSP SSSLPRFLRM 
        60         70         80         90        100
ESQSQLRQSI SCSASSSSSM ALGRIGEVKR VTKETNVSVK INLDGTGVAD 
       110        120        130        140        150
SSSGIPFLDH MLDQLASHGL FDVHVRATGD VHIDDHHTNE DIALAIGTAL 
       160        170        180        190        200
LKALGERKGI NRFGDFTAPL DEALIHVSLD LSGRPYLGYN LEIPTQRVGT 
       210        220        230        240        250
YDTQLVEHFF QSLVNTSGMT LHIRQLAGEN SHHIIEATFK AFARALRQAT 
       260        270
ETDPRRGGTI PSSKGVLSRS
Length:270
Mass (Da):29,225
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7132D80CC687E20C
GO
Isoform 2 (identifier: P34047-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-270: LVEHFFQSLV...PSSKGVLSRS → VLSLLLELSS...YDSSHPAARW

Note: May be due to an intron retention.Curated
Show »
Length:264
Mass (Da):28,691
Checksum:i8551F5DED1EB8CAD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti201Y → C in BAD44082 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008895205 – 270LVEHF…VLSRS → VLSLLLELSSFGFICVIRCL VIIESVAKNCLTFRFVVGGA LFPVVGEYFWYDSSHPAARW in isoform 2. 1 PublicationAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U02689 mRNA Translation: AAA93196.1
AB022215 Genomic DNA Translation: BAB01781.1
CP002686 Genomic DNA Translation: AEE76636.1
CP002686 Genomic DNA Translation: AEE76637.1
AK118815 mRNA Translation: BAC43405.1
AY070442 mRNA Translation: AAL49845.1
AK176319 mRNA Translation: BAD44082.1
AK176429 mRNA Translation: BAD44192.1
AY087948 mRNA Translation: AAM65496.1

NCBI Reference Sequences

More...RefSeqi		NP_850624.1, NM_180293.1 [P34047-2]
NP_850625.1, NM_180294.2 [P34047-1]

Genome annotation databases

Ensembl plant genome annotation project

More...EnsemblPlantsi		AT3G22425.1; AT3G22425.1; AT3G22425 [P34047-2]
AT3G22425.2; AT3G22425.2; AT3G22425 [P34047-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		821812

Gramene; a comparative resource for plants

More...Gramenei		AT3G22425.1; AT3G22425.1; AT3G22425 [P34047-2]
AT3G22425.2; AT3G22425.2; AT3G22425 [P34047-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ath:AT3G22425

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02689 mRNA Translation: AAA93196.1
AB022215 Genomic DNA Translation: BAB01781.1
CP002686 Genomic DNA Translation: AEE76636.1
CP002686 Genomic DNA Translation: AEE76637.1
AK118815 mRNA Translation: BAC43405.1
AY070442 mRNA Translation: AAL49845.1
AK176319 mRNA Translation: BAD44082.1
AK176429 mRNA Translation: BAD44192.1
AY087948 mRNA Translation: AAM65496.1
RefSeqiNP_850624.1, NM_180293.1 [P34047-2]
NP_850625.1, NM_180294.2 [P34047-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F1DX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P64-270[»]
SMRiP34047
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi7144, 1 interactor
DIPiDIP-48462N
STRINGi3702.AT3G22425.2

PTM databases

iPTMnetiP34047

Proteomic databases

PaxDbiP34047
PRIDEiP34047
ProteomicsDBi230245 [P34047-1]

Genome annotation databases

EnsemblPlantsiAT3G22425.1; AT3G22425.1; AT3G22425 [P34047-2]
AT3G22425.2; AT3G22425.2; AT3G22425 [P34047-1]
GeneIDi821812
GrameneiAT3G22425.1; AT3G22425.1; AT3G22425 [P34047-2]
AT3G22425.2; AT3G22425.2; AT3G22425 [P34047-1]
KEGGiath:AT3G22425

Organism-specific databases

AraportiAT3G22425
TAIRilocus:1005716545, AT3G22425

Phylogenomic databases

eggNOGiKOG3143, Eukaryota
HOGENOMiCLU_044308_1_1_1
OMAiARHGLFD
PhylomeDBiP34047

Enzyme and pathway databases

UniPathwayiUPA00031;UER00011
BioCyciMetaCyc:AT3G22425-MONOMER

Miscellaneous databases

EvolutionaryTraceiP34047

Protein Ontology

More...PROi		PR:P34047

Gene expression databases

ExpressionAtlasiP34047, baseline and differential
GenevisibleiP34047, AT

Family and domain databases

CDDicd07914, IGPD, 1 hit
Gene3Di3.30.230.40, 2 hits
HAMAPiMF_00076, HisB, 1 hit
InterProiView protein in InterPro
IPR038494, IGPD_sf
IPR000807, ImidazoleglycerolP_deHydtase
IPR020565, ImidazoleglycerP_deHydtase_CS
IPR020568, Ribosomal_S5_D2-typ_fold
PANTHERiPTHR23133, PTHR23133, 1 hit
PfamiView protein in Pfam
PF00475, IGPD, 1 hit
SUPFAMiSSF54211, SSF54211, 2 hits
PROSITEiView protein in PROSITE
PS00954, IGP_DEHYDRATASE_1, 1 hit
PS00955, IGP_DEHYDRATASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHIS5A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34047
Secondary accession number(s): Q67YN9, Q67YZ9, Q8VYM1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: April 7, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again