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Protein

Interferon alpha/beta receptor 1

Gene

Ifnar1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:1533935, PubMed:14532120, PubMed:23872679). Functions in general as heterodimer with IFNAR2 (By similarity). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:14532120). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679). Contributes to modulate the innate immune response to bacterial lipopolysaccharide (PubMed:23872679).By similarity4 Publications

Miscellaneous

The interferon signaling pathway is not identical between species. Thus, the interaction with STAT1 and STAT2 may not be conserved in mouse; in human it requires phosphorylation at 'Tyr-466', but the mouse protein has a Phe at the equivalent position. Likewise, cysteine palmitoylation is required for the activation of STAT1 and STAT2 in human, but the Cys is not conserved in mouse.Curated

GO - Molecular functioni

  • interferon receptor activity Source: MGI
  • type I interferon binding Source: UniProtKB
  • type I interferon receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha/beta receptor 1
Short name:
IFN-R-1
Short name:
IFN-alpha/beta receptor 1
Alternative name(s):
Type I interferon receptor 1
Gene namesi
Name:Ifnar1
Synonyms:Ifar, Ifnar
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107658 Ifnar1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 429ExtracellularSequence analysisAdd BLAST403
Transmembranei430 – 449HelicalSequence analysisAdd BLAST20
Topological domaini450 – 590CytoplasmicSequence analysisAdd BLAST141

Keywords - Cellular componenti

Cell membrane, Endosome, Lysosome, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice are protected from the lethal septic effects of intraperitoneal LPS administration observed in wild-type mice (PubMed:23872679). Double knockout with TREX1 does not show a visible phenotype (PubMed:18724932).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi526S → A: Abolishes interaction with FBXW11. Prevents interalization from the cell membrane and lysosomal degradation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001100227 – 590Interferon alpha/beta receptor 1Add BLAST564

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi78 ↔ 86By similarity
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi199 ↔ 2201 Publication
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi284 ↔ 2921 Publication
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi370N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi397 ↔ 4191 Publication
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
Cross-linki517Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei526Phosphoserine1 Publication1

Post-translational modificationi

Ubiquitinated (PubMed:14532120). This leads to its internalization and lysosomal degradation. The 'Lys-63'-linked ubiquitin chains are cleaved off by the BRISC complex; this prevents receptor internalization and degradation. Probable ubiquitination sites have been identified in human, but are poorly conserved across species.By similarity1 Publication
Phosphorylated on serine residues in response to interferon binding; this promotes interaction with FBXW11 and ubiquitination (PubMed:14532120). Phosphorylated on tyrosine residues by TYK2 tyrosine kinase. Phosphorylated on tyrosine residues in response to interferon (By similarity).By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP33896
PaxDbiP33896
PRIDEiP33896

PTM databases

iPTMnetiP33896
PhosphoSitePlusiP33896

Expressioni

Gene expression databases

BgeeiENSMUSG00000022967 Expressed in 299 organ(s), highest expression level in retina
CleanExiMM_IFNAR1
ExpressionAtlasiP33896 baseline and differential
GenevisibleiP33896 MM

Interactioni

Subunit structurei

Heterodimer with IFNAR2. Interacts (serine-phosphorylated form) with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:14532120). Interacts with SHMT2; this promotes interaction with ABRAXAS2 and the BRISC complex (By similarity). Interacts with TYK2 (By similarity).By similarityCurated1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP33896, 4 interactors
STRINGi10090.ENSMUSP00000023689

Structurei

Secondary structure

1590
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP33896
SMRiP33896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 125Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST95
Domaini127 – 226Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini230 – 327Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST98
Domaini332 – 425Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni483 – 492Important for interaction with TYK2By similarity10

Sequence similaritiesi

Belongs to the type II cytokine receptor family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKIP Eukaryota
ENOG4111QEU LUCA
GeneTreeiENSGT00530000063449
HOGENOMiHOG000113067
HOVERGENiHBG052126
InParanoidiP33896
KOiK05130
OMAiWIKLPGC
OrthoDBiEOG091G04H5

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR016669 Interferon_alpha/beta_rcpt-1
PfamiView protein in Pfam
PF09294 Interfer-bind, 2 hits
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P33896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLAVVGAAAL VLVAGAPWVL PSAAGGENLK PPENIDVYII DDNYTLKWSS
60 70 80 90 100
HGESMGSVTF SAEYRTKDEA KWLKVPECQH TTTTKCEFSL LDTNVYIKTQ
110 120 130 140 150
FRVRAEEGNS TSSWNEVDPF IPFYTAHMSP PEVRLEAEDK AILVHISPPG
160 170 180 190 200
QDGNMWALEK PSFSYTIRIW QKSSSDKKTI NSTYYVEKIP ELLPETTYCL
210 220 230 240 250
EVKAIHPSLK KHSNYSTVQC ISTTVANKMP VPGNLQVDAQ GKSYVLKWDY
260 270 280 290 300
IASADVLFRA QWLPGYSKSS SGSRSDKWKP IPTCANVQTT HCVFSQDTVY
310 320 330 340 350
TGTFFLHVQA SEGNHTSFWS EEKFIDSQKH ILPPPPVITV TAMSDTLLVY
360 370 380 390 400
VNCQDSTCDG LNYEIIFWEN TSNTKISMEK DGPEFTLKNL QPLTVYCVQA
410 420 430 440 450
RVLFRALLNK TSNFSEKLCE KTRPGSFSTI WIITGLGVVF FSVMVLYALR
460 470 480 490 500
SVWKYLCHVC FPPLKPPRSI DEFFSEPPSK NLVLLTAEEH TERCFIIENT
510 520 530 540 550
DTVAVEVKHA PEEDLRKYSS QTSQDSGNYS NEEEESVGTE SGQAVLSKAP
560 570 580 590
CGGPCSVPSP PGTLEDGTCF LGNEKYLQSP ALRTEPALLC
Length:590
Mass (Da):65,796
Last modified:July 27, 2011 - v2
Checksum:iE887ADFA6DFEAF3C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PWM1E9PWM1_MOUSE
Interferon alpha/beta receptor 1
Ifnar1
135Annotation score:
A0A338P6T9A0A338P6T9_MOUSE
Interferon alpha/beta receptor 1
Ifnar1
77Annotation score:
A0A384DVB8A0A384DVB8_MOUSE
Interferon alpha/beta receptor 1
Ifnar1
283Annotation score:
A0A338P6X7A0A338P6X7_MOUSE
Interferon alpha/beta receptor 1
Ifnar1
35Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274R → H in AAA37890 (PubMed:1533935).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89641 mRNA Translation: AAA37890.1
AK132431 mRNA Translation: BAE21165.1
AK141630 mRNA Translation: BAE24775.1
CH466602 Genomic DNA Translation: EDL03825.1
BC043935 mRNA Translation: AAH43935.1
BC052429 mRNA Translation: AAH52429.1
CCDSiCCDS28326.1
PIRiA45283
RefSeqiNP_034638.2, NM_010508.2
UniGeneiMm.502

Genome annotation databases

EnsembliENSMUST00000023689; ENSMUSP00000023689; ENSMUSG00000022967
ENSMUST00000117748; ENSMUSP00000112670; ENSMUSG00000022967
GeneIDi15975
KEGGimmu:15975
UCSCiuc007zxn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M89641 mRNA Translation: AAA37890.1
AK132431 mRNA Translation: BAE21165.1
AK141630 mRNA Translation: BAE24775.1
CH466602 Genomic DNA Translation: EDL03825.1
BC043935 mRNA Translation: AAH43935.1
BC052429 mRNA Translation: AAH52429.1
CCDSiCCDS28326.1
PIRiA45283
RefSeqiNP_034638.2, NM_010508.2
UniGeneiMm.502

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WCYX-ray2.90A27-429[»]
ProteinModelPortaliP33896
SMRiP33896
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP33896, 4 interactors
STRINGi10090.ENSMUSP00000023689

PTM databases

iPTMnetiP33896
PhosphoSitePlusiP33896

Proteomic databases

MaxQBiP33896
PaxDbiP33896
PRIDEiP33896

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023689; ENSMUSP00000023689; ENSMUSG00000022967
ENSMUST00000117748; ENSMUSP00000112670; ENSMUSG00000022967
GeneIDi15975
KEGGimmu:15975
UCSCiuc007zxn.2 mouse

Organism-specific databases

CTDi3454
MGIiMGI:107658 Ifnar1

Phylogenomic databases

eggNOGiENOG410IKIP Eukaryota
ENOG4111QEU LUCA
GeneTreeiENSGT00530000063449
HOGENOMiHOG000113067
HOVERGENiHBG052126
InParanoidiP33896
KOiK05130
OMAiWIKLPGC
OrthoDBiEOG091G04H5

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling

Miscellaneous databases

ChiTaRSiIfnar1 mouse
PROiPR:P33896
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022967 Expressed in 299 organ(s), highest expression level in retina
CleanExiMM_IFNAR1
ExpressionAtlasiP33896 baseline and differential
GenevisibleiP33896 MM

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR015373 Interferon/interleukin_rcp_dom
IPR016669 Interferon_alpha/beta_rcpt-1
PfamiView protein in Pfam
PF09294 Interfer-bind, 2 hits
PF01108 Tissue_fac, 1 hit
PIRSFiPIRSF016567 IFN_alpha/beta_recept-1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiINAR1_MOUSE
AccessioniPrimary (citable) accession number: P33896
Secondary accession number(s): Q80UJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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