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UniProtKB - P33927 (CCMF_ECOLI)

Entry version 144 (02 Jun 2021)
Sequence version 1 (01 Feb 1994)
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Protein

Cytochrome c-type biogenesis protein CcmF

Gene

ccmF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCytochrome c-type biogenesis

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG12054-MONOMER
MetaCyc:EG12054-MONOMER

Protein family/group databases

Transport Classification Database

More...TCDBi		9.B.14.1.3, the putative heme handling protein (hhp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ccmF
Synonyms:yejR
Ordered Locus Names:b2196, JW2184
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8PeriplasmicSequence analysis8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 41CytoplasmicSequence analysisAdd BLAST12
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 93PeriplasmicSequence analysisAdd BLAST31
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 120CytoplasmicSequence analysis6
Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Topological domaini142 – 175PeriplasmicSequence analysisAdd BLAST34
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 210CytoplasmicSequence analysisAdd BLAST14
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 235PeriplasmicSequence analysis4
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 273CytoplasmicSequence analysisAdd BLAST17
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 311PeriplasmicSequence analysisAdd BLAST17
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 350CytoplasmicSequence analysisAdd BLAST18
Transmembranei351 – 371HelicalSequence analysisAdd BLAST21
Topological domaini372 – 389PeriplasmicSequence analysisAdd BLAST18
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Topological domaini411 – 424CytoplasmicSequence analysisAdd BLAST14
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21
Topological domaini446 – 447PeriplasmicSequence analysis2
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 481CytoplasmicSequence analysisAdd BLAST13
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 608PeriplasmicSequence analysisAdd BLAST106
Transmembranei609 – 629HelicalSequence analysisAdd BLAST21
Topological domaini630 – 647CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002015831 – 647Cytochrome c-type biogenesis protein CcmFAdd BLAST647

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P33927

PRoteomics IDEntifications database

More...PRIDEi		P33927

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260482, 42 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3569, CcmFH system I cytochrome c biogenesis complex

Database of interacting proteins

More...DIPi		DIP-9256N

Protein interaction database and analysis system

More...IntActi		P33927, 3 interactors

Molecular INTeraction database

More...MINTi		P33927

STRING: functional protein association networks

More...STRINGi		511145.b2196

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1138, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_015041_3_0_6

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P33927

Database for complete collections of gene phylogenies

More...PhylomeDBi		P33927

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032523, CcmF_C
IPR002541, Cyt_c_assembly
IPR003567, Cyt_c_biogenesis
IPR003568, Cyt_c_biogenesis_CcmF

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16327, CcmF_C, 1 hit
PF01578, Cytochrom_C_asm, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01410, CCBIOGENESIS
PR01411, CCMFBIOGNSIS

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00353, nrfE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P33927-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPEIGNGLL CLALGIALLL SVYPLWGVAR GDARMMASSR LFAWLLFMSV 
        60         70         80         90        100
AGAFLVLVNA FVVNDFTVTY VASNSNTQLP VWYRVAATWG AHEGSLLLWV 
       110        120        130        140        150
LLMSGWTFAV AIFSQRIPLD IVARVLAIMG MVSVGFLLFI LFTSNPFSRT 
       160        170        180        190        200
LPNFPIEGRD LNPLLQDPGL IFHPPLLYMG YVGFSVAFAF AIASLLSGRL 
       210        220        230        240        250
DSTYARFTRP WTLAAWIFLT LGIVLGSAWA YYELGWGGWW FWDPVENASF 
       260        270        280        290        300
MPWLVGTALM HSLAVTEQRA SFKAWTLLLA ISAFSLCLLG TFLVRSGVLV 
       310        320        330        340        350
SVHAFASDPA RGMFILAFMV LVIGGSLLLF AARGHKVRSR VNNALWSRES 
       360        370        380        390        400
LLLANNVLLV AAMLVVLLGT LLPLVHKQLG LGSISIGEPF FNTMFTWLMV 
       410        420        430        440        450
PFALLLGVGP LVRWGRDRPR KIRNLLIIAF ISTLVLSLLL PWLFESKVVA 
       460        470        480        490        500
MTVLGLAMAC WIAVLAIAEA ALRISRGTKT TFSYWGMVAA HLGLAVTIVG 
       510        520        530        540        550
IAFSQNYSVE RDVRMKSGDS VDIHEYRFTF RDVKEVTGPN WRGGVATIGV 
       560        570        580        590        600
TRDGKPETVL YAEKRYYNTA GSMMTEAAID GGITRDLYAA LGEELENGAW 
       610        620        630        640 
AVRLYYKPFV RWIWAGGLMM ALGGLLCLFD PRYRKRVSPQ KTAPEAV
Length:647
Mass (Da):71,389
Last modified:February 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i162316A1ED156DA8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16388.1
U00096 Genomic DNA Translation: AAC75256.1
AP009048 Genomic DNA Translation: BAE76659.1

Protein sequence database of the Protein Information Resource

More...PIRi		B64989

NCBI Reference Sequences

More...RefSeqi		NP_416700.1, NC_000913.3
WP_000982447.1, NZ_SSZK01000027.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC75256; AAC75256; b2196
BAE76659; BAE76659; BAE76659

Database of genes from NCBI RefSeq genomes

More...GeneIDi		61754501
948783

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW2184
eco:b2196

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.40

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00008 Genomic DNA Translation: AAA16388.1
U00096 Genomic DNA Translation: AAC75256.1
AP009048 Genomic DNA Translation: BAE76659.1
PIRiB64989
RefSeqiNP_416700.1, NC_000913.3
WP_000982447.1, NZ_SSZK01000027.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi4260482, 42 interactors
ComplexPortaliCPX-3569, CcmFH system I cytochrome c biogenesis complex
DIPiDIP-9256N
IntActiP33927, 3 interactors
MINTiP33927
STRINGi511145.b2196

Protein family/group databases

TCDBi9.B.14.1.3, the putative heme handling protein (hhp) family

Proteomic databases

PaxDbiP33927
PRIDEiP33927

Genome annotation databases

EnsemblBacteriaiAAC75256; AAC75256; b2196
BAE76659; BAE76659; BAE76659
GeneIDi61754501
948783
KEGGiecj:JW2184
eco:b2196
PATRICifig|1411691.4.peg.40

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB1985

Phylogenomic databases

eggNOGiCOG1138, Bacteria
HOGENOMiCLU_015041_3_0_6
InParanoidiP33927
PhylomeDBiP33927

Enzyme and pathway databases

BioCyciEcoCyc:EG12054-MONOMER
MetaCyc:EG12054-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P33927

Family and domain databases

InterProiView protein in InterPro
IPR032523, CcmF_C
IPR002541, Cyt_c_assembly
IPR003567, Cyt_c_biogenesis
IPR003568, Cyt_c_biogenesis_CcmF
PfamiView protein in Pfam
PF16327, CcmF_C, 1 hit
PF01578, Cytochrom_C_asm, 1 hit
PRINTSiPR01410, CCBIOGENESIS
PR01411, CCMFBIOGNSIS
TIGRFAMsiTIGR00353, nrfE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCMF_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P33927
Secondary accession number(s): Q2MAP7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: June 2, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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