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Entry version 139 (11 Dec 2019)
Sequence version 2 (04 Dec 2007)
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Protein

Dynein heavy chain, cytoplasmic

Gene

dhcA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1974 – 1981ATPSequence analysis8
Nucleotide bindingi2276 – 2283ATPSequence analysis8
Nucleotide bindingi2674 – 2681ATPSequence analysis8
Nucleotide bindingi3016 – 3023ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DDI-6798695 Neutrophil degranulation
R-DDI-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain, cytoplasmic
Alternative name(s):
Dynein heavy chain, cytosolic
Short name:
DYHC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dhcA
ORF Names:DDB_G0276355
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0276355 dhcA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146351 – 4730Dynein heavy chain, cytoplasmicAdd BLAST4730

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P34036

PRoteomics IDEntifications database

More...
PRIDEi
P34036

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59087N

STRING: functional protein association networks

More...
STRINGi
44689.DDB0185096

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

14730
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P34036

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1935StemAdd BLAST1935
Regioni1936 – 2158AAA 1Add BLAST223
Regioni2238 – 2531AAA 2Add BLAST294
Regioni2635 – 2885AAA 3Add BLAST251
Regioni2978 – 3252AAA 4Add BLAST275
Regioni3271 – 3585StalkAdd BLAST315
Regioni3638 – 3867AAA 5Add BLAST230
Regioni4098 – 4312AAA 6Add BLAST215

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili867 – 900Sequence analysisAdd BLAST34
Coiled coili1204 – 1224Sequence analysisAdd BLAST21
Coiled coili1343 – 1372Sequence analysisAdd BLAST30
Coiled coili1425 – 1441Sequence analysisAdd BLAST17
Coiled coili1661 – 1689Sequence analysisAdd BLAST29
Coiled coili2231 – 2253Sequence analysisAdd BLAST23
Coiled coili2442 – 2462Sequence analysisAdd BLAST21
Coiled coili3271 – 3349Sequence analysisAdd BLAST79
Coiled coili3483 – 3585Sequence analysisAdd BLAST103
Coiled coili3854 – 3881Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P34036

KEGG Orthology (KO)

More...
KOi
K10413

Identification of Orthologs from Complete Genome Data

More...
OMAi
FAPDICS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P34036

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P34036-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDQQINVDS PTSGTNTPPV VTPTTSVISE QTLEETVKYL CKICPTLLDG
60 70 80 90 100
DQSVFQNNLS NQIPPENMNK LKKFISDSKI PVLLIQKTNP TINSSNQTST
110 120 130 140 150
TTSSSSSSDD NTLTSSQQQS KESFNFEIEV KFGGENKSTL AIVKRIPESI
160 170 180 190 200
VEYSSNKSIA SQLQVLNLGD GSPMDTLHNY IHNSVAPFVR SYILSASKDD
210 220 230 240 250
ATTPSGGSAD KSITSQNLDK EMKQSIGAVN QKIAELEISL YNCKQQVQIP
260 270 280 290 300
EVTLAINPEI KSISKRLKET TGRTIKPDDL GDKASSPEFL NLLQAGTTTW
310 320 330 340 350
AKNIQNVTKH NLIENLPSDV STSQEINFWI ELETSLQNID QQLKSPEVEV
360 370 380 390 400
TLATLRQAKR FIASAPFETD TIGVRKAMDK VQSYKTLFKD FPITPLLTAT
410 420 430 440 450
DLDSISSSVA AIFSHLKKTK NPYYPIPRYL SFLEAIGRDM CNKVYQILRQ
460 470 480 490 500
KNLMNIDYND FEHLNRSVRA LFTLWDDQFG AFRDILRDLA KKRGNERIPL
510 520 530 540 550
IVNIDNRIQL VIIKIGKFRK QHEDLKNVVS NVLPGSQLGG GVVQTNTSNP
560 570 580 590 600
TSPQKQEINA IEEINQAYLE FKEIDVLQLS KEGEEIWDAV VKRYNSRTDR
610 620 630 640 650
VETYITVKLR DRLATAKNAN EMFRVYQKFK DLLKRPKIRG ATHEYESQLI
660 670 680 690 700
ERVKEDIRVL HDKFKMQYNN SEAYYMSQLR DLPPVSGAII WARQIERQLD
710 720 730 740 750
TYMKRVANVL GDSWESDAEG QKLKSESDQF RHKLNTDHIF SKWADETEKR
760 770 780 790 800
SFDISGRILT IVKRGNKLAL DINFDSHIIM LFKEVRNLQW LGFRVPLKIS
810 820 830 840 850
FISQGAKQVY PFAVSLKETL RTYAQTSGKV TPEFSTLVAS YKRDVQANIT
860 870 880 890 900
EGFRLKWETI PKVDPYVRKL STSINNFRDK VDDLIVKYSE IKKQLDGLKS
910 920 930 940 950
CPFKSESFNE IIANIQKVVD ELNLANYSNL PQWVTQLDAQ VESMLIERLI
960 970 980 990 1000
DAINSWVQLI EGKEDQKDSQ STSGSSNKGG KLNRMNYSIR NKSDEENSSD
1010 1020 1030 1040 1050
LTQPQQSQQQ QQTISIKPKL EKTIHEIVIR NQILSLSPPL EVARVNWIDQ
1060 1070 1080 1090 1100
LHSWLNICCD LPRIQSSRYD ESAMVHRGGV DSKKQSTFRD MLPKLPQGSL
1110 1120 1130 1140 1150
ESAYSAITNK LEQVQQYVSI WLQYQSLWDM DSSFVYSKLG DDLNKWQLLL
1160 1170 1180 1190 1200
NQIKKSRSTF DNSSTEKQFG PLTIDYTQVQ ASVNNKYDYW HKDILGHFGS
1210 1220 1230 1240 1250
KLAEKMNQFY ETISSSRQEL EKLSVETVST EEAVHFIIQI QDMKKKLSSW
1260 1270 1280 1290 1300
EADLRYYRTG QDLLQRQRFS FPNDWLDCER VEGEWSAFNE ILNRKNATIS
1310 1320 1330 1340 1350
EAIPQLQAKI LQESKSINDR IKDFIDEWTA NKPLQGSIKH STALETLKIF
1360 1370 1380 1390 1400
EGRLIRLREE SDRLSKAKQA LDLTDTTGSS SSDQDRLVPV EEEIQDLKAV
1410 1420 1430 1440 1450
WVELSNTWQE IDSLKETAWS AIIPRKVRKS LEDTLQKLKN LPNRIRQYSA
1460 1470 1480 1490 1500
FDHAQNLIKI YLKGNAIITD LHSEAIKDRH WKILKKRLNT NWIITELTLG
1510 1520 1530 1540 1550
SIWDSDLARN ENIYREVITA AQGEIALEEF LKGVREFWTT LELDLVNYQR
1560 1570 1580 1590 1600
KCKLVRGWDD LFNKLAEHLN SISAMKMSPY YKVFEEEANH WDDRLNKVRS
1610 1620 1630 1640 1650
LLDVWIDVQR RWVYLEGIFS GSGDINQLLP AESTRFKSIN SEFIAILKKV
1660 1670 1680 1690 1700
SGAPLILEVL AIERIQQTME RLSDLLGKVQ KALGEYLERQ RSAFARFYFV
1710 1720 1730 1740 1750
GDEDLLEIIG NSKDIIKIQK HFRKMFAGLA NLTLDDEKTT IIGMSSAEGE
1760 1770 1780 1790 1800
TVTFKKPISI ANGPKIHEWL TMVESEMKST LATLLSESLQ HFNQVDVNDH
1810 1820 1830 1840 1850
SKYSEWVDNY PTQLVLLTSQ IVWSTQVDQA LGGGTLQQSK IQEQLQSIEQ
1860 1870 1880 1890 1900
TTQMILNNLA DSVLQDLSAQ KRKKFEHLIT ELVHQRDVVR QLQKCKNLTG
1910 1920 1930 1940 1950
NKDFDWLYHM RYYYDATQEN VLHKLVIHMA NATFYYGFEY LGIGERLVQT
1960 1970 1980 1990 2000
PLTDRCYLTL TQALESRMGG NPFGPAGTGK TETVKALGSQ LGRFVLVFCC
2010 2020 2030 2040 2050
DEGFDLQAMS RIFVGLCQCG AWGCFDEFNR LEERILSAVS QQIQTIQVAL
2060 2070 2080 2090 2100
KENSKEVELL GGKNISLHQD MGIFVTMNPG YAGRSNLPDN LKKLFRSMAM
2110 2120 2130 2140 2150
IKPDREMIAQ VMLYSQGFKT AEVLAGKIVP LFKLCQEQLS AQSHYDFGLR
2160 2170 2180 2190 2200
ALKSVLVSAG GIKRKCQPPQ LPPITDAESK TKADQIYCQY EIGVLLNSIN
2210 2220 2230 2240 2250
DTMIPKLVAD DIPLIQSLLL DVFPGSQLQP IQMDQLRKKI QEIAKQRHLV
2260 2270 2280 2290 2300
TKQEWVEKIL QLHQILNINH GVMMVGPSGG GKTTSWEVYL EAIEQVDNIK
2310 2320 2330 2340 2350
SEAHVMDPKA ITKDQLFGSL DLTTREWTDG LFTATLRRII DNVRGESTKR
2360 2370 2380 2390 2400
HWIIFDGDVD PEWVENLNSL LDDNKLLTLP NGERLALPNN VRVMFEVQDL
2410 2420 2430 2440 2450
KYATLATISR CGMVWFSEEI LTTQMIFQNY LDTLSNEPFD PQEKEQQKRN
2460 2470 2480 2490 2500
ENAQLQQQQQ TTITSPILTS PPTTSSSSRS TTSTTSMIPA GLKVQKECAA
2510 2520 2530 2540 2550
IISQYFEPGG LVHKVLEDAG QRPHIMDFTR LRVLNSFFSL MNRSIVNVIE
2560 2570 2580 2590 2600
YNQLHSDFPM SPENQSNYIT NRLLYSLMWG LGGSMGLVER ENFSKFIQTI
2610 2620 2630 2640 2650
AITPVPANTI PLLDYSVSID DANWSLWKNK VPSVEVETHK VASPDVVIPT
2660 2670 2680 2690 2700
VDTTRHVDVL HAWLSEHRPL ILCGPPGSGK TMTLTSTLRA FPDFEVVSLN
2710 2720 2730 2740 2750
FSSATTPELL LKTFDHHCEY KRTPSGETVL RPTQLGKWLV VFCDEINLPS
2760 2770 2780 2790 2800
TDKYGTQRVI TFIRQMVEKG GFWRTSDHTW IKLDKIQFVG ACNPPTDAGR
2810 2820 2830 2840 2850
VQLTHRFLRH APILLVDFPS TSSLTQIYGT FNRALMKLLP NLRSFADNLT
2860 2870 2880 2890 2900
DAMVEFYSES QKRFTPDIQA HYIYSPRELS RWDRALLEAI QTMDGCTLEG
2910 2920 2930 2940 2950
LVRLWAHEAL RLFQDRLVET EEKEWTDKKI DEVALKHFPS VNLDALKRPI
2960 2970 2980 2990 3000
LYSNWLTKDY QPVNRSDLRE YVKARLKVFY EEELDVPLVL FNEVLDHILR
3010 3020 3030 3040 3050
IDRVFRQPQG HALLIGVSGG GKSVLSRFVA WMNGLSIYTI KVNNNYKSSD
3060 3070 3080 3090 3100
FDDDLRMLLK RAGCKEEKIC FIFDESNVLE SSFLERMNTL LAGGEVPGLF
3110 3120 3130 3140 3150
EGEEFTALMH ACKETAQRNG LILDSEEELY KYFTSQVRRN LHVVFTMNPA
3160 3170 3180 3190 3200
SPDFHNRSAT SPALFNRCVL DWFGEWSPEA LFQVGSEFTR NLDLENPQYI
3210 3220 3230 3240 3250
APPVFIQEAE IMGNNLMAIP PSHRDAVVSS LVYIHQTIGE ANIRLLKRQG
3260 3270 3280 3290 3300
RQNYVTPRHY LDFINQVVLL INEKRDQLEE EQLHLNIGLK KLRDTEAQVK
3310 3320 3330 3340 3350
DLQVSLAQKN RELDVKNEQA NQKLKQMVQD QQAAEIKQKD ARELQVQLDV
3360 3370 3380 3390 3400
RNKEIAVQKV KAYADLEKAE PAIIEAQEAV STIKKKHLDE IKSLPKPPTP
3410 3420 3430 3440 3450
VKLAMEAVCL MLGGKKLEWA DIRKKIMEPN FITSIINYDT KKMMTPKIRE
3460 3470 3480 3490 3500
AITKGYLEDP GFDYETVNRA SKACGPLVKW ATAQTYYSEI LDRIKPLREE
3510 3520 3530 3540 3550
VEQLENAANE LKLKQDEIVA TITALEKSIA TYKEEYATLI RETEQIKTES
3560 3570 3580 3590 3600
SKVKNKVDRS IALLDNLNSE RGRWEQQSEN FNTQMSTVVG DVVLASAFLA
3610 3620 3630 3640 3650
YIGFFDQNFR TDLMRKWMIR LDSVGIKFKS DLSVPSFLSK PEERLNWHAN
3660 3670 3680 3690 3700
SLPSDELCIE NAIMLKRFNR YPLVIDPSGQ AMEFLMNQYA DKKITKTSFL
3710 3720 3730 3740 3750
DSSFMKNLES ALRFGCPLLV QDVENIDPVL NPVLNKEIRK KGGRILIRLG
3760 3770 3780 3790 3800
DQDVDFSPSF MIFLFTRDPT AHFTPDLCSR VTFVNFTVTP SSLQSQCLHE
3810 3820 3830 3840 3850
ALKTERPDTH KKRSDLLKIQ GEFQVKLRIL EKSLLNALSQ ASGNILDDDS
3860 3870 3880 3890 3900
VISTLETLKK ETTEIALKVE ETETVMQEIS EVSALYNPMA LSCSRVYFAM
3910 3920 3930 3940 3950
EELSQFHLYQ FSLRAFLDIF YNLLNNNPNL VDKKDPNERL VYLSKDIFSM
3960 3970 3980 3990 4000
TFNRVTRTLL NDDKLTFALQ LTIISVKGTS NEIEESEWDF LLKGGDNLTS
4010 4020 4030 4040 4050
IKETIPQLDS LLSTTQQKWL ICLRQQVPSF SKLVDHIQQN SSDWKQFFGK
4060 4070 4080 4090 4100
DQVGEPIIPE SWIVAQAQLS NQQSTIVSNF RKILLMKAFH SDRVLQYSHS
4110 4120 4130 4140 4150
FVCSVFGEDF LNTQELDMAN IVEKEVKSSS PLLLCSVPGY DASSKVDDLA
4160 4170 4180 4190 4200
LQLHKQYKSF AIGSPEGFEL AEKSIYAAAK SGTWVLLKNI HLAPQWLVQL
4210 4220 4230 4240 4250
EKKLHSLSPH PSFRLFMTSE IHPALPANLL RMSNVFSYEN PPGVKANLLH
4260 4270 4280 4290 4300
TFIGIPATRM DKQPAERSRI YFLLAWFHAI IQERLRYIPL GWTKFFEFND
4310 4320 4330 4340 4350
ADLRGALDSI DYWVDLYSKG RSNIDPDKIP WIAVRTILGS TIYGGRIDNE
4360 4370 4380 4390 4400
FDMRLLYSFL EQLFTPSAFN PDFPLVPSIG LSVPEGTTRA HFMKWIEALP
4410 4420 4430 4440 4450
EISTPIWLGL PENAESLLLS NKARKMINDL QKMQSSEEDG EDDQVSGSSK
4460 4470 4480 4490 4500
KESSSSSSED KGKAKLRATI TEWTKLLPKP LKQLKRTTQN IKDPLFRCFE
4510 4520 4530 4540 4550
REISTGGKLV KKITNDLANL LELISGNIKS TNYLRSLTTS ISKGIVPKEW
4560 4570 4580 4590 4600
KWYSVPETIS LSVWISDFSK RMQQLSEISE SSDYSSIQVW LGGLLNPEAY
4610 4620 4630 4640 4650
ITATRQSASQ LNGWSLENLR LHASSLGKIS SEGGASFNVK GMALEGAVWN
4660 4670 4680 4690 4700
NDQLTPTDIL STPISIATLT WKDKDDPIFN NSSSKLSVPV YLNETRSELL
4710 4720 4730
FSIDLPYDQS TSKQNWYQRS VSISSWKSDI
Length:4,730
Mass (Da):539,613
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12B7133BEE7CCB7C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA78827 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1604V → L in CAA78827 (PubMed:1469051).Curated1
Sequence conflicti1616E → Q in CAA78827 (PubMed:1469051).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Z15124 mRNA Translation: CAA78827.1 Frameshift.
AAFI02000014 Genomic DNA Translation: EAL69258.1

Protein sequence database of the Protein Information Resource

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PIRi
A44357

NCBI Reference Sequences

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RefSeqi
XP_643185.1, XM_638093.1

Genome annotation databases

Ensembl protists genome annotation project

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EnsemblProtistsi
EAL69258; EAL69258; DDB_G0276355

Database of genes from NCBI RefSeq genomes

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GeneIDi
8620457

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0276355

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z15124 mRNA Translation: CAA78827.1 Frameshift.
AAFI02000014 Genomic DNA Translation: EAL69258.1
PIRiA44357
RefSeqiXP_643185.1, XM_638093.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GF8model-A1931-3209[»]
B3633-4721[»]
3J6Pelectron microscopy8.20D3382-3489[»]
3VKGX-ray2.81A/B1388-3371[»]
A/B3496-4730[»]
3VKHX-ray3.80A/B1388-4730[»]
SMRiP34036
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-59087N
STRINGi44689.DDB0185096

Proteomic databases

PaxDbiP34036
PRIDEiP34036

Genome annotation databases

EnsemblProtistsiEAL69258; EAL69258; DDB_G0276355
GeneIDi8620457
KEGGiddi:DDB_G0276355

Organism-specific databases

dictyBaseiDDB_G0276355 dhcA

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
InParanoidiP34036
KOiK10413
OMAiFAPDICS
PhylomeDBiP34036

Enzyme and pathway databases

ReactomeiR-DDI-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DDI-6798695 Neutrophil degranulation
R-DDI-6807878 COPI-mediated anterograde transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P34036

Family and domain databases

Gene3Di1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR041589 DNAH3_AAA_lid_1
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF17857 AAA_lid_1, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC_DICDI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34036
Secondary accession number(s): Q551T4, Q8T128
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: December 4, 2007
Last modified: December 11, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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