UniProtKB - P33947 (ERD22_HUMAN)
Protein
ER lumen protein-retaining receptor 2
Gene
KDELR2
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (PubMed:1325562, PubMed:18086916). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).By similarity2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 193 | Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity | 1 |
GO - Molecular functioni
- ER retention sequence binding Source: GO_Central
- KDEL sequence binding Source: UniProtKB
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- protein retention in ER lumen Source: GO_Central
- protein transport Source: UniProtKB-KW
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P33947 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Names & Taxonomyi
Protein namesi | Recommended name: ER lumen protein-retaining receptor 2Alternative name(s): ERD2-like protein 1 Short name: ELP-1 KDEL endoplasmic reticulum protein retention receptor 2 Short name: KDEL receptor 2 |
Gene namesi | Name:KDELR2 Synonyms:ERD2.21 Publication |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6305, KDELR2 |
MIMi | 609024, gene |
neXtProti | NX_P33947 |
VEuPathDBi | HostDB:ENSG00000136240.9 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 2 Publications; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein By similarity
Other locations
- COPI-coated vesicle membrane 1 Publication; Multi-pass membrane protein By similarity
Note: Localized in the Golgi in the absence of bound proteins with the sequence motif K-D-E-L. Trafficks back to the endoplasmic reticulum together with cargo proteins containing the sequence motif K-D-E-L.1 Publication1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB
Golgi apparatus
- cis-Golgi network Source: GO_Central
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: UniProtKB
Other locations
- COPI-coated vesicle membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB
- transport vesicle Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 4 | LumenalCurated | 4 | |
Transmembranei | 5 – 24 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 25 – 32 | CytoplasmicCurated | 8 | |
Transmembranei | 33 – 52 | HelicalBy similarityAdd BLAST | 20 | |
Topological domaini | 53 – 58 | LumenalCurated | 6 | |
Transmembranei | 59 – 79 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 80 – 92 | CytoplasmicCuratedAdd BLAST | 13 | |
Transmembranei | 93 – 110 | HelicalBy similarityAdd BLAST | 18 | |
Topological domaini | 111 – 116 | LumenalCurated | 6 | |
Transmembranei | 117 – 135 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 136 – 149 | CytoplasmicCuratedAdd BLAST | 14 | |
Transmembranei | 150 – 168 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 169 – 178 | LumenalCurated | 10 | |
Transmembranei | 179 – 199 | HelicalBy similarityAdd BLAST | 21 | |
Topological domaini | 200 – 212 | CytoplasmicCuratedAdd BLAST | 13 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 11014 |
OpenTargetsi | ENSG00000136240 |
PharmGKBi | PA30084 |
Miscellaneous databases
Pharosi | P33947, Tdark |
Genetic variation databases
BioMutai | KDELR2 |
DMDMi | 462018 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000194155 | 1 – 212 | ER lumen protein-retaining receptor 2Add BLAST | 212 |
Proteomic databases
EPDi | P33947 |
jPOSTi | P33947 |
MassIVEi | P33947 |
MaxQBi | P33947 |
PaxDbi | P33947 |
PeptideAtlasi | P33947 |
PRIDEi | P33947 |
ProteomicsDBi | 54930 [P33947-1] 54931 [P33947-2] |
TopDownProteomicsi | P33947-1 [P33947-1] P33947-2 [P33947-2] |
PTM databases
iPTMneti | P33947 |
PhosphoSitePlusi | P33947 |
SwissPalmi | P33947 |
Expressioni
Gene expression databases
Bgeei | ENSG00000136240, Expressed in tibia and 250 other tissues |
ExpressionAtlasi | P33947, baseline and differential |
Genevisiblei | P33947, HS |
Organism-specific databases
HPAi | ENSG00000136240, Low tissue specificity |
Interactioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 5 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 1 | |
Sitei | 54 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 1 | |
Sitei | 117 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 1 |
Protein-protein interaction databases
BioGRIDi | 116204, 45 interactors |
IntActi | P33947, 10 interactors |
MINTi | P33947 |
STRINGi | 9606.ENSP00000258739 |
Miscellaneous databases
RNActi | P33947, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 47 – 48 | Interaction with the K-D-E-L motif on target proteinsBy similarity | 2 | |
Regioni | 159 – 169 | Interaction with the K-D-E-L motif on target proteinsBy similarityAdd BLAST | 11 | |
Regioni | 204 – 207 | Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity | 4 |
Domaini
Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).By similarity
Sequence similaritiesi
Belongs to the ERD2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3106, Eukaryota |
GeneTreei | ENSGT00390000004010 |
HOGENOMi | CLU_057784_0_0_1 |
InParanoidi | P33947 |
OMAi | WVSLYNF |
PhylomeDBi | P33947 |
TreeFami | TF314792 |
Family and domain databases
InterProi | View protein in InterPro IPR000133, ER_ret_rcpt |
PANTHERi | PTHR10585, PTHR10585, 1 hit |
Pfami | View protein in Pfam PF00810, ER_lumen_recept, 1 hit |
PRINTSi | PR00660, ERLUMENR |
PROSITEi | View protein in PROSITE PS00951, ER_LUMEN_RECEPTOR_1, 1 hit PS00952, ER_LUMEN_RECEPTOR_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P33947-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT
210
KVLKGKKLSL PA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH7BYF7 | H7BYF7_HUMAN | ER lumen protein-retaining receptor... | KDELR2 | 38 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 137 | M → V in AAH12994 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036712 | 118 – 212 | ILWTF…LSLPA → YSRERSSVCQHKCQRPSPAS VLQGARTEFLPQQRHKMLDT ENQKLNSFVADSHQWLCKNA EEKSQKVSV in isoform 2. 1 PublicationAdd BLAST | 95 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63745 mRNA Translation: CAA45277.1 M88458 mRNA No translation available. AC072052 Genomic DNA Translation: AAS02002.1 AK315702 mRNA Translation: BAG38064.1 CH236963 Genomic DNA Translation: EAL23722.1 CH878731 Genomic DNA Translation: EAW55030.1 BC008081 mRNA Translation: AAH08081.1 BC012994 mRNA Translation: AAH12994.1 BC071982 mRNA Translation: AAH71982.1 |
CCDSi | CCDS43550.1 [P33947-2] CCDS5351.1 [P33947-1] |
PIRi | A42286 |
RefSeqi | NP_001094073.1, NM_001100603.1 [P33947-2] NP_006845.1, NM_006854.3 [P33947-1] |
Genome annotation databases
Ensembli | ENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1] ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2] |
GeneIDi | 11014 |
KEGGi | hsa:11014 |
UCSCi | uc003sqe.5, human [P33947-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X63745 mRNA Translation: CAA45277.1 M88458 mRNA No translation available. AC072052 Genomic DNA Translation: AAS02002.1 AK315702 mRNA Translation: BAG38064.1 CH236963 Genomic DNA Translation: EAL23722.1 CH878731 Genomic DNA Translation: EAW55030.1 BC008081 mRNA Translation: AAH08081.1 BC012994 mRNA Translation: AAH12994.1 BC071982 mRNA Translation: AAH71982.1 |
CCDSi | CCDS43550.1 [P33947-2] CCDS5351.1 [P33947-1] |
PIRi | A42286 |
RefSeqi | NP_001094073.1, NM_001100603.1 [P33947-2] NP_006845.1, NM_006854.3 [P33947-1] |
3D structure databases
SMRi | P33947 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116204, 45 interactors |
IntActi | P33947, 10 interactors |
MINTi | P33947 |
STRINGi | 9606.ENSP00000258739 |
PTM databases
iPTMneti | P33947 |
PhosphoSitePlusi | P33947 |
SwissPalmi | P33947 |
Genetic variation databases
BioMutai | KDELR2 |
DMDMi | 462018 |
Proteomic databases
EPDi | P33947 |
jPOSTi | P33947 |
MassIVEi | P33947 |
MaxQBi | P33947 |
PaxDbi | P33947 |
PeptideAtlasi | P33947 |
PRIDEi | P33947 |
ProteomicsDBi | 54930 [P33947-1] 54931 [P33947-2] |
TopDownProteomicsi | P33947-1 [P33947-1] P33947-2 [P33947-2] |
Protocols and materials databases
Antibodypediai | 11644, 169 antibodies |
DNASUi | 11014 |
Genome annotation databases
Ensembli | ENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1] ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2] |
GeneIDi | 11014 |
KEGGi | hsa:11014 |
UCSCi | uc003sqe.5, human [P33947-1] |
Organism-specific databases
CTDi | 11014 |
DisGeNETi | 11014 |
GeneCardsi | KDELR2 |
HGNCi | HGNC:6305, KDELR2 |
HPAi | ENSG00000136240, Low tissue specificity |
MIMi | 609024, gene |
neXtProti | NX_P33947 |
OpenTargetsi | ENSG00000136240 |
PharmGKBi | PA30084 |
VEuPathDBi | HostDB:ENSG00000136240.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3106, Eukaryota |
GeneTreei | ENSGT00390000004010 |
HOGENOMi | CLU_057784_0_0_1 |
InParanoidi | P33947 |
OMAi | WVSLYNF |
PhylomeDBi | P33947 |
TreeFami | TF314792 |
Enzyme and pathway databases
PathwayCommonsi | P33947 |
Reactomei | R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic |
Miscellaneous databases
BioGRID-ORCSi | 11014, 36 hits in 876 CRISPR screens |
ChiTaRSi | KDELR2, human |
GeneWikii | KDELR2 |
GenomeRNAii | 11014 |
Pharosi | P33947, Tdark |
PROi | PR:P33947 |
RNActi | P33947, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000136240, Expressed in tibia and 250 other tissues |
ExpressionAtlasi | P33947, baseline and differential |
Genevisiblei | P33947, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000133, ER_ret_rcpt |
PANTHERi | PTHR10585, PTHR10585, 1 hit |
Pfami | View protein in Pfam PF00810, ER_lumen_recept, 1 hit |
PRINTSi | PR00660, ERLUMENR |
PROSITEi | View protein in PROSITE PS00951, ER_LUMEN_RECEPTOR_1, 1 hit PS00952, ER_LUMEN_RECEPTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERD22_HUMAN | |
Accessioni | P33947Primary (citable) accession number: P33947 Secondary accession number(s): A4D2P4, Q6IPC5, Q96E30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM