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Entry version 198 (13 Feb 2019)
Sequence version 2 (13 Nov 2007)
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Protein

Dual specificity protein kinase TTK

Gene

TTK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the ATP-competitive kinase inhibitor, SP600125.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei553ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei647Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi531 – 539ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
2.7.12.1 2681

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P33981

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P33981

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity protein kinase TTK (EC:2.7.12.1)
Alternative name(s):
Phosphotyrosine picked threonine-protein kinase
Short name:
PYT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTK
Synonyms:MPS1, MPS1L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000112742.9

Human Gene Nomenclature Database

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HGNCi
HGNC:12401 TTK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604092 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_P33981

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi664D → A: Loss of kinase activity. 2 Publications1
Mutagenesisi686T → A: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7272

Open Targets

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OpenTargetsi
ENSG00000112742

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37066

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL3983

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2264

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TTK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
160112977

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000867741 – 857Dual specificity protein kinase TTKAdd BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei33PhosphothreonineCombined sources1
Modified residuei37PhosphoserineCombined sources1
Modified residuei80PhosphoserineCombined sources1
Modified residuei281PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei393PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei455PhosphoserineCombined sources1
Modified residuei821PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P33981

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P33981

MaxQB - The MaxQuant DataBase

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MaxQBi
P33981

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P33981

PeptideAtlas

More...
PeptideAtlasi
P33981

PRoteomics IDEntifications database

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PRIDEi
P33981

ProteomicsDB human proteome resource

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ProteomicsDBi
54932
54933 [P33981-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P33981

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P33981

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in rapidly proliferating cell lines.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112742 Expressed in 125 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P33981 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P33981 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB010166
CAB013229

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TPR; the interactions occurs in a microtubule-independent manner.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113123, 84 interactors

Database of interacting proteins

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DIPi
DIP-40642N

Protein interaction database and analysis system

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IntActi
P33981, 42 interactors

Molecular INTeraction database

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MINTi
P33981

STRING: functional protein association networks

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STRINGi
9606.ENSP00000358813

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P33981

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1857
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X9EX-ray3.10A514-828[»]
2ZMCX-ray3.14A510-857[»]
2ZMDX-ray2.88A510-857[»]
3CEKX-ray2.30A519-808[»]
3DBQX-ray2.70A515-857[»]
3GFWX-ray2.74A519-808[»]
3H9FX-ray2.60A519-808[»]
3HMNX-ray2.70A510-809[»]
3HMOX-ray2.40A510-809[»]
3HMPX-ray2.30A510-809[»]
3VQUX-ray2.40A516-820[»]
3W1FX-ray2.70A516-820[»]
3WYXX-ray2.90A516-820[»]
3WYYX-ray3.05A516-820[»]
3WZJX-ray2.75A516-820[»]
3WZKX-ray2.30A516-820[»]
4B94X-ray2.20A/B/C/D62-239[»]
4BHZX-ray2.85A519-808[»]
4BI0X-ray2.84A519-808[»]
4BI1X-ray2.70A519-808[»]
4BI2X-ray3.11A519-808[»]
4C4EX-ray2.60A519-808[»]
4C4FX-ray2.36A519-808[»]
4C4GX-ray2.65A519-808[»]
4C4HX-ray2.80A519-808[»]
4C4IX-ray2.65A519-808[»]
4C4JX-ray2.50A519-808[»]
4CV8X-ray3.00A519-808[»]
4CV9X-ray2.50A519-808[»]
4CVAX-ray2.50A519-808[»]
4D2SX-ray2.50A514-795[»]
4H7XX-ray2.60A/B55-210[»]
4H7YX-ray1.80A/B/C/D55-210[»]
4JS8X-ray1.94A515-795[»]
4JT3X-ray2.20A515-795[»]
4O6LX-ray2.38A/B515-795[»]
4ZEGX-ray2.33A515-795[»]
5AP0X-ray2.15A519-808[»]
5AP1X-ray2.05A519-808[»]
5AP2X-ray2.80A519-808[»]
5AP3X-ray2.70A519-808[»]
5AP4X-ray2.85A519-808[»]
5AP5X-ray2.80A519-808[»]
5AP6X-ray2.10A519-808[»]
5AP7X-ray2.45A519-808[»]
5EH0X-ray2.18A519-794[»]
5EHLX-ray2.66A519-808[»]
5EHOX-ray2.18A519-808[»]
5EHYX-ray2.26A519-808[»]
5EI2X-ray2.67A519-808[»]
5EI6X-ray2.01A519-808[»]
5EI8X-ray2.17A519-753[»]
5LJJX-ray3.00A519-808[»]
5MRBX-ray2.20A519-808[»]
5N7VX-ray2.52A519-808[»]
5N84X-ray2.30A519-808[»]
5N87X-ray2.29A519-808[»]
5N93X-ray2.10A519-808[»]
5N9SX-ray2.30A519-808[»]
5NA0X-ray2.90A519-808[»]
5NADX-ray2.80A519-808[»]
5NTTX-ray2.75A519-797[»]
5O91X-ray3.20A519-808[»]
6B4WX-ray2.90A515-795[»]
6H3KX-ray2.48A519-794[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P33981

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P33981

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P33981

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini525 – 791Protein kinasePROSITE-ProRule annotationAdd BLAST267

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0596 Eukaryota
ENOG410XRRQ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013174

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG001029

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P33981

KEGG Orthology (KO)

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KOi
K08866

Identification of Orthologs from Complete Genome Data

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OMAi
MSCFRTP

Database of Orthologous Groups

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OrthoDBi
172948at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P33981

TreeFam database of animal gene trees

More...
TreeFami
TF105420

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR027084 Prot_kin_Mps1_fam
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR011990 TPR-like_helical_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22974:SF21 PTHR22974:SF21, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P33981-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESEDLSGRE LTIDSIMNKV RDIKNKFKNE DLTDELSLNK ISADTTDNSG
60 70 80 90 100
TVNQIMMMAN NPEDWLSLLL KLEKNSVPLS DALLNKLIGR YSQAIEALPP
110 120 130 140 150
DKYGQNESFA RIQVRFAELK AIQEPDDARD YFQMARANCK KFAFVHISFA
160 170 180 190 200
QFELSQGNVK KSKQLLQKAV ERGAVPLEML EIALRNLNLQ KKQLLSEEEK
210 220 230 240 250
KNLSASTVLT AQESFSGSLG HLQNRNNSCD SRGQTTKARF LYGENMPPQD
260 270 280 290 300
AEIGYRNSLR QTNKTKQSCP FGRVPVNLLN SPDCDVKTDD SVVPCFMKRQ
310 320 330 340 350
TSRSECRDLV VPGSKPSGND SCELRNLKSV QNSHFKEPLV SDEKSSELII
360 370 380 390 400
TDSITLKNKT ESSLLAKLEE TKEYQEPEVP ESNQKQWQSK RKSECINQNP
410 420 430 440 450
AASSNHWQIP ELARKVNTEQ KHTTFEQPVF SVSKQSPPIS TSKWFDPKSI
460 470 480 490 500
CKTPSSNTLD DYMSCFRTPV VKNDFPPACQ LSTPYGQPAC FQQQQHQILA
510 520 530 540 550
TPLQNLQVLA SSSANECISV KGRIYSILKQ IGSGGSSKVF QVLNEKKQIY
560 570 580 590 600
AIKYVNLEEA DNQTLDSYRN EIAYLNKLQQ HSDKIIRLYD YEITDQYIYM
610 620 630 640 650
VMECGNIDLN SWLKKKKSID PWERKSYWKN MLEAVHTIHQ HGIVHSDLKP
660 670 680 690 700
ANFLIVDGML KLIDFGIANQ MQPDTTSVVK DSQVGTVNYM PPEAIKDMSS
710 720 730 740 750
SRENGKSKSK ISPKSDVWSL GCILYYMTYG KTPFQQIINQ ISKLHAIIDP
760 770 780 790 800
NHEIEFPDIP EKDLQDVLKC CLKRDPKQRI SIPELLAHPY VQIQTHPVNQ
810 820 830 840 850
MAKGTTEEMK YVLGQLVGLN SPNSILKAAK TLYEHYSGGE SHNSSSSKTF

EKKRGKK
Length:857
Mass (Da):97,072
Last modified:November 13, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51F40A3CD1677AC5
GO
Isoform 2 (identifier: P33981-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-420: Missing.

Note: No experimental confirmation available.
Show »
Length:856
Mass (Da):96,944
Checksum:i13FDD345AE1B52DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6REX1D6REX1_HUMAN
Dual-specificity protein kinase TTK
TTK
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF82D6RF82_HUMAN
Dual-specificity protein kinase TTK
TTK
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIC6D6RIC6_HUMAN
Dual-specificity protein kinase TTK
TTK
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFY1D6RFY1_HUMAN
Dual-specificity protein kinase TTK
TTK
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA61239 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti389S → A in AAA61239 (PubMed:1639825).Curated1
Sequence conflicti768L → V in CAA49912 (PubMed:7678926).Curated1
Sequence conflicti768L → V (PubMed:1956325).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03714197A → V. Corresponds to variant dbSNP:rs2230513Ensembl.1
Natural variantiVAR_037142758D → N. Corresponds to variant dbSNP:rs2230512Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043072420Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86699 mRNA Translation: AAA61239.1 Different initiation.
AK292460 mRNA Translation: BAF85149.1
AK315696 mRNA Translation: BAG38059.1
AL133475 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48699.1
CH471051 Genomic DNA Translation: EAW48700.1
BC000633 mRNA Translation: AAH00633.1
BC032858 mRNA Translation: AAH32858.1
X70500 mRNA Translation: CAA49912.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4993.1 [P33981-1]
CCDS55040.1 [P33981-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
A42861

NCBI Reference Sequences

More...
RefSeqi
NP_001160163.1, NM_001166691.1 [P33981-2]
NP_003309.2, NM_003318.4 [P33981-1]
XP_011534401.1, XM_011536099.2 [P33981-1]
XP_011534402.1, XM_011536100.2 [P33981-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.169840

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230510; ENSP00000230510; ENSG00000112742 [P33981-2]
ENST00000369798; ENSP00000358813; ENSG00000112742 [P33981-1]
ENST00000509894; ENSP00000422936; ENSG00000112742 [P33981-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7272

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7272

UCSC genome browser

More...
UCSCi
uc003pjb.5 human [P33981-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86699 mRNA Translation: AAA61239.1 Different initiation.
AK292460 mRNA Translation: BAF85149.1
AK315696 mRNA Translation: BAG38059.1
AL133475 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48699.1
CH471051 Genomic DNA Translation: EAW48700.1
BC000633 mRNA Translation: AAH00633.1
BC032858 mRNA Translation: AAH32858.1
X70500 mRNA Translation: CAA49912.1
CCDSiCCDS4993.1 [P33981-1]
CCDS55040.1 [P33981-2]
PIRiA42861
RefSeqiNP_001160163.1, NM_001166691.1 [P33981-2]
NP_003309.2, NM_003318.4 [P33981-1]
XP_011534401.1, XM_011536099.2 [P33981-1]
XP_011534402.1, XM_011536100.2 [P33981-2]
UniGeneiHs.169840

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X9EX-ray3.10A514-828[»]
2ZMCX-ray3.14A510-857[»]
2ZMDX-ray2.88A510-857[»]
3CEKX-ray2.30A519-808[»]
3DBQX-ray2.70A515-857[»]
3GFWX-ray2.74A519-808[»]
3H9FX-ray2.60A519-808[»]
3HMNX-ray2.70A510-809[»]
3HMOX-ray2.40A510-809[»]
3HMPX-ray2.30A510-809[»]
3VQUX-ray2.40A516-820[»]
3W1FX-ray2.70A516-820[»]
3WYXX-ray2.90A516-820[»]
3WYYX-ray3.05A516-820[»]
3WZJX-ray2.75A516-820[»]
3WZKX-ray2.30A516-820[»]
4B94X-ray2.20A/B/C/D62-239[»]
4BHZX-ray2.85A519-808[»]
4BI0X-ray2.84A519-808[»]
4BI1X-ray2.70A519-808[»]
4BI2X-ray3.11A519-808[»]
4C4EX-ray2.60A519-808[»]
4C4FX-ray2.36A519-808[»]
4C4GX-ray2.65A519-808[»]
4C4HX-ray2.80A519-808[»]
4C4IX-ray2.65A519-808[»]
4C4JX-ray2.50A519-808[»]
4CV8X-ray3.00A519-808[»]
4CV9X-ray2.50A519-808[»]
4CVAX-ray2.50A519-808[»]
4D2SX-ray2.50A514-795[»]
4H7XX-ray2.60A/B55-210[»]
4H7YX-ray1.80A/B/C/D55-210[»]
4JS8X-ray1.94A515-795[»]
4JT3X-ray2.20A515-795[»]
4O6LX-ray2.38A/B515-795[»]
4ZEGX-ray2.33A515-795[»]
5AP0X-ray2.15A519-808[»]
5AP1X-ray2.05A519-808[»]
5AP2X-ray2.80A519-808[»]
5AP3X-ray2.70A519-808[»]
5AP4X-ray2.85A519-808[»]
5AP5X-ray2.80A519-808[»]
5AP6X-ray2.10A519-808[»]
5AP7X-ray2.45A519-808[»]
5EH0X-ray2.18A519-794[»]
5EHLX-ray2.66A519-808[»]
5EHOX-ray2.18A519-808[»]
5EHYX-ray2.26A519-808[»]
5EI2X-ray2.67A519-808[»]
5EI6X-ray2.01A519-808[»]
5EI8X-ray2.17A519-753[»]
5LJJX-ray3.00A519-808[»]
5MRBX-ray2.20A519-808[»]
5N7VX-ray2.52A519-808[»]
5N84X-ray2.30A519-808[»]
5N87X-ray2.29A519-808[»]
5N93X-ray2.10A519-808[»]
5N9SX-ray2.30A519-808[»]
5NA0X-ray2.90A519-808[»]
5NADX-ray2.80A519-808[»]
5NTTX-ray2.75A519-797[»]
5O91X-ray3.20A519-808[»]
6B4WX-ray2.90A515-795[»]
6H3KX-ray2.48A519-794[»]
ProteinModelPortaliP33981
SMRiP33981
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113123, 84 interactors
DIPiDIP-40642N
IntActiP33981, 42 interactors
MINTiP33981
STRINGi9606.ENSP00000358813

Chemistry databases

BindingDBiP33981
ChEMBLiCHEMBL3983
GuidetoPHARMACOLOGYi2264

PTM databases

iPTMnetiP33981
PhosphoSitePlusiP33981

Polymorphism and mutation databases

BioMutaiTTK
DMDMi160112977

Proteomic databases

EPDiP33981
jPOSTiP33981
MaxQBiP33981
PaxDbiP33981
PeptideAtlasiP33981
PRIDEiP33981
ProteomicsDBi54932
54933 [P33981-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7272
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230510; ENSP00000230510; ENSG00000112742 [P33981-2]
ENST00000369798; ENSP00000358813; ENSG00000112742 [P33981-1]
ENST00000509894; ENSP00000422936; ENSG00000112742 [P33981-2]
GeneIDi7272
KEGGihsa:7272
UCSCiuc003pjb.5 human [P33981-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7272
DisGeNETi7272
EuPathDBiHostDB:ENSG00000112742.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTK
HGNCiHGNC:12401 TTK
HPAiCAB010166
CAB013229
MIMi604092 gene
neXtProtiNX_P33981
OpenTargetsiENSG00000112742
PharmGKBiPA37066

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0596 Eukaryota
ENOG410XRRQ LUCA
GeneTreeiENSGT00940000153344
HOGENOMiHOG000013174
HOVERGENiHBG001029
InParanoidiP33981
KOiK08866
OMAiMSCFRTP
OrthoDBi172948at2759
PhylomeDBiP33981
TreeFamiTF105420

Enzyme and pathway databases

BRENDAi2.7.12.1 2681
SignaLinkiP33981
SIGNORiP33981

Miscellaneous databases

EvolutionaryTraceiP33981

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TTK_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7272

Protein Ontology

More...
PROi
PR:P33981

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112742 Expressed in 125 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiP33981 baseline and differential
GenevisibleiP33981 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR027084 Prot_kin_Mps1_fam
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR22974:SF21 PTHR22974:SF21, 1 hit
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33981
Secondary accession number(s): A8K8U5
, B2RDW2, E1P543, Q15272, Q5TCS0, Q9BW51, Q9NTM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 13, 2007
Last modified: February 13, 2019
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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