UniProtKB - P33931 (CCMA_ECOLI)
Protein
Cytochrome c biogenesis ATP-binding export protein CcmA
Gene
ccmA
Organism
Escherichia coli (strain K12)
Status
Functioni
Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system.
Catalytic activityi
- EC:7.6.2.5UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 36 – 43 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: EcoCyc
- ATPase-coupled heme transmembrane transporter activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- cytochrome complex assembly Source: UniProtKB-KW
- heme transport Source: EcoCyc
Keywordsi
Molecular function | Translocase |
Biological process | Cytochrome c-type biogenesis, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:CCMA-MONOMER MetaCyc:CCMA-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c biogenesis ATP-binding export protein CcmAUniRule annotation (EC:7.6.2.5UniRule annotation)Alternative name(s): Heme exporter protein AUniRule annotation |
Gene namesi | Name:ccmAUniRule annotation Synonyms:yejW Ordered Locus Names:b2201, JW5366 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
- Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation
GO - Cellular componenti
- ATP-binding cassette (ABC) transporter complex Source: EcoCyc
- extrinsic component of cytoplasmic side of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000092177 | 1 – 207 | Cytochrome c biogenesis ATP-binding export protein CcmAAdd BLAST | 207 |
Proteomic databases
jPOSTi | P33931 |
PaxDbi | P33931 |
PRIDEi | P33931 |
Interactioni
Subunit structurei
The complex is composed of two ATP-binding proteins (CcmA) and two transmembrane proteins (CcmB).
UniRule annotationBinary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 4261550, 10 interactors 851055, 2 interactors |
ComplexPortali | CPX-3568, CcmABCDE system I cytochrome c biogenesis complex |
IntActi | P33931, 5 interactors |
STRINGi | 511145.b2201 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 207 | ABC transporterUniRule annotationAdd BLAST | 204 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. [View classification]UniRule annotation
Phylogenomic databases
eggNOGi | COG4133, Bacteria |
HOGENOMi | CLU_000604_1_2_6 |
InParanoidi | P33931 |
PhylomeDBi | P33931 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR005895, ABC_transptr_haem_export_CcmA IPR027417, P-loop_NTPase |
PANTHERi | PTHR43499, PTHR43499, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01189, ccmA, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51243, CCMA, 1 hit |
i Sequence
Sequence statusi: Complete.
P33931-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGMLEARELL CERDERTLFS GLSFTLNAGE WVQITGSNGA GKTTLLRLLT
60 70 80 90 100
GLSRPDAGEV LWQGQPLHQV RDSYHQNLLW IGHQPGIKTR LTALENLHFY
110 120 130 140 150
HRDGDTAQCL EALAQAGLAG FEDIPVNQLS AGQQRRVALA RLWLTRATLW
160 170 180 190 200
ILDEPFTAID VNGVDRLTQR MAQHTEQGGI VILTTHQPLN VAESKIRRIS
LTQTRAA
Sequence cautioni
The sequence AAA16393 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16393.1 Different initiation. U00096 Genomic DNA Translation: AAC75261.2 AP009048 Genomic DNA Translation: BAE76664.1 |
PIRi | G64989 |
RefSeqi | NP_416705.2, NC_000913.3 |
Genome annotation databases
EnsemblBacteriai | AAC75261; AAC75261; b2201 BAE76664; BAE76664; BAE76664 |
GeneIDi | 946714 |
KEGGi | ecj:JW5366 eco:b2201 |
PATRICi | fig|511145.12.peg.2290 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16393.1 Different initiation. U00096 Genomic DNA Translation: AAC75261.2 AP009048 Genomic DNA Translation: BAE76664.1 |
PIRi | G64989 |
RefSeqi | NP_416705.2, NC_000913.3 |
3D structure databases
SMRi | P33931 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261550, 10 interactors 851055, 2 interactors |
ComplexPortali | CPX-3568, CcmABCDE system I cytochrome c biogenesis complex |
IntActi | P33931, 5 interactors |
STRINGi | 511145.b2201 |
Proteomic databases
jPOSTi | P33931 |
PaxDbi | P33931 |
PRIDEi | P33931 |
Genome annotation databases
EnsemblBacteriai | AAC75261; AAC75261; b2201 BAE76664; BAE76664; BAE76664 |
GeneIDi | 946714 |
KEGGi | ecj:JW5366 eco:b2201 |
PATRICi | fig|511145.12.peg.2290 |
Organism-specific databases
EchoBASEi | EB1989 |
Phylogenomic databases
eggNOGi | COG4133, Bacteria |
HOGENOMi | CLU_000604_1_2_6 |
InParanoidi | P33931 |
PhylomeDBi | P33931 |
Enzyme and pathway databases
BioCyci | EcoCyc:CCMA-MONOMER MetaCyc:CCMA-MONOMER |
Miscellaneous databases
PROi | PR:P33931 |
Family and domain databases
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR005895, ABC_transptr_haem_export_CcmA IPR027417, P-loop_NTPase |
PANTHERi | PTHR43499, PTHR43499, 1 hit |
Pfami | View protein in Pfam PF00005, ABC_tran, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01189, ccmA, 1 hit |
PROSITEi | View protein in PROSITE PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 1 hit PS51243, CCMA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCMA_ECOLI | |
Accessioni | P33931Primary (citable) accession number: P33931 Secondary accession number(s): Q2MAP2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families