UniProtKB - P33892 (GCN1_YEAST)
eIF-2-alpha kinase activator GCN1
GCN1
Functioni
Miscellaneous
GO - Molecular functioni
- ATP-dependent protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- protein kinase regulator activity Source: SGD
- ribosome binding Source: UniProtKB
- translation initiation factor binding Source: UniProtKB
GO - Biological processi
- cellular response to amino acid starvation Source: UniProtKB
- cellular response to benomyl Source: UniProtKB
- cellular response to hydrogen peroxide Source: UniProtKB
- cellular stress response to acidic pH Source: UniProtKB
- negative regulation of TORC1 signaling Source: SGD
- positive regulation of kinase activity Source: UniProtKB
- positive regulation of macroautophagy Source: SGD
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of translational initiation in response to starvation Source: UniProtKB
- regulation of eIF2 alpha phosphorylation by amino acid starvation Source: UniProtKB
- regulation of translational elongation Source: SGD
Keywordsi
Molecular function | Activator |
Biological process | Stress response, Translation regulation |
Names & Taxonomyi
Protein namesi | Recommended name: eIF-2-alpha kinase activator GCN1CuratedAlternative name(s): General control non-derepressible protein 1Imported Translational activator GCN1Curated |
Gene namesi | Name:GCN1Imported Ordered Locus Names:YGL195W ORF Names:G1318 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003163, GCN1 |
VEuPathDBi | FungiDB:YGL195W |
Subcellular locationi
Other locations
- Cytoplasm 1 Publication
Cytosol
- cytosol Source: SGD
- cytosolic ribosome Source: SGD
Mitochondrion
- mitochondrion Source: SGD
Other locations
- polysomal ribosome Source: UniProtKB
- polysome Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 757 – 758 | KK → AA or DD: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-762; A-765; A-775; 777-A-A-778; 782-A-A-783; 786-A-A-787 and A-790. 2 Publications | 2 | |
Mutagenesisi | 762 | K → A: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-765; A-775; 777-A-A-778; 782-A-A-783; 786-A-A-787 and A-790. 2 Publications | 1 | |
Mutagenesisi | 765 | K → A: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-762; A-775; 777-A-A-778; 782-A-A-783; 786-A-A-787 and A-790. 2 Publications | 1 | |
Mutagenesisi | 775 | K → A: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-762; A-765; 777-A-A-778; 782-A-A-783; 786-A-A-787 and A-790. 2 Publications | 1 | |
Mutagenesisi | 777 – 778 | RK → AA: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-762; A-765; A-775; 782-A-A-783; 786-A-A-787 and A-790. 2 Publications | 2 | |
Mutagenesisi | 782 – 783 | KK → AA: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-762; A-765; A-775; 777-A-A-778; 786-A-A-787 and A-790. 2 Publications | 2 | |
Mutagenesisi | 786 – 787 | KK → AA: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-762; A-765; A-775; 777-A-A-778; 782-A-A-783 and A-790. 2 Publications | 2 | |
Mutagenesisi | 790 | K → A: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20, weakly impairs eIF-2-alpha phosphorylation but strongly impairs eIF-2-alpha phosphorylation in a YEF3-dependent manner; when associated with A-757-758-A; A-762; A-765; A-775; 777-A-A-778; 782-A-A-783 and 786-A-A-787. 2 Publications | 1 | |
Mutagenesisi | 1444 | G → D: Decreases interaction with GCN20 and polysomal association. 1 Publication | 1 | |
Mutagenesisi | 1458 | E → A: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20 and strongly impairs eIF-2-alpha phosphorylation; when associated with 1461-A--A-1465. 1 Publication | 1 | |
Mutagenesisi | 1461 – 1465 | WRTKR → AAAAA: Does not inhibit interaction with GCN20, reduces ribosome binding, ribosome binding by GCN20 and strongly impairs eIF-2-alpha phosphorylation; when associated with A-1458. 1 Publication | 5 | |
Mutagenesisi | 2259 | R → A: Decreases interaction with GCN2 and YIH1 but not with GCN20 and ribosomes. 3 Publications | 1 | |
Mutagenesisi | 2291 | F → L: Does not interact with GCN2, impairs eIF-2-alpha phosphorylation and fails to derepress GCN4 translation in amino acid-starved cells. 1 Publication | 1 | |
Mutagenesisi | 2304 | S → P: Does not interact with GCN2. 1 Publication | 1 | |
Mutagenesisi | 2353 | L → P: Does not interact with GCN2. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087444 | 1 – 2672 | eIF-2-alpha kinase activator GCN1Add BLAST | 2672 |
Proteomic databases
MaxQBi | P33892 |
PaxDbi | P33892 |
PRIDEi | P33892 |
PTM databases
iPTMneti | P33892 |
Interactioni
Subunit structurei
Interacts (via N- and C-terminus) with GCN2 (via N-terminal RWD domain); this interaction stimulates GCN2 kinase activity in a GCN20-dependent manner in response to amino acid starvation (PubMed:10775272, PubMed:11101534, PubMed:10801780, PubMed:11350982, PubMed:15126500, PubMed:15722345, PubMed:21849502).
Interacts (via C-terminus) with GCN20 (via N-terminus); this interaction stimulates GCN2 kinase activity in response to amino acid starvation (PubMed:7621831, PubMed:9234705, PubMed:11101534). The GCN1-GCN20 complex interacts with GCN2 on translating ribosomes in amino acid-starved cells; GCN1 may bind near the ribosomal A-site and promotes the transfer of uncharged tRNAs from the A-site to the tRNA-binding domain in GCN2 for its subsequent kinase activation, and hence allowing GCN4 translational activation and derepression of amino acid biosynthetic genes (PubMed:7621831, PubMed:9234705, PubMed:10775272, PubMed:11101534).
Interacts (via C-terminus) with YIH1 (via N-terminus); this interaction reduces the GCN1-GCN20 complex formation and prevents the interaction of GCN1 with GCN2 and GCN2 kinase activation in amino acid-starved cells (PubMed:15126500, PubMed:21239490, PubMed:22404850).
Interacts with GIR2; this interaction prevents the interaction of GCN1 with GCN2 and GCN2 kinase activation in amino acid-starved cells (PubMed:19448108).
Interacts (via middle region) with RPS10A and RPS10B; these interactions are direct and promote GCN2 kinase activation (PubMed:25437641). Associates (via N-terminus) with ribosomes; this association is stimulated in a ATP- and GCN20-dependent manner and is necessary to activate GCN2 kinase activity (PubMed:7621831, PubMed:9234705, PubMed:11101534, PubMed:15722345, PubMed:19448108, PubMed:21849502, PubMed:22888004, PubMed:25437641).
14 PublicationsBinary interactionsi
P33892
With | #Exp. | IntAct |
---|---|---|
GCN20 [P43535] | 3 | EBI-7442,EBI-7423 |
GO - Molecular functioni
- ATP-dependent protein binding Source: UniProtKB
- protein kinase binding Source: UniProtKB
- translation initiation factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 33062, 469 interactors |
ComplexPortali | CPX-1808, GCN1-GCN20 complex |
DIPi | DIP-2344N |
IntActi | P33892, 134 interactors |
MINTi | P33892 |
STRINGi | 4932.YGL195W |
Miscellaneous databases
RNActi | P33892, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 5 – 42 | HEAT 1Sequence analysisAdd BLAST | 38 | |
Repeati | 79 – 117 | HEAT 2Sequence analysisAdd BLAST | 39 | |
Repeati | 174 – 211 | HEAT 3Sequence analysisAdd BLAST | 38 | |
Repeati | 227 – 267 | HEAT 4Sequence analysisAdd BLAST | 41 | |
Repeati | 329 – 366 | HEAT 5Sequence analysisAdd BLAST | 38 | |
Repeati | 372 – 410 | HEAT 6Sequence analysisAdd BLAST | 39 | |
Repeati | 509 – 549 | HEAT 7Sequence analysisAdd BLAST | 41 | |
Repeati | 611 – 648 | HEAT 8Sequence analysisAdd BLAST | 38 | |
Repeati | 706 – 745 | HEAT 9Sequence analysisAdd BLAST | 40 | |
Repeati | 902 – 932 | HEAT 10Sequence analysisAdd BLAST | 31 | |
Repeati | 933 – 970 | HEAT 11Sequence analysisAdd BLAST | 38 | |
Repeati | 975 – 994 | HEAT 12; degenerateSequence analysisAdd BLAST | 20 | |
Repeati | 995 – 1030 | HEAT 13; degenerateSequence analysisAdd BLAST | 36 | |
Repeati | 1031 – 1067 | HEAT 14Sequence analysisAdd BLAST | 37 | |
Repeati | 1099 – 1138 | HEAT 15Sequence analysisAdd BLAST | 40 | |
Repeati | 1185 – 1224 | HEAT 16Sequence analysisAdd BLAST | 40 | |
Repeati | 1243 – 1281 | HEAT 17Sequence analysisAdd BLAST | 39 | |
Repeati | 1284 – 1321 | HEAT 18Sequence analysisAdd BLAST | 38 | |
Repeati | 1363 – 1401 | HEAT 19Sequence analysisAdd BLAST | 39 | |
Repeati | 1405 – 1442 | HEAT 20Sequence analysisAdd BLAST | 38 | |
Repeati | 1444 – 1480 | HEAT 21Sequence analysisAdd BLAST | 37 | |
Repeati | 1484 – 1521 | HEAT 22Sequence analysisAdd BLAST | 38 | |
Repeati | 1523 – 1559 | HEAT 23Sequence analysisAdd BLAST | 37 | |
Repeati | 1561 – 1598 | HEAT 24Sequence analysisAdd BLAST | 38 | |
Repeati | 1603 – 1640 | HEAT 25Sequence analysisAdd BLAST | 38 | |
Repeati | 1641 – 1679 | HEAT 26Sequence analysisAdd BLAST | 39 | |
Repeati | 1681 – 1717 | HEAT 27Sequence analysisAdd BLAST | 37 | |
Repeati | 1721 – 1758 | HEAT 28Sequence analysisAdd BLAST | 38 | |
Repeati | 1760 – 1796 | HEAT 29Sequence analysisAdd BLAST | 37 | |
Repeati | 1825 – 1862 | HEAT 30Sequence analysisAdd BLAST | 38 | |
Repeati | 1863 – 1903 | HEAT 31Sequence analysisAdd BLAST | 41 | |
Repeati | 1905 – 1942 | HEAT 32Sequence analysisAdd BLAST | 38 | |
Repeati | 1947 – 1984 | HEAT 33Sequence analysisAdd BLAST | 38 | |
Repeati | 1985 – 2024 | HEAT 34Sequence analysisAdd BLAST | 40 | |
Repeati | 2026 – 2055 | HEAT 35Sequence analysisAdd BLAST | 30 | |
Repeati | 2057 – 2095 | HEAT 36Sequence analysisAdd BLAST | 39 | |
Repeati | 2097 – 2134 | HEAT 37Sequence analysisAdd BLAST | 38 | |
Repeati | 2138 – 2175 | HEAT 38Sequence analysisAdd BLAST | 38 | |
Repeati | 2206 – 2243 | HEAT 39Sequence analysisAdd BLAST | 38 | |
Repeati | 2250 – 2286 | HEAT 40Sequence analysisAdd BLAST | 37 | |
Repeati | 2290 – 2328 | HEAT 41Sequence analysisAdd BLAST | 39 | |
Repeati | 2347 – 2384 | HEAT 42Sequence analysisAdd BLAST | 38 | |
Repeati | 2392 – 2429 | HEAT 43Sequence analysisAdd BLAST | 38 | |
Repeati | 2450 – 2487 | HEAT 44Sequence analysisAdd BLAST | 38 | |
Repeati | 2506 – 2546 | HEAT 45Sequence analysisAdd BLAST | 41 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1330 – 1641 | EF3-like region1 PublicationAdd BLAST | 312 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1242, Eukaryota |
GeneTreei | ENSGT00940000153612 |
HOGENOMi | CLU_000504_2_0_1 |
InParanoidi | P33892 |
OMAi | QHRKRIR |
Family and domain databases
Gene3Di | 1.25.10.10, 3 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR033173, Gcn1 IPR022716, Gcn1_N IPR021133, HEAT_type_2 IPR034085, TOG |
PANTHERi | PTHR23346:SF7, PTHR23346:SF7, 1 hit |
Pfami | View protein in Pfam PF12074, Gcn1_N, 2 hits |
SMARTi | View protein in SMART SM01349, TOG, 1 hit |
SUPFAMi | SSF48371, SSF48371, 4 hits |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 4 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MTAILNWEDI SPVLEKGTRE SHVSKRVPFL QDISQLVRQE TLEKPQLSEI
60 70 80 90 100
AFVLLNTFTI YEDNRSKSLV TSILLDILNL EPCLLENFIR FISDVVISNP
110 120 130 140 150
ATKAVADYLN LLDWINSFLI FVSHNSNLFE EYIPKLLVAH SYATFGVETI
160 170 180 190 200
LDNQEEGKKS QDKQNQHRKR IRYCIFQTTV KAFLKCLKDN DDSISFMKIS
210 220 230 240 250
IKTVLESYSK LKITSVGVVM IMGALTQAAL QLLSRQPALH SVLKENSAEK
260 270 280 290 300
YCEYLGKEVF LGKNPPSSFC LEIGLKPFLK EFVSQELFIK FFIPNIEKAV
310 320 330 340 350
LRSPEVGFSI LSELYAGVSP EKVNLLNAFA SSKLINQYFS SFKSSKEVVR
360 370 380 390 400
SVSLQSMIIL LRKISNTDTT LEDLTKLIDE IFKNIKSNLN ADYKSLISKI
410 420 430 440 450
LIEIPLTHYE VSEKICKGLS PYIGKEGNEA ALTLMLNAFF VHYFSLGKPI
460 470 480 490 500
EDLDKIISAG FADKKPALKK CWFAAFLNNS NAASEEVILN FIDGCLEFVK
510 520 530 540 550
DSIIHYQTHG HACILASIEF TNKILALDNT ELNDRVMQLI ETLPENSSIG
560 570 580 590 600
DAILTAALST ELSIENRIHA VNLLQELFYK KPEFIGFSVI DAIERRMRVQ
610 620 630 640 650
ELIPQQNTSF KYVTSVLLAI TSELPDKEAS IKVLINALVI AQWNIFNIKN
660 670 680 690 700
GWAGLVLRAR LDPAEVVKEH ASVIMEKILE ITGSCEWIDT IYGACGLQAA
710 720 730 740 750
AYAAFIQPNE FTPILCKTIE ADLTADDFSR LSEEDFEIFA GEEGVLVVDV
760 770 780 790 800
LEESMNKKLS NKNSKEYETL MWEQKIRKEQ AKKNVKKLSK EEQELVNEQL
810 820 830 840 850
AKESAVRSHV SEISTRLKRG IRLVSELSKA ACLVQNGIAT WFPLAVTKLL
860 870 880 890 900
YLCSEPNISK LTEDVNNVFL QLSQNVSERL GNIRLFLGLA TLRVHNANGI
910 920 930 940 950
SQDYLQEPLV ELLTRVLFRI KFVSNQAAID SISLTYILPL LINVLEKGKA
960 970 980 990 1000
IALKNADKPV VKAEFVEEDE EEEHLLLAME IISVHAEAFE DPSIPRISIV
1010 1020 1030 1040 1050
EVLLSLLSLP SKAKIAKDCF NALCQSISVA PNQEDLDMIL SNLLSPNQFV
1060 1070 1080 1090 1100
RSTILETLDN EFELEPFMKY SPEVFICRFD SDPSNREIAD FIWEFNKFVV
1110 1120 1130 1140 1150
NDELLKSLFP LFNQDDSGLR LFAANAYAFG AVSLFTSEEN SSKDYLNDLL
1160 1170 1180 1190 1200
NFYKEKAKPL EPILDQFGLV LVSASEQKDP WQGRSTVAIT LKIMAKAFSA
1210 1220 1230 1240 1250
EDDTVVNIIK FLVDDGGLVD REPIVRQEMK EAGVELITLH GSQNSKDLIP
1260 1270 1280 1290 1300
IFEEALSSST DSALKENVII LYGTLARHLQ QSDARIHTII ERLLSTLDTP
1310 1320 1330 1340 1350
SADIQQAVSA CIAPLVFQFK QKVGDYLGIL MEKLLNPTVA SSMRKGAAWG
1360 1370 1380 1390 1400
IAGLVKGYGI SALSEFDIIR NLIEAAEDKK EPKRRESVGF CFQYLSESLG
1410 1420 1430 1440 1450
KFFEPYVIEI LPNILKNLGD AVPEVRDATA RATKAIMAHT TGYGVKKLIP
1460 1470 1480 1490 1500
VAVSNLDEIA WRTKRGSVQL LGNMAYLDPT QLSASLSTIV PEIVGVLNDS
1510 1520 1530 1540 1550
HKEVRKAADE SLKRFGEVIR NPEIQKLVPV LLQAIGDPTK YTEEALDSLI
1560 1570 1580 1590 1600
QTQFVHYIDG PSLALIIHII HRGMHDRSAN IKRKACKIVG NMAILVDTKD
1610 1620 1630 1640 1650
LIPYLQQLID EVEIAMVDPV PNTRATAARA LGALVERLGE EQFPDLIPRL
1660 1670 1680 1690 1700
LDTLSDESKS GDRLGSAQAL AEVISGLGLT KLDEMLPTIL AGVTNFRAYI
1710 1720 1730 1740 1750
REGFMPLLLF LPVCFGSQFA PYINQIIQPI LSGLADNDEN IRDTALKAGK
1760 1770 1780 1790 1800
LIVKNYATKA VDLLLPELER GMFDENDRIR LSSVQLTGEL LFQVTGISSR
1810 1820 1830 1840 1850
NEFSEEDGDH NGEFSGKLVD VLGQDRRDRI LAALFVCRND TSGIVRATTV
1860 1870 1880 1890 1900
DIWKALVPNT PRAVKEILPT LTGMIVTHLA SSSNVLRNIA AQTLGDLVRR
1910 1920 1930 1940 1950
VGGNALSQLL PSLEESLIET SNSDSRQGVC IALYELIESA STETISQFQS
1960 1970 1980 1990 2000
TIVNIIRTAL IDESATVREA AALSFDVFQD VVGKTAVDEV LPYLLHMLES
2010 2020 2030 2040 2050
SDNSDFALLG LQEIMSKKSD VIFPILIPTL LAPPIDAFRA SALGSLAEVA
2060 2070 2080 2090 2100
GSALYKRLSI IINALVDAII GTSEDESTKG ALELALDRVF LSVNDDEGLH
2110 2120 2130 2140 2150
PLLQQIMSLL KSDNIEKRIA VLERLPNFFD KTVLDFDVYI PNFVSHAILS
2160 2170 2180 2190 2200
LDDEDQRVVN GNFNALSTLL KKVDKPTLEK LVKPAKQSLA LTGRQGQDVA
2210 2220 2230 2240 2250
AFKLPRGPNC VLPIFLHGLM YGSNDEREES ALAIADVVSK TPAANLKPFV
2260 2270 2280 2290 2300
SVITGPLIRV VGERFSSDIK AAILFALNVL FIKIPMFLRP FIPQLQRTFV
2310 2320 2330 2340 2350
KSLSDATNET LRLRAAKALG ALIEHQPRVD PLVIELVTGA KQATDEGVKT
2360 2370 2380 2390 2400
AMLKALLEVI MKAGSKLNEN SKTNIVNLVE EEMLGSNDKL AVAYAKLIGS
2410 2420 2430 2440 2450
LSEILSNDEA HKILQDKVLN ADLDGETGKF AILTLNSFLK DAPTHIFNTG
2460 2470 2480 2490 2500
LIDEFVSYIL NAIRSPDVYF GENGTIAAGK LLLLEGEKRS PFVKKDAAEP
2510 2520 2530 2540 2550
FKIGDENINL LINELSKAVL QPASNSTDVR RLALVVIRTL ARFKFDECIK
2560 2570 2580 2590 2600
QYFDVVGPSV FSCLRDPVIP IKLAAEKAYL ALFKLVEEDD MHTFNEWFAK
2610 2620 2630 2640 2650
ISDRGNSIET VTGTTIQLRS VGDYTKRVGK RLANVERERI AAGGDAETMF
2660 2670
SDRFEDEREI WAVGGVELTT DI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12467 Genomic DNA Translation: AAA34635.1 X91837 Genomic DNA Translation: CAA62949.1 Z72717 Genomic DNA Translation: CAA96907.1 BK006941 Genomic DNA Translation: DAA07919.1 |
PIRi | A48126 |
RefSeqi | NP_011320.3, NM_001181060.3 |
Genome annotation databases
EnsemblFungii | YGL195W_mRNA; YGL195W; YGL195W |
GeneIDi | 852680 |
KEGGi | sce:YGL195W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L12467 Genomic DNA Translation: AAA34635.1 X91837 Genomic DNA Translation: CAA62949.1 Z72717 Genomic DNA Translation: CAA96907.1 BK006941 Genomic DNA Translation: DAA07919.1 |
PIRi | A48126 |
RefSeqi | NP_011320.3, NM_001181060.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 33062, 469 interactors |
ComplexPortali | CPX-1808, GCN1-GCN20 complex |
DIPi | DIP-2344N |
IntActi | P33892, 134 interactors |
MINTi | P33892 |
STRINGi | 4932.YGL195W |
PTM databases
iPTMneti | P33892 |
Proteomic databases
MaxQBi | P33892 |
PaxDbi | P33892 |
PRIDEi | P33892 |
Genome annotation databases
EnsemblFungii | YGL195W_mRNA; YGL195W; YGL195W |
GeneIDi | 852680 |
KEGGi | sce:YGL195W |
Organism-specific databases
SGDi | S000003163, GCN1 |
VEuPathDBi | FungiDB:YGL195W |
Phylogenomic databases
eggNOGi | KOG1242, Eukaryota |
GeneTreei | ENSGT00940000153612 |
HOGENOMi | CLU_000504_2_0_1 |
InParanoidi | P33892 |
OMAi | QHRKRIR |
Miscellaneous databases
PROi | PR:P33892 |
RNActi | P33892, protein |
Family and domain databases
Gene3Di | 1.25.10.10, 3 hits |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR033173, Gcn1 IPR022716, Gcn1_N IPR021133, HEAT_type_2 IPR034085, TOG |
PANTHERi | PTHR23346:SF7, PTHR23346:SF7, 1 hit |
Pfami | View protein in Pfam PF12074, Gcn1_N, 2 hits |
SMARTi | View protein in SMART SM01349, TOG, 1 hit |
SUPFAMi | SSF48371, SSF48371, 4 hits |
PROSITEi | View protein in PROSITE PS50077, HEAT_REPEAT, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GCN1_YEAST | |
Accessioni | P33892Primary (citable) accession number: P33892 Secondary accession number(s): D6VTV8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 181 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - SIMILARITY comments
Index of protein domains and families