MAN1A1

Functionⁱ

Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man₉GlcNAc₂ to produce Man₅GlcNAc₂.

Catalytic activityⁱ

4
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A_1,2,3B_1,2,3)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
= 4
β-D-mannose
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
EC:
3.2.1.113
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
4
H₂O
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 9A_1,2,3B_1,2,3)
N⁴-[α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc]-L-Asn residue
zoom
=
4
β-D-mannose
zoom
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-Asn residue
zoom
3
H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A_1,2,3B_1,3)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
= 3
β-D-mannose
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
EC:
3.2.1.113
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:P32906 (MNS1_YEAST)
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
3
H₂O
+
N⁴-(α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 8A_1,2,3B_1,3)
N⁴-{α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→2)-α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc}-L-Asn residue
zoom
=
3
β-D-mannose
zoom
+
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A_1,2)
N⁴-(α-D-Man-(1→3)-[α-D-Man-(1→3)-[α-D-Man-(1→6)]-α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-β-D-GlcNAc)-L-Asn residue
zoom

Cofactorⁱ

Ca²⁺By similarity

Activity regulationⁱ

Inhibited by both 1-deoxymannojirimycin and kifunensine.

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.By similarity
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	522	Proton donorBy similarity		1

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosidase, Hydrolase
Ligand	Calcium

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS03480-MONOMER
PathwayCommonsⁱ	P33908
Reactomeⁱ	R-HSA-6811438, Intra-Golgi traffic R-HSA-964827, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GH47, Glycoside Hydrolase Family 47

CAZyⁱ

GH47, Glycoside Hydrolase Family 47

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (EC:3.2.1.113By similarity) Alternative name(s): Man(9)-alpha-mannosidase Short name: Man9-mannosidase Mannosidase alpha class 1A member 1 Processing alpha-1,2-mannosidase IA Short name: Alpha-1,2-mannosidase IA
Gene namesⁱ	Name:MAN1A1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000111885.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6821, MAN1A1
MIMⁱ	604344, gene
neXtProtⁱ	NX_P33908

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 41	CytoplasmicSequence analysisAdd BLAST	41
Transmembraneⁱ	42 – 62	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	63 – 653	LumenalSequence analysisAdd BLAST	591

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4121
Open Targets More...OpenTargetsⁱ	ENSG00000111885
PharmGKBⁱ	PA30570

Miscellaneous databases

Pharosⁱ	P33908, Tbio

Pharosⁱ

P33908, Tbio

Chemistry databases

ChEMBLⁱ	CHEMBL5915

ChEMBLⁱ

CHEMBL5915

Polymorphism and mutation databases

BioMutaⁱ	MAN1A1
DMDMⁱ	62906886

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000210308	1 – 653	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IAAdd BLAST		653

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	476 ↔ 508	By similarity
Glycosylationⁱ	513	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P33908
jPOSTⁱ	P33908
MassIVEⁱ	P33908
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P33908
PaxDbⁱ	P33908
PeptideAtlas More...PeptideAtlasⁱ	P33908
PRIDEⁱ	P33908
ProteomicsDBⁱ	54929 [P33908-1] 66803
TopDownProteomicsⁱ	P33908-1 [P33908-1]

PTM databases

GlyGenⁱ	P33908, 1 site
iPTMnetⁱ	P33908
PhosphoSitePlusⁱ	P33908

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000111885, Expressed in synovial joint and 249 other tissues
Genevisibleⁱ	P33908, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000111885, Tissue enhanced (liver)

HPAⁱ

ENSG00000111885, Tissue enhanced (liver)

Interactionⁱ

Protein-protein interaction databases

BioGRIDⁱ	110294, 56 interactors
IntActⁱ	P33908, 13 interactors
Molecular INTeraction database More...MINTⁱ	P33908
STRINGⁱ	9606.ENSP00000357453

Miscellaneous databases

RNActⁱ	P33908, protein

RNActⁱ

P33908, protein

Structureⁱ

3D structure databases

SMRⁱ	P33908
ModBaseⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycosyl hydrolase 47 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2204, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158188
HOGENOMⁱ	CLU_003818_3_2_1
InParanoidⁱ	P33908
KEGG Orthology (KO) More...KOⁱ	K01230
OMAⁱ	QKVMNIR
Database of Orthologous Groups More...OrthoDBⁱ	693882at2759
PhylomeDBⁱ	P33908
TreeFamⁱ	TF313420

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01532, Glyco_hydro_47, 1 hit
PRINTSⁱ	PR00747, GLYHDRLASE47
SUPFAMⁱ	SSF48225, SSF48225, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P33908-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA 
        60         70         80         90        100
FITLCFGAIF FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG 
       110        120        130        140        150
RARRREEGAP GDPEAALEDN LARIRENHER ALREAKETLQ KLPEEIQRDI 
       160        170        180        190        200
LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI GVESREPADA AIREKRAKIK 
       210        220        230        240        250
EMMKHAWNNY KGYAWGLNEL KPISKGGHSS SLFGNIKGAT IVDALDTLFI 
       260        270        280        290        300
MEMKHEFEEA KSWVEENLDF NVNAEISVFE VNIRFVGGLL SAYYLSGEEI 
       310        320        330        340        350
FRKKAVELGV KLLPAFHTPS GIPWALLNMK SGIGRNWPWA SGGSSILAEF 
       360        370        380        390        400
GTLHLEFMHL SHLSGNPIFA EKVMNIRTVL NKLEKPQGLY PNYLNPSSGQ 
       410        420        430        440        450
WGQHHVSVGG LGDSFYEYLL KAWLMSDKTD LEAKKMYFDA VQAIETHLIR 
       460        470        480        490        500
KSSSGLTYIA EWKGGLLEHK MGHLTCFAGG MFALGADAAP EGMAQHYLEL 
       510        520        530        540        550
GAEIARTCHE SYNRTFMKLG PEAFRFDGGV EAIATRQNEK YYILRPEVME 
       560        570        580        590        600
TYMYMWRLTH DPKYRKWAWE AVEALENHCR VNGGYSGLRD VYLLHESYDD 
       610        620        630        640        650
VQQSFFLAET LKYLYLIFSD DDLLPLEHWI FNSEAHLLPI LPKDKKEVEI 

REE

Length:653

Mass (Da):72,969

Last modified:April 26, 2005 - v3

Checksum:ⁱ9B164926636D8554

GO

Isoform 2 (identifier: P33908-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: E → EEIEARKGQANCPGSSSSCEVEIQ
     331-344: SGIGRNWPWASGGS → RWMCNIPRAMEATI
     345-653: Missing.

« Hide

        10         20         30         40         50
MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA 
        60         70         80         90        100
FITLCFGAIF FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG 
       110        120        130        140        150
RARRREEGAP GDPEAALEDN LARIRENHER ALREAKETLQ KLPEEIQRDI 
       160        170        180        190        200
LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI GVESREPADA AIREKRAKIK 
       210        220        230        240        250
EEIEARKGQA NCPGSSSSCE VEIQMMKHAW NNYKGYAWGL NELKPISKGG 
       260        270        280        290        300
HSSSLFGNIK GATIVDALDT LFIMEMKHEF EEAKSWVEEN LDFNVNAEIS 
       310        320        330        340        350
VFEVNIRFVG GLLSAYYLSG EEIFRKKAVE LGVKLLPAFH TPSGIPWALL 
       360 
NMKRWMCNIP RAMEATI

Show »

Length:367

Mass (Da):40,037

Checksum:ⁱ3A5E1D30321CAFF8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	29 – 47	KGSGP…VLLLV → MNSNFITFDLKMSLLPSNL in CAA52831 (PubMed:8223597).CuratedAdd BLAST		19
Sequence conflictⁱ	464	G → R in CAA52831 (PubMed:8223597).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034102	651	R → G. Corresponds to variant dbSNP:rs35544784Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_056372	201	E → EEIEARKGQANCPGSSSSCE VEIQ in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_056373	331 – 344	SGIGR…ASGGS → RWMCNIPRAMEATI in isoform 2. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_056374	345 – 653	Missing in isoform 2. 1 PublicationAdd BLAST	309

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL022722 Genomic DNA No translation available. AL078600 Genomic DNA No translation available. AL138886 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48185.1 BC065827 mRNA Translation: AAH65827.1 X74837 mRNA Translation: CAA52831.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5122.1 [P33908-1]
PIRⁱ	S38965
NCBI Reference Sequences More...RefSeqⁱ	NP_005898.2, NM_005907.3 [P33908-1]

Genome annotation databases

Ensemblⁱ	ENST00000368468; ENSP00000357453; ENSG00000111885 [P33908-1]
GeneIDⁱ	4121
KEGGⁱ	hsa:4121
UCSC genome browser More...UCSCⁱ	uc003pym.3, human [P33908-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P33908	alpha-1,2-Mannosidase		PONAB		813	UniRef90_P33908
alpha-1,2-Mannosidase		MACMU		736
alpha-1,2-Mannosidase		MACFA		653
alpha-1,2-Mannosidase		CALJA		681
alpha-1,2-Mannosidase		PANPA		679
+27

Protein	Similar proteins		Species	Score	Length	Source
P33908	Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB		MOUSE		641	UniRef50_P33908
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB		HUMAN		641
alpha-1,2-Mannosidase		PONAB		813
alpha-1,2-Mannosidase		MACMU		736
alpha-1,2-Mannosidase		MACFA		653
+438

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL022722 Genomic DNA No translation available. AL078600 Genomic DNA No translation available. AL138886 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48185.1 BC065827 mRNA Translation: AAH65827.1 X74837 mRNA Translation: CAA52831.1
CCDSⁱ	CCDS5122.1 [P33908-1]
PIRⁱ	S38965
RefSeqⁱ	NP_005898.2, NM_005907.3 [P33908-1]

3D structure databases

SMRⁱ	P33908
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	110294, 56 interactors
IntActⁱ	P33908, 13 interactors
MINTⁱ	P33908
STRINGⁱ	9606.ENSP00000357453

Chemistry databases

ChEMBLⁱ	CHEMBL5915

ChEMBLⁱ

CHEMBL5915

Protein family/group databases

CAZyⁱ	GH47, Glycoside Hydrolase Family 47

CAZyⁱ

GH47, Glycoside Hydrolase Family 47

PTM databases

GlyGenⁱ	P33908, 1 site
iPTMnetⁱ	P33908
PhosphoSitePlusⁱ	P33908

Polymorphism and mutation databases

BioMutaⁱ	MAN1A1
DMDMⁱ	62906886

Proteomic databases

EPDⁱ	P33908
jPOSTⁱ	P33908
MassIVEⁱ	P33908
MaxQBⁱ	P33908
PaxDbⁱ	P33908
PeptideAtlasⁱ	P33908
PRIDEⁱ	P33908
ProteomicsDBⁱ	54929 [P33908-1] 66803
TopDownProteomicsⁱ	P33908-1 [P33908-1]

Protocols and materials databases

Antibodypediaⁱ	32605, 78 antibodies

Antibodypediaⁱ

32605, 78 antibodies

Genome annotation databases

Ensemblⁱ	ENST00000368468; ENSP00000357453; ENSG00000111885 [P33908-1]
GeneIDⁱ	4121
KEGGⁱ	hsa:4121
UCSCⁱ	uc003pym.3, human [P33908-1]

Organism-specific databases

CTDⁱ	4121
DisGeNETⁱ	4121
EuPathDBⁱ	HostDB:ENSG00000111885.6
GeneCardsⁱ	MAN1A1
HGNCⁱ	HGNC:6821, MAN1A1
HPAⁱ	ENSG00000111885, Tissue enhanced (liver)
MIMⁱ	604344, gene
neXtProtⁱ	NX_P33908
OpenTargetsⁱ	ENSG00000111885
PharmGKBⁱ	PA30570
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2204, Eukaryota
GeneTreeⁱ	ENSGT00940000158188
HOGENOMⁱ	CLU_003818_3_2_1
InParanoidⁱ	P33908
KOⁱ	K01230
OMAⁱ	QKVMNIR
OrthoDBⁱ	693882at2759
PhylomeDBⁱ	P33908
TreeFamⁱ	TF313420

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BioCycⁱ	MetaCyc:HS03480-MONOMER
PathwayCommonsⁱ	P33908
Reactomeⁱ	R-HSA-6811438, Intra-Golgi traffic R-HSA-964827, Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2

Miscellaneous databases

BioGRID-ORCSⁱ	4121, 4 hits in 870 CRISPR screens
ChiTaRSⁱ	MAN1A1, human
GeneWikiⁱ	MAN1A1
GenomeRNAiⁱ	4121
Pharosⁱ	P33908, Tbio
Protein Ontology More...PROⁱ	PR:P33908
RNActⁱ	P33908, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000111885, Expressed in synovial joint and 249 other tissues
Genevisibleⁱ	P33908, HS

Family and domain databases

Gene3Dⁱ	1.50.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR012341, 6hp_glycosidase-like_sf IPR001382, Glyco_hydro_47 IPR036026, Seven-hairpin_glycosidases
Pfamⁱ	View protein in Pfam PF01532, Glyco_hydro_47, 1 hit
PRINTSⁱ	PR00747, GLYHDRLASE47
SUPFAMⁱ	SSF48225, SSF48225, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MA1A1_HUMAN
Accessionⁱ	P33908Primary (citable) accession number: P33908 Secondary accession number(s): E7EU32 , Q6P052, Q9NU44, Q9UJI3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
	Last sequence update:	April 26, 2005
	Last modified:	August 12, 2020
	This is version 183 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families
Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P33908 (MA1A1_HUMAN)

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Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ