KDELR2

Functionⁱ

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.

GO - Molecular functionⁱ

KDEL sequence binding
Source: ProtInc
Traceable author statementⁱ
- 1316805

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ER to Golgi vesicle-mediated transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
intracellular protein transport
Source: ProtInc
Traceable author statementⁱ
- 1325562
protein retention in ER lumen
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
retrograde vesicle-mediated transport, Golgi to ER Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Reactomeⁱ

R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ER lumen protein-retaining receptor 2 Alternative name(s): ERD2-like protein 1 Short name: ELP-1 KDEL endoplasmic reticulum protein retention receptor 2 Short name: KDEL receptor 2
Gene namesⁱ	Name:KDELR2 Synonyms:ERD2.2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136240.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6305 KDELR2
MIMⁱ	609024 gene
neXtProtⁱ	NX_P33947

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 2	LumenalSequence analysis	2
Transmembraneⁱ	3 – 21	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	22 – 35	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	36 – 53	HelicalSequence analysisAdd BLAST	18
Topological domainⁱ	54 – 61	LumenalSequence analysis	8
Transmembraneⁱ	62 – 80	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	81 – 96	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	97 – 110	HelicalSequence analysisAdd BLAST	14
Topological domainⁱ	111 – 117	LumenalSequence analysis	7
Transmembraneⁱ	118 – 137	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	138 – 149	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	150 – 168	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	169 – 178	LumenalSequence analysis	10
Transmembraneⁱ	179 – 199	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	200 – 212	CytoplasmicSequence analysisAdd BLAST	13

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	11014
Open Targets More...OpenTargetsⁱ	ENSG00000136240
PharmGKBⁱ	PA30084

Polymorphism and mutation databases

BioMutaⁱ	KDELR2
DMDMⁱ	462018

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000194155	1 – 212	ER lumen protein-retaining receptor 2Add BLAST		212

Proteomic databases

EPDⁱ	P33947
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P33947
PaxDbⁱ	P33947
PeptideAtlas More...PeptideAtlasⁱ	P33947
PRIDEⁱ	P33947
ProteomicsDBⁱ	54930 54931 [P33947-2]
TopDownProteomicsⁱ	P33947-1 [P33947-1] P33947-2 [P33947-2]

PTM databases

iPTMnetⁱ	P33947
PhosphoSitePlusⁱ	P33947
SwissPalmⁱ	P33947

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136240 Expressed in 240 organ(s), highest expression level in tibia
CleanExⁱ	HS_KDELR2
ExpressionAtlasⁱ	P33947 baseline and differential
Genevisibleⁱ	P33947 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016459

HPAⁱ

HPA016459

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	116204, 16 interactors
IntActⁱ	P33947, 7 interactors
Molecular INTeraction database More...MINTⁱ	P33947
STRINGⁱ	9606.ENSP00000258739

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P33947
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ERD2 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3106 Eukaryota COG5196 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004010
HOGENOMⁱ	HOG000231400
HOVERGENⁱ	HBG001398
InParanoidⁱ	P33947
KEGG Orthology (KO) More...KOⁱ	K10949
OMAⁱ	QTTRSCR
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Q1H
PhylomeDBⁱ	P33947
TreeFamⁱ	TF314792

Family and domain databases

InterProⁱ	View protein in InterPro IPR000133 ER_ret_rcpt
PANTHERⁱ	PTHR10585 PTHR10585, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00810 ER_lumen_recept, 1 hit
PRINTSⁱ	PR00660 ERLUMENR
PROSITEⁱ	View protein in PROSITE PS00951 ER_LUMEN_RECEPTOR_1, 1 hit PS00952 ER_LUMEN_RECEPTOR_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P33947-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD 
        60         70         80         90        100
LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV 
       110        120        130        140        150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH 
       160        170        180        190        200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT 
       210 
KVLKGKKLSL PA

Length:212

Mass (Da):24,422

Last modified:February 1, 1994 - v1

Checksum:ⁱ81BECB983E503142

GO

Isoform 2 (identifier: P33947-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
118-212: ILWTFSIYLE...LKGKKLSLPA → YSRERSSVCQ...AEEKSQKVSV

« Hide

        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD 
        60         70         80         90        100
LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV 
       110        120        130        140        150
PVGGLSFLVN HDFSPLEYSR ERSSVCQHKC QRPSPASVLQ GARTEFLPQQ 
       160        170        180 
RHKMLDTENQ KLNSFVADSH QWLCKNAEEK SQKVSV

Show »

Length:186

Mass (Da):21,242

Checksum:ⁱB7224397F0243996

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H7BYF7	H7BYF7_HUMAN		ER lumen protein-retaining receptor... ER lumen protein-retaining receptor 2	KDELR2	38	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	137	M → V in AAH12994 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036712	118 – 212	ILWTF…LSLPA → YSRERSSVCQHKCQRPSPAS VLQGARTEFLPQQRHKMLDT ENQKLNSFVADSHQWLCKNA EEKSQKVSV in isoform 2. 1 PublicationAdd BLAST		95

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63745 mRNA Translation: CAA45277.1 M88458 mRNA No translation available. AC072052 Genomic DNA Translation: AAS02002.1 AK315702 mRNA Translation: BAG38064.1 CH236963 Genomic DNA Translation: EAL23722.1 CH878731 Genomic DNA Translation: EAW55030.1 BC008081 mRNA Translation: AAH08081.1 BC012994 mRNA Translation: AAH12994.1 BC071982 mRNA Translation: AAH71982.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43550.1 [P33947-2] CCDS5351.1 [P33947-1]
PIRⁱ	A42286
NCBI Reference Sequences More...RefSeqⁱ	NP_001094073.1, NM_001100603.1 [P33947-2] NP_006845.1, NM_006854.3 [P33947-1]
UniGeneⁱ	Hs.654552

Genome annotation databases

Ensemblⁱ	ENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1] ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2]
GeneIDⁱ	11014
KEGGⁱ	hsa:11014
UCSC genome browser More...UCSCⁱ	uc003sqe.5 human [P33947-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P33947	ER lumen protein-retaining receptor		HUMAN		212	UniRef100_P33947
ER lumen protein-retaining receptor		MACMU		212
ER lumen protein-retaining receptor		CALJA		212
ER lumen protein-retaining receptor		PANTR		212
ER lumen protein-retaining receptor		PONAB		212
+9
P33947-2	KDELR2 isoform 5		PANTR		186	UniRef100_A0A2I3RMU2
KDELR2 isoform 5		PONAB		186
Uncharacterized protein		CERAT		186
Uncharacterized protein		PAPAN		186
Uncharacterized protein		MANLE		155
+1

Protein	Similar proteins		Species	Score	Length	Source
P33947	ER lumen protein-retaining receptor 2		CHICK		212	UniRef90_P33947
ER lumen protein-retaining receptor 2		XENTR		212
ER lumen protein-retaining receptor		HUMAN		212
ER lumen protein-retaining receptor		MACMU		212
ER lumen protein-retaining receptor		CALJA		212
+113
P33947-2	Uncharacterized protein		CALJA		207	UniRef90_F6ZGC3
KDELR2 isoform 5		PANTR		186
KDELR2 isoform 5		PONAB		186
Uncharacterized protein		CERAT		186
Uncharacterized protein		PAPAN		186
+22

Protein	Similar proteins		Species	Score	Length	Source
P33947	ER lumen protein-retaining receptor 2		XENTR		212	UniRef50_P33947
ER lumen protein-retaining receptor 2		CHICK		212
ER lumen protein-retaining receptor		HUMAN		212
ER lumen protein-retaining receptor		MACMU		212
ER lumen protein-retaining receptor		CALJA		212
+161
P33947-2	Uncharacterized protein		CALJA		207	UniRef50_F6ZGC3
KDELR2 isoform 5		PANTR		186
KDELR2 isoform 5		PONAB		186
Uncharacterized protein		CERAT		186
Uncharacterized protein		PAPAN		186
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X63745 mRNA Translation: CAA45277.1 M88458 mRNA No translation available. AC072052 Genomic DNA Translation: AAS02002.1 AK315702 mRNA Translation: BAG38064.1 CH236963 Genomic DNA Translation: EAL23722.1 CH878731 Genomic DNA Translation: EAW55030.1 BC008081 mRNA Translation: AAH08081.1 BC012994 mRNA Translation: AAH12994.1 BC071982 mRNA Translation: AAH71982.1
CCDSⁱ	CCDS43550.1 [P33947-2] CCDS5351.1 [P33947-1]
PIRⁱ	A42286
RefSeqⁱ	NP_001094073.1, NM_001100603.1 [P33947-2] NP_006845.1, NM_006854.3 [P33947-1]
UniGeneⁱ	Hs.654552

3D structure databases

ProteinModelPortalⁱ	P33947
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116204, 16 interactors
IntActⁱ	P33947, 7 interactors
MINTⁱ	P33947
STRINGⁱ	9606.ENSP00000258739

PTM databases

iPTMnetⁱ	P33947
PhosphoSitePlusⁱ	P33947
SwissPalmⁱ	P33947

Polymorphism and mutation databases

BioMutaⁱ	KDELR2
DMDMⁱ	462018

Proteomic databases

EPDⁱ	P33947
MaxQBⁱ	P33947
PaxDbⁱ	P33947
PeptideAtlasⁱ	P33947
PRIDEⁱ	P33947
ProteomicsDBⁱ	54930 54931 [P33947-2]
TopDownProteomicsⁱ	P33947-1 [P33947-1] P33947-2 [P33947-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	11014
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1] ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2]
GeneIDⁱ	11014
KEGGⁱ	hsa:11014
UCSCⁱ	uc003sqe.5 human [P33947-1]

Organism-specific databases

CTDⁱ	11014
DisGeNETⁱ	11014
EuPathDBⁱ	HostDB:ENSG00000136240.9
GeneCardsⁱ	KDELR2
H-InvDBⁱ	HIX0021543
HGNCⁱ	HGNC:6305 KDELR2
HPAⁱ	HPA016459
MIMⁱ	609024 gene
neXtProtⁱ	NX_P33947
OpenTargetsⁱ	ENSG00000136240
PharmGKBⁱ	PA30084
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3106 Eukaryota COG5196 LUCA
GeneTreeⁱ	ENSGT00390000004010
HOGENOMⁱ	HOG000231400
HOVERGENⁱ	HBG001398
InParanoidⁱ	P33947
KOⁱ	K10949
OMAⁱ	QTTRSCR
OrthoDBⁱ	EOG091G0Q1H
PhylomeDBⁱ	P33947
TreeFamⁱ	TF314792

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Reactomeⁱ

R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

GeneWikiⁱ	KDELR2
GenomeRNAiⁱ	11014
Protein Ontology More...PROⁱ	PR:P33947
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136240 Expressed in 240 organ(s), highest expression level in tibia
CleanExⁱ	HS_KDELR2
ExpressionAtlasⁱ	P33947 baseline and differential
Genevisibleⁱ	P33947 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000133 ER_ret_rcpt
PANTHERⁱ	PTHR10585 PTHR10585, 1 hit
Pfamⁱ	View protein in Pfam PF00810 ER_lumen_recept, 1 hit
PRINTSⁱ	PR00660 ERLUMENR
PROSITEⁱ	View protein in PROSITE PS00951 ER_LUMEN_RECEPTOR_1, 1 hit PS00952 ER_LUMEN_RECEPTOR_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ERD22_HUMAN
Accessionⁱ	P33947Primary (citable) accession number: P33947 Secondary accession number(s): A4D2P4, Q6IPC5, Q96E30
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	February 1, 1994
	Last modified:	November 7, 2018
	This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P33947 (ERD22_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

ER lumen protein-retaining receptor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ