Ecdysone receptor

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• core promoter sequence-specific DNA binding Source: CAFA <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development."
    Johnston D.M., Sedkov Y., Petruk S., Riley K.M., Fujioka M., Jaynes J.B., Mazo A.
    Mol Cell 44:51-61(2011) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily."
    Koelle M.R., Talbot W.S., Segraves W.A., Bender M.T., Cherbas P., Hogness D.S.
    Cell 67:59-77(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ECR-B1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: FlyBaseInferred from direct assayⁱ
  • "Pri peptides are mediators of ecdysone for the temporal control of development."
    Chanut-Delalande H., Hashimoto Y., Pelissier-Monier A., Spokony R., Dib A., Kondo T., Bohere J., Niimi K., Latapie Y., Inagaki S., Dubois L., Valenti P., Polesello C., Kobayashi S., Moussian B., White K.P., Plaza S., Kageyama Y., Payre F.
    Nat. Cell Biol. 16:1035-1044(2014) [PubMed] [Europe PMC] [Abstract]
• ecdysone binding Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily."
    Koelle M.R., Talbot W.S., Segraves W.A., Bender M.T., Cherbas P., Hogness D.S.
    Cell 67:59-77(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ECR-B1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  • Ref.7

    "Functional ecdysone receptor is the product of EcR and Ultraspiracle genes."
    Yao T.-P., Froman B.M., Jiang Z., Cherbas L., Chen J.-D., McKeown M.M., Cherbas P., Evans R.M.
    Nature 366:476-479(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: SUBUNIT.
• nuclear receptor activity Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily."
    Koelle M.R., Talbot W.S., Segraves W.A., Bender M.T., Cherbas P., Hogness D.S.
    Cell 67:59-77(1991) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ECR-B1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  • Ref.6

    "Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms."
    Talbot W.S., Swyryd E.A., Hogness D.S.
    Cell 73:1323-1337(1993) [PubMed] [Europe PMC] [Abstract]

    Cited for: ALTERNATIVE SPLICING.
• protein heterodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• repressing transcription factor binding Source: FlyBase <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily."
    Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S.P., Renkawitz R., Baniahmad A.
    Mol. Cell. Biol. 19:3383-3394(1999) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription coactivator binding Source: FlyBaseInferred from physical interactionⁱ
  • "Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2."
    Gauthier S.A., VanHaaften E., Cherbas L., Cherbas P., Hewes R.S.
    PLoS Genet 8:e1002883-e1002883(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription corepressor binding Source: FlyBaseInferred from physical interactionⁱ
  • "dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes."
    Cakouros D., Mills K., Denton D., Paterson A., Daish T., Kumar S.
    J Cell Biol 182:481-495(2008) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "UTX coordinates steroid hormone-mediated autophagy and cell death."
    Denton D., Aung-Htut M.T., Lorensuhewa N., Nicolson S., Zhu W., Mills K., Cakouros D., Bergmann A., Kumar S.
    Nat Commun 4:2916-2916(2013) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: CAFAInferred from physical interactionⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• steroid binding Source: FlyBase <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Steroid regulation of postembryonic development and reproduction in Drosophila."
    Kozlova T., Thummel C.S.
    Trends Endocrinol Metab 11:276-280(2000) [PubMed] [Europe PMC] [Abstract]
• transcription regulatory region sequence-specific DNA binding Source: FlyBaseInferred from direct assayⁱ
  • "Ecdysone regulation of the Drosophila Sgs-4 gene is mediated by the synergistic action of ecdysone receptor and SEBP 3."
    Lehmann M., Korge G.
    EMBO J 14:716-726(1995) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• autophagy Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Programmed autophagy in the Drosophila fat body is induced by ecdysone through regulation of the PI3K pathway."
    Rusten T.E., Lindmo K., Juhasz G., Sass M., Seglen P.O., Brech A., Stenmark H.
    Dev Cell 7:179-192(2004) [PubMed] [Europe PMC] [Abstract]
• border follicle cell migration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Regulation of invasive cell behavior by taiman, a Drosophila protein related to AIB1, a steroid receptor coactivator amplified in breast cancer."
    Bai J., Uehara Y., Montell D.J.
    Cell 103:1047-1058(2000) [PubMed] [Europe PMC] [Abstract]
  • "Dynamics of the basement membrane in invasive epithelial clusters in Drosophila."
    Medioni C., Noselli S.
    Development 132:3069-3077(2005) [PubMed] [Europe PMC] [Abstract]
  • "Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt."
    Jang A.C., Chang Y.C., Bai J., Montell D.
    Nat Cell Biol 11:569-579(2009) [PubMed] [Europe PMC] [Abstract]
• cardiac muscle tissue development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart."
    Monier B., Astier M., Semeriva M., Perrin L.
    Development 132:5283-5293(2005) [PubMed] [Europe PMC] [Abstract]
• cardioblast differentiation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart."
    Monier B., Astier M., Semeriva M., Perrin L.
    Development 132:5283-5293(2005) [PubMed] [Europe PMC] [Abstract]
• cell adhesion Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis."
    D'Avino P.P., Thummel C.S.
    Dev Biol 220:211-224(2000) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chitin-based cuticle development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Pri peptides are mediators of ecdysone for the temporal control of development."
    Chanut-Delalande H., Hashimoto Y., Pelissier-Monier A., Spokony R., Dib A., Kondo T., Bohere J., Niimi K., Latapie Y., Inagaki S., Dubois L., Valenti P., Polesello C., Kobayashi S., Moussian B., White K.P., Plaza S., Kageyama Y., Payre F.
    Nat. Cell Biol. 16:1035-1044(2014) [PubMed] [Europe PMC] [Abstract]
• chitin-based embryonic cuticle biosynthetic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential roles for ecdysone signaling during Drosophila mid-embryonic development."
    Kozlova T., Thummel C.S.
    Science 301:1911-1914(2003) [PubMed] [Europe PMC] [Abstract]
• cholesterol homeostasis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing."
    Danielsen E.T., Moeller M.E., Yamanaka N., Ou Q., Laursen J.M., Soenderholm C., Zhuo R., Phelps B., Tang K., Zeng J., Kondo S., Nielsen C.H., Harvald E.B., Faergeman N.J., Haley M.J., O'Connor K.A., King-Jones K., O'Connor M.B., Rewitz K.F.
    Dev Cell 37:558-570(2016) [PubMed] [Europe PMC] [Abstract]
• dendrite morphogenesis Source: FlyBaseNon-traceable author statementⁱ
  • "Dendritic development: lessons from Drosophila and related branches."
    Grueber W.B., Jan Y.N.
    Curr Opin Neurobiol 14:74-82(2004) [PubMed] [Europe PMC] [Abstract]
• determination of adult lifespan Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Steroid control of longevity in Drosophila melanogaster."
    Simon A.F., Shih C., Mack A., Benzer S.
    Science 299:1407-1410(2003) [PubMed] [Europe PMC] [Abstract]
• dorsal vessel heart proper cell fate commitment Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart."
    Monier B., Astier M., Semeriva M., Perrin L.
    Development 132:5283-5293(2005) [PubMed] [Europe PMC] [Abstract]
• ecdysis, chitin-based cuticle Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila."
    Li T., Bender M.
    Development 127:2897-2905(2000) [PubMed] [Europe PMC] [Abstract]
• ecdysone-mediated induction of salivary gland cell autophagic cell death Source: FlyBaseNon-traceable author statementⁱ
  • "Insect metamorphosis: out with the old, in with the new."
    Buszczak M., Segraves W.A.
    Curr Biol 10:R830-3(2000) [PubMed] [Europe PMC] [Abstract]
• ecdysone receptor-mediated signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.11

    "A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila."
    Okamoto N., Viswanatha R., Bittar R., Li Z., Haga-Yamanaka S., Perrimon N., Yamanaka N.
    Dev. Cell 47:294-305(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
• epidermis development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis."
    Ninov N., Chiarelli D.A., Martin-Blanco E.
    Development 134:367-379(2007) [PubMed] [Europe PMC] [Abstract]
• germ-band shortening Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential roles for ecdysone signaling during Drosophila mid-embryonic development."
    Kozlova T., Thummel C.S.
    Science 301:1911-1914(2003) [PubMed] [Europe PMC] [Abstract]
• germ cell development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysteroids affect Drosophila ovarian stem cell niche formation and early germline differentiation."
    Konig A., Yatsenko A.S., Weiss M., Shcherbata H.R.
    EMBO J 30:1549-1562(2011) [PubMed] [Europe PMC] [Abstract]
• hatching Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila."
    Li T., Bender M.
    Development 127:2897-2905(2000) [PubMed] [Europe PMC] [Abstract]
• head involution Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Essential roles for ecdysone signaling during Drosophila mid-embryonic development."
    Kozlova T., Thummel C.S.
    Science 301:1911-1914(2003) [PubMed] [Europe PMC] [Abstract]
• histoblast morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis."
    Ninov N., Chiarelli D.A., Martin-Blanco E.
    Development 134:367-379(2007) [PubMed] [Europe PMC] [Abstract]
• imaginal disc-derived wing morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis."
    D'Avino P.P., Thummel C.S.
    Dev Biol 220:211-224(2000) [PubMed] [Europe PMC] [Abstract]
• larval central nervous system remodeling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila."
    Brown H.L., Cherbas L., Cherbas P., Truman J.W.
    Development 133:275-285(2006) [PubMed] [Europe PMC] [Abstract]
  • "Fine-tuning of secondary arbor development: the effects of the ecdysone receptor on the adult neuronal lineages of the Drosophila thoracic CNS."
    Brown H.L., Truman J.W.
    Development 136:3247-3256(2009) [PubMed] [Europe PMC] [Abstract]
• larval development Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.11

    "A Membrane Transporter Is Required for Steroid Hormone Uptake in Drosophila."
    Okamoto N., Viswanatha R., Bittar R., Li Z., Haga-Yamanaka S., Perrimon N., Yamanaka N.
    Dev. Cell 47:294-305(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
• larval wandering behavior Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development."
    Davis M.B., Carney G.E., Robertson A.E., Bender M.
    Dev Biol 282:385-396(2005) [PubMed] [Europe PMC] [Abstract]
• long-term memory Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysone signaling regulates the formation of long-term courtship memory in adult Drosophila melanogaster."
    Ishimoto H., Sakai T., Kitamoto T.
    Proc Natl Acad Sci U S A 106:6381-6386(2009) [PubMed] [Europe PMC] [Abstract]
• Malpighian tubule morphogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysone signaling is required for proper organization and fluid secretion of stellate cells in the Malpighian tubules of Drosophila melanogaster."
    Gautam N.K., Tapadia M.G.
    Int J Dev Biol 54:635-642(2010) [PubMed] [Europe PMC] [Abstract]
• metamorphosis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila."
    Li T., Bender M.
    Development 127:2897-2905(2000) [PubMed] [Europe PMC] [Abstract]
• mushroom body development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons."
    Lin S., Huang Y., Lee T.
    PLoS One 4:e8392-e8392(2009) [PubMed] [Europe PMC] [Abstract]
  • "Steroid-induced microRNA let-7 acts as a spatio-temporal code for neuronal cell fate in the developing Drosophila brain."
    Kucherenko M.M., Barth J., Fiala A., Shcherbata H.R.
    EMBO J 31:4511-4523(2012) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: FlyBase <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "Steroid regulation of postembryonic development and reproduction in Drosophila."
    Kozlova T., Thummel C.S.
    Trends Endocrinol Metab 11:276-280(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neuron remodeling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila."
    Lee T., Marticke S., Sung C., Robinow S., Luo L.
    Neuron 28:807-818(2000) [PubMed] [Europe PMC] [Abstract]
  • "Engulfing action of glial cells is required for programmed axon pruning during Drosophila metamorphosis."
    Awasaki T., Ito K.
    Curr Biol 14:668-677(2004) [PubMed] [Europe PMC] [Abstract]
  • "Use of time-lapse imaging and dominant negative receptors to dissect the steroid receptor control of neuronal remodeling in Drosophila."
    Brown H.L., Cherbas L., Cherbas P., Truman J.W.
    Development 133:275-285(2006) [PubMed] [Europe PMC] [Abstract]
  • "Metamorphosis of an identified serotonergic neuron in the Drosophila olfactory system."
    Roy B., Singh A.P., Shetty C., Chaudhary V., North A., Landgraf M., Vijayraghavan K., Rodrigues V.
    Neural Dev 2:20-20(2007) [PubMed] [Europe PMC] [Abstract]
  • "Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons."
    Lin S., Huang Y., Lee T.
    PLoS One 4:e8392-e8392(2009) [PubMed] [Europe PMC] [Abstract]
• oogenesis Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The Drosophila ecdysone receptor (EcR) gene is required maternally for normal oogenesis."
    Carney G.E., Bender M.
    Genetics 154:1203-1211(2000) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ligand-dependent de-repression via EcR/USP acts as a gate to coordinate the differentiation of sensory neurons in the Drosophila wing."
    Schubiger M., Carre C., Antoniewski C., Truman J.W.
    Development 132:5239-5248(2005) [PubMed] [Europe PMC] [Abstract]
• phagocytosis, engulfment Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons."
    Tasdemir-Yilmaz O.E., Freeman M.R.
    Genes Dev 28:20-33(2014) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic process Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons."
    Sprecher S.G., Desplan C.
    Nature 454:533-537(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of circadian sleep/wake cycle, sleep Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The steroid molting hormone Ecdysone regulates sleep in adult Drosophila melanogaster."
    Ishimoto H., Kitamoto T.
    Genetics 185:269-281(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neuron remodeling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A Cullin1-based SCF E3 ubiquitin ligase targets the InR/PI3K/TOR pathway to regulate neuronal pruning."
    Wong J.J., Li S., Lim E.K., Wang Y., Wang C., Zhang H., Kirilly D., Wu C., Liou Y.C., Wang H., Yu F.
    PLoS Biol. 11:E1001657-E1001657(2013) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription, DNA-templated Source: FlyBaseInferred from mutant phenotypeⁱ
  • "EcR-B1 and Usp nuclear hormone receptors regulate expression of the VM32E eggshell gene during Drosophila oogenesis."
    Bernardi F., Romani P., Tzertzinis G., Gargiulo G., Cavaliere V.
    Dev Biol 328:541-551(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2."
    Gauthier S.A., VanHaaften E., Cherbas L., Cherbas P., Hewes R.S.
    PLoS Genet 8:e1002883-e1002883(2012) [PubMed] [Europe PMC] [Abstract]
  • "Pri peptides are mediators of ecdysone for the temporal control of development."
    Chanut-Delalande H., Hashimoto Y., Pelissier-Monier A., Spokony R., Dib A., Kondo T., Bohere J., Niimi K., Latapie Y., Inagaki S., Dubois L., Valenti P., Polesello C., Kobayashi S., Moussian B., White K.P., Plaza S., Kageyama Y., Payre F.
    Nat. Cell Biol. 16:1035-1044(2014) [PubMed] [Europe PMC] [Abstract]
• pupariation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A conditional rescue system reveals essential functions for the ecdysone receptor (EcR) gene during molting and metamorphosis in Drosophila."
    Li T., Bender M.
    Development 127:2897-2905(2000) [PubMed] [Europe PMC] [Abstract]
  • "Phenotypic analysis of EcR-A mutants suggests that EcR isoforms have unique functions during Drosophila development."
    Davis M.B., Carney G.E., Robertson A.E., Bender M.
    Dev Biol 282:385-396(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of autophagy Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Balancing crosstalk between 20-hydroxyecdysone-induced autophagy and caspase activity in the fat body during Drosophila larval-prepupal transition."
    Liu H., Jia Q., Tettamanti G., Li S.
    Insect Biochem Mol Biol 43:1068-1078(2013) [PubMed] [Europe PMC] [Abstract]
• regulation of cellular respiration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysone and mediator change energy metabolism to terminate proliferation in Drosophila neural stem cells."
    Homem C.C.F., Steinmann V., Burkard T.R., Jais A., Esterbauer H., Knoblich J.A.
    Cell 158:874-888(2014) [PubMed] [Europe PMC] [Abstract]
• regulation of development, heterochronic Source: FlyBaseTraceable author statementⁱ
  • "Molecular mechanisms of developmental timing in C. elegans and Drosophila."
    Thummel C.S.
    Dev Cell 1:453-465(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of hemocyte proliferation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model."
    Sinenko S.A., Hung T., Moroz T., Tran Q.M., Sidhu S., Cheney M.D., Speck N.A., Banerjee U.
    Blood 116:4612-4620(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of Malpighian tubule diameter Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysone signaling is required for proper organization and fluid secretion of stellate cells in the Malpighian tubules of Drosophila melanogaster."
    Gautam N.K., Tapadia M.G.
    Int J Dev Biol 54:635-642(2010) [PubMed] [Europe PMC] [Abstract]
• regulation of neuron remodeling Source: FlyBaseInferred from mutant phenotypeⁱ
  • "An interaction screen identifies headcase as a regulator of large-scale pruning."
    Loncle N., Williams D.W.
    J Neurosci 32:17086-17096(2012) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: FlyBaseInferred from mutant phenotypeⁱ
  • "The ecdysone regulatory pathway controls wing morphogenesis and integrin expression during Drosophila metamorphosis."
    D'Avino P.P., Thummel C.S.
    Dev Biol 220:211-224(2000) [PubMed] [Europe PMC] [Abstract]
• response to cocaine Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Chronic cocaine exposure in Drosophila: life, cell death and oogenesis."
    Willard S.S., Koss C.M., Cronmiller C.
    Dev Biol 296:150-163(2006) [PubMed] [Europe PMC] [Abstract]
• response to ecdysone Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Ecdysone- and NO-mediated gene regulation by competing EcR/Usp and E75A nuclear receptors during Drosophila development."
    Johnston D.M., Sedkov Y., Petruk S., Riley K.M., Fujioka M., Jaynes J.B., Mazo A.
    Mol Cell 44:51-61(2011) [PubMed] [Europe PMC] [Abstract]
• salivary gland cell autophagic cell death Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genetic control of specificity to steroid-triggered responses in Drosophila."
    Ihry R.J., Bashirullah A.
    Genetics 196:767-780(2014) [PubMed] [Europe PMC] [Abstract]
• sperm individualization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Genetic dissection of sperm individualization in Drosophila melanogaster."
    Fabrizio J.J., Hime G., Lemmon S.K., Bazinet C.
    Development 125:1833-1843(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: CAFAInferred from mutant phenotypeⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]
• repressing transcription factor binding Source: FlyBaseInferred from physical interactionⁱ
  • "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily."
    Dressel U., Thormeyer D., Altincicek B., Paululat A., Eggert M., Schneider S., Tenbaum S.P., Renkawitz R., Baniahmad A.
    Mol. Cell. Biol. 19:3383-3394(1999) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription coactivator binding Source: FlyBaseInferred from physical interactionⁱ
  • "Cryptocephal, the Drosophila melanogaster ATF4, is a specific coactivator for ecdysone receptor isoform B2."
    Gauthier S.A., VanHaaften E., Cherbas L., Cherbas P., Hewes R.S.
    PLoS Genet 8:e1002883-e1002883(2012) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II transcription corepressor binding Source: FlyBaseInferred from physical interactionⁱ
  • "dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes."
    Cakouros D., Mills K., Denton D., Paterson A., Daish T., Kumar S.
    J Cell Biol 182:481-495(2008) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: CAFAInferred from physical interactionⁱ
  • "The composite nature of the interaction between nuclear receptors EcR and DHR38."
    Zoglowek A., Orlowski M., Pakula S., Dutko-Gwozdz J., Pajdzik D., Gwozdz T., Rymarczyk G., Wieczorek E., Dobrucki J., Dobryszycki P., Ozyhar A.
    Biol Chem 393:457-471(2012) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MKRRWSNNGG FMRLPEESSS EVTSSSNGLV LPSGVNMSPS SLDSHDYCDQ 
        60         70         80         90        100
DLWLCGNESG SFGGSNGHGL SQQQQSVITL AMHGCSSTLP AQTTIIPING 
       110        120        130        140        150
NANGNGGSTN GQYVPGATNL GALANGMLNG GFNGMQQQIQ NGHGLINSTT 
       160        170        180        190        200
PSTPTTPLHL QQNLGGAGGG GIGGMGILHH ANGTPNGLIG VVGGGGGVGL 
       210        220        230        240        250
GVGGGGVGGL GMQHTPRSDS VNSISSGRDD LSPSSSLNGY SANESCDAKK 
       260        270        280        290        300
SKKGPAPRVQ EELCLVCGDR ASGYHYNALT CEGCKGFFRR SVTKSAVYCC 
       310        320        330        340        350
KFGRACEMDM YMRRKCQECR LKKCLAVGMR PECVVPENQC AMKRREKKAQ 
       360        370        380        390        400
KEKDKMTTSP SSQHGGNGSL ASGGGQDFVK KEILDLMTCE PPQHATIPLL 
       410        420        430        440        450
PDEILAKCQA RNIPSLTYNQ LAVIYKLIWY QDGYEQPSEE DLRRIMSQPD 
       460        470        480        490        500
ENESQTDVSF RHITEITILT VQLIVEFAKG LPAFTKIPQE DQITLLKACS 
       510        520        530        540        550
SEVMMLRMAR RYDHSSDSIF FANNRSYTRD SYKMAGMADN IEDLLHFCRQ 
       560        570        580        590        600
MFSMKVDNVE YALLTAIVIF SDRPGLEKAQ LVEAIQSYYI DTLRIYILNR 
       610        620        630        640        650
HCGDSMSLVF YAKLLSILTE LRTLGNQNAE MCFSLKLKNR KLPKFLEEIW 
       660        670        680        690        700
DVHAIPPSVQ SHLQITQEEN ERLERAERMR ASVGGAITAG IDCDSASTSA 
       710        720        730        740        750
AAAAAQHQPQ PQPQPQPSSL TQNDSQHQTQ PQLQPQLPPQ LQGQLQPQLQ 
       760        770        780        790        800
PQLQTQLQPQ IQPQPQLLPV SAPVPASVTA PGSLSAVSTS SEYMGGSAAI 
       810        820        830        840        850
GPITPATTSS ITAAVTASST TSAVPMGNGV GVGVGVGGNV SMYANAQTAM 
       860        870 
ALMGVALHSH QEQLIGGVAV KSEHSTTA                         

        10         20         30         40         50
MLTTSGQQQS KQKLSTLPSH ILLQQQLAAS AGPSSSVSLS PSSSAALTLH 
        60         70         80         90        100
VASANGGARE TTSAAAVKDK LRPTPTAIKI EPMPDVISVG TVAGGSSVAT 
       110        120        130        140        150
VVAPAATTTS NKPNSTAAPS TSAAAANGHL VLVPNKRPRL DVTEDWMSTP 
       160        170        180        190        200
SPGSVPSSAP PLSPSPGSQN HSYNMSNGYA SPMSAGSYDP YSPTGKTGRD 
       210        220        230        240        250
DLSPSSSLNG YSANESCDAK KSKKGPAPRV QEELCLVCGD RASGYHYNAL 
       260        270        280        290        300
TCEGCKGFFR RSVTKSAVYC CKFGRACEMD MYMRRKCQEC RLKKCLAVGM 
       310        320        330        340        350
RPECVVPENQ CAMKRREKKA QKEKDKMTTS PSSQHGGNGS LASGGGQDFV 
       360        370        380        390        400
KKEILDLMTC EPPQHATIPL LPDEILAKCQ ARNIPSLTYN QLAVIYKLIW 
       410        420        430        440        450
YQDGYEQPSE EDLRRIMSQP DENESQTDVS FRHITEITIL TVQLIVEFAK 
       460        470        480        490        500
GLPAFTKIPQ EDQITLLKAC SSEVMMLRMA RRYDHSSDSI FFANNRSYTR 
       510        520        530        540        550
DSYKMAGMAD NIEDLLHFCR QMFSMKVDNV EYALLTAIVI FSDRPGLEKA 
       560        570        580        590        600
QLVEAIQSYY IDTLRIYILN RHCGDSMSLV FYAKLLSILT ELRTLGNQNA 
       610        620        630        640        650
EMCFSLKLKN RKLPKFLEEI WDVHAIPPSV QSHLQITQEE NERLERAERM 
       660        670        680        690        700
RASVGGAITA GIDCDSASTS AAAAAAQHQP QPQPQPQPSS LTQNDSQHQT 
       710        720        730        740        750
QPQLQPQLPP QLQGQLQPQL QPQLQTQLQP QIQPQPQLLP VSAPVPASVT 
       760        770        780        790        800
APGSLSAVST SSEYMGGSAA IGPITPATTS SITAAVTASS TTSAVPMGNG 
       810        820        830        840 
VGVGVGVGGN VSMYANAQTA MALMGVALHS HQEQLIGGVA VKSEHSTTA  

        10         20         30         40         50
MDTCGLVAEL AHYIDAYGRD DLSPSSSLNG YSANESCDAK KSKKGPAPRV 
        60         70         80         90        100
QEELCLVCGD RASGYHYNAL TCEGCKGFFR RSVTKSAVYC CKFGRACEMD 
       110        120        130        140        150
MYMRRKCQEC RLKKCLAVGM RPECVVPENQ CAMKRREKKA QKEKDKMTTS 
       160        170        180        190        200
PSSQHGGNGS LASGGGQDFV KKEILDLMTC EPPQHATIPL LPDEILAKCQ 
       210        220        230        240        250
ARNIPSLTYN QLAVIYKLIW YQDGYEQPSE EDLRRIMSQP DENESQTDVS 
       260        270        280        290        300
FRHITEITIL TVQLIVEFAK GLPAFTKIPQ EDQITLLKAC SSEVMMLRMA 
       310        320        330        340        350
RRYDHSSDSI FFANNRSYTR DSYKMAGMAD NIEDLLHFCR QMFSMKVDNV 
       360        370        380        390        400
EYALLTAIVI FSDRPGLEKA QLVEAIQSYY IDTLRIYILN RHCGDSMSLV 
       410        420        430        440        450
FYAKLLSILT ELRTLGNQNA EMCFSLKLKN RKLPKFLEEI WDVHAIPPSV 
       460        470        480        490        500
QSHLQITQEE NERLERAERM RASVGGAITA GIDCDSASTS AAAAAAQHQP 
       510        520        530        540        550
QPQPQPQPSS LTQNDSQHQT QPQLQPQLPP QLQGQLQPQL QPQLQTQLQP 
       560        570        580        590        600
QIQPQPQLLP VSAPVPASVT APGSLSAVST SSEYMGGSAA IGPITPATTS 
       610        620        630        640        650
SITAAVTASS TTSAVPMGNG VGVGVGVGGN VSMYANAQTA MALMGVALHS 
       660 
HQEQLIGGVA VKSEHSTTA                                   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
3. SIMILARITY comments
   Index of protein domains and families