Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P33947 (ERD22_HUMAN)

Entry version 184 (10 Feb 2021)
Sequence version 1 (01 Feb 1994)
Previous versions | rss
Add a publicationFeedback
Protein

ER lumen protein-retaining receptor 2

Gene

KDELR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the C-terminal sequence motif K-D-E-L that is present on endoplasmic reticulum resident proteins and that mediates their recycling from the Golgi back to the endoplasmic reticulum (PubMed:1325562, PubMed:18086916). Binding is pH dependent, and is optimal at pH 5-5.4 (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei193Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P33947

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ER lumen protein-retaining receptor 2
Alternative name(s):
ERD2-like protein 1
Short name:
ELP-1
KDEL endoplasmic reticulum protein retention receptor 2
Short name:
KDEL receptor 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KDELR2
Synonyms:ERD2.21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6305, KDELR2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609024, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P33947

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000136240.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 4LumenalCurated4
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei5 – 24HelicalBy similarityAdd BLAST20
Topological domaini25 – 32CytoplasmicCurated8
Transmembranei33 – 52HelicalBy similarityAdd BLAST20
Topological domaini53 – 58LumenalCurated6
Transmembranei59 – 79HelicalBy similarityAdd BLAST21
Topological domaini80 – 92CytoplasmicCuratedAdd BLAST13
Transmembranei93 – 110HelicalBy similarityAdd BLAST18
Topological domaini111 – 116LumenalCurated6
Transmembranei117 – 135HelicalBy similarityAdd BLAST19
Topological domaini136 – 149CytoplasmicCuratedAdd BLAST14
Transmembranei150 – 168HelicalBy similarityAdd BLAST19
Topological domaini169 – 178LumenalCurated10
Transmembranei179 – 199HelicalBy similarityAdd BLAST21
Topological domaini200 – 212CytoplasmicCuratedAdd BLAST13

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		11014

Open Targets

More...OpenTargetsi		ENSG00000136240

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30084

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P33947, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KDELR2

Domain mapping of disease mutations (DMDM)

More...DMDMi		462018

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001941551 – 212ER lumen protein-retaining receptor 2Add BLAST212

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P33947

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P33947

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P33947

MaxQB - The MaxQuant DataBase

More...MaxQBi		P33947

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33947

PeptideAtlas

More...PeptideAtlasi		P33947

PRoteomics IDEntifications database

More...PRIDEi		P33947

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		54930 [P33947-1]
54931 [P33947-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P33947-1 [P33947-1]
P33947-2 [P33947-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P33947

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P33947

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P33947

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000136240, Expressed in tibia and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P33947, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P33947, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000136240, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei5Interaction with the K-D-E-L motif on target proteinsBy similarity1
Sitei54Interaction with the K-D-E-L motif on target proteinsBy similarity1
Sitei117Interaction with the K-D-E-L motif on target proteinsBy similarity1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116204, 45 interactors

Protein interaction database and analysis system

More...IntActi		P33947, 10 interactors

Molecular INTeraction database

More...MINTi		P33947

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000258739

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P33947, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P33947

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 48Interaction with the K-D-E-L motif on target proteinsBy similarity2
Regioni159 – 169Interaction with the K-D-E-L motif on target proteinsBy similarityAdd BLAST11
Regioni204 – 207Important for recycling of cargo proteins with the sequence motif K-D-E-L from the Golgi to the endoplasmic reticulumBy similarity4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds the C-terminal sequence motif K-D-E-L in a hydrophilic cavity between the transmembrane domains. This triggers a conformation change that exposes a Lys-rich patch on the cytosolic surface of the protein (By similarity). This patch mediates recycling from the Golgi to the endoplasmic reticulum, probably via COPI vesicles (By similarity).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3106, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000004010

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_057784_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33947

Identification of Orthologs from Complete Genome Data

More...OMAi		WVSLYNF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33947

TreeFam database of animal gene trees

More...TreeFami		TF314792

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000133, ER_ret_rcpt

The PANTHER Classification System

More...PANTHERi		PTHR10585, PTHR10585, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00810, ER_lumen_recept, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00660, ERLUMENR

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00951, ER_LUMEN_RECEPTOR_1, 1 hit
PS00952, ER_LUMEN_RECEPTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P33947-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD 
        60         70         80         90        100
LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV 
       110        120        130        140        150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH 
       160        170        180        190        200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT 
       210 
KVLKGKKLSL PA
Length:212
Mass (Da):24,422
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81BECB983E503142
GO
Isoform 2 (identifier: P33947-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-212: ILWTFSIYLE...LKGKKLSLPA → YSRERSSVCQ...AEEKSQKVSV

Show »
Length:186
Mass (Da):21,242
Checksum:iB7224397F0243996
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYF7H7BYF7_HUMAN
ER lumen protein-retaining receptor...
KDELR2
38Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti137M → V in AAH12994 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036712118 – 212ILWTF…LSLPA → YSRERSSVCQHKCQRPSPAS VLQGARTEFLPQQRHKMLDT ENQKLNSFVADSHQWLCKNA EEKSQKVSV in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X63745 mRNA Translation: CAA45277.1
M88458 mRNA No translation available.
AC072052 Genomic DNA Translation: AAS02002.1
AK315702 mRNA Translation: BAG38064.1
CH236963 Genomic DNA Translation: EAL23722.1
CH878731 Genomic DNA Translation: EAW55030.1
BC008081 mRNA Translation: AAH08081.1
BC012994 mRNA Translation: AAH12994.1
BC071982 mRNA Translation: AAH71982.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43550.1 [P33947-2]
CCDS5351.1 [P33947-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A42286

NCBI Reference Sequences

More...RefSeqi		NP_001094073.1, NM_001100603.1 [P33947-2]
NP_006845.1, NM_006854.3 [P33947-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1]
ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		11014

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:11014

UCSC genome browser

More...UCSCi		uc003sqe.5, human [P33947-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63745 mRNA Translation: CAA45277.1
M88458 mRNA No translation available.
AC072052 Genomic DNA Translation: AAS02002.1
AK315702 mRNA Translation: BAG38064.1
CH236963 Genomic DNA Translation: EAL23722.1
CH878731 Genomic DNA Translation: EAW55030.1
BC008081 mRNA Translation: AAH08081.1
BC012994 mRNA Translation: AAH12994.1
BC071982 mRNA Translation: AAH71982.1
CCDSiCCDS43550.1 [P33947-2]
CCDS5351.1 [P33947-1]
PIRiA42286
RefSeqiNP_001094073.1, NM_001100603.1 [P33947-2]
NP_006845.1, NM_006854.3 [P33947-1]

3D structure databases

SMRiP33947
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116204, 45 interactors
IntActiP33947, 10 interactors
MINTiP33947
STRINGi9606.ENSP00000258739

PTM databases

iPTMnetiP33947
PhosphoSitePlusiP33947
SwissPalmiP33947

Genetic variation databases

BioMutaiKDELR2
DMDMi462018

Proteomic databases

EPDiP33947
jPOSTiP33947
MassIVEiP33947
MaxQBiP33947
PaxDbiP33947
PeptideAtlasiP33947
PRIDEiP33947
ProteomicsDBi54930 [P33947-1]
54931 [P33947-2]
TopDownProteomicsiP33947-1 [P33947-1]
P33947-2 [P33947-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11644, 169 antibodies

The DNASU plasmid repository

More...DNASUi		11014

Genome annotation databases

EnsembliENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1]
ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2]
GeneIDi11014
KEGGihsa:11014
UCSCiuc003sqe.5, human [P33947-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		11014
DisGeNETi11014

GeneCards: human genes, protein and diseases

More...GeneCardsi		KDELR2
HGNCiHGNC:6305, KDELR2
HPAiENSG00000136240, Low tissue specificity
MIMi609024, gene
neXtProtiNX_P33947
OpenTargetsiENSG00000136240
PharmGKBiPA30084
VEuPathDBiHostDB:ENSG00000136240.9

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3106, Eukaryota
GeneTreeiENSGT00390000004010
HOGENOMiCLU_057784_0_0_1
InParanoidiP33947
OMAiWVSLYNF
PhylomeDBiP33947
TreeFamiTF314792

Enzyme and pathway databases

PathwayCommonsiP33947
ReactomeiR-HSA-6807878, COPI-mediated anterograde transport
R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		11014, 36 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KDELR2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KDELR2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		11014
PharosiP33947, Tdark

Protein Ontology

More...PROi		PR:P33947
RNActiP33947, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000136240, Expressed in tibia and 250 other tissues
ExpressionAtlasiP33947, baseline and differential
GenevisibleiP33947, HS

Family and domain databases

InterProiView protein in InterPro
IPR000133, ER_ret_rcpt
PANTHERiPTHR10585, PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810, ER_lumen_recept, 1 hit
PRINTSiPR00660, ERLUMENR
PROSITEiView protein in PROSITE
PS00951, ER_LUMEN_RECEPTOR_1, 1 hit
PS00952, ER_LUMEN_RECEPTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERD22_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33947
Secondary accession number(s): A4D2P4, Q6IPC5, Q96E30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: February 10, 2021
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again