UniProtKB - P33766 (FPR1_MOUSE)
Protein
fMet-Leu-Phe receptor
Gene
Fpr1
Organism
Mus musculus (Mouse)
Status
Functioni
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (By similarity).By similarity1 Publication
GO - Molecular functioni
- complement receptor activity Source: GO_Central
- G protein-coupled receptor activity Source: GO_Central
- G protein-coupled receptor binding Source: MGI
- N-formyl peptide receptor activity Source: MGI
- RAGE receptor binding Source: MGI
- scavenger receptor binding Source: MGI
GO - Biological processi
- chemotaxis Source: MGI
- complement receptor mediated signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: MGI
- inflammatory response Source: GO_Central
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: fMet-Leu-Phe receptorShort name: fMLP receptor Alternative name(s): N-formyl peptide receptor Short name: FPR N-formylpeptide chemoattractant receptor |
Gene namesi | Name:Fpr1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107443, Fpr1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Note: Internalizes in presence of its ligand, TAFA4.By similarity
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- cytoplasm Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 58 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 59 – 69 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 70 – 91 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 92 – 108 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 109 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 148 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 149 – 170 | Helical; Name=4Sequence analysisAdd BLAST | 22 | |
Topological domaini | 171 – 216 | ExtracellularSequence analysisAdd BLAST | 46 | |
Transmembranei | 217 – 237 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 238 – 253 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 254 – 277 | Helical; Name=6Sequence analysisAdd BLAST | 24 | |
Topological domaini | 278 – 296 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 297 – 316 | Helical; Name=7Sequence analysisAdd BLAST | 20 | |
Topological domaini | 317 – 364 | CytoplasmicSequence analysisAdd BLAST | 48 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069446 | 1 – 364 | fMet-Leu-Phe receptorAdd BLAST | 364 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 10 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 18 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 187 | PROSITE-ProRule annotation |
Post-translational modificationi
Phosphorylated; which is necessary for desensitization.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P33766 |
PaxDbi | P33766 |
PRIDEi | P33766 |
PTM databases
GlyGeni | P33766, 3 sites |
iPTMneti | P33766 |
PhosphoSitePlusi | P33766 |
Expressioni
Tissue specificityi
Expressed in neutrophils, dendritic cells, microglia, spleen, lung and liver. Low level of expression in the vomeronasal organ.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000045551, Expressed in granulocyte and 56 other tissues |
Genevisiblei | P33766, MM |
Interactioni
GO - Molecular functioni
- G protein-coupled receptor binding Source: MGI
- RAGE receptor binding Source: MGI
- scavenger receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052894 |
Chemistry databases
BindingDBi | P33766 |
Miscellaneous databases
RNActi | P33766, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | P33766 |
OMAi | GHWPFGW |
OrthoDBi | 910274at2759 |
PhylomeDBi | P33766 |
TreeFami | TF330976 |
Family and domain databases
InterProi | View protein in InterPro IPR027345, Formyl_pep_1_rcpt IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit PTHR24225:SF15, PTHR24225:SF15, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P33766-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDTNMSLLMN KSAVNLMNVS GSTQSVSAGY IVLDVFSYLI FAVTFVLGVL
60 70 80 90 100
GNGLVIWVAG FRMKHTVTTI SYLNLAIADF CFTSTLPFYI ASMVMGGHWP
110 120 130 140 150
FGWFMCKFIY TVIDINLFGS VFLIALIALD RCICVLHPVW AQNHRTVSLA
160 170 180 190 200
KKVIIVPWIC AFLLTLPVII RLTTVPNSRL GPGKTACTFD FSPWTKDPVE
210 220 230 240 250
KRKVAVTMLT VRGIIRFIIG FSTPMSIVAI CYGLITTKIH RQGLIKSSRP
260 270 280 290 300
LRVLSFVVAA FFLCWCPFQV VALISTIQVR ERLKNMTPGI VTALKITSPL
310 320 330 340 350
AFFNSCLNPM LYVFMGQDFR ERLIHSLPAS LERALTEDSA QTSDTGTNLG
360
TNSTSLSENT LNAM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22181 Unassigned DNA Translation: AAA16110.1 AK137714 mRNA Translation: BAE23472.1 CH466642 Genomic DNA Translation: EDL20512.1 |
CCDSi | CCDS28418.1 |
PIRi | A49542 |
RefSeqi | NP_038549.1, NM_013521.2 |
Genome annotation databases
Ensembli | ENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551 |
GeneIDi | 14293 |
KEGGi | mmu:14293 |
UCSCi | uc008apt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22181 Unassigned DNA Translation: AAA16110.1 AK137714 mRNA Translation: BAE23472.1 CH466642 Genomic DNA Translation: EDL20512.1 |
CCDSi | CCDS28418.1 |
PIRi | A49542 |
RefSeqi | NP_038549.1, NM_013521.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000052894 |
Chemistry databases
BindingDBi | P33766 |
ChEMBLi | CHEMBL1770037 |
GuidetoPHARMACOLOGYi | 222 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P33766, 3 sites |
iPTMneti | P33766 |
PhosphoSitePlusi | P33766 |
Proteomic databases
MaxQBi | P33766 |
PaxDbi | P33766 |
PRIDEi | P33766 |
Protocols and materials databases
Antibodypediai | 19049, 421 antibodies |
DNASUi | 14293 |
Genome annotation databases
Ensembli | ENSMUST00000061516; ENSMUSP00000052894; ENSMUSG00000045551 |
GeneIDi | 14293 |
KEGGi | mmu:14293 |
UCSCi | uc008apt.1, mouse |
Organism-specific databases
CTDi | 2357 |
MGIi | MGI:107443, Fpr1 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01010000222346 |
HOGENOMi | CLU_009579_8_0_1 |
InParanoidi | P33766 |
OMAi | GHWPFGW |
OrthoDBi | 910274at2759 |
PhylomeDBi | P33766 |
TreeFami | TF330976 |
Enzyme and pathway databases
Reactomei | R-MMU-418594, G alpha (i) signalling events R-MMU-444473, Formyl peptide receptors bind formyl peptides and many other ligands R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 14293, 2 hits in 18 CRISPR screens |
PROi | PR:P33766 |
RNActi | P33766, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000045551, Expressed in granulocyte and 56 other tissues |
Genevisiblei | P33766, MM |
Family and domain databases
InterProi | View protein in InterPro IPR027345, Formyl_pep_1_rcpt IPR000826, Formyl_rcpt-rel IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24225, PTHR24225, 1 hit PTHR24225:SF15, PTHR24225:SF15, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FPR1_MOUSE | |
Accessioni | P33766Primary (citable) accession number: P33766 Secondary accession number(s): Q3UV01 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1994 |
Last sequence update: | February 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries