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Protein

ER lumen protein-retaining receptor 2

Gene

KDELR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L.

GO - Molecular functioni

  • KDEL sequence binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Names & Taxonomyi

Protein namesi
Recommended name:
ER lumen protein-retaining receptor 2
Alternative name(s):
ERD2-like protein 1
Short name:
ELP-1
KDEL endoplasmic reticulum protein retention receptor 2
Short name:
KDEL receptor 2
Gene namesi
Name:KDELR2
Synonyms:ERD2.2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000136240.9
HGNCiHGNC:6305 KDELR2
MIMi609024 gene
neXtProtiNX_P33947

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2LumenalSequence analysis2
Transmembranei3 – 21HelicalSequence analysisAdd BLAST19
Topological domaini22 – 35CytoplasmicSequence analysisAdd BLAST14
Transmembranei36 – 53HelicalSequence analysisAdd BLAST18
Topological domaini54 – 61LumenalSequence analysis8
Transmembranei62 – 80HelicalSequence analysisAdd BLAST19
Topological domaini81 – 96CytoplasmicSequence analysisAdd BLAST16
Transmembranei97 – 110HelicalSequence analysisAdd BLAST14
Topological domaini111 – 117LumenalSequence analysis7
Transmembranei118 – 137HelicalSequence analysisAdd BLAST20
Topological domaini138 – 149CytoplasmicSequence analysisAdd BLAST12
Transmembranei150 – 168HelicalSequence analysisAdd BLAST19
Topological domaini169 – 178LumenalSequence analysis10
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Topological domaini200 – 212CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11014
OpenTargetsiENSG00000136240
PharmGKBiPA30084

Polymorphism and mutation databases

BioMutaiKDELR2
DMDMi462018

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001941551 – 212ER lumen protein-retaining receptor 2Add BLAST212

Proteomic databases

EPDiP33947
MaxQBiP33947
PaxDbiP33947
PeptideAtlasiP33947
PRIDEiP33947
ProteomicsDBi54930
54931 [P33947-2]
TopDownProteomicsiP33947-1 [P33947-1]
P33947-2 [P33947-2]

PTM databases

iPTMnetiP33947
PhosphoSitePlusiP33947
SwissPalmiP33947

Expressioni

Gene expression databases

BgeeiENSG00000136240 Expressed in 240 organ(s), highest expression level in tibia
CleanExiHS_KDELR2
ExpressionAtlasiP33947 baseline and differential
GenevisibleiP33947 HS

Organism-specific databases

HPAiHPA016459

Interactioni

Protein-protein interaction databases

BioGridi116204, 16 interactors
IntActiP33947, 7 interactors
MINTiP33947
STRINGi9606.ENSP00000258739

Structurei

3D structure databases

ProteinModelPortaliP33947
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERD2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOGENOMiHOG000231400
HOVERGENiHBG001398
InParanoidiP33947
KOiK10949
OMAiQTTRSCR
OrthoDBiEOG091G0Q1H
PhylomeDBiP33947
TreeFamiTF314792

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P33947-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNIFRLTGDL SHLAAIVILL LKIWKTRSCA GISGKSQLLF ALVFTTRYLD
60 70 80 90 100
LFTSFISLYN TSMKVIYLAC SYATVYLIYL KFKATYDGNH DTFRVEFLVV
110 120 130 140 150
PVGGLSFLVN HDFSPLEILW TFSIYLESVA ILPQLFMISK TGEAETITTH
160 170 180 190 200
YLFFLGLYRA LYLVNWIWRF YFEGFFDLIA VVAGVVQTIL YCDFFYLYIT
210
KVLKGKKLSL PA
Length:212
Mass (Da):24,422
Last modified:February 1, 1994 - v1
Checksum:i81BECB983E503142
GO
Isoform 2 (identifier: P33947-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-212: ILWTFSIYLE...LKGKKLSLPA → YSRERSSVCQ...AEEKSQKVSV

Show »
Length:186
Mass (Da):21,242
Checksum:iB7224397F0243996
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYF7H7BYF7_HUMAN
ER lumen protein-retaining receptor...
KDELR2
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti137M → V in AAH12994 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036712118 – 212ILWTF…LSLPA → YSRERSSVCQHKCQRPSPAS VLQGARTEFLPQQRHKMLDT ENQKLNSFVADSHQWLCKNA EEKSQKVSV in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63745 mRNA Translation: CAA45277.1
M88458 mRNA No translation available.
AC072052 Genomic DNA Translation: AAS02002.1
AK315702 mRNA Translation: BAG38064.1
CH236963 Genomic DNA Translation: EAL23722.1
CH878731 Genomic DNA Translation: EAW55030.1
BC008081 mRNA Translation: AAH08081.1
BC012994 mRNA Translation: AAH12994.1
BC071982 mRNA Translation: AAH71982.1
CCDSiCCDS43550.1 [P33947-2]
CCDS5351.1 [P33947-1]
PIRiA42286
RefSeqiNP_001094073.1, NM_001100603.1 [P33947-2]
NP_006845.1, NM_006854.3 [P33947-1]
UniGeneiHs.654552

Genome annotation databases

EnsembliENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1]
ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2]
GeneIDi11014
KEGGihsa:11014
UCSCiuc003sqe.5 human [P33947-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63745 mRNA Translation: CAA45277.1
M88458 mRNA No translation available.
AC072052 Genomic DNA Translation: AAS02002.1
AK315702 mRNA Translation: BAG38064.1
CH236963 Genomic DNA Translation: EAL23722.1
CH878731 Genomic DNA Translation: EAW55030.1
BC008081 mRNA Translation: AAH08081.1
BC012994 mRNA Translation: AAH12994.1
BC071982 mRNA Translation: AAH71982.1
CCDSiCCDS43550.1 [P33947-2]
CCDS5351.1 [P33947-1]
PIRiA42286
RefSeqiNP_001094073.1, NM_001100603.1 [P33947-2]
NP_006845.1, NM_006854.3 [P33947-1]
UniGeneiHs.654552

3D structure databases

ProteinModelPortaliP33947
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116204, 16 interactors
IntActiP33947, 7 interactors
MINTiP33947
STRINGi9606.ENSP00000258739

PTM databases

iPTMnetiP33947
PhosphoSitePlusiP33947
SwissPalmiP33947

Polymorphism and mutation databases

BioMutaiKDELR2
DMDMi462018

Proteomic databases

EPDiP33947
MaxQBiP33947
PaxDbiP33947
PeptideAtlasiP33947
PRIDEiP33947
ProteomicsDBi54930
54931 [P33947-2]
TopDownProteomicsiP33947-1 [P33947-1]
P33947-2 [P33947-2]

Protocols and materials databases

DNASUi11014
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258739; ENSP00000258739; ENSG00000136240 [P33947-1]
ENST00000490996; ENSP00000420501; ENSG00000136240 [P33947-2]
GeneIDi11014
KEGGihsa:11014
UCSCiuc003sqe.5 human [P33947-1]

Organism-specific databases

CTDi11014
DisGeNETi11014
EuPathDBiHostDB:ENSG00000136240.9
GeneCardsiKDELR2
H-InvDBiHIX0021543
HGNCiHGNC:6305 KDELR2
HPAiHPA016459
MIMi609024 gene
neXtProtiNX_P33947
OpenTargetsiENSG00000136240
PharmGKBiPA30084
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3106 Eukaryota
COG5196 LUCA
GeneTreeiENSGT00390000004010
HOGENOMiHOG000231400
HOVERGENiHBG001398
InParanoidiP33947
KOiK10949
OMAiQTTRSCR
OrthoDBiEOG091G0Q1H
PhylomeDBiP33947
TreeFamiTF314792

Enzyme and pathway databases

ReactomeiR-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

GeneWikiiKDELR2
GenomeRNAii11014
PROiPR:P33947
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136240 Expressed in 240 organ(s), highest expression level in tibia
CleanExiHS_KDELR2
ExpressionAtlasiP33947 baseline and differential
GenevisibleiP33947 HS

Family and domain databases

InterProiView protein in InterPro
IPR000133 ER_ret_rcpt
PANTHERiPTHR10585 PTHR10585, 1 hit
PfamiView protein in Pfam
PF00810 ER_lumen_recept, 1 hit
PRINTSiPR00660 ERLUMENR
PROSITEiView protein in PROSITE
PS00951 ER_LUMEN_RECEPTOR_1, 1 hit
PS00952 ER_LUMEN_RECEPTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERD22_HUMAN
AccessioniPrimary (citable) accession number: P33947
Secondary accession number(s): A4D2P4, Q6IPC5, Q96E30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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