UniProtKB - P33927 (CCMF_ECOLI)
Protein
Cytochrome c-type biogenesis protein CcmF
Gene
ccmF
Organism
Escherichia coli (strain K12)
Status
Functioni
Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase.
GO - Molecular functioni
- heme binding Source: EcoCyc
- heme transmembrane transporter activity Source: InterPro
GO - Biological processi
- cytochrome c-heme linkage Source: EcoCyc
Keywordsi
Biological process | Cytochrome c-type biogenesis |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12054-MONOMER MetaCyc:EG12054-MONOMER |
Protein family/group databases
TCDBi | 9.B.14.1.3, the putative heme handling protein (hhp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome c-type biogenesis protein CcmF |
Gene namesi | Name:ccmF Synonyms:yejR Ordered Locus Names:b2196, JW2184 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 8 | PeriplasmicSequence analysis | 8 | |
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 30 – 41 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 42 – 62 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 93 | PeriplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 115 – 120 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 121 – 141 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 142 – 175 | PeriplasmicSequence analysisAdd BLAST | 34 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 210 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 211 – 231 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 232 – 235 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 236 – 256 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 257 – 273 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 274 – 294 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 295 – 311 | PeriplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 333 – 350 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 351 – 371 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 372 – 389 | PeriplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 390 – 410 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 411 – 424 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 447 | PeriplasmicSequence analysis | 2 | |
Transmembranei | 448 – 468 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 469 – 481 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 482 – 502 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 503 – 608 | PeriplasmicSequence analysisAdd BLAST | 106 | |
Transmembranei | 609 – 629 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 630 – 647 | CytoplasmicSequence analysisAdd BLAST | 18 |
GO - Cellular componenti
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000201583 | 1 – 647 | Cytochrome c-type biogenesis protein CcmFAdd BLAST | 647 |
Proteomic databases
PaxDbi | P33927 |
PRIDEi | P33927 |
Interactioni
Binary interactionsi
P33927
With | #Exp. | IntAct |
---|---|---|
ccmH [P0ABM9] | 3 | EBI-763370,EBI-560309 |
Protein-protein interaction databases
BioGRIDi | 4260482, 42 interactors |
ComplexPortali | CPX-3569, CcmFH system I cytochrome c biogenesis complex |
DIPi | DIP-9256N |
IntActi | P33927, 3 interactors |
MINTi | P33927 |
STRINGi | 511145.b2196 |
Family & Domainsi
Sequence similaritiesi
Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1138, Bacteria |
HOGENOMi | CLU_015041_3_0_6 |
InParanoidi | P33927 |
PhylomeDBi | P33927 |
Family and domain databases
InterProi | View protein in InterPro IPR032523, CcmF_C IPR002541, Cyt_c_assembly IPR003567, Cyt_c_biogenesis IPR003568, Cyt_c_biogenesis_CcmF |
Pfami | View protein in Pfam PF16327, CcmF_C, 1 hit PF01578, Cytochrom_C_asm, 1 hit |
PRINTSi | PR01410, CCBIOGENESIS PR01411, CCMFBIOGNSIS |
TIGRFAMsi | TIGR00353, nrfE, 1 hit |
i Sequence
Sequence statusi: Complete.
P33927-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMPEIGNGLL CLALGIALLL SVYPLWGVAR GDARMMASSR LFAWLLFMSV
60 70 80 90 100
AGAFLVLVNA FVVNDFTVTY VASNSNTQLP VWYRVAATWG AHEGSLLLWV
110 120 130 140 150
LLMSGWTFAV AIFSQRIPLD IVARVLAIMG MVSVGFLLFI LFTSNPFSRT
160 170 180 190 200
LPNFPIEGRD LNPLLQDPGL IFHPPLLYMG YVGFSVAFAF AIASLLSGRL
210 220 230 240 250
DSTYARFTRP WTLAAWIFLT LGIVLGSAWA YYELGWGGWW FWDPVENASF
260 270 280 290 300
MPWLVGTALM HSLAVTEQRA SFKAWTLLLA ISAFSLCLLG TFLVRSGVLV
310 320 330 340 350
SVHAFASDPA RGMFILAFMV LVIGGSLLLF AARGHKVRSR VNNALWSRES
360 370 380 390 400
LLLANNVLLV AAMLVVLLGT LLPLVHKQLG LGSISIGEPF FNTMFTWLMV
410 420 430 440 450
PFALLLGVGP LVRWGRDRPR KIRNLLIIAF ISTLVLSLLL PWLFESKVVA
460 470 480 490 500
MTVLGLAMAC WIAVLAIAEA ALRISRGTKT TFSYWGMVAA HLGLAVTIVG
510 520 530 540 550
IAFSQNYSVE RDVRMKSGDS VDIHEYRFTF RDVKEVTGPN WRGGVATIGV
560 570 580 590 600
TRDGKPETVL YAEKRYYNTA GSMMTEAAID GGITRDLYAA LGEELENGAW
610 620 630 640
AVRLYYKPFV RWIWAGGLMM ALGGLLCLFD PRYRKRVSPQ KTAPEAV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16388.1 U00096 Genomic DNA Translation: AAC75256.1 AP009048 Genomic DNA Translation: BAE76659.1 |
PIRi | B64989 |
RefSeqi | NP_416700.1, NC_000913.3 WP_000982447.1, NZ_SSZK01000027.1 |
Genome annotation databases
EnsemblBacteriai | AAC75256; AAC75256; b2196 BAE76659; BAE76659; BAE76659 |
GeneIDi | 948783 |
KEGGi | ecj:JW2184 eco:b2196 |
PATRICi | fig|1411691.4.peg.40 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00008 Genomic DNA Translation: AAA16388.1 U00096 Genomic DNA Translation: AAC75256.1 AP009048 Genomic DNA Translation: BAE76659.1 |
PIRi | B64989 |
RefSeqi | NP_416700.1, NC_000913.3 WP_000982447.1, NZ_SSZK01000027.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4260482, 42 interactors |
ComplexPortali | CPX-3569, CcmFH system I cytochrome c biogenesis complex |
DIPi | DIP-9256N |
IntActi | P33927, 3 interactors |
MINTi | P33927 |
STRINGi | 511145.b2196 |
Protein family/group databases
TCDBi | 9.B.14.1.3, the putative heme handling protein (hhp) family |
Proteomic databases
PaxDbi | P33927 |
PRIDEi | P33927 |
Genome annotation databases
EnsemblBacteriai | AAC75256; AAC75256; b2196 BAE76659; BAE76659; BAE76659 |
GeneIDi | 948783 |
KEGGi | ecj:JW2184 eco:b2196 |
PATRICi | fig|1411691.4.peg.40 |
Organism-specific databases
EchoBASEi | EB1985 |
Phylogenomic databases
eggNOGi | COG1138, Bacteria |
HOGENOMi | CLU_015041_3_0_6 |
InParanoidi | P33927 |
PhylomeDBi | P33927 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12054-MONOMER MetaCyc:EG12054-MONOMER |
Miscellaneous databases
PROi | PR:P33927 |
Family and domain databases
InterProi | View protein in InterPro IPR032523, CcmF_C IPR002541, Cyt_c_assembly IPR003567, Cyt_c_biogenesis IPR003568, Cyt_c_biogenesis_CcmF |
Pfami | View protein in Pfam PF16327, CcmF_C, 1 hit PF01578, Cytochrom_C_asm, 1 hit |
PRINTSi | PR01410, CCBIOGENESIS PR01411, CCMFBIOGNSIS |
TIGRFAMsi | TIGR00353, nrfE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCMF_ECOLI | |
Accessioni | P33927Primary (citable) accession number: P33927 Secondary accession number(s): Q2MAP7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families