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UniProtKB - P34021 (ECR_DROME)

Entry version 232 (25 May 2022)
Sequence version 1 (01 Feb 1994)
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Protein

Ecdysone receptor

Gene

EcR

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ecdysone (PubMed:1913820, PubMed:30293839).

Binds to ecdysone response elements (ECRES) following ecdysone-binding, and recruitment of a complex containing the histone methyltransferase trr, leads to activate transcription of target genes (PubMed:1913820, PubMed:30293839).

2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi264 – 336Nuclear receptorPROSITE-ProRule annotationAdd BLAST73
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri264 – 284NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri300 – 324NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-159418, Recycling of bile acids and salts
R-DME-196791, Vitamin D (calciferol) metabolism
R-DME-383280, Nuclear Receptor transcription pathway
R-DME-4090294, SUMOylation of intracellular receptors
R-DME-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-DME-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P34021

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ecdysone receptor
Alternative name(s):
20-hydroxy-ecdysone receptor
Short name:
20E receptor
EcRH
Ecdysteroid receptor
Nuclear receptor subfamily 1 group H member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EcR
Synonyms:NR1H1
ORF Names:CG1765
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0000546, EcR

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0000546

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown blocks ecdysone-dependent fat body cell migration into the pupal head.1 Publication

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5676

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000535241 – 878Ecdysone receptorAdd BLAST878

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P34021

PRoteomics IDEntifications database

More...PRIDEi		P34021

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform B1 predominates over isoform A in larval tissues, imaginal histoblast nests and midgut islands. Isoform A predominates over B1 in imaginal disks, and the larval prothoracic gland.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

In the salivary glands of mid instar larvae levels increase during puff stage 1 at 86-94 hours of development then remain relatively constant until the premetamorphic pulse of ecdysone in late larvae. Levels diminish dramatically from puff stage 7 onwards. Levels increase in the prepupal period during puff stage 13-14, the level remains stable until stage 21. A decrease in levels at puff stage 7 is also seen in the Malpighian tubules and less dramatically in the fat body and gut. In the wing disk the relatively low level remains unchanged.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0000546, Expressed in pupa and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P34021, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P34021, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of USP and ECR (PubMed:8247157). Only the heterodimer is capable of high-affinity binding to ecdysone (PubMed:8247157).

Interacts with trr in an ecdysone-dependent manner (PubMed:14603321). Upon ecdysone stimulation, interacts with Nup98 (PubMed:28366641).

3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		61444, 120 interactors

Database of interacting proteins

More...DIPi		DIP-158N

Protein interaction database and analysis system

More...IntActi		P34021, 38 interactors

Molecular INTeraction database

More...MINTi		P34021

STRING: functional protein association networks

More...STRINGi		7227.FBpp0291631

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P34021

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1878
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P34021

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P34021

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P34021

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini419 – 654NR LBDPROSITE-ProRule annotationAdd BLAST236

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 263ModulatingAdd BLAST263
Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni209 – 254DisorderedSequence analysisAdd BLAST46
Regioni344 – 374DisorderedSequence analysisAdd BLAST31
Regioni698 – 759DisorderedSequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 27Polar residuesSequence analysisAdd BLAST16
Compositional biasi215 – 245Polar residuesSequence analysisAdd BLAST31
Compositional biasi344 – 358Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi717 – 759Polar residuesSequence analysisAdd BLAST43

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri264 – 284NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri300 – 324NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3575, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000173863

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P34021

Identification of Orthologs from Complete Genome Data

More...OMAi		GMSLNTH

Database for complete collections of gene phylogenies

More...PhylomeDBi		P34021

Family and domain databases

Conserved Domains Database

More...CDDi		cd06938, NR_LBD_EcR, 1 hit

Database of protein disorder

More...DisProti		DP01569 [P34021-2]

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.565.10, 1 hit
3.30.50.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50251

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003069, Ecdystd_rcpt
IPR035500, NHR-like_dom_sf
IPR041889, NR_LBD_EcR
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01283, ECDYSTEROIDR
PR00398, STRDHORMONER
PR00047, STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48508, SSF48508, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform ECR-B1 (identifier: P34021-1) [UniParc]FASTAAdd to basket
Also known as: B

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRRWSNNGG FMRLPEESSS EVTSSSNGLV LPSGVNMSPS SLDSHDYCDQ 
        60         70         80         90        100
DLWLCGNESG SFGGSNGHGL SQQQQSVITL AMHGCSSTLP AQTTIIPING 
       110        120        130        140        150
NANGNGGSTN GQYVPGATNL GALANGMLNG GFNGMQQQIQ NGHGLINSTT 
       160        170        180        190        200
PSTPTTPLHL QQNLGGAGGG GIGGMGILHH ANGTPNGLIG VVGGGGGVGL 
       210        220        230        240        250
GVGGGGVGGL GMQHTPRSDS VNSISSGRDD LSPSSSLNGY SANESCDAKK 
       260        270        280        290        300
SKKGPAPRVQ EELCLVCGDR ASGYHYNALT CEGCKGFFRR SVTKSAVYCC 
       310        320        330        340        350
KFGRACEMDM YMRRKCQECR LKKCLAVGMR PECVVPENQC AMKRREKKAQ 
       360        370        380        390        400
KEKDKMTTSP SSQHGGNGSL ASGGGQDFVK KEILDLMTCE PPQHATIPLL 
       410        420        430        440        450
PDEILAKCQA RNIPSLTYNQ LAVIYKLIWY QDGYEQPSEE DLRRIMSQPD 
       460        470        480        490        500
ENESQTDVSF RHITEITILT VQLIVEFAKG LPAFTKIPQE DQITLLKACS 
       510        520        530        540        550
SEVMMLRMAR RYDHSSDSIF FANNRSYTRD SYKMAGMADN IEDLLHFCRQ 
       560        570        580        590        600
MFSMKVDNVE YALLTAIVIF SDRPGLEKAQ LVEAIQSYYI DTLRIYILNR 
       610        620        630        640        650
HCGDSMSLVF YAKLLSILTE LRTLGNQNAE MCFSLKLKNR KLPKFLEEIW 
       660        670        680        690        700
DVHAIPPSVQ SHLQITQEEN ERLERAERMR ASVGGAITAG IDCDSASTSA 
       710        720        730        740        750
AAAAAQHQPQ PQPQPQPSSL TQNDSQHQTQ PQLQPQLPPQ LQGQLQPQLQ 
       760        770        780        790        800
PQLQTQLQPQ IQPQPQLLPV SAPVPASVTA PGSLSAVSTS SEYMGGSAAI 
       810        820        830        840        850
GPITPATTSS ITAAVTASST TSAVPMGNGV GVGVGVGGNV SMYANAQTAM 
       860        870 
ALMGVALHSH QEQLIGGVAV KSEHSTTA
Length:878
Mass (Da):93,853
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB48D610D722F014F
GO
Isoform ECR-A (identifier: P34021-2) [UniParc]FASTAAdd to basket
Also known as: A, D

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: MKRRWSNNGG...RSDSVNSISS → MLTTSGQQQS...YDPYSPTGKT

Show »
Length:849
Mass (Da):91,182
Checksum:iE93D93A38236AD58
GO
Isoform ECR-B2 (identifier: P34021-3) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-226: MKRRWSNNGG...RSDSVNSISS → MDTCGLVAELAHYIDAY

Show »
Length:669
Mass (Da):73,348
Checksum:iA9DE3D365161A34E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JGY2E1JGY2_DROME
Ecdysone receptor
EcR anon-WO0229075.1, CG8347, DEcR, dECR, Dhr23
878Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4UZ51A4UZ51_DROME
Ecdysone receptor
EcR anon-WO0229075.1, CG8347, DEcR, dECR, Dhr23
849Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13804 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti867 – 878GVAVK…HSTTA → EWRLSRSTRRLHSRRRVSST NITTTTSTSCWSRKRS in AAL68274 (PubMed:12537569).CuratedAdd BLAST12

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0036611 – 226MKRRW…NSISS → MLTTSGQQQSKQKLSTLPSH ILLQQQLAASAGPSSSVSLS PSSSAALTLHVASANGGARE TTSAAAVKDKLRPTPTAIKI EPMPDVISVGTVAGGSSVAT VVAPAATTTSNKPNSTAAPS TSAAAANGHLVLVPNKRPRL DVTEDWMSTPSPGSVPSSAP PLSPSPGSQNHSYNMSNGYA SPMSAGSYDPYSPTGKT in isoform ECR-A. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_0036621 – 226MKRRW…NSISS → MDTCGLVAELAHYIDAY in isoform ECR-B2. CuratedAdd BLAST226

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M74078 mRNA Translation: AAA28498.1
S63761 mRNA Translation: AAB27496.2
AE013599 Genomic DNA Translation: AAF57278.3
AE013599 Genomic DNA Translation: AAF57280.2
AE013599 Genomic DNA Translation: AAM68347.1
AY075461 mRNA Translation: AAL68274.1
AY058575 mRNA Translation: AAL13804.1 Different initiation.
BT012469 mRNA Translation: AAS93740.1
BT015234 mRNA Translation: AAT94463.1

Protein sequence database of the Protein Information Resource

More...PIRi		A40709
A41055

NCBI Reference Sequences

More...RefSeqi		NP_001163061.1, NM_001169590.2 [P34021-1]
NP_724456.1, NM_165461.3 [P34021-2]
NP_724457.1, NM_165462.2 [P34021-2]
NP_724458.1, NM_165463.2 [P34021-2]
NP_724459.1, NM_165464.3 [P34021-3]
NP_724460.1, NM_165465.3 [P34021-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0086008; FBpp0085349; FBgn0000546 [P34021-2]
FBtr0086009; FBpp0085350; FBgn0000546 [P34021-2]
FBtr0086010; FBpp0085351; FBgn0000546 [P34021-2]
FBtr0086011; FBpp0085352; FBgn0000546 [P34021-1]
FBtr0086012; FBpp0085353; FBgn0000546 [P34021-3]
FBtr0302439; FBpp0291631; FBgn0000546 [P34021-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		35540

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG1765

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M74078 mRNA Translation: AAA28498.1
S63761 mRNA Translation: AAB27496.2
AE013599 Genomic DNA Translation: AAF57278.3
AE013599 Genomic DNA Translation: AAF57280.2
AE013599 Genomic DNA Translation: AAM68347.1
AY075461 mRNA Translation: AAL68274.1
AY058575 mRNA Translation: AAL13804.1 Different initiation.
BT012469 mRNA Translation: AAS93740.1
BT015234 mRNA Translation: AAT94463.1
PIRiA40709
A41055
RefSeqiNP_001163061.1, NM_001169590.2 [P34021-1]
NP_724456.1, NM_165461.3 [P34021-2]
NP_724457.1, NM_165462.2 [P34021-2]
NP_724458.1, NM_165463.2 [P34021-2]
NP_724459.1, NM_165464.3 [P34021-3]
NP_724460.1, NM_165465.3 [P34021-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R0NX-ray2.60B256-364[»]
1R0OX-ray2.24B256-364[»]
2HANX-ray1.95B256-365[»]
AlphaFoldDBiP34021
SMRiP34021
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi61444, 120 interactors
DIPiDIP-158N
IntActiP34021, 38 interactors
MINTiP34021
STRINGi7227.FBpp0291631

Chemistry databases

BindingDBiP34021
ChEMBLiCHEMBL5676

Proteomic databases

PaxDbiP34021
PRIDEiP34021

Genome annotation databases

EnsemblMetazoaiFBtr0086008; FBpp0085349; FBgn0000546 [P34021-2]
FBtr0086009; FBpp0085350; FBgn0000546 [P34021-2]
FBtr0086010; FBpp0085351; FBgn0000546 [P34021-2]
FBtr0086011; FBpp0085352; FBgn0000546 [P34021-1]
FBtr0086012; FBpp0085353; FBgn0000546 [P34021-3]
FBtr0302439; FBpp0291631; FBgn0000546 [P34021-1]
GeneIDi35540
KEGGidme:Dmel_CG1765

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		35540
FlyBaseiFBgn0000546, EcR
VEuPathDBiVectorBase:FBgn0000546

Phylogenomic databases

eggNOGiKOG3575, Eukaryota
GeneTreeiENSGT00940000173863
InParanoidiP34021
OMAiGMSLNTH
PhylomeDBiP34021

Enzyme and pathway databases

ReactomeiR-DME-159418, Recycling of bile acids and salts
R-DME-196791, Vitamin D (calciferol) metabolism
R-DME-383280, Nuclear Receptor transcription pathway
R-DME-4090294, SUMOylation of intracellular receptors
R-DME-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
R-DME-9623433, NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
SignaLinkiP34021

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		35540, 1 hit in 3 CRISPR screens
EvolutionaryTraceiP34021

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		35540

Protein Ontology

More...PROi		PR:P34021

Gene expression databases

BgeeiFBgn0000546, Expressed in pupa and 35 other tissues
ExpressionAtlasiP34021, baseline and differential
GenevisibleiP34021, DM

Family and domain databases

CDDicd06938, NR_LBD_EcR, 1 hit
DisProtiDP01569 [P34021-2]
Gene3Di1.10.565.10, 1 hit
3.30.50.10, 1 hit
IDEALiIID50251
InterProiView protein in InterPro
IPR003069, Ecdystd_rcpt
IPR035500, NHR-like_dom_sf
IPR041889, NR_LBD_EcR
IPR000536, Nucl_hrmn_rcpt_lig-bd
IPR001723, Nuclear_hrmn_rcpt
IPR001628, Znf_hrmn_rcpt
IPR013088, Znf_NHR/GATA
PfamiView protein in Pfam
PF00104, Hormone_recep, 1 hit
PF00105, zf-C4, 1 hit
PRINTSiPR01283, ECDYSTEROIDR
PR00398, STRDHORMONER
PR00047, STROIDFINGER
SMARTiView protein in SMART
SM00430, HOLI, 1 hit
SM00399, ZnF_C4, 1 hit
SUPFAMiSSF48508, SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843, NR_LBD, 1 hit
PS00031, NUCLEAR_REC_DBD_1, 1 hit
PS51030, NUCLEAR_REC_DBD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECR_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P34021
Secondary accession number(s): Q0E9N8
, Q6AWL4, Q8SY10, Q95TS4, Q9V9K8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: May 25, 2022
This is version 232 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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